{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:24:41Z","timestamp":1790706281901,"version":"4.1.0"},"reference-count":191,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T00:00:00Z","timestamp":1715904000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fundamental Fund of Khon Kaen University"},{"name":"Postdoctoral Researcher Fellowship Training Program from Khon Kaen University","award":["PD2566-03"],"award-info":[{"award-number":["PD2566-03"]}]},{"name":"Centre of Research and Development of Medical Diagnostic Laboratories (CMDL), Khon Kaen University"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Meningioma is the most common primary brain tumor and many studies have evaluated numerous biomarkers for their prognostic value, often with inconsistent results. Currently, no reliable biomarkers are available to predict the survival, recurrence, and progression of meningioma patients in clinical practice. This study aims to evaluate the prognostic value of immunohistochemistry-based (IHC) biomarkers of meningioma patients. A systematic literature search was conducted up to November 2023 on PubMed, CENTRAL, CINAHL Plus, and Scopus databases. Two authors independently reviewed the identified relevant studies, extracted data, and assessed the risk of bias of the studies included. Meta-analyses were performed with the hazard ratio (HR) and 95% confidence interval (CI) of overall survival (OS), recurrence-free survival (RFS), and progression-free survival (PFS). The risk of bias in the included studies was evaluated using the Quality in Prognosis Studies (QUIPS) tool. A total of 100 studies with 16,745 patients were included in this review. As the promising markers to predict OS of meningioma patients, Ki-67\/MIB-1 (HR = 1.03, 95%CI 1.02 to 1.05) was identified to associate with poor prognosis of the patients. Overexpression of cyclin A (HR = 4.91, 95%CI 1.38 to 17.44), topoisomerase II \u03b1 (TOP2A) (HR = 4.90, 95%CI 2.96 to 8.12), p53 (HR = 2.40, 95%CI 1.73 to 3.34), vascular endothelial growth factor (VEGF) (HR = 1.61, 95%CI 1.36 to 1.90), and Ki-67 (HR = 1.33, 95%CI 1.21 to 1.46), were identified also as unfavorable prognostic biomarkers for poor RFS of meningioma patients. Conversely, positive progesterone receptor (PR) and p21 staining were associated with longer RFS and are considered biomarkers of favorable prognosis of meningioma patients (HR = 0.60, 95% CI 0.41 to 0.88 and HR = 1.89, 95%CI 1.11 to 3.20). Additionally, high expression of Ki-67 was identified as a prognosis biomarker for poor PFS of meningioma patients (HR = 1.02, 95%CI 1.00 to 1.04). Although only in single studies, KPNA2, CDK6, Cox-2, MCM7 and PCNA are proposed as additional markers with high expression that are related with poor prognosis of meningioma patients. In conclusion, the results of the meta-analysis demonstrated that PR, cyclin A, TOP2A, p21, p53, VEGF and Ki-67 are either positively or negatively associated with survival of meningioma patients and might be useful biomarkers to assess the prognosis.<\/jats:p>","DOI":"10.1371\/journal.pone.0303337","type":"journal-article","created":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T13:44:43Z","timestamp":1715953483000},"page":"e0303337","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biomarkers for prognosis of meningioma patients: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"19","author":[{"given":"Tin May","family":"Aung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chetta","family":"Ngamjarus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanakorn","family":"Proungvitaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charupong","family":"Saengboonmee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2170-4934","authenticated-orcid":true,"given":"Siriporn","family":"Proungvitaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,5,17]]},"reference":[{"key":"pone.0303337.ref001","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.3389\/fonc.2019.01472","article-title":"Recent advances in meningioma immunogenetics","volume":"9","author":"M Al-Rashed","year":"2019","journal-title":"Front. Oncol"},{"issue":"6","key":"pone.0303337.ref002","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1007\/s00401-016-1545-1","article-title":"The 2016 World Health Organization classification of tumors of the central nervous system: a summary","volume":"131","author":"DN Louis","year":"2016","journal-title":"Acta Neuropathol"},{"key":"pone.0303337.ref003","first-page":"40","article-title":"Meningioma genomics: diagnostic, prognostic, and therapeutic applications","volume":"3","author":"WL Bi","year":"2016","journal-title":"Front. Surg"},{"issue":"3","key":"pone.0303337.ref004","first-page":"319","article-title":"Meningioma: a review of epidemiology, pathology, diagnosis, treatment, and future directions","volume":"9","author":"C Ogasawara","year":"2021","journal-title":"Biomed"},{"issue":"3","key":"pone.0303337.ref005","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s11060-010-0386-3","article-title":"Epidemiology and etiology of meningioma","volume":"99","author":"J Wiemels","year":"2010","journal-title":"J. Neurooncol"},{"issue":"5","key":"pone.0303337.ref006","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/neuonc\/not325","article-title":"Proposal for a new risk stratification classification for meningioma based on patient age, WHO tumor grade, size, localization, and karyotype","volume":"16","author":"PH Domingues","year":"2014","journal-title":"Neuro Oncol"},{"key":"pone.0303337.ref007","article-title":"Primarily resected meningiomas: outcome and prognostic factors in 581 Mayo Clinic patients, 1978 through 1988","author":"SL Stafford","year":"1998","journal-title":"Mayo Clin. Proc"},{"key":"pone.0303337.ref008","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.3389\/fonc.2019.01031","article-title":"Circulating tumor biomarkers in meningiomas reveal a signature of equilibrium between tumor growth and immune modulation","volume":"9","author":"EP Erkan","year":"2019","journal-title":"Front. Oncol"},{"issue":"1","key":"pone.0303337.ref009","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1515\/med-2016-0032","article-title":"Meningioma recurrence","volume":"11","author":"T Hortob\u00e1gyi","year":"2016","journal-title":"Open Med"},{"issue":"3","key":"pone.0303337.ref010","doi-asserted-by":"crossref","first-page":"405","DOI":"10.21037\/jgo.2016.11.15","article-title":"Predictive and prognostic biomarkers in personalized gastrointestinal cancer treatment","volume":"8","author":"H Verdaguer","year":"2017","journal-title":"J Gastrointest Oncol"},{"key":"pone.0303337.ref011","doi-asserted-by":"crossref","DOI":"10.5772\/intechopen.101050","article-title":"Methods of protein detection in cancer for diagnosis, prognosis and therapy","volume":"47","author":"S Sundarraj","year":"2022","journal-title":"Protein Detection"},{"issue":"9","key":"pone.0303337.ref012","doi-asserted-by":"crossref","first-page":"e18644","DOI":"10.1097\/MD.0000000000018644","article-title":"The prognostic role of Ki-67\/MIB-1 in meningioma: a systematic review with meta-analysis","volume":"99","author":"N Liu","year":"2020","journal-title":"Medicine"},{"issue":"6","key":"pone.0303337.ref013","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1080\/02688697.2021.1940853","article-title":"Biomarkers for differentiating grade II meningiomas from grade I: a systematic review","volume":"35","author":"AA Sofela","year":"2021","journal-title":"Br. J. Neurosurg"},{"issue":"6","key":"pone.0303337.ref014","doi-asserted-by":"crossref","first-page":"707","DOI":"10.3109\/02688697.2010.522743","article-title":"Recurrence of benign meningiomas: predictive value of proliferative index, BCL2, p53, hormonal receptors and HER2 expression","volume":"25","author":"E Abdelzaher","year":"2011","journal-title":"Br. J. Neurosurg"},{"issue":"5","key":"pone.0303337.ref015","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1136\/jnnp.2007.121582","article-title":"Atypical