{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T00:06:41Z","timestamp":1789344401673,"version":"build-2803163510"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T00:00:00Z","timestamp":1716508800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This meta-analysis aims to assess the efficacy and safety of platelet-rich plasma (PRP) for osteonecrosis of the femoral head (ONFH).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>We comprehensively searched randomized controlled trials in PubMed, Web of Science, EMBASE, the Cochrane Central Register of Controlled Trials, Chinese National Knowledge Infrastructure, China Science and Technology Journal Database, WanFang, and Chinese BioMedical Literature Database from inception until October 25, 2024. The literature on the clinical efficacy of autologous PRP for ONFH was collated. According to the inclusion and exclusion criteria, the literature was screened, quality evaluated and the data was extracted. Meta-analysis was carried out with the software Review Manager 5.4.1 software and Stata 17.0 software. In addition, potential publication bias was detected by the funnel plot test and Egger\u2019s test. The GRADE system was used to evaluate the quality of evidence for outcome indicators.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Fourteen studies involving 909 patients were included in this study. Compared with non-PRP, PRP exhibited significant improvements in the Harris hip score (HHS) at 3 months (MD = 3.58, 95% Cl: 1.59 to 5.58, P = 0.0004), 6 months (MD = 6.19, 95% Cl: 3.96 to 8.41, P &lt; 0.00001), 12 months (MD = 4.73, 95% Cl: 3.24 to 6.22, P &lt; 0.00001), \u2265 24 months (MD = 6.83, 95% Cl: 2.09 to 11.59, P = 0.0003), and the last follow-up (MD = 6.57, 95% Cl: 4.81 to 8.33, P &lt; 0.00001). The PRP also showed improvement in HHS compared to baseline than the non-PRP at 3 months (MD = 3.60, 95% Cl: 1.26 to 5.94, P = 0.003), 6 months (MD = 6.17, 95% Cl: 3.74 to 8.61, P &lt; 0.00001), 12 months (MD = 5.35, 95% Cl: 3.44 to 7.25, P &lt; 0.00001), \u2265 24 months (MD = 8.19, 95% Cl: 3.76 to 12.62, P = 0.0003), and the last follow-up (MD = 6.94, 95% Cl: 5.09 to 8.78, P &lt; 0.00001). The change in visual analog scale (VAS) score 3 months post intervention (MD = -0.33, 95% Cl: -0.52 to -0.13, P = 0.001), 6 months (MD = -0.69, 95% Cl: -0.90 to -0.48, P &lt; 0.00001), 12 months (MD = -0.75, 95% Cl: -1.05 to -0.46, P &lt; 0.00001), \u2265 24 months (MD = -1.05, 95% Cl: -1.20 to -0.89, P &lt; 0.00001), and the last follow-up (MD = -0.75, 95% Cl: -0.97 to -0.54, P &lt; 0.00001). The PRP also showed a decrease in VAS score compared to baseline than the non-PRP at 3 months (MD = -0.29, 95% Cl: -0.41 to -0.17, P = 0.003), 6 months (MD = -0.63, 95% Cl: -0.96 to -0.30, P = 0.0002), 12 months (MD = -0.78, 95% Cl: -1.22 to -0.33, P = 0.0006), \u2265 24 months (MD = -1.11, 95% Cl: -1.27 to -0.96, P &lt; 0.00001), and the last follow-up (MD = -0.74, 95% Cl: -1.05 to -0.43, P &lt; 0.00001). Additionally, it was found that the PRP group had the advantages in the following aspects: collapse rate of the femoral head (RR = 0.33, 95% Cl: 0.17 to 0.62, P = 0.0006), rate of conversion to total hip arthroplasty (RR = 0.37, 95% Cl: 0.18 to 0.74, P = 0.005), and overall complications (RR = 0.33, 95% Cl: 0.13 to 0.83, P = 0.02). The GRADE evidence evaluation showed overall complication as very low quality and other indicators as low quality.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>There is limited evidence showing benefit of PRP therapy for treatment of ONFH patients, and most of this evidence is of low quality. Caution should therefore be exercised in interpreting these results. It is recommended that future research involve a greater number of high-quality studies to validate the aforementioned conclusions.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Systematic review registration<\/jats:title>\n<jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/\" xlink:type=\"simple\">https:\/\/www.crd.york.ac.uk\/prospero\/<\/jats:ext-link> #recordDetails, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42023463031\" xlink:type=\"simple\">CRD42023463031<\/jats:ext-link>.