{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T03:38:04Z","timestamp":1768448284211,"version":"3.49.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T00:00:00Z","timestamp":1716163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013043","name":"Ariel University","doi-asserted-by":"publisher","award":["RA1800000372"],"award-info":[{"award-number":["RA1800000372"]}],"id":[{"id":"10.13039\/501100013043","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013043","name":"Ariel University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013043","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background and purpose<\/jats:title>\n<jats:p>Whereas motor skills of the untrained upper limb (UL) can improve following practice with the other UL, it has yet to be determined if an UL motor skill can improve following practice of that skill with the lower limb (LL).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Forty-five healthy subjects randomly participated in a 10-minute single-session intervention of (1) practicing 50 reaching movement (RM) sequences with the non-dominant left LL toward light switches (LL group); or (2) observing the identical 50 light switches sequences (Switches Observation (SO) group); or (3) observing nature films (Nature Observation (NO) group). RM sequence performance with the left UL toward the light switches was tested before and immediately after the intervention and retested after 24 h.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Reaching response time improved in the LL group more than in the SO and NO groups in the posttest (pBonferroni = 0.038 and pBonferroni &lt; 0.001, respectively), and improved in the LL group more than in the NO group in the retest (pBonferroni = 0.004). Percentage of fails did not differ between groups across the timepoints.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>It appears that the actual practice of the RM sequence skill with the UL together with the cognitive element embedded in the observation of the RM sequences contributes to ipsilateral transfer from LL to UL.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0303459","type":"journal-article","created":{"date-parts":[[2024,5,20]],"date-time":"2024-05-20T17:41:29Z","timestamp":1716226889000},"page":"e0303459","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Ipsilateral transfer of motor skill from lower to upper limb in healthy adults: A randomized controlled trial"],"prefix":"10.1371","volume":"19","author":[{"given":"Noa Efrat","family":"Sherman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Orit","family":"Elion","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zvi","family":"Kozol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moshe","family":"Einat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8991-3428","authenticated-orcid":true,"given":"Silvi","family":"Frenkel-Toledo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,5,20]]},"reference":[{"key":"pone.0303459.ref001","doi-asserted-by":"crossref","first-page":"e5763","DOI":"10.7717\/peerj.5763","article-title":"Thumbs up: movements made by the thumb are smoother and larger than fingers in finger-thumb opposition tasks","volume":"6","author":"D Rachaveti","year":"2018","journal-title":"Peer J"},{"issue":"6","key":"pone.0303459.ref002","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1123\/jsep.30.6.723","article-title":"Especial skills: specificity embedded within generality","volume":"30","author":"KM Keetch","year":"2008","journal-title":"J Sport Exerc Psychol"},{"issue":"4","key":"pone.0303459.ref003","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1007\/s00221-003-1799-4","article-title":"When practice leads to co-articulation: the evolution of geometrically defined movement primitives","volume":"156","author":"R Sosnik","year":"2004","journal-title":"Exp Brain Res"},{"issue":"21","key":"pone.0303459.ref004","doi-asserted-by":"crossref","first-page":"12492","DOI":"10.1073\/pnas.2035019100","article-title":"Multiple shifts in the representation of a motor sequence during the acquisition of skilled performance","volume":"100","author":"M Korman","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0303459.ref005","doi-asserted-by":"crossref","first-page":"642","DOI":"10.3389\/fnhum.2015.00642","article-title":"Transfer in Motor Sequence Learning: Effects of Practice Schedule and Sequence Context","volume":"9","author":"DM M\u00fcssgens","year":"2015","journal-title":"Front Hum Neurosci"},{"issue":"3","key":"pone.0303459.ref006","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1073\/pnas.95.3.861","article-title":"The acquisition of skilled motor performance: fast and slow experience-driven changes in primary motor cortex","volume":"95","author":"A Karni","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0303459.ref007","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.brainres.2015.03.020","article-title":"Balance maintenance as an acquired motor skill: Delayed gains and robust retention after a single session of training in a virtual environment","volume":"1609","author":"O Elion","year":"2015","journal-title":"Brain Res"},{"issue":"1","key":"pone.0303459.ref008","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/15622971003637637","article-title":"Slow-wave sleep and the consolidation of long-term memory","volume":"11","author":"J. 