{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:45:19Z","timestamp":1792601119991,"version":"4.5.0"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000764","name":"King's College London","doi-asserted-by":"publisher","award":["Scholarship - No award number"],"award-info":[{"award-number":["Scholarship - No award number"]}],"id":[{"id":"10.13039\/501100000764","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>Africa presents a higher diabetic foot ulcer prevalence estimate of 7.2% against global figures of 6.3%. Engaging family members in self-care education interventions has been shown to be effective at preventing diabetes-related foot ulcers. This study culturally adapted and tested the feasibility and acceptability of an evidence-based footcare family intervention in Ghana.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>The initial phase of the study involved stakeholder engagement, comprising Patient Public Involvement activities and interviews with key informant nurses and people with diabetes (N = 15). In the second phase, adults at risk of diabetes-related foot ulcers and nominated caregivers (N = 50 dyads) participated in an individually randomised feasibility trial of the adapted intervention (N = 25) compared to usual care (N = 25). The study aimed to assess feasibility outcomes and to identify efficacy signals on clinical outcomes at 12 weeks post randomisation. Patient reported outcomes were foot care behaviour, foot self-care efficacy, diabetes knowledge and caregiver diabetes distress.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Adjustments were made to the evidence-based intervention to reflect the literacy, information needs and preferences of stakeholders and to develop a context appropriate diabetic foot self-care intervention. A feasibility trial was then conducted which met all recruitment, retention, data quality and randomisation progression criteria. At 12 weeks post randomisation, efficacy signals favoured the intervention group on improved footcare behaviour, foot self-care efficacy, diabetes knowledge and reduced diabetes distress. Future implementation issues to consider include the staff resources needed to deliver the intervention, family members availability to attend in-person sessions and consideration of remote intervention delivery.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>A contextual family-oriented foot self-care education intervention is feasible, acceptable, and may improve knowledge and self-care with the potential to decrease diabetes-related complications. The education intervention is a strategic approach to improving diabetes care and prevention of foot disease, especially in settings with limited diabetes care resources. Future research will investigate the possibility of remote delivery to better meet patient and staff needs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p>Pan African Clinical Trials Registry (PACTR) \u2010 PACTR202201708421484: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/pactr.samrc.ac.za\/TrialDisplay.aspx?TrialID=19363\" xlink:type=\"simple\">https:\/\/pactr.samrc.ac.za\/TrialDisplay.aspx?TrialID=19363<\/jats:ext-link> or <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/pactr.samrc.ac.za\/Search.aspx\" xlink:type=\"simple\">pactr.samrc.ac.za\/Search.aspx<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0302385","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T17:35:32Z","timestamp":1715189732000},"page":"e0302385","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Improving foot self-care in people with diabetes in Ghana: A development and feasibility randomised trial of a context appropriate, family-orientated diabetic footcare intervention"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8751-7042","authenticated-orcid":true,"given":"Joseph Ngmenesegre","family":"Suglo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsty","family":"Winkley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackie","family":"Sturt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,5,8]]},"reference":[{"key":"pone.0302385.ref001","unstructured":"International Diabetes Federation. IDF Atlas 9th edition and other resources [Internet]. 2019 [cited 2021 May 24]. Available from: https:\/\/diabetesatlas.org\/en\/resources\/."