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0304096","type":"journal-article","created":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T17:39:05Z","timestamp":1716572345000},"page":"e0304096","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Clinical evaluation of platelet-rich plasma therapy for osteonecrosis of the femoral head: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"19","author":[{"given":"Guimei","family":"Guo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensi","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guochen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenhai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7211-2798","authenticated-orcid":true,"given":"Changwei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,5,24]]},"reference":[{"issue":"2","key":"pone.0304096.ref001","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1093\/mr\/roac023","article-title":"Association between magnitude of femoral head collapse and quality of life in patients with osteonecrosis of the femoral head","volume":"33","author":"M. Iwasa","year":"2023","journal-title":"Mod Rheumatol"},{"issue":"3","key":"pone.0304096.ref002","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1097\/JS9.0000000000000231","article-title":"Bone grafting for femoral head necrosis in the past decade: a systematic review and network meta-analysis","volume":"109","author":"P. Lou","year":"2023","journal-title":"Int J Surg"},{"issue":"7S","key":"pone.0304096.ref003","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.arth.2023.03.071","article-title":"Trends in Surgical Management of Osteonecrosis of the Femoral Head: A 2010 to 2020 Nationwide Study","volume":"38","author":"M. K. Ng","year":"2023","journal-title":"J Arthroplasty"},{"issue":"1","key":"pone.0304096.ref004","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1186\/s13018-023-04086-9","article-title":"Efficacy and safety of traditional Chinese medicine in the treatment of osteonecrosis of the femoral head","volume":"18","author":"W. Ouyang","year":"2023","journal-title":"J Orthop Surg Res"},{"issue":"1","key":"pone.0304096.ref005","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1186\/s13287-020-01956-5","article-title":"Efficacy and safety of stem cell therapy for the early-stage osteonecrosis of femoral head: a systematic review and meta-analysis of randomized controlled trials","volume":"11","author":"L. Mao","year":"2020","journal-title":"Stem cell research & therapy"},{"issue":"11","key":"pone.0304096.ref006","first-page":"1319","article-title":"Expert consensus on clinical diagnosis and treatment technique of osteonecrosis of the femoral head (2022 version)","volume":"36","author":"W. Sun","year":"2022","journal-title":"Chinese Journal of Reparative and Reconstructive Surgery"},{"issue":"4","key":"pone.0304096.ref007","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1016\/j.arth.2019.11.029","article-title":"The 2019 Revised Version of Association Research Circulation Osseous Staging System of Osteonecrosis of the Femoral Head","volume":"35","author":"B. H. Yoon","year":"2020","journal-title":"J Arthroplasty"},{"key":"pone.0304096.ref008","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.jot.2019.12.004","article-title":"Guidelines for clinical diagnosis and treatment of osteonecrosis of the femoral head in adults (2019 version)","volume":"21","author":"D. Zhao","year":"2020","journal-title":"J Orthop Translat"},{"key":"pone.0304096.ref009","doi-asserted-by":"crossref","first-page":"1258727","DOI":"10.3389\/fmed.2023.1258727","article-title":"Impact of autologous platelet-rich plasma therapy vs. hyaluronic acid on synovial fluid biomarkers in knee osteoarthritis: a randomized controlled clinical trial","volume":"10","author":"T. Li","year":"2023","journal-title":"Front Med"},{"issue":"6","key":"pone.0304096.ref010","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s13770-023-00560-x","article-title":"Biotherapeutic Applications of Platelet-Rich Plasma in Regenerative Medicine","volume":"20","author":"M. R. Pineda-Cortel","year":"2023","journal-title":"Tissue Eng Regen Med"},{"issue":"16","key":"pone.0304096.ref011","doi-asserted-by":"crossref","first-page":"12608","DOI":"10.3390\/ijms241612608","article-title":"Current Progress of Platelet-Rich Derivatives in Cartilage and Joint Repairs","volume":"24","author":"M. Y. Bai","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"9","key":"pone.0304096.ref012","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.3390\/genes14091669","article-title":"Progress in Regenerative Medicine: Exploring Autologous Platelet Concentrates and