and anaplastic meningiomas: prognostic implications of clinicopathological features","volume":"79","author":"SY Yang","year":"2008","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"1","key":"pone.0303337.ref016","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1309\/HXUNAG34B3CEFDU8","article-title":"Prognostic significance of the mitotic index using the mitosis marker anti-phosphohistone H3 in meningiomas","volume":"128","author":"YJ Kim","year":"2007","journal-title":"Am. J. Clin. Pathol"},{"issue":"3","key":"pone.0303337.ref017","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1111\/bpa.12174","article-title":"Mitotic index is an independent predictor of recurrence-free survival in meningioma","volume":"25","author":"A Olar","year":"2015","journal-title":"Brain Pathol"},{"issue":"9","key":"pone.0303337.ref018","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1053\/hupa.2001.27119","article-title":"Immunohistochemical study of Ki-67 (MIB-1), p53 protein, p21WAF1, and p27KIP1 expression in benign, atypical, and anaplastic meningiomas","volume":"32","author":"VJ Amatya","year":"2001","journal-title":"Hum. Pathol"},{"issue":"5","key":"pone.0303337.ref019","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1002\/cncr.10351","article-title":"Histopathology and MIB-1 labeling index predicted recurrence of meningiomas: a proposal of diagnostic criteria for patients with atypical meningioma","volume":"94","author":"DM Ho","year":"2002","journal-title":"Cancer"},{"issue":"1","key":"pone.0303337.ref020","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1186\/s13643-021-01626-4","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"10","author":"MJ Page","year":"2021","journal-title":"Syst Rev"},{"issue":"4","key":"pone.0303337.ref021","doi-asserted-by":"crossref","first-page":"280","DOI":"10.7326\/0003-4819-158-4-201302190-00009","article-title":"Assessing bias in studies of prognostic factors","volume":"158","author":"JA Hayden","year":"2013","journal-title":"Ann. Intern. Med"},{"key":"pone.0303337.ref022","unstructured":"Review Manager (RevMan) [Computer program]. Version 5.4.1. The Cochrane Collaboration."},{"key":"pone.0303337.ref023","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2013\/375139","article-title":"Biological and demographic profile of meningiomas in a cohort of egyptian patients: impact on tumor recurrence","author":"E Abdelzaher","year":"2013","journal-title":"Sci. World J"},{"issue":"7","key":"pone.0303337.ref024","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14071718","article-title":"The immunohistochemical loss of H3K27me3 in intracranial meningiomas predicts shorter progression-free survival after stereotactic radiosurgery","volume":"14","author":"S Ammendola","year":"2022","journal-title":"Cancers"},{"issue":"5","key":"pone.0303337.ref025","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1080\/01616412.2021.2022915","article-title":"Radiopathologic predictors of recurrence in patients with a gross totally resected atypical meningioma","volume":"44","author":"SK Anand","year":"2022","journal-title":"Neurol. Res"},{"issue":"4","key":"pone.0303337.ref026","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/PAI.0000000000001113","article-title":"Polycystin-2 Associates With Malignancy in Meningiomas","volume":"31","author":"M Assimakopoulou","year":"2023","journal-title":"Appl. Immunohistochem. Mol. Morphol"},{"key":"pone.0303337.ref027","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11060-014-1706-9","article-title":"p-CREB expression in human meningiomas: correlation with angiogenesis and recurrence risk","volume":"122","author":"V Barresi","year":"2015","journal-title":"J. Neuro Oncol"},{"key":"pone.0303337.ref028","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1007\/s00401-006-0097-1","article-title":"Caveolin-1 in meningiomas: expression and clinico-pathological correlations","volume":"112","author":"V Barresi","year":"2006","journal-title":"Acta Neuropathol"},{"issue":"3","key":"pone.0303337.ref029","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00401-016-1598-1","article-title":"Brain invasion in otherwise benign meningiomas does not predict tumor recurrence","volume":"132","author":"P Baumgarten","year":"2016","journal-title":"Acta Neuropathol"},{"issue":"8","key":"pone.0303337.ref030","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/neuonc\/noaa303","article-title":"H3K27me3 loss indicates an increased risk of recurrence in the T\u00fcbingen meningioma cohort","volume":"23","author":"F Behling","year":"2021","journal-title":"Neuro Oncol"},{"issue":"7","key":"pone.0303337.ref031","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1007\/s00432-022-04186-9","article-title":"The prognostic role of the immunohistochemical expression of S100 in meningiomas","volume":"149","author":"F Behling","year":"2023","journal-title":"J. Cancer Res. Clin. Oncol"},{"issue":"2","key":"pone.0303337.ref032","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1440-1789.2007.00750.x","article-title":"Ki-67 proliferative index predicts clinical outcome in patients with atypical or anaplastic meningioma","volume":"27","author":"J Bruna","year":"2007","journal-title":"Neuropathol"},{"issue":"4","key":"pone.0303337.ref033","first-page":"660","article-title":"Tissue thioredoxin-interacting protein expression predicted recurrence in patients with meningiomas","volume":"22","author":"Z Cai","year":"2017","journal-title":"Int. J. Oncol"},{"issue":"6","key":"pone.0303337.ref034","doi-asserted-by":"crossref","first-page":"e0217340","DOI":"10.1371\/journal.pone.0217340","article-title":"Systemic management of malignant meningiomas: A comparative survival and molecular marker analysis between Octreotide in combination with Everolimus and Sunitinib","volume":"14","author":"AF Cardona","year":"2019","journal-title":"PLoS One"},{"key":"pone.0303337.ref035","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.wneu.2016.01.055","article-title":"World Health Organization grade II meningioma: A 10-year retrospective study for recurrence and prognostic factor assessment","volume":"89","author":"C Champeaux","year":"2016","journal-title":"World Neurosurg"},{"issue":"4","key":"pone.0303337.ref036","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neuchi.2017.03.004","article-title":"Atypical meningioma. A study on recurrence and disease-specific survival","volume":"63","author":"C Champeaux","year":"2017","journal-title":"Neurochir"},{"issue":"3","key":"pone.0303337.ref037","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1227\/neu.0000000000002457","article-title":"Novel postoperative serum biomarkers in atypical meningiomas: A multicenter study","volume":"93","author":"WI Chang","year":"2023","journal-title":"Neurosurgery"},{"key":"pone.0303337.ref038","article-title":"Establishment and validation of an integrated model to predict postoperative recurrence in patients with atypical meningioma","volume":"11","author":"XY Chen","year":"2021","journal-title":"Front. Oncol"},{"issue":"1","key":"pone.0303337.ref039","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1097\/COC.0000000000000224","article-title":"Prognostic value of Ki-67 labeling index and postoperative radiotherapy in WHO grade II meningioma","volume":"41","author":"Y Choi","year":"2018","journal-title":"Am. J. Clin. Oncol"},{"issue":"1","key":"pone.0303337.ref040","doi-asserted-by":"crossref","first-page":"16432","DOI":"10.1038\/s41598-021-95956-x","article-title":"WHO grade I meningiomas that show regrowth after gamma knife radiosurgery often show 1p36 loss","volume":"11","author":"PJJ Damen","year":"2021","journal-title":"Sci Rep"},{"key":"pone.0303337.ref041","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.clinimag.2020.01.009","article-title":"A practical predictor of the growth potential of benign meningiomas: