{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:39:14Z","timestamp":1793313554549,"version":"4.5.0"},"reference-count":14,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T00:00:00Z","timestamp":1717027200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To investigate the correlation between oxygen saturation index (OSI) and oxygenation index (OI) for evaluating the blood oxygenation status in neonates with respiratory failure requiring mechanical ventilation support and to assess the predictive capability of OSI in determining clinically relevant OI cutoffs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A prospective study was conducted on neonates who received invasive mechanical ventilation at the neonatal intensive care unit of tertiary hospital in Vietnam. Bland-Altman analysis was utilized to evaluate the agreement between OSI and OI.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 123 neonates, including both term and preterm infants, were included in the study. A high agreement rate of 94.3% within the 95% limits of agreement (between OI and OSI), with a narrow similarity value of 3.3 (95% CI: -5.1 to 11.8) and high correlation coefficient (r = 0.791, p&lt;0.001) was observed. The OSI cut-off value for predicting an OI of &gt;15 was determined to be 7.45, with a sensitivity of 100% and a specificity of 87.4% (AUC 0.955; 95% CI: 0.922\u20130.989, p &lt; 0.05). Similarly, an OSI cutoff value of 9.9 corresponded to an OI of 25, displaying a sensitivity of 100% and specificity of 87.4% (AUC 0.92). The receiver operating characteristic (ROC) curves for OSI exhibited statistically significant results (p &lt; 0.05).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The findings demonstrate a strong correlation between OSI and OI in neonates with respiratory failure. Furthermore, OSI, as a non-invasive method, can serve as a substitute for OI to evaluate the severity of hypoxic respiratory failure and lung injury in neonates.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0304278","type":"journal-article","created":{"date-parts":[[2024,5,30]],"date-time":"2024-05-30T17:31:20Z","timestamp":1717090280000},"page":"e0304278","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Assessing hypoxic respiratory failure in mechanically ventilated neonates: A comparative study of oxygen saturation index and oxygenation index"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7373-8300","authenticated-orcid":true,"given":"Son","family":"Bui-Binh-Bao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dao","family":"Nguyen 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trial.","volume":"180","author":"Z Rong","year":"2021","journal-title":"European Journal of Pediatrics"},{"issue":"6","key":"pone.0304278.ref006","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/sj.jp.7211110","article-title":"Predicting outcome in neonatal hypoxic respiratory failure with the score for neonatal acute physiology (SNAP) and highest oxygen index (OI) in the first 24 hours of admission.","volume":"24","author":"D Kumar","year":"2004","journal-title":"J Journal of perinatology"},{"issue":"3","key":"pone.0304278.ref007","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000369774","article-title":"Oxygen saturation index and severity of hypoxic respiratory failure.","volume":"107","author":"M Rawat","year":"2015","journal-title":"J Neonatology"},{"issue":"8476","key":"pone.0304278.ref008","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0140-6736(86)90837-8","article-title":"Statistical methods for assessing agreement between two 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network open"},{"key":"pone.0304278.ref012","article-title":"Correlation and prediction of oxygen index from oxygen saturation index in neonates with acute respiratory failure","author":"G Maneenil","year":"2021","journal-title":"American Journal of Perinatology"},{"key":"pone.0304278.ref013","first-page":"376","article-title":"Evaluation of Oxygenation Index Compared With Oxygen Saturation Index Among Neonates Admitted to the NICU.","author":"M Zadkarami","year":"2021","journal-title":"Acta Med Iran."},{"key":"pone.0304278.ref014","article-title":"Oxygen Saturation Index\u2013A Noninvasive Tool for Monitoring Hypoxemic Respiratory Failure in Newborns.","author":"SM Doreswamy","year":"2016","journal-title":"Indian Pediatr"}],"container-title":["PLOS 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