Their Clinical Applications","volume":"14","author":"L. Giannotti","year":"2023","journal-title":"Genes"},{"key":"pone.0304096.ref013","doi-asserted-by":"crossref","first-page":"1187974","DOI":"10.3389\/fbioe.2023.1187974","article-title":"Platelet-rich plasma in the pathologic processes of tendinopathy: a review of basic science studies","volume":"11","author":"J. Lu","year":"2023","journal-title":"Front Bioeng Biotechnol"},{"issue":"1","key":"pone.0304096.ref014","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/coa.13977","article-title":"The analgesic and anti-haemorrhagic efficacy of platelet-rich plasma in tonsillectomy: A systematic review and meta-analysis of randomised controlled trials.","volume":"48","author":"E. Albazee","year":"2023","journal-title":"Clinical otolaryngology: official journal of ENT-UK; official journal of Netherlands Society for Oto-Rhino-Laryngology & Cervico-Facial Surgery"},{"issue":"1","key":"pone.0304096.ref015","first-page":"24","article-title":"Platelet-rich plasma for the treatment of alopecia: a systematic review and meta-analysis.","volume":"21","author":"M. Cruciani","year":"2023","journal-title":"Blood transfusion = Trasfusione del sangue"},{"issue":"2","key":"pone.0304096.ref016","first-page":"119","article-title":"Ultrasound-guided injection of platelet-rich plasma for tendinopathies: a systematic review and meta-analysis.","volume":"21","author":"F. Masiello","year":"2023","journal-title":"Blood transfusion = Trasfusione del sangue"},{"issue":"2","key":"pone.0304096.ref017","doi-asserted-by":"crossref","first-page":"102276","DOI":"10.1016\/j.jogoh.2021.102276","article-title":"Platelet-rich plasma for the management of intrauterine adhesions: A systematic review and meta-analysis of randomized controlled trials","volume":"51","author":"E. Albazee","year":"2022","journal-title":"Journal of gynecology obstetrics and human reproduction"},{"key":"pone.0304096.ref018","doi-asserted-by":"crossref","first-page":"105906","DOI":"10.1016\/j.ijsu.2021.105906","article-title":"The PRISMA 2020 statement: An updated guideline for reporting systematic reviews","volume":"88","author":"M. J. Page","year":"2021","journal-title":"Int J Surg"},{"key":"pone.0304096.ref019","volume-title":"Cochrane Handbook for Systematic Reviews of Intervention","author":"JPT Higgins","year":"2022"},{"issue":"1","key":"pone.0304096.ref020","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1302\/0301-620X.67B1.3155745","article-title":"Idiopathic bone necrosis of the femoral head. Early diagnosis and treatment","volume":"67","author":"R. P. Ficat","year":"1985","journal-title":"J Bone Joint Surg Br"},{"key":"pone.0304096.ref021","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"J. P. Higgins","year":"2011","journal-title":"BMJ"},{"issue":"7454","key":"pone.0304096.ref022","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1136\/bmj.328.7454.1490","article-title":"Grading quality of evidence and strength of recommendations","volume":"328","author":"D. Atkins","year":"2004","journal-title":"BMJ (Clinical research ed.)"},{"issue":"4","key":"pone.0304096.ref023","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.jclinepi.2010.04.026","article-title":"GRADE guidelines: 1. Introduction-GRADE evidence profiles and summary of findings tables","volume":"64","author":"G. Guyatt","year":"2011","journal-title":"Journal of clinical epidemiology"},{"issue":"2","key":"pone.0304096.ref024","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.arth.2019.09.001","article-title":"Platelet-Rich Plasma-Incorporated Autologous Granular Bone Grafts Improve Outcomes of Post-Traumatic Osteonecrosis of the Femoral Head","volume":"35","author":"H. Xian","year":"2020","journal-title":"The Journal of arthroplasty"},{"key":"pone.0304096.ref025","article-title":"Who Benefits From Hip Arthroplasty or Knee Arthroplasty? Preoperative Patient-reported Outcome Thresholds Predict Meaningful Improvement","author":"B. angenberger","year":"2024","journal-title":"Clinical orthopaedics and related research"},{"issue":"15","key":"pone.0304096.ref026","first-page":"2347","article-title":"Effect of platelet-rich plasma with bioceramic system on the treatment of ARCO stage II osteonecrosis of the femoral head","volume":"26","author":"L. Chai","year":"2022","journal-title":"Chinese Journal of Tissue Engineering Research"},{"issue":"08","key":"pone.0304096.ref027","first-page":"575","article-title":"Clinical