{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T19:55:39Z","timestamp":1768679739990,"version":"3.49.0"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T00:00:00Z","timestamp":1714694400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Network oscillation in the anterior cingulate cortex (ACC) plays a key role in attention, novelty detection and anxiety; however, its involvement in cognitive impairment caused by acute systemic inflammation is unclear. To investigate the acute effects of systemic inflammation on ACC network oscillation and cognitive function, we analyzed cytokine level and cognitive performance as well as network oscillation in the mouse ACC Cg1 region, within 4 hours after lipopolysaccharide (LPS, 30 \u03bcg\/kg) administration. While the interleukin-6 concentration in the serum was evidently higher in LPS-treated mice, the increases in the cerebral cortex interleukin-6 did not reach statistical significance. The power of kainic acid (KA)-induced network oscillation in the ACC Cg1 region slice preparation increased in LPS-treated mice. Notably, histamine, which was added <jats:italic>in vitro<\/jats:italic>, increased the oscillation power in the brain slices from LPS-untreated mice; for the LPS-treated mice, however, the effect of histamine was suppressive. In the open field test, frequency of entries into the center area showed a negative correlation with the power of network oscillation (0.3 \u03bcM of KA, theta band (3\u20138 Hz); 3.0 \u03bcM of KA, high-gamma band (50\u201380 Hz)). These results suggest that LPS-induced systemic inflammation results in increased network oscillation and a drastic change in histamine sensitivity in the ACC, accompanied by the robust production of systemic pro-inflammatory cytokines in the periphery, and that these alterations in the network oscillation and animal behavior as an acute phase reaction relate with each other. We suggest that our experimental setting has a distinct advantage in obtaining mechanistic insights into inflammatory cognitive impairment through comprehensive analyses of hormonal molecules and neuronal functions.<\/jats:p>","DOI":"10.1371\/journal.pone.0302470","type":"journal-article","created":{"date-parts":[[2024,5,3]],"date-time":"2024-05-03T17:22:53Z","timestamp":1714756973000},"page":"e0302470","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of systemic inflammation on the network oscillation in the anterior cingulate cortex and cognitive behavior"],"prefix":"10.1371","volume":"19","author":[{"given":"Ayumi","family":"Hirao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0977-792X","authenticated-orcid":true,"given":"Yasushi","family":"Hojo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gen","family":"Murakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Ito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Murakoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naonori","family":"Uozumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,5,3]]},"reference":[{"issue":"1\u20132","key":"pone.0302470.ref001","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.pain.2004.10.006","article-title":"Acute and persistent pain modulation of attention-related anterior cingulate fMRI activations","volume":"113","author":"ALH Buffington","year":"2005","journal-title":"Pain"},{"issue":"4","key":"pone.0302470.ref002","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1152\/jn.00214.2009","article-title":"Neural correlates of novel object and novel location recognition behavior in the mouse anterior cingulate cortex","volume":"102","author":"AP Weible","year":"2009","journal-title":"J Neurophysiol"},{"issue":"3","key":"pone.0302470.ref003","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/S0306-4522(01)00291-3","article-title":"Individual differences in novelty-seeking behavior in rats: A c-fos study","volume":"106","author":"M Kabbaj","year":"2001","journal-title":"Neuroscience"},{"issue":"43","key":"pone.0302470.ref004","doi-asserted-by":"crossref","first-page":"14543","DOI":"10.1523\/JNEUROSCI.3037-10.2010","article-title":"Locus ceruleus and anterior cingulate cortex sustain wakefulness in a novel environment","volume":"30","author":"HS Gompf","year":"2010","journal-title":"J Neurosci"},{"issue":"22","key":"pone.0302470.ref005","doi-asserted-by":"crossref","first-page":"4371","DOI":"10.1007\/s00213-014-3581-7","article-title":"Differential regulation of observational fear and neural oscillations by serotonin and dopamine in the mouse anterior cingulate cortex","volume":"231","author":"BS Kim","year":"2014","journal-title":"Psychopharmacology (Berl)."},{"issue":"1","key":"pone.0302470.ref006","first-page":"1","article-title":"Neurabin in the anterior cingulate cortex regulates anxiety-like behavior in adult mice","volume":"4","author":"SS Kim","year":"2011","journal-title":"Mol Brain"},{"issue":"5679","key":"pone.0302470.ref007","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1126\/science.1099745","article-title":"Neuronal Oscillations in Cortical Networks.","volume":"304","author":"B Gyorgy","year":"2004","journal-title":"Science (80-)"},{"issue":"4","key":"pone.0302470.ref008","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nrn1650","article-title":"Normal and pathological oscillatory communication in the brain","volume":"6","author":"A Schnitzler","year":"2005","journal-title":"Nat Rev Neurosci"},{"issue":"2\u20133","key":"pone.0302470.ref009","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0165-0173(98)00056-3","article-title":"EEG alpha and theta oscillations reflect cognitive and memory performance: a review and analysis","volume":"29","author":"W. 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