},{"issue":"4","key":"pone.0302385.ref002","first-page":"35","article-title":"Assessment of Knowledge and Practice of Diabetes Mellitus Patients Regarding Foot Care in Tertiary Care Hospitals in Quetta, Pakistan","volume":"2","author":"NU Hag","year":"2017","journal-title":"Specialty J Med Res Health Sci"},{"issue":"6","key":"pone.0302385.ref003","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.12968\/bjon.2017.26.6.S6","article-title":"Foot ulceration in patients with diabetes: A risk analysis","volume":"26","author":"MA Rossaneis","year":"2017","journal-title":"British Journal of Nursing"},{"issue":"2","key":"pone.0302385.ref004","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1001\/jama.293.2.217","article-title":"Preventing foot ulcers in patients with diabetes","volume":"293","author":"N Singh","year":"2005","journal-title":"JAMA"},{"issue":"9498","key":"pone.0302385.ref005","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1016\/S0140-6736(05)67698-2","article-title":"The global burden of diabetic foot disease","volume":"366","author":"AJ Boulton","year":"2005","journal-title":"Lancet"},{"issue":"11","key":"pone.0302385.ref006","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1111\/dme.13054","article-title":"Association of diabetic foot ulcer and death in a population-based cohort from the United Kingdom","volume":"33","author":"JW Walsh","year":"2016","journal-title":"Diabetic Medicine"},{"issue":"2","key":"pone.0302385.ref007","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1080\/07853890.2016.1231932","article-title":"Global epidemiology of diabetic foot ulceration: a systematic review and meta-analysis\u2020","volume":"49","author":"P Zhang","year":"2017","journal-title":"Ann Med"},{"issue":"2","key":"pone.0302385.ref008","doi-asserted-by":"crossref","first-page":"127","DOI":"10.18821\/0023-2149-2016-94-2-127-132","article-title":"Multidisciplinary team approach for diabetic foot patients in an out-patient clinic","volume":"94","author":"E Komelyagina","year":"2016","journal-title":"Klin Med (Mosk)"},{"key":"pone.0302385.ref009","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD001488.pub4","article-title":"Patient education for preventing diabetic foot ulceration","volume":"10","author":"JA Dorresteijn","year":"2012","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"pone.0302385.ref010","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/615680","article-title":"Effects of a short educational program for the prevention of foot ulcers in high-risk patients: a randomized controlled trial","volume":"2015","author":"M Monami","year":"2015","journal-title":"Int J Endocrinol"},{"issue":"S1","key":"pone.0302385.ref011","doi-asserted-by":"crossref","first-page":"e3269","DOI":"10.1002\/dmrr.3269","article-title":"Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2019 update)","volume":"36","author":"SA Bus","year":"2020","journal-title":"Diabetes Metab Res Rev"},{"key":"pone.0302385.ref012","unstructured":"NICE. NICE GUIDELINES. 2019 [cited 2021 Dec 29]. Diabetic foot problems: prevention and management. Available from: https:\/\/www.nice.org.uk\/guidance\/ng19."},{"issue":"1","key":"pone.0302385.ref013","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/nyas.12844","article-title":"Family interventions to improve diabetes outcomes for adults","volume":"1353","author":"AA Baig","year":"2015","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"pone.0302385.ref014","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/0145721717712457","article-title":"The Impact of Social Support on Self-care of Patients With Diabetes: What Is the Effect of Diabetes Type? 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Gavin","year":"2018","journal-title":"Chronic Disease Care, Family Health Supporters are Key, But Feel Left Out"},{"issue":"7519","key":"pone.0302385.ref023","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1136\/bmj.331.7519.737","article-title":"Healer shopping in Africa: new evidence from rural-urban qualitative study of Ghanaian diabetes experiences","volume":"331","author":"A. de-Graft Aikins","year":"2005","journal-title":"BMJ"},{"key":"pone.0302385.ref024","article-title":"Caring for the chronically sick within Ga families: A study of modern innovations and traditional practices. (PhD), University of Ghana","author":"D. Atobrah","year":"2009","journal-title":"Google Nudidi"},{"key":"pone.0302385.ref025","first-page":"83","volume-title":"Prevalence and risk factors for diabetes mellitus among adults in Ghana: A systematic review and meta-analysis","author":"International Health","year":"2019"},{"key":"pone.0302385.ref026","unstructured":"World Health Organization. World Health Organization (2016) Diabetes country profile. Available from https:\/\/www.who.int\/diabetes\/country-profiles\/gha_en.pdf?ua=1 - Google Nudidi [Internet]. 