study on treatment of early necrosis of femoral head with porous tantalum rod and Platelet-rich plasma implantation after core decompression.","volume":"43","author":"F. Guo","year":"2022","journal-title":"Journal of Shandong First Medical University & Shandong Academy of Medical Sciences"},{"issue":"14","key":"pone.0304096.ref028","first-page":"53","article-title":"Effect analysis of platelet-rich plasma combined with core decompression and bone grafting in the treatment of ARCO \u2161 non-traumatic femoral head necrosis","volume":"20","author":"N. Yang","year":"2022","journal-title":"Contemporary Medical Symposium"},{"issue":"08","key":"pone.0304096.ref029","first-page":"1169","article-title":"Effect of hip preservation combined with platelet rich plasma on clinical efficacy and coagulation status in patients with osteonecrosis of femoral head","volume":"22","author":"B. A. Zhang","year":"2021","journal-title":"Chronic Pathematology J"},{"issue":"1","key":"pone.0304096.ref030","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.arth.2020.07.010","article-title":"Combining Platelet-Rich Plasma Instillation With Core Decompression Improves Functional Outcome and Delays Progression in Early-Stage Avascular Necrosis of Femoral Head: a 4.5- to 6-Year Prospective Randomized Comparative Study","volume":"36","author":"A. K. Aggarwal","year":"2021","journal-title":"J Arthroplasty"},{"issue":"12","key":"pone.0304096.ref031","first-page":"1778","article-title":"Therapeutic effect of ceramic bone compression and bone grafting combined with platelet rich plasma on early femoral head necrosis","volume":"32","author":"A. M. Li","year":"2020","journal-title":"Med J West China"},{"issue":"22","key":"pone.0304096.ref032","first-page":"3116","article-title":"Application of calcium phosphate mixture PRP reconstruction of necrotic areas for early metaphase osteonecrosis of the femeral head","volume":"36","author":"X. Zhang","year":"2020","journal-title":"The Journal of Practical Medicine"},{"issue":"25","key":"pone.0304096.ref033","first-page":"92","article-title":"Clinical effect of core decompression and bone grafting combined with platelet -rich plasma in the treatment of early avascular necrosis of femoral head","volume":"26","author":"Z. H. Dai","year":"2019","journal-title":"China Modern Medicine"},{"issue":"04","key":"pone.0304096.ref034","first-page":"14","article-title":"Evaluation of short-term efficacy of autologous platelet-rich plasma combined with ceramic bone grafting in the treatment of early femoral head necrosis","volume":"28","author":"X. Wang","year":"2019","journal-title":"Journal of Logistics University of PAP (Medical Sciences)"},{"issue":"06","key":"pone.0304096.ref035","first-page":"596","article-title":"Analysis of the efficacy of core decompression combined with platelet-rich plasma and \u03b2-tricalcium phosphate ceramic bone in the treatment of early femoral head necrosis","volume":"34","author":"M. W. Yuan","year":"2019","journal-title":"Chin J Bone Joint Injury"},{"issue":"10","key":"pone.0304096.ref036","first-page":"36","article-title":"Clinical Observation of Platelet Rich Plasma Combined with Opening Bone Grafting in Head and Neck in the Treatment of Osteonecrosis of the Femoral Head. Chinese J Trad Med Traum &","volume":"26","author":"X. L. Zhu","year":"2018","journal-title":"Orthop"},{"issue":"07","key":"pone.0304096.ref037","first-page":"878","article-title":"Efficacy and postoperative complications of core decompression and bone grafting with platelet-rich plasma for the treatment of avascular necrosis of femoral head","volume":"30","author":"C. J. Zhao","year":"2017","journal-title":"Chinese Journal of Clinical Research"},{"issue":"02","key":"pone.0304096.ref038","first-page":"140","article-title":"Platelet-rich plasma mixed with bone graft during core decompression in treatment of osteonecrosis of femoral head: prospective randomised controlled trial","volume":"10","author":"F. Q. Yang","year":"2016","journal-title":"Chin J Joint Surg (Electronic Edition)"},{"issue":"11","key":"pone.0304096.ref039","first-page":"1319","article-title":"2022. Expert consensus on clinical diagnosis and treatment technique of osteonecrosis of the femoral head","volume":"36","author":"W. Sun","year":"2022","journal-title":"Chinese Journal of Reparative and Reconstructive Surgery"},{"key":"pone.0304096.ref040","first-page":"2642439","article-title":"The