Hypointensity of surface layer in T2-weighted magnetic resonance imaging","volume":"62","author":"S Deguchi","year":"2020","journal-title":"Clin. imaging"},{"issue":"19","key":"pone.0303337.ref042","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911690","article-title":"Dissecting stemness in aggressive intracranial meningiomas: prognostic role of SOX2 expression","volume":"23","author":"R Di Bonaventura","year":"2022","journal-title":"Int J Mol Sci"},{"key":"pone.0303337.ref043","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s00701-016-2900-7","article-title":"A study of prognostic factors in 45 cases of atypical meningioma","volume":"158","author":"T Endo","year":"2016","journal-title":"Acta Neurochir"},{"issue":"2","key":"pone.0303337.ref044","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15020535","article-title":"A high MCM6 proliferative index in atypical meningioma Is associated with shorter progression free and overall survivals","volume":"15","author":"G Gauchotte","year":"2023","journal-title":"Cancers"},{"issue":"4","key":"pone.0303337.ref045","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1002\/path.4916","article-title":"Cytoplasmic overexpression of RNA-binding protein HuR is a marker of poor prognosis in meningioma, and HuR knockdown decreases meningioma cell growth and resistance to hypoxia","volume":"242","author":"G Gauchotte","year":"2017","journal-title":"J. Pathol"},{"issue":"7","key":"pone.0303337.ref046","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1093\/jnen\/nlaa038","article-title":"Prognostic value of histopathological features and loss of H3K27me3 immunolabeling in anaplastic meningioma: a multicenter retrospective study","volume":"79","author":"G Gauchotte","year":"2020","journal-title":"J. Neuropathol. Exp. Neurol"},{"issue":"2","key":"pone.0303337.ref047","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11060-014-1423-4","article-title":"Karyopherin a2 and chromosome region maintenance protein 1 expression in meningiomas: novel biomarkers for recurrence and malignant progression","volume":"118","author":"K Gousias","year":"2014","journal-title":"J. Neurooncol"},{"issue":"3","key":"pone.0303337.ref048","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1007\/s11060-016-2205-y","article-title":"Expression of p40 (\u0394Np63) protein in meningiomas, an unexpected finding: immunohistochemical study and evaluation of its possible prognostic role","volume":"129","author":"E Guadagno","year":"2016","journal-title":"J. Neurooncol"},{"issue":"5","key":"pone.0303337.ref049","doi-asserted-by":"crossref","first-page":"e37204","DOI":"10.1371\/journal.pone.0037204","article-title":"EGFR soluble isoforms and their transcripts are expressed in meningiomas","volume":"7","author":"A Guillaudeau","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"pone.0303337.ref050","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1007\/s11060-016-2256-0","article-title":"Expression and prognostic impact of immune modulatory molecule PD-L1 in meningioma","volume":"130","author":"SJ Han","year":"2016","journal-title":"J. Neurooncol"},{"issue":"6","key":"pone.0303337.ref051","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1365-2990.1998.00150.x","article-title":"MIB-1 (Ki-67) index and transforming growth factor-alpha (TGF alpha) immunoreactivity are significant prognostic predictors for meningiomas","volume":"24","author":"DW Hsu","year":"1998","journal-title":"Neuropathol. Appl. Neurobiol"},{"issue":"2","key":"pone.0303337.ref052","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s11060-022-04169-3","article-title":"Loss of H3K27me3 expression enriches in recurrent grade 1 & 2 meningiomas and maintains as a biomarker stratifying progression risk","volume":"161","author":"L Hua","year":"2023","journal-title":"J. Neurooncol"},{"issue":"2","key":"pone.0303337.ref053","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s11060-020-03440-9","article-title":"Long-term outcomes of multimodality management for parasagittal meningiomas","volume":"147","author":"L Hua","year":"2020","journal-title":"J. Neurooncol"},{"issue":"6","key":"pone.0303337.ref054","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.3171\/2017.2.JNS162566","article-title":"Prognostic value of estrogen receptor in WHO Grade III meningioma: a long-term follow-up study from a single institution","volume":"128","author":"L Hua","year":"2017","journal-title":"J. Neurosurg"},{"issue":"1","key":"pone.0303337.ref055","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1227\/NEU.0b013e3182567886","article-title":"Predicting outcomes of patients with intracranial meningiomas using molecular markers of hypoxia, vascularity, and proliferation","volume":"71","author":"R Jensen","year":"2012","journal-title":"Neurosurg"},{"issue":"3","key":"pone.0303337.ref056","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/jso.22141","article-title":"A study of UbcH10 expression and its association with recurrence of meningiomas","volume":"106","author":"L Jiang","year":"2012","journal-title":"J. Surg. Oncol"},{"key":"pone.0303337.ref057","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.humpath.2021.06.005","article-title":"The substantial loss of H3K27me3 can stratify risk in grade 2, but not in grade 3 meningioma","volume":"115","author":"M Jung","year":"2021","journal-title":"Hum. Pathol"},{"issue":"4","key":"pone.0303337.ref058","first-page":"411","article-title":"Primary resected meningiomas: relapses and proliferation markers","volume":"18","author":"J-P Kalala","year":"2004","journal-title":"In Vivo"},{"issue":"3","key":"pone.0303337.ref059","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3171\/2016.10.JNS161825","article-title":"Microvascularization of grade I meningiomas: effect on tumor volume, blood loss, and patient outcome","volume":"128","author":"M Karsy","year":"2018","journal-title":"J. Neurosurg"},{"issue":"6","key":"pone.0303337.ref060","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1007\/s00401-018-1844-9","article-title":"Loss of histone H3K27me3 identifies a subset of meningiomas with increased risk of recurrence","volume":"135","author":"LM Katz","year":"2018","journal-title":"Acta Neuropathol"},{"issue":"2","key":"pone.0303337.ref061","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s11060-014-1441-2","article-title":"Decreased expression of LASS2 is associated with worse prognosis in meningiomas","volume":"118","author":"RH Ke","year":"2014","journal-title":"J. Neurooncol"},{"issue":"4","key":"pone.0303337.ref062","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.3171\/2016.11.JNS16913","article-title":"Histopathological prognostic factors of recurrence following definitive therapy for atypical and malignant meningiomas","volume":"128","author":"D Kim","year":"2018","journal-title":"J. Neurosurg"},{"issue":"5","key":"pone.0303337.ref063","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1159\/000338253","article-title":"Radiosurgery for atypical and anaplastic meningiomas: histopathological predictors of local tumor control","volume":"90","author":"JW Kim","year":"2012","journal-title":"Stereotact. Funct. Neurosurg"},{"issue":"5","key":"pone.0303337.ref064","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.3171\/2014.7.JNS132661","article-title":"Results of immunohistochemical staining for cell cycle regulators predict the recurrence of atypical meningiomas","volume":"121","author":"MS Kim","year":"2014","journal-title":"J. Neurosurg"},{"key":"pone.0303337.ref065","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s00428-006-0285-3","article-title":"Histopathologic indicators of recurrence in meningiomas: correlation with clinical and genetic parameters","volume":"449","author":"Y-J Kim","year":"2006","journal-title":"Virchows Archiv"},{"issue":"3","key":"pone.0303337.ref066","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1016\/j.wneu.2015.04.033","article-title":"Atypical