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The\n                      <jats:italic>CRP<\/jats:italic>\n                      gene codes for a critical component of the innate immune system and\n                      <jats:italic>CRP<\/jats:italic>\n                      variants have been reported associated with infectious disease and vaccination outcomes. We investigated possible associations between COVID-19 outcome and a limited number of candidate gene variants including rs1205.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methodology\/Principal findings<\/jats:title>\n                    <jats:p>\n                      The Strong Heart and Strong Heart Family studies have accumulated detailed genetic, cardiovascular risk and event data in geographically dispersed American Indian communities since 1988. Genotypic data and 91 COVID-19 adjudicated deaths or hospitalizations from 2\/1\/20 through 3\/1\/23 were identified among 3,780 participants in two subsets. Among 21 candidate variants including genes in the interferon response pathway,\n                      <jats:italic>APOE<\/jats:italic>\n                      ,\n                      <jats:italic>TMPRSS2<\/jats:italic>\n                      ,\n                      <jats:italic>TLR3<\/jats:italic>\n                      , the HLA complex and the ABO blood group, only rs1205, a 3\u2019 untranslated region variant in the\n                      <jats:italic>CRP<\/jats:italic>\n                      gene, showed nominally significant association in T-dominant model analyses (odds ratio 1.859, 95%CI 1.001\u20133.453, p = 0.049) after adjustment for age, sex, center, body mass index, and a history of cardiovascular disease. Within the younger subset, association with the rs1205 T-Dom genotype was stronger, both in the same adjusted logistic model and in the SOLAR analysis also adjusting for other genetic relatedness.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      A T-dominant genotype of rs1205 in the\n                      <jats:italic>CRP<\/jats:italic>\n                      gene is associated with COVID-19 death or hospitalization, even after adjustment for relevant clinical factors and potential participant relatedness. Additional study of other populations and genetic variants of this gene are warranted.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0302464","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T13:26:19Z","timestamp":1714051579000},"page":"e0302464","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic variant rs1205 is associated with COVID-19 outcomes: The Strong Heart Study and Strong Heart Family Study"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7813-0724","authenticated-orcid":true,"given":"Lyle G.","family":"Best","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7563-0774","authenticated-orcid":true,"given":"Esther","family":"Erdei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Haack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0758-7639","authenticated-orcid":true,"given":"Jack W.","family":"Kent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly M.","family":"Malloy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4025-6601","authenticated-orcid":true,"given":"Deborah E.","family":"Newman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcia","family":"O\u2019Leary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rae A.","family":"O\u2019Leary","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8324-2803","authenticated-orcid":true,"given":"Quan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Navas-Acien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Franceschini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelley A.","family":"Cole","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,4,25]]},"reference":[{"key":"pone.0302464.ref001","unstructured":"Risk for COVID-19 Infection, Hospitalization, and Death By Race\/Ethnicity, https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/covid-data\/investigations-discovery\/hospitalization-death-by-race-ethnicity.html (accessed 1\/7\/2022)."},{"issue":"7821","key":"pone.0302464.ref002","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-020-2521-4","article-title":"Factors associated with COVID-19-related death using OpenSAFELY","volume":"584","author":"EJ Williamson","year":"2020","journal-title":"Nature"},{"key":"pone.0302464.ref003","first-page":"e2283","article-title":"Systematic review of host genetic association with Covid-19 prognosis and susceptibility: What have we learned in 2020?","volume":"2","author":"JL Ferreira de Ara\u00fajo","journal-title":"Rev Med Virol. 2021 Aug"},{"issue":"6","key":"pone.0302464.ref004","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/oxfordjournals.aje.a115757","article-title":"The Strong Heart Study. 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