Use of Platelet-Rich Plasma for the Treatment of Osteonecrosis of the Femoral Head","volume":"2020","author":"J. Han","year":"2020","journal-title":"A Systematic Review. Biomed Res Int"},{"issue":"11","key":"pone.0304096.ref041","first-page":"1677","article-title":"Platelet-rich plasma combined with core decompression regulates oxidative stress in a rabbit model of steroid-induced femoral head necrosis","volume":"24","author":"Z. Wang","year":"2020","journal-title":"Chinese Journal of Tissue Engineering Research"},{"issue":"6","key":"pone.0304096.ref042","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.3390\/biomedicines11061729","article-title":"Evaluation of Bone Regenerative Capacity in Rabbit Femoral Defect Using Thermally Disinfected Bone Human Femoral Head Combined with Platelet-Rich Plasma, Recombinant Human Bone Morphogenetic Protein 2, and Zoledronic Acid","volume":"11","author":"D. Saginova","year":"2023","journal-title":"Biomedicines"},{"issue":"12","key":"pone.0304096.ref043","first-page":"1569","article-title":"Clinical efficacy of platelet-rich plasma perfusion alone versus combined core decompression in the treatment of ARCO stage I to III femoral head necrosis","volume":"34","author":"J. C. Su","year":"2022","journal-title":"Modern Practical Medicine"},{"issue":"11","key":"pone.0304096.ref044","doi-asserted-by":"crossref","first-page":"2933","DOI":"10.3390\/biomedicines10112933","article-title":"Modifying Orthobiological PRP Therapies Are Imperative for the Advancement of Treatment Outcomes in Musculoskeletal Pathologies","volume":"10","author":"P. A. Everts","year":"2022","journal-title":"Biomedicines"},{"issue":"20","key":"pone.0304096.ref045","doi-asserted-by":"crossref","first-page":"7794","DOI":"10.3390\/ijms21207794","article-title":"Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020","volume":"21","author":"P. Everts","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"11","key":"pone.0304096.ref046","first-page":"1048","article-title":"Platelet rich plasma combined with core decompression and bone grafting in the treatment of non traumatic necrosis of femoral head in ARCO stage \u2161","volume":"33","author":"D. D. Chen","year":"2020","journal-title":"China J Orthop Trauma"},{"issue":"3","key":"pone.0304096.ref047","first-page":"265","article-title":"A study on the Therapeutic Effect of Platelet-rich Plasma Induced Bone Marrow Stromal Stem Cells Combined with Cartilage Scaffold in Treating Steroid-induced Femoral Head Necrosis of Rabbis","volume":"12","author":"D. S. Chen","year":"2017","journal-title":"Journal of Chengdu Medical College"},{"issue":"15\u201316","key":"pone.0304096.ref048","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1089\/ten.tea.2021.0211","article-title":"3D Printed Platelet-Rich Plasma-Loaded Scaffold with Sustained Cytokine Release for Bone Defect Repair","volume":"28","author":"C. Liu","year":"2022","journal-title":"Tissue Eng Part A"},{"issue":"1","key":"pone.0304096.ref049","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1038\/s41598-020-63496-5","article-title":"Platelet-rich plasma enhances the repair capacity of muscle-derived mesenchymal stem cells to large humeral bone defect in rabbits","volume":"10","author":"N. Yin","year":"2020","journal-title":"Sci Rep"},{"key":"pone.0304096.ref050","doi-asserted-by":"crossref","first-page":"7487452","DOI":"10.1155\/2022\/7487452","article-title":"Application of PRP in Chloasma: A Meta-Analysis and Systematic Review","volume":"2022","author":"T. Deng","year":"2022","journal-title":"Computational intelligence and neuroscience"},{"issue":"1","key":"pone.0304096.ref051","doi-asserted-by":"crossref","first-page":"364S","DOI":"10.1177\/1947603520931170","article-title":"PRP Injections for the Treatment of Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials","volume":"13","author":"G. Filardo","year":"2021","journal-title":"Cartilage"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0304096","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,24]],"date-time":"2024-05-24T17:39:38Z","timestamp":1716572378000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0304096"}},"subtitle":[],"editor":[{"given":"Sameh","family":"Attia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,5,24]]},"references-count":51,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0304096","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,24]]}}}