meningiomas: recurrence, reoperation, and radiotherapy","volume":"84","author":"DR Klinger","year":"2015","journal-title":"World Neurosurg"},{"issue":"3","key":"pone.0303337.ref067","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1046\/j.1365-2559.2003.01712.x","article-title":"Hormone receptors in non-malignant meningiomas correlate with apoptosis, cell proliferation and recurrence-free survival","volume":"43","author":"AE Konstantinidou","year":"2003","journal-title":"Histopathology"},{"issue":"9","key":"pone.0303337.ref068","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.5858\/2002-126-1079-DTIACA","article-title":"DNA topoisomerase II-\u03b1 and cyclin A immunoexpression in meningiomas and its prognostic significance: an analysis of 263 cases","volume":"126","author":"A Korshunov","year":"2002","journal-title":"Arch. Pathol. Lab. Med"},{"issue":"6","key":"pone.0303337.ref069","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/ijc.11013","article-title":"Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome","volume":"104","author":"A Korshunov","year":"2003","journal-title":"Int. J. Cancer"},{"issue":"2","key":"pone.0303337.ref070","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.prp.2014.11.002","article-title":"WHO grade related expression of TRAIL-receptors and apoptosis regulators in meningioma","volume":"211","author":"R Koschny","year":"2015","journal-title":"Pathol Res Pract"},{"issue":"12","key":"pone.0303337.ref071","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1111\/apm.12995","article-title":"Higher expression of beclin 1 in human meningiomas is related to better clinical outcome and pathological grade","volume":"127","author":"KL Kuo","year":"2019","journal-title":"APMIS"},{"issue":"1","key":"pone.0303337.ref072","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/s00701-015-2635-x","article-title":"Clinical features of clear cell meningioma: a retrospective study of 36 cases among 10,529 patients in a single institution","volume":"158","author":"P Li","year":"2016","journal-title":"Acta Neurochir"},{"issue":"12","key":"pone.0303337.ref073","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1093\/jnen\/nlw095","article-title":"Endothelial cell hypertrophy and microvascular proliferation in meningiomas are correlated with higher histological grade and shorter progression-free survival","volume":"75","author":"C Ling","year":"2016","journal-title":"J. Neuropathol. Exp. Neurol"},{"key":"pone.0303337.ref074","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.clineuro.2017.06.003","article-title":"STMN1 as a candidate gene associated with atypical meningioma progression","volume":"159","author":"H Liu","year":"2017","journal-title":"Clin. Neurol. Neurosurg"},{"key":"pone.0303337.ref075","doi-asserted-by":"crossref","first-page":"e1056","DOI":"10.1016\/j.wneu.2021.01.016","article-title":"High expression of Sp1 is associated with recurrence of meningioma","volume":"149","author":"PC Liu","year":"2021","journal-title":"World Neurosurg"},{"issue":"2","key":"pone.0303337.ref076","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1007\/s10143-019-01093-5","article-title":"Clinical and histopathological predictors of outcome in malignant meningioma","volume":"43","author":"AD Maier","year":"2020","journal-title":"Neurosurg. Rev"},{"issue":"1","key":"pone.0303337.ref077","doi-asserted-by":"crossref","first-page":"106","DOI":"10.3171\/2015.1.JNS142228","article-title":"Benign meningiomas (WHO grade I) with atypical histological features: correlation of histopathological features with clinical outcomes","volume":"124","author":"AE Marciscano","year":"2016","journal-title":"J. Neurosurg"},{"key":"pone.0303337.ref078","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1007\/s004010050458","article-title":"Clinical and histopathological analysis of proliferative potentials of recurrent and non-recurrent meningiomas","volume":"91","author":"A Matsuno","year":"1996","journal-title":"Acta Neuropathol"},{"issue":"6","key":"pone.0303337.ref079","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1093\/neuros\/nyaa226","article-title":"The Ki-67 proliferation index as a marker of time to recurrence in intracranial meningioma","volume":"87","author":"C Mirian","year":"2020","journal-title":"Neurosurgery"},{"issue":"6","key":"pone.0303337.ref080","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1007\/s10735-021-10025-x","article-title":"Heat shock factor 1 in brain tumors: a link with transient receptor potential channels TRPV1 and TRPA1","volume":"52","author":"A Moutafidi","year":"2021","journal-title":"J. Mol. Histol"},{"issue":"1","key":"pone.0303337.ref081","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00129039-200303000-00002","article-title":"Prognostic significance of cyclin A expression in meningiomas","volume":"11","author":"H Nakabayashi","year":"2003","journal-title":"Appl. Immunohistochem. Mol. Morphol"},{"issue":"2","key":"pone.0303337.ref082","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/s10014-009-0251-2","article-title":"Recurrence and regrowth of benign meningiomas","volume":"26","author":"S Nakasu","year":"2009","journal-title":"Brain tumor pathol"},{"issue":"5\u20136","key":"pone.0303337.ref083","first-page":"216","article-title":"Risk factors for regrowth of intracranial meningiomas after gamma knife radiosurgery: importance of the histopathological grade and MIB-1 index","volume":"52","author":"K Nakaya","year":"2009","journal-title":"Minim. Invasive Surg"},{"key":"pone.0303337.ref084","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jocn.2016.02.021","article-title":"Outcome of resection of WHO Grade II meningioma and correlation of pathological and radiological predictive factors for recurrence","volume":"31","author":"A Nanda","year":"2016","journal-title":"J. Clin. Neurosci"},{"issue":"8","key":"pone.0303337.ref085","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1093\/neuonc\/noab036","article-title":"Loss of H3K27me3 in meningiomas","volume":"23","author":"F Nassiri","year":"2021","journal-title":"Neuro Oncol"},{"issue":"1","key":"pone.0303337.ref086","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s11060-020-03688-1","article-title":"Resected WHO grade I meningioma and predictors of local control","volume":"152","author":"K Nowak-Choi","year":"2021","journal-title":"J. Neurooncol"},{"issue":"5","key":"pone.0303337.ref087","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.3171\/2010.11.JNS10701","article-title":"Long-term surgical outcome and biological prognostic factors in patients with skull base meningiomas","volume":"114","author":"S Ohba","year":"2011","journal-title":"J. Neurosurg"},{"issue":"3","key":"pone.0303337.ref088","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1007\/s00401-017-1678-x","article-title":"Global epigenetic profiling identifies methylation subgroups associated with recurrence-free survival in meningioma","volume":"133","author":"A Olar","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"1","key":"pone.0303337.ref089","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3171\/2012.3.JNS111945","article-title":"Significance of Simpson grading system in modern meningioma surgery: integration of the grade with MIB-1 labeling index as a key to predict the recurrence of WHO Grade I meningiomas","volume":"117","author":"S Oya","year":"2012","journal-title":"J. Neurosurg"},{"issue":"1","key":"pone.0303337.ref090","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-19308-y","article-title":"Kinome and phosphoproteome of high-grade meningiomas reveal AKAP12 as a central regulator of aggressiveness and its possible role in progression","volume":"8","author":"CA Parada","year":"2018","journal-title":"Sci. Rep"},{"issue":"1","key":"pone.0303337.ref091","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1158\/1078-0432.CCR-18-0641","article-title":"Phosphoproteomic and