2016 [cited 2021 Dec 19]. Available from: https:\/\/www.google.com\/search?q=World+Health+Organization+(2016)+Diabetes+country+profile.+Retrieved+03%2F01%2F2021+from+https%3A%2F%2Fwww.who.int%2Fdiabetes%2Fcountry-profiles%2Fgha_en.pdf%3Fua%3D1&rlz=1C1GCEA_enGB955GB955&oq=World+Health+Organization+(2016)+Diabetes+country+profile.+Retrieved+03%2F01%2F2021+from+https%3A%2F%2Fwww.who.int%2Fdiabetes%2Fcountry-profiles%2Fgha_en.pdf%3Fua%3D1&aqs=chrome..69i57.1854j0j7&sourceid=chrome&ie=UTF-8."},{"issue":"1","key":"pone.0302385.ref027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40814-023-01280-8","article-title":"Culturally adapted family intervention for people with schizophrenia in Indonesia (FUSION): a development and feasibility study protocol","volume":"9","author":"L Renwick","year":"2023","journal-title":"Pilot Feasibility Stud"},{"key":"pone.0302385.ref028","unstructured":"Ministry of Health Ghana: Medium Term Health Strategy."},{"key":"pone.0302385.ref029","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.jcjd.2011.08.002","article-title":"Two-Year Foot Care Program for Minority Patients with Type 2 Diabetes Mellitus of Zhuang Tribe in Guangxi","volume":"36","author":"R Liang","year":"2012","journal-title":"China. Can J Diabetes"},{"issue":"5","key":"pone.0302385.ref030","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.dsx.2020.05.028","article-title":"Improving clinical outcomes of diabetic foot ulcers by the 3-month self- and family management support programs in Indonesia: a randomized controlled trial study","volume":"14","author":"SA Subrata","year":"2020","journal-title":"Diabetes and metabolic syndrome: clinical research and reviews"},{"key":"pone.0302385.ref031","article-title":"Adapting interventions to new contexts\u2014the ADAPT guidance","author":"G Moore","year":"2021","journal-title":"BMJ"},{"issue":"5","key":"pone.0302385.ref032","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.dsx.2020.05.028","article-title":"Improving clinical outcomes of diabetic foot ulcers by the 3-month self- and family management support programs in Indonesia: A randomized controlled trial study","volume":"14","author":"SA Subrata","year":"2020","journal-title":"Diabetes and Metabolic Syndrome: Clinical Research and Reviews"},{"key":"pone.0302385.ref033","doi-asserted-by":"crossref","first-page":"n2061","DOI":"10.1136\/bmj.n2061","article-title":"A new framework for developing and evaluating complex interventions: update of Medical Research Council guidance","volume":"374","author":"K Skivington","year":"2021","journal-title":"BMJ"},{"issue":"1","key":"pone.0302385.ref034","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/1471-2288-10-67","article-title":"What is a pilot or feasibility study? A review of current practice and editorial policy","volume":"10","author":"M Arain","year":"2010","journal-title":"BMC Med Res Methodol"},{"issue":"2","key":"pone.0302385.ref035","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1111\/j..2002.384.doc.x","article-title":"Design and analysis of pilot studies: Recommendations for good practice","volume":"10","author":"GA Lancaster","year":"2004","journal-title":"J Eval Clin Pract"},{"issue":"3","key":"pone.0302385.ref036","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1177\/0962280215588241","article-title":"Estimating the sample size for a pilot randomised trial to minimise the overall trial sample size for the external pilot and main trial for a continuous outcome variable","volume":"25","author":"AL Whitehead","year":"2016","journal-title":"Stat Methods Med Res"},{"issue":"4","key":"pone.0302385.ref037","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/pst.185","article-title":"Sample size of 12 per group rule of thumb for a pilot study","volume":"4","author":"SA Julious","year":"2005","journal-title":"Pharm Stat"},{"issue":"2","key":"pone.0302385.ref038","first-page":"307","volume":"10","author":"G Lancaster","year":"2004","journal-title":"Design and analysis of pilot studies: recommendations for good practice. Wiley Online LibraryGA Lancaster, S Dodd, PR WilliamsonJournal of evaluation in clinical practice, 2004\u2022Wiley Online Library"},{"issue":"1","key":"pone.0302385.ref039","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/MLR.0000000000001664","article-title":"Guidelines for Designing and Evaluating Feasibility Pilot