{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T08:54:10Z","timestamp":1768812850298,"version":"3.49.0"},"reference-count":34,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>The study investigated the association between knee joint muscle strength and the prevalence of depression in a cohort of young adults.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>The observational, population-based study was performed with 909 participants (29.02 \u00b1 2.03 years; 48.73% male) from the Central European Longitudinal Studies of Parents and Children: Young Adults (CELSPAC: YA), who were retained to analysis. Quadriceps and hamstring knee muscle strength were assessed by isokinetic dynamometry, and depression by Beck\u2019s Depression Inventory (BDI-II). Statistical comparisons (Mann-Whitney and Chi-squared test) and effect size analyses (Eta-Squared, and Odds Ratio) were conducted.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>The main findings revealed an inverse association between knee joint muscle strength and depression, with individuals who had low muscle strength having 3.15 (95% CI = 2.74\u20133.62) times higher odds of experiencing depression. Specifically, participants with low extensor strength had 4.63 (95% CI = 2.20\u20139.74) times higher odds, and those with low flexor strength had 2.68 (95% CI = 1.47\u20134.89) times higher odds of experiencing depression compared to those individuals with high muscle strength. Furthermore, gender-specific analyses revealed that males with low muscle strength had 2.51 (95% CI = 1.53\u20134.14) times higher odds, while females had 3.46 (95% CI = 2.93\u20134.08) times higher odds of experiencing depression compared to individuals with high muscle strength.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusions<\/jats:title><jats:p>Strong knee muscles seems to be a key factor in preventing depression, specially in female young adults. The results support the importance of promoting an increase in muscle strength through physical activity as a preventive strategy against depression in this population.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0303925","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T18:54:41Z","timestamp":1717181681000},"page":"e0303925","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Association between muscle strength and depression in a cohort of young adults"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8483-8622","authenticated-orcid":true,"given":"Tom\u00e1\u0161","family":"Vodi\u010dka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1065-0619","authenticated-orcid":true,"given":"Michal","family":"Bozd\u011bch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1804-4581","authenticated-orcid":true,"given":"Tom\u00e1\u0161","family":"Vespalec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4342-1852","authenticated-orcid":true,"given":"Pavel","family":"Piler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina","family":"Paludo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"issue":"7","key":"pone.0303925.ref001","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1176\/appi.ajp.2018.17111194","article-title":"Physical activity and incident depression: A meta-analysis of prospective cohort studies","volume":"175","author":"FB Schuch","year":"2018","journal-title":"American Journal of Psychiatry"},{"issue":"3","key":"pone.0303925.ref002","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jshs.2019.03.007","article-title":"New scientific basis for the 2018 U.S. Physical Activity Guidelines","volume":"8","author":"L DiPietro","year":"2019","journal-title":"J Sport Health Sci"},{"key":"pone.0303925.ref003","volume-title":"Transforming mental health for all","author":"WHO","year":"2022"},{"issue":"1","key":"pone.0303925.ref004","article-title":"Understanding the somatic consequences of depression: Biological mechanisms and the role of depression symptom profile","volume":"11","author":"BWJH Penninx","year":"2013","journal-title":"BMC Med"},{"issue":"5","key":"pone.0303925.ref005","first-page":"837","article-title":"Depression as a risk factor for the onset of type 2 diabetes mellitus","volume":"49","author":"MJ Knol","year":"2006","journal-title":"A meta-analysis. 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