kinomic signature of clinically aggressive grade I (1.5) meningiomas reveals RB1 signaling as a novel mediator and biomarker","volume":"26","author":"CA Parada","year":"2020","journal-title":"Clin. Cancer Res"},{"issue":"6","key":"pone.0303337.ref092","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.3171\/2022.3.JNS2299","article-title":"Regrowth factors of WHO grade I skull base meningiomas following incomplete resection","volume":"137","author":"HH Park","year":"2022","journal-title":"J. Neurosurg"},{"issue":"11","key":"pone.0303337.ref093","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2262::AID-CNCR23>3.0.CO;2-R","article-title":"The prognostic significance of MIB-1, p53, and DNA flow cytometry in completely resected primary meningiomas","volume":"82","author":"A Perry","year":"1998","journal-title":"Cancer"},{"issue":"5","key":"pone.0303337.ref094","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/01.coc.0000128724.63600.c7","article-title":"Role of her-2\/neu overexpression and clinical features at presentation as predictive factors in meningiomas","volume":"27","author":"A Potti","year":"2004","journal-title":"Am. J. Clin. Oncol"},{"key":"pone.0303337.ref095","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jocn.2021.01.009","article-title":"Value of KI-67\/MIB-1 labeling index and simpson grading system to predict the recurrence of WHO grade I intracranial meningiomas compared to WHO grade II","volume":"86","author":"R Prat-Ac\u00edn","year":"2021","journal-title":"J. Clin. Neurosci"},{"issue":"1","key":"pone.0303337.ref096","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3171\/2022.9.JNS221530","article-title":"Progesterone receptor expression and prediction of benefits of adjuvant radiotherapy in de novo atypical meningiomas after gross-total resection","volume":"139","author":"L Ren","year":"2022","journal-title":"J. Neurosurg"},{"issue":"1","key":"pone.0303337.ref097","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00701-003-0173-4","article-title":"The Ki-67 proliferation antigen in meningiomas. Experience in 600 cases","volume":"146","author":"F Roser","year":"2004","journal-title":"Acta Neurochir"},{"issue":"2","key":"pone.0303337.ref098","doi-asserted-by":"crossref","first-page":"133","DOI":"10.5114\/fn.2020.96970","article-title":"Altered expression of epigenetic modifiers EZH2, H3K27me3, and DNA methyltransferases in meningiomas\u2014prognostic biomarkers for routine practice","volume":"58","author":"S Samal","year":"2020","journal-title":"Folia Neuropathol"},{"issue":"1","key":"pone.0303337.ref099","first-page":"14","article-title":"Chromosome 1p36 loss and COX-2 overexpression predict recurrence-free survival in completely removed meningioma grade I and II","volume":"46","author":"J Sanz","year":"2013","journal-title":"Rev. Esp. Patol"},{"issue":"26","key":"pone.0303337.ref100","doi-asserted-by":"crossref","first-page":"e7385","DOI":"10.1097\/MD.0000000000007385","article-title":"Prognostic factors for patients with World Health Organization grade III meningiomas treated at a single center","volume":"96","author":"B Shan","year":"2017","journal-title":"Medicine"},{"key":"pone.0303337.ref101","article-title":"The preferred locations of meningioma according to different biological characteristics based on Voxel-Wise analysis","volume":"10","author":"C Sun","year":"2020","journal-title":"Front. Oncol"},{"issue":"6","key":"pone.0303337.ref102","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1111\/bpa.12884","article-title":"Pediatric meningioma: a clinicopathologic and molecular study with potential grading implications","volume":"30","author":"A Toland","year":"2020","journal-title":"Brain Pathol"},{"issue":"5","key":"pone.0303337.ref103","article-title":"Nrf2 expressions correlate with WHO grades in gliomas and meningiomas","volume":"17","author":"WC Tsai","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"4","key":"pone.0303337.ref104","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1097\/PAI.0000000000000422","article-title":"Applying DDX3X biomarker to discriminate atypical from benign meningiomas in tissue microarray","volume":"26","author":"W-C Tsai","year":"2018","journal-title":"Appl. Immunohistochem. Mol. Morphol"},{"key":"pone.0303337.ref105","doi-asserted-by":"crossref","first-page":"e520","DOI":"10.1016\/j.wneu.2018.11.201","article-title":"Meningiomas display a specific immunoexpression pattern in a rostrocaudal gradient: an analysis of 366 patients","volume":"123","author":"E \u00dclgen","year":"2019","journal-title":"World Neurosurg"},{"issue":"1","key":"pone.0303337.ref106","article-title":"Genomic markers of recurrence risk in atypical meningioma following gross total resection","volume":"5","author":"RA Vaubel","year":"2023","journal-title":"Neuro-oncol. Adv"},{"issue":"4","key":"pone.0303337.ref107","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1227\/NEU.0b013e3181eb95b7","article-title":"Mitotic count, brain invasion, and location are independent predictors of recurrence-free survival in primary atypical and malignant meningiomas: a study of 86 patients","volume":"67","author":"A Vranic","year":"2010","journal-title":"Neurosurgery"},{"issue":"9","key":"pone.0303337.ref108","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.ejso.2014.02.243","article-title":"AKT2 expression in histopathologic grading and recurrence of meningiomas","volume":"40","author":"Q Wang","year":"2014","journal-title":"Eur J Surg Oncol"},{"issue":"5","key":"pone.0303337.ref109","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3171\/2012.7.PEDS12179","article-title":"Clinical features and treatment of World Health Organization grade II and III meningiomas in childhood: report of 23 cases","volume":"10","author":"XQ Wang","year":"2012","journal-title":"J. Neurosurg. Pediatr"},{"issue":"5","key":"pone.0303337.ref110","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1227\/NEU.0000000000000133","article-title":"Intracranial papillary meningioma: a clinicopathologic study of 30 cases at a single institution","volume":"73","author":"X-Q Wang","year":"2013","journal-title":"Neurosurgery"},{"issue":"4","key":"pone.0303337.ref111","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1093\/ajcp\/aqw141","article-title":"Phosphohistone-H3 proliferation index is superior to mitotic index and MIB-1 expression as a predictor of recurrence in human meningiomas. Am","volume":"146","author":"TL Winther","year":"2016","journal-title":"J. Clin. Pathol"},{"issue":"3","key":"pone.0303337.ref112","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s11060-016-2329-0","article-title":"MCM7 expression is a promising predictor of recurrence in patients surgically resected for meningiomas","volume":"131","author":"TL Winther","year":"2017","journal-title":"J. Neurooncol"},{"issue":"5","key":"pone.0303337.ref113","doi-asserted-by":"crossref","first-page":"e97108","DOI":"10.1371\/journal.pone.0097108","article-title":"Prognostic factors for survival in patients with high-grade meningioma and recurrence-risk stratification for application of radiotherapy","volume":"9","author":"S Yamaguchi","year":"2014","journal-title":"PLoS One"},{"issue":"6","key":"pone.0303337.ref114","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1093\/neuonc\/noab015","article-title":"Roles for hENT1 and dCK in gemcitabine sensitivity and malignancy of meningioma","volume":"23","author":"M Yamamoto","year":"2021","journal-title":"Neuro Oncol"},{"issue":"5","key":"pone.0303337.ref115","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1002\/1097-0142(20000901)89:5<1102::AID-CNCR20>3.0.CO;2-L","article-title":"Recurrence of meningiomas: influence of vascular endothelial growth factor expression","volume":"89","author":"F Yamasaki","year":"2000","journal-title":"Cancer"},{"issue":"1","key":"pone.0303337.ref116","doi-asserted-by":"crossref","first-page":"59","DOI":"10.4103\/0973-1482.148708","article-title":"Atypical