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Karni","year":"1997","journal-title":"Science and Medicine"},{"issue":"2","key":"pone.0303459.ref013","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1249\/JES.0000000000000009","article-title":"Restoring symmetry: clinical applications of cross-education","volume":"42","author":"JP Farthing","year":"2014","journal-title":"Exerc Sport Sci Rev"},{"issue":"4\u20135","key":"pone.0303459.ref014","first-page":"238","article-title":"Gabriel. The effect of unilateral training on contralateral limb strength in young, older, and patient populations: a meta-analysis of cross education","volume":"23","author":"A Green Lara","year":"2018","journal-title":"Physical Therapy Reviews"},{"issue":"11","key":"pone.0303459.ref015","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1007\/s00421-017-3720-z","article-title":"Cross-education of muscular strength following unilateral resistance training: a meta-analysis","volume":"117","author":"A Manca","year":"2017","journal-title":"Eur J Appl Physiol"},{"issue":"5","key":"pone.0303459.ref016","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1152\/japplphysiol.00559.2005","article-title":"Training with unilateral resistance exercise increases contralateral strength","volume":"99","author":"J Munn","year":"2005","journal-title":"J Appl Physiol 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Kumar","year":"2005","journal-title":"Laterality"},{"issue":"6","key":"pone.0303459.ref023","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1152\/japplphysiol.00597.2010","article-title":"Effects of cross-education on the muscle after a period of unilateral limb immobilization using a shoulder sling and swathe","volume":"109","author":"CR Magnus","year":"2010","journal-title":"J Appl Physiol (1985)"},{"issue":"3","key":"pone.0303459.ref024","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1152\/japplphysiol.91331.2008","article-title":"Strength training the free limb attenuates strength loss during unilateral immobilization","volume":"106","author":"JP Farthing","year":"2009","journal-title":"J Appl Physiol (1985)"},{"issue":"2","key":"pone.0303459.ref025","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.bbr.2004.03.022","article-title":"Inter- and intralimb transfer of a bimanual task: generalisability of limb 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Broken movement: the neurobiology of motor recovery after stroke"},{"issue":"2","key":"pone.0303459.ref032","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1152\/jn.00123.2017","article-title":"Separable systems for recovery of finger strength and control after stroke","volume":"118","author":"J Xu","year":"2017","journal-title":"J Neurophysiol"},{"issue":"1","key":"pone.0303459.ref033","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1152\/jn.00083.2003","article-title":"Motor outputs from the primate reticular formation to shoulder muscles as revealed by stimulus-triggered averaging","volume":"92","author":"AG Davidson","year":"2004","journal-title":"J Neurophysiol"},{"issue":"4","key":"pone.0303459.ref034","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0190-20.2021","article-title":"Interlimb Transfer of Reach Adaptation Does Not Require an Intact Corpus Callosum: Evidence from Patients with Callosal Lesions and Agenesis","volume":"8","author":"PA Tilsley","year":"2021","journal-title":"eNeuro"},{"key":"pone.0303459.ref035","first-page":"2022","article-title":"A mind-body interface alternates with effector-specific regions in motor cortex","author":"Gordon","year":"2022","journal-title":"bioRxiv"},{"issue":"7","key":"pone.0303459.ref036","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1038\/s41593-023-01346-z","article-title":"A motor association area in the depths of the central sulcus","volume":"26","author":"MA Jensen","year":"2023","journal-title":"Nat Neurosci"},{"issue":"37","key":"pone.0303459.ref037","doi-asserted-by":"crossref","first-page":"8084","DOI":"10.1523\/JNEUROSCI.1742-04.2004","article-title":"Is interlimb transfer of force-field adaptation a cognitive response to the sudden introduction of load?","volume":"24","author":"N Malfait","year":"2004","journal-title":"J 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Javidialsaadi","year":"2021","journal-title":"Brain Cogn"},{"key":"pone.0303459.ref041","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1152\/jn.00254.2011","article-title":"The extent of interlimb transfer following adaptation to a novel visuomotor condition does not depend on awareness of the condition","volume":"106","author":"J Wang","year":"2011","journal-title":"J Neurophysiol"},{"issue":"6","key":"pone.0303459.ref042","doi-asserted-by":"crossref","first-page":"3157","DOI":"10.1152\/jn.01008.2010","article-title":"Trial-by-trial analysis of intermanual transfer during visuomotor adaptation","volume":"106","author":"JA Taylor","year":"2011","journal-title":"J Neurophysiol"},{"issue":"4","key":"pone.0303459.ref043","doi-asserted-by":"crossref","first-page":"e0123321","DOI":"10.1371\/journal.pone.0123321","article-title":"Awareness of sensorimotor adaptation to visual rotations of different size","volume":"10","author":"S Werner","year":"2015","journal-title":"PLoS 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