Studies","volume":"60","author":"JA Teresi","year":"2022","journal-title":"Med Care"},{"issue":"5","key":"pone.0302385.ref040","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1177\/0145721720954070","article-title":"Pilot Mobile Phone Intervention in Promoting Type 2 Diabetes Management in an Urban Area in Ghana: A Randomized Controlled Trial","volume":"46","author":"E Asante","year":"2020","journal-title":"Diabetes Educator"},{"key":"pone.0302385.ref041","doi-asserted-by":"crossref","DOI":"10.1007\/s00125-008-1110-0","article-title":"Education for secondary prevention of foot ulcers in people with diabetes: a randomised controlled trial","volume":"51","author":"NB Lincoln","year":"2008","journal-title":"Diabetologia"},{"issue":"6","key":"pone.0302385.ref042","doi-asserted-by":"crossref","first-page":"330","DOI":"10.12968\/ijtr.2011.18.6.330","article-title":"Psychometric properties of the Nottingham Assessment of Functional Footcare (NAFF)","volume":"18","author":"M Senussi","year":"2011","journal-title":"Int J Ther Rehabil"},{"issue":"3","key":"pone.0302385.ref043","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1891\/jnum.10.3.207.52564","article-title":"Developing and testing of the foot care confidence scale","volume":"10","author":"HL Sloan","year":"2002","journal-title":"J Nurs Meas"},{"issue":"1","key":"pone.0302385.ref044","doi-asserted-by":"crossref","first-page":"16","DOI":"10.2337\/diacare.24.1.16","article-title":"The Starr County Diabetes Education Study","volume":"24","author":"AA Garcia","year":"2001","journal-title":"Diabetes Care"},{"issue":"5","key":"pone.0302385.ref045","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1089\/dia.2015.0451","article-title":"Emotional distress in the partners of type 1 diabetes adults: Worries about hypoglycemia and other key concerns","volume":"18","author":"WH Polonsky","year":"2016","journal-title":"Diabetes Technol Ther"},{"issue":"1","key":"pone.0302385.ref046","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/j.1365-2648.2007.04569.x","article-title":"The qualitative content analysis process","volume":"62","author":"S Elo","year":"2008","journal-title":"J Adv Nurs"},{"issue":"1","key":"pone.0302385.ref047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1748-5908-4-50","article-title":"Fostering implementation of health services research findings into practice: A consolidated framework for advancing implementation science","volume":"4","author":"LJ Damschroder","year":"2009","journal-title":"Implementation Science"},{"key":"pone.0302385.ref048","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: A practical primer for t-tests and ANOVAs","author":"D Lakens","year":"2013","journal-title":"Front Psychol"},{"issue":"1","key":"pone.0302385.ref049","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2193-1801-2-222","article-title":"Principled missing data methods for researchers","volume":"2","author":"Y Dong","year":"2013","journal-title":"Springerplus"},{"key":"pone.0302385.ref050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40814-023-01291-5","article-title":"Recommendations for progression criteria during external randomised pilot trial design, conduct, analysis and reporting","volume":"9","author":"K Mellor","year":"2023","journal-title":"Pilot and Feasibility Studies"},{"issue":"5","key":"pone.0302385.ref051","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1007\/s13187-021-01988-2","article-title":"Stakeholder Engagement in Adoption, Implementation, and Sustainment of an Evidence-Based Intervention to Increase Mammography Adherence Among Low-Income Women","volume":"37","author":"J Holcomb","year":"2022","journal-title":"Journal of Cancer Education"},{"issue":"1","key":"pone.0302385.ref052","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13643-020-1272-5","article-title":"Protocol for the development of guidance for stakeholder engagement in health and healthcare guideline development and implementation","volume":"9","author":"J Petkovic","year":"2020","journal-title":"Syst Rev"},{"issue":"1","key":"pone.0302385.ref053","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1748-5908-7-67","article-title":"Integrating guideline development and implementation: analysis of guideline development manual instructions for generating implementation advice","volume":"7","author":"AR Gagliardi","year":"2012","journal-title":"Implementation Science"},{"issue":"3","key":"pone.0302385.ref054","first-page":"435","article-title":"The nuclearization of Ghanaian families","volume":"8","author":"A. Kpoor","year":"2015","journal-title":"Current Politics and Economics of Africa"},{"key":"pone.0302385.ref055","author":"L Silver","year":"2018","journal-title":"PEW RESEARCH CENTER"},{"key":"pone.0302385.ref056","unstructured":"Whatsapp. WhatsApp [Internet]. [cited 2023 May 6]. Available from: https:\/\/www.whatsapp.com\/."