meningioma: randomized trials are required to resolve contradictory retrospective results regarding the role of adjuvant radiotherapy","volume":"11","author":"H Yoon","year":"2015","journal-title":"J Cancer Res Ther"},{"issue":"1","key":"pone.0303337.ref117","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1186\/s12885-022-10249-4","article-title":"Programmed death ligand 1 and tumor-infiltrating CD8(+) T lymphocytes are associated with the clinical features in meningioma","volume":"22","author":"Y Zhang","year":"2022","journal-title":"BMC Cancer"},{"issue":"4","key":"pone.0303337.ref118","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.jocn.2014.10.023","article-title":"Analysis of prognostic factors and treatment of anaplastic meningioma in China","volume":"22","author":"H Zhu","year":"2015","journal-title":"J. Clin. Neurosci"},{"issue":"12 Suppl 2","key":"pone.0303337.ref119","doi-asserted-by":"crossref","first-page":"iii1","DOI":"10.1093\/neuonc\/noab200","article-title":"CBTRUS Statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2014\u20132018","volume":"23","author":"QT Ostrom","year":"2021","journal-title":"Neuro Oncol"},{"issue":"12","key":"pone.0303337.ref120","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1093\/neuonc\/nox101","article-title":"Diagnostic challenges in meningioma","volume":"19","author":"M Nowosielski","year":"2017","journal-title":"Neuro Oncol"},{"issue":"6","key":"pone.0303337.ref121","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1227\/01.NEU.0000188281.91351.B9","article-title":"Epidemiology of intracranial meningioma","volume":"57","author":"EB Claus","year":"2005","journal-title":"Neurosurgery"},{"issue":"1","key":"pone.0303337.ref122","doi-asserted-by":"crossref","first-page":"1","DOI":"10.54029\/2023wxj","article-title":"Estrogen and progesterone in meningioma: Bridging the gap of knowledge","volume":"28","author":"S Ichwan","year":"2023","journal-title":"Neurol. Asia"},{"key":"pone.0303337.ref123","doi-asserted-by":"crossref","first-page":"611218","DOI":"10.3389\/fonc.2021.611218","article-title":"Progesterone receptor expression in meningiomas: pathological and prognostic implications","volume":"11","author":"F Maiuri","year":"2021","journal-title":"Front Oncol"},{"issue":"3","key":"pone.0303337.ref124","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15030980","article-title":"Hormone receptor expression in meningiomas: a systematic review","volume":"15","author":"M Agopiantz","year":"2023","journal-title":"Cancers"},{"key":"pone.0303337.ref125","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1016\/j.wneu.2020.04.168","article-title":"New insights into expression of hormonal receptors by meningiomas","volume":"140","author":"S Portet","year":"2020","journal-title":"World Neurosurg"},{"issue":"3","key":"pone.0303337.ref126","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1002\/j.1460-2075.1992.tb05135.x","article-title":"Cyclin A is required at two points in the human cell cycle","volume":"11","author":"M Pagano","year":"1992","journal-title":"EMBO J"},{"key":"pone.0303337.ref127","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1007\/s00018-002-8510-y","article-title":"Cyclin A in cell cycle control and cancer","volume":"59","author":"C Yam","year":"2002","journal-title":"Cell. Mol. Life Sci"},{"issue":"6562","key":"pone.0303337.ref128","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/379225a0","article-title":"Structure and mechanism of DNA topoisomerase II","volume":"379","author":"JM Berger","year":"1996","journal-title":"Nature"},{"issue":"4","key":"pone.0303337.ref129","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S1470-2045(02)00715-5","article-title":"Culprit and victim\u2014DNA topoisomerase II","volume":"3","author":"U Kellner","year":"2002","journal-title":"Lancet Oncol"},{"issue":"6","key":"pone.0303337.ref130","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1158\/1535-7163.MCT-06-0163","article-title":"Is p21 an oncogene?","volume":"5","author":"AL Gartel","year":"2006","journal-title":"Mol. Cancer Ther"},{"issue":"8","key":"pone.0303337.ref131","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1038\/nrm3629","article-title":"Control of cell cycle transcription during G1 and S phases","volume":"14","author":"C Bertoli","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol"},{"key":"pone.0303337.ref132","first-page":"6520259","article-title":"Clinical and Prognostic Implications of P21 (WAF1\/CIP1) Expression in Patients with Esophageal Cancer: A Systematic Review and Meta-Analysis","volume":"2020","author":"J Wu","year":"2020","journal-title":"Dis Markers"},{"issue":"1","key":"pone.0303337.ref133","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1128\/MMBR.68.1.109-131.2004","article-title":"Eukaryotic MCM proteins: beyond replication initiation","volume":"68","author":"SL Forsburg","year":"2004","journal-title":"Microbiol. Mol. Biol. Rev"},{"key":"pone.0303337.ref134","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.humpath.2018.04.024","article-title":"Overexpression of MCM6 predicts poor survival in patients with glioma","volume":"78","author":"H-Q Cai","year":"2018","journal-title":"Hum. pathol"},{"key":"pone.0303337.ref135","first-page":"1","article-title":"MCM family in HCC: MCM6 indicates adverse tumor features and poor outcomes and promotes S\/G2 cell cycle progression","volume":"18","author":"Z Liu","year":"2018","journal-title":"BMC cancer"},{"key":"pone.0303337.ref136","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s00428-017-2278-9","article-title":"Minichromosome maintenance complex component 6 (MCM6) expression correlates with histological grade and survival in endometrioid endometrial adenocarcinoma","volume":"472","author":"J Hotton","year":"2018","journal-title":"Virchows Archiv"},{"issue":"3","key":"pone.0303337.ref137","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/cr.2011.22","article-title":"Regulation of chromatin by histone modifications","volume":"21","author":"AJ Bannister","year":"2011","journal-title":"Cell Res"},{"issue":"7","key":"pone.0303337.ref138","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/S0092-8674(02)00798-5","article-title":"Histone methylation: dynamic or static?","volume":"109","author":"AJ Bannister","year":"2002","journal-title":"Cell"},{"issue":"1","key":"pone.0303337.ref139","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/s41467-019-09140-x","article-title":"H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2\/me3 and is essential for glioma tumorigenesis","volume":"10","author":"AS Harutyunyan","year":"2019","journal-title":"Nat. Commun"},{"issue":"1","key":"pone.0303337.ref140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12885-017-3256-y","article-title":"Global analysis of H3K27me3 as an epigenetic marker in prostate cancer progression","volume":"17","author":"M Ngollo","year":"2017","journal-title":"BMC Cancer"},{"issue":"1","key":"pone.0303337.ref141","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/modpathol.2015.134","article-title":"Loss of H3K27 trimethylation distinguishes malignant peripheral nerve sheath tumors from histologic mimics","volume":"29","author":"I-M Schaefer","year":"2016","journal-title":"Mod Pathol"},{"issue":"1","key":"pone.0303337.ref142","doi-asserted-by":"crossref","first-page":"59","DOI":"10.7150\/ijbs.8.59","article-title":"EZH2 methyltransferase and H3K27 methylation in breast cancer","volume":"8","author":"KH Yoo","year":"2012","journal-title":"Int. J. Biol. Sci"},{"key":"pone.0303337.ref143","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.wneu.2022.04.048","article-title":"The emerging relevance of H3K27 trimethylation loss in meningioma: a systematic review of recurrence and overall survival with meta-analysis","volume":"163","author":"VM Lu","year":"2022","journal-title":"World Neurosurg"},{"issue":"1","key":"pone.0303337.ref144","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/nrm3722","article-title":"Control of apoptosis by the BCL-2 protein family: implications for physiology and therapy","volume":"15","author":"PE Czabotar","year":"2014","journal-title":"Nat Rev Mol Cell Biol"},{"key":"pone.0303337.ref145","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1007\/s00432-016-2144-1","article-title":"Hematologic malignancies: newer strategies to counter the BCL-2 protein","volume":"142","author":"AS Ebrahim","year":"2016","journal-title":"J. Cancer Res. Clin. Oncol"},{"issue":"1","key":"pone.0303337.ref146","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0092-8674(86)90362-4","article-title":"Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2\/immunoglobulin transcript resulting from the t (14; 18) translocation","volume":"47","author":"ML Cleary","year":"1986","journal-title":"Cell"},{"issue":"4678","key":"pone.0303337.ref147","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1126\/science.6093263","article-title":"Cloning of the chromosome breakpoint of neoplastic B cells with the t (14; 18) chromosome translocation","volume":"226","author":"Y Tsujimoto","year":"1984","journal-title":"Science"},{"key":"pone.0303337.ref148","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1186\/1471-2407-8-153","article-title":"Meta-analysis confirms BCL2 is an independent prognostic marker in breast cancer","volume":"8","author":"GM Callagy","year":"2008","journal-title":"BMC Cancer"},{"issue":"1","key":"pone.0303337.ref149","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s12032-014-0389-6","article-title":"Bcl-2 expression and patient survival in gastric cancer: a systematic review of the literature with meta-analysis","volume":"32","author":"H Cheng","year":"2015","journal-title":"Med Oncol"},{"issue":"1","key":"pone.0303337.ref150","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/sj.bjc.6601095","article-title":"Role of Bcl-2 as a prognostic factor for survival in lung cancer: a systematic review of the literature with meta-analysis","volume":"89","author":"B Martin","year":"2003","journal-title":"Br J Cancer"},{"key":"pone.0303337.ref151","doi-asserted-by":"crossref","first-page":"104021","DOI":"10.1016\/j.critrevonc.2023.104021","article-title":"Correlation of Bcl-2 expression with prognosis and survival in patients with head and neck cancer: a systematic review and meta-analysis","volume":"187","author":"F Silva","year":"2023","journal-title":"Crit. Rev. Oncol.\/Hematol"},{"issue":"20","key":"pone.0303337.ref152","doi-asserted-by":"crossref","first-page":"8861","DOI":"10.7314\/APJCP.2014.15.20.8861","article-title":"High expression of Bcl-2 protein predicts favorable outcome in non-small cell lung cancer: evidence from a systematic review and meta-analysis","volume":"15","author":"XD Zhao","year":"2014","journal-title":"Asian Pac J Cancer Prev"},{"issue":"6810","key":"pone.0303337.ref153","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35042675","article-title":"Surfing the p53 network","volume":"408","author":"B Vogelstein","year":"2000","journal-title":"Nature"},{"issue":"3","key":"pone.0303337.ref154","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.clgc.2012.12.009","article-title":"The role of p53 on survival of upper urinary tract urothelial carcinoma: a systematic review and meta-analysis","volume":"11","author":"JH Ku","year":"2013","journal-title":"Clin. Genitourin. Cancer"},{"issue":"15","key":"pone.0303337.ref155","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1016\/j.ejca.2012.03.001","article-title":"Alterations of TP53 are associated with a poor outcome for patients with hepatocellular carcinoma: evidence from a systematic review and meta-analysis","volume":"48","author":"J Liu","year":"2012","journal-title":"Eur. J. Cancer"},{"issue":"3","key":"pone.0303337.ref156","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/s11060-010-0204-y","article-title":"P53 immunoexpression as a prognostic marker for human astrocytomas: a meta-analysis and review of the literature","volume":"100","author":"G Levidou","year":"2010","journal-title":"J. Neurooncol"},{"key":"pone.0303337.ref157","doi-asserted-by":"crossref","first-page":"153370","DOI":"10.1016\/j.prp.2021.153370","article-title":"Prognostic value of Bcl2 and p53 in Hodgkin lymphoma: a systematic review and meta-analysis","volume":"219","author":"A Travaglino","year":"2021","journal-title":"Pathol Res Pract"},{"issue":"Suppl. 3","key":"pone.0303337.ref158","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1159\/000088478","article-title":"VEGF as a key mediator of angiogenesis in cancer","volume":"69","author":"P Carmeliet","year":"2005","journal-title":"Oncology"},{"issue":"3","key":"pone.0303337.ref159","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.ygyno.2018.01.009","article-title":"Cervical cancer\u2014state of the science: from angiogenesis blockade to checkpoint inhibition","volume":"148","author":"LE Minion","year":"2018","journal-title":"Gynecologic oncology"},{"issue":"12","key":"pone.0303337.ref160","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1038\/sj.bjc.6603176","article-title":"Microvessel density and VEGF expression are prognostic factors in colorectal cancer. Meta-analysis of the literature","volume":"94","author":"G Des Guetz","year":"2006","journal-title":"Br. J. Cancer"},{"issue":"4","key":"pone.0303337.ref161","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1158\/1078-0432.CCR-04-1870","article-title":"Prognostic significance of vascular endothelial growth factor immunohistochemical expression in head and neck squamous cell carcinoma: a meta-analysis","volume":"11","author":"PA Kyzas","year":"2005","journal-title":"Clin. Cancer Res"},{"key":"pone.0303337.ref162","doi-asserted-by":"crossref","first-page":"9473","DOI":"10.1007\/s11033-012-1812-8","article-title":"Prognostic significance of vascular endothelial growth factor immunohistochemical expression in gastric cancer: a meta-analysis","volume":"39","author":"L Peng","year":"2012","journal-title":"Mol. Biol. Rep"},{"issue":"9","key":"pone.0303337.ref163","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1038\/sj.bjc.6605017","article-title":"Prognostic role of vascular endothelial growth factor in hepatocellular carcinoma: systematic review and meta-analysis","volume":"100","author":"S Schoenleber","year":"2009","journal-title":"Br. J. Cancer"},{"issue":"9","key":"pone.0303337.ref164","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/JTO.0b013e3181a97e31","article-title":"Prognostic value of vascular endothelial growth factor expression in patients with lung cancer: a systematic review with meta-analysis","volume":"4","author":"P Zhan","year":"2009","journal-title":"J Thorac Oncol"},{"issue":"2","key":"pone.0303337.ref165","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1515\/revneuro-2020-0062","article-title":"VEGF levels in patients with glioma: a systematic review and meta-analysis","volume":"32","author":"H Seyedmirzaei","year":"2021","journal-title":"Rev Neurosci"},{"issue":"9","key":"pone.0303337.ref166","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/PAI.0000000000000499","article-title":"Phosphorylated histone H3 (PHH3) as a novel cell proliferation marker and prognosticator for meningeal tumors: a short review","volume":"26","author":"I Elmaci","year":"2018","journal-title":"Appl. Immunohistochem. Mol. Morphol"},{"issue":"3","key":"pone.0303337.ref167","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1038\/modpathol.2012.188","article-title":"Proliferation indices of phosphohistone H3 and Ki67: strong prognostic markers in a consecutive cohort with stage I\/II melanoma","volume":"26","author":"PS Nielsen","year":"2013","journal-title":"Mod Pathol"},{"issue":"7","key":"pone.0303337.ref168","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1136\/jcp.2003.010777","article-title":"Prognostic value of proliferation in invasive breast