},{"issue":"6","key":"pone.0302385.ref057","doi-asserted-by":"crossref","DOI":"10.2196\/32964","article-title":"Remote Consulting in Primary Health Care in Low- and Middle-Income Countries: Feasibility Study of an Online Training Program to Support Care Delivery During the COVID-19 Pandemic","volume":"6","author":"A Downie","year":"2022","journal-title":"JMIR Form Res"},{"issue":"6","key":"pone.0302385.ref058","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/rnj.188","article-title":"Clinical Implications of Family-Centered Care in Stroke Rehabilitation","volume":"40","author":"KR Creasy","year":"2015","journal-title":"Rehabil Nurs"},{"issue":"6","key":"pone.0302385.ref059","first-page":"453","article-title":"Do family-oriented interventions reduce poststroke depression?","volume":"22","author":"KDB Vallury","year":"2016","journal-title":"A systematic review and recommendations for practice"},{"issue":"1","key":"pone.0302385.ref060","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jpainsymman.2011.03.013","article-title":"The Effectiveness of Patient-Family Carer (Couple) Intervention for the Management of Symptoms and Other Health-Related Problems in People Affected by Cancer: A Systematic Literature Search and Narrative Review","volume":"43","author":"JB Hopkinson","year":"2012","journal-title":"J Pain Symptom Manage"},{"issue":"9","key":"pone.0302385.ref061","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1007\/s11606-014-2873-2","article-title":"Effectiveness of Family and Caregiver Interventions on Patient Outcomes in Adults with Cancer: A Systematic Review","volume":"29","author":"JM Griffin","year":"2014","journal-title":"Journal of General Internal Medicine"},{"issue":"1","key":"pone.0302385.ref062","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1177\/1074840718822365","article-title":"Family Involvement in Adult Chronic Disease Care: Reviewing the Systematic Reviews","volume":"25","author":"CL Gilliss","year":"2019","journal-title":"J Fam Nurs"},{"issue":"3","key":"pone.0302385.ref063","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1037\/1091-7527.23.3.312","article-title":"The \u201crelative\u201d efficacy of involving family in psychosocial interventions for chronic illness: Are there added benefits to patients and family members?","volume":"23","author":"LM Martire","year":"2005","journal-title":"Families, Systems and Health"},{"issue":"3","key":"pone.0302385.ref064","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000286958","article-title":"Effects of Interventions Involving the Family in the Treatment of Adult Patients with Chronic Physical Diseases: A Meta-Analysis","volume":"79","author":"M Hartmann","year":"2010","journal-title":"Psychother Psychosom"},{"key":"pone.0302385.ref065","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.apnr.2017.05.009","article-title":"Contribution of family social support to the metabolic control of people with diabetes mellitus: A randomized controlled clinical trial","volume":"36","author":"LC Gomes","year":"2017","journal-title":"Applied Nursing Research"},{"issue":"4","key":"pone.0302385.ref066","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1177\/0145721717712457","article-title":"The Impact of Social Support on Self-care of Patients With Diabetes: What Is the Effect of Diabetes Type? 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Diabetic foot ulcer incidence and survival with improved diabetic foot services: an 18\u2010year study","volume":"36","author":"R Paisey","year":"2019","journal-title":"Wiley Online Library"},{"issue":"8","key":"pone.0302385.ref072","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.3899\/jrheum.130675","article-title":"ESTIMATING DISEASE PREVALENCE AND INCIDENCE USING ADMINISTRATIVE DATA: SOME ASSEMBLY REQUIRED","volume":"40","author":"MM Ward","year":"2013","journal-title":"J Rheumatol"},{"issue":"6","key":"pone.0302385.ref073","doi-asserted-by":"crossref","first-page":"2025","DOI":"10.1007\/s13300-019-00694-z","article-title":"Is There a Role for Informal Caregivers in the Management of Diabetic Foot Ulcers? 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