cancer: a review","volume":"57","author":"PJ Van Diest","year":"2004","journal-title":"J. Clin. Pathol"},{"issue":"3","key":"pone.0303337.ref169","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1002\/bies.950050303","article-title":"Molecular mechanisms of the chromosome condensation and decondensation cycle in mammalian cells","volume":"5","author":"RC Adlakha","year":"1986","journal-title":"BioEssays"},{"issue":"1","key":"pone.0303337.ref170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1432-1033.1978.tb12135.x","article-title":"Histone phosphorylation and chromatin structure during mitosis in Chinese hamster cells","volume":"84","author":"LR Gurley","year":"1978","journal-title":"Eur. J. Biochem"},{"issue":"2","key":"pone.0303337.ref171","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/(SICI)1097-0320(19980601)32:2<71::AID-CYTO1>3.0.CO;2-H","article-title":"Histone H3 phosphorylation and expression of cyclins A and B1 measured in individual cells during their progression through G2 and mitosis","volume":"32","author":"G Juan","year":"1998","journal-title":"Cytom.,: J. Int. Soc. Anal. Cytol"},{"key":"pone.0303337.ref172","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.wneu.2020.06.189","article-title":"Mitotic index and progression-free survival in atypical meningiomas","volume":"142","author":"RA Domingo","year":"2020","journal-title":"World Neurosurg"},{"issue":"2","key":"pone.0303337.ref173","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s10014-021-00419-w","article-title":"Histopathological predictors of progression-free survival in atypical meningioma: a single-center retrospective cohort and meta-analysis","volume":"39","author":"MS Kim","year":"2022","journal-title":"Brain tumor pathol"},{"issue":"3","key":"pone.0303337.ref174","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/(SICI)1097-4652(200003)182:3<311::AID-JCP1>3.0.CO;2-9","article-title":"The Ki\u201067 protein: from the known and the unknown","volume":"182","author":"T Scholzen","year":"2000","journal-title":"J. Cell. Physiol"},{"key":"pone.0303337.ref175","article-title":"Prognostic role of Ki-67 score in localized prostate cancer: a systematic review and meta-analysis","author":"A Berlin","year":"2017","journal-title":"Urol. Oncol.: Semin. Orig. Investig"},{"issue":"2","key":"pone.0303337.ref176","doi-asserted-by":"crossref","first-page":"411","DOI":"10.7314\/APJCP.2015.16.2.411","article-title":"Ki-67 is a valuable prognostic factor in gliomas: evidence from a systematic review and meta-analysis","volume":"16","author":"WJ Chen","year":"2015","journal-title":"Asian Pac J Cancer Prev"},{"key":"pone.0303337.ref177","doi-asserted-by":"crossref","first-page":"3261","DOI":"10.2147\/OTT.S135593","article-title":"The diagnostic and prognostic values of Ki-67\/MIB-1 expression in thyroid cancer: a meta-analysis with 6,051 cases","volume":"10","author":"D-h Pan","year":"2017","journal-title":"Onco Targets Ther"},{"issue":"7","key":"pone.0303337.ref178","doi-asserted-by":"crossref","first-page":"e0158891","DOI":"10.1371\/journal.pone.0158891","article-title":"Clinicopathological and prognostic value of Ki-67 expression in bladder cancer: a systematic review and meta-analysis","volume":"11","author":"Y Tian","year":"2016","journal-title":"PloS one"},{"issue":"1","key":"pone.0303337.ref179","doi-asserted-by":"crossref","first-page":"44281","DOI":"10.1038\/srep44281","article-title":"Prognostic and clinicopathological role of high Ki-67 expression in patients with renal cell carcinoma: a systematic review and meta-analysis","volume":"7","author":"Y Xie","year":"2017","journal-title":"Sci. Rep"},{"issue":"12","key":"pone.0303337.ref180","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.prp.2010.09.002","article-title":"The significance of Ki-67\/MIB-1 labeling index in human meningiomas: a literature study","volume":"206","author":"E Abry","year":"2010","journal-title":"Pathol Res Pract"},{"issue":"6","key":"pone.0303337.ref181","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/CCO.0000000000000687","article-title":"Molecular alterations in meningioma: prognostic and therapeutic perspectives","volume":"32","author":"C Birzu","year":"2020","journal-title":"Curr Opin Oncol"},{"issue":"10","key":"pone.0303337.ref182","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.3390\/diagnostics11101852","article-title":"Discovering the molecular landscape of meningioma: the struggle to find new therapeutic targets","volume":"11","author":"I Maggio","year":"2021","journal-title":"Diagnostics"},{"key":"pone.0303337.ref183","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-018-03067-x","article-title":"The prognostic significance of TERT promoter mutations in meningioma: A systematic review and meta-analysis","volume":"142","author":"VM Lu","year":"2019","journal-title":"J. Neurooncol"},{"issue":"9","key":"pone.0303337.ref184","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.3390\/diagnostics11091624","article-title":"Human tert promoter mutations in atypical and anaplastic meningiomas","volume":"11","author":"M Mellai","year":"2021","journal-title":"Diagnostics"},{"issue":"4","key":"pone.0303337.ref185","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1136\/jnnp-2019-322257","article-title":"Poor prognosis associated with TERT gene alterations in meningioma is independent of the WHO classification: an individual patient data meta-analysis","volume":"91","author":"C Mirian","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"12","key":"pone.0303337.ref186","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1093\/neuonc\/noy104","article-title":"TERT promoter mutations are associated with poor prognosis and cell immortalization in meningioma","volume":"20","author":"S Spiegl-Kreinecker","year":"2018","journal-title":"Neuro. Oncol"},{"key":"pone.0303337.ref187","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s11060-019-03333-6","article-title":"Analysis of CDKN2A gene alterations in recurrent and non-recurrent meningioma","volume":"145","author":"A Guyot","year":"2019","journal-title":"J. NeuroOncol"},{"key":"pone.0303337.ref188","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s00401-020-02188-w","article-title":"CDKN2A\/B homozygous deletion is associated with early recurrence in meningiomas","volume":"140","author":"P Sievers","year":"2020","journal-title":"Acta Neuropathol"},{"issue":"22","key":"pone.0303337.ref189","doi-asserted-by":"crossref","first-page":"5339","DOI":"10.3390\/cancers15225339","article-title":"Unveiling a biomarker signature of meningioma: the need for a panel of genomic, epigenetic, proteomic, and RNA biomarkers to advance diagnosis and prognosis","volume":"15","author":"R Halabi","year":"2023","journal-title":"Cancers"},{"issue":"1","key":"pone.0303337.ref190","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1158\/1078-0432.CCR-18-0641","article-title":"Phosphoproteomic and kinomic signature of clinically aggressive grade I (1.5) meningiomas reveals RB1 signaling as a novel mediator and biomarker","volume":"26","author":"CA Parada","year":"2020","journal-title":"Clin Cancer Res"},{"key":"pone.0303337.ref191","doi-asserted-by":"crossref","first-page":"e392","DOI":"10.1016\/j.wneu.2019.02.062","article-title":"A logistic regression model for detecting the presence of malignant progression in atypical meningiomas","volume":"126","author":"Q Zhang","year":"2019","journal-title":"World Neurosurg"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0303337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,17]],"date-time":"2024-05-17T13:46:48Z","timestamp":1715953608000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0303337"}},"subtitle":[],"editor":[{"given":"Chien-Feng","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,5,17]]},"references-count":191,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0303337","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,17]]}}}