{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:13:36Z","timestamp":1791922416660,"version":"4.3.4"},"reference-count":111,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Researchers supporting project number King Saud University","award":["RSP2024R349"],"award-info":[{"award-number":["RSP2024R349"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    Lindane is a broad-spectrum insecticide widely used on fruits, vegetables, crops, livestock and on animal premises to control the insects and pests. The extensive use of pesticides and their residues in the soil and water typically join the food chain and thus accumulate in the body tissues of human and animals causing severe health effects. The study was designed to determine the toxicity effects of sub-lethal concentrations of lindane on hemato-biochemical profile and histo-pathological changes in Rohu (\n                    <jats:italic>Labeo rohita<\/jats:italic>\n                    ). A significant increase in the absolute (p&lt;0.05) and relative (p&lt;0.05) weights was observed along with severe histo-pathological alterations in liver, kidneys, gills, heart and brain at 30\u03bcg\/L and 45\u03bcg\/L concentration of lindane. A significant (p&lt;0.05) decrease in RBCs count, PCV and Hb concentration while a significant (p&lt;0.05) increased leukocytes were observed by 30\u03bcg\/L and 45\u03bcg\/L concentrations of lindane at 45 and 60 days of the experiment. Serum total protein and albumin were significantly (p&lt;0.05) decreased while hepatic and renal enzymes were significantly (p&lt;0.05) increased due to 30\u03bcg\/L and 45\u03bcg\/L concentrations of lindane at days-45 and 60 of experiment compared to control group. The observations of thin blood smear indicated significantly increased number of erythrocytes having nuclear abnormalities in the fish exposed at 30\u03bcg\/L and 45\u03bcg\/L concentrations of lindane. ROS and TBARS were found to be significantly increased while CAT, SOD, POD and GSH were significantly decreased with an increase in the concentration and exposure time of lindane. The results showed that lindane causes oxidative stress and severe hematological, serum biochemical and histo-pathological alterations in the fish even at sub-lethal concentrations.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0304387","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T13:35:15Z","timestamp":1720186515000},"page":"e0304387","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Effects of sub-lethal concentrations of lindane on histo-morphometric and physio-biochemical parameters of Labeo rohita"],"prefix":"10.1371","volume":"19","author":[{"given":"Gulnaz","family":"Afzal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9885-5933","authenticated-orcid":true,"given":"Hafiz Muhammad","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tariq","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shujaat","family":"Hussain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Zishan","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4673-2579","authenticated-orcid":true,"given":"Adeeba","family":"Naseer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rehana","family":"Iqbal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jawaria","family":"Aslam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahrar","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed Farouk","family":"Elsadek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bandar 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Abolhassani","year":"2019","journal-title":"Ecotoxicol Environ Saf"},{"key":"pone.0304387.ref025","doi-asserted-by":"crossref","first-page":"14847","DOI":"10.1002\/jcb.28746","article-title":"Organochlorine and organophosphorus pesticides and bladder cancer: A case-control study","volume":"120","author":"N Mortazavi","year":"2019","journal-title":"J Cell Biochem"},{"key":"pone.0304387.ref026","doi-asserted-by":"crossref","first-page":"26274","DOI":"10.1080\/19443994.2015.1119757","article-title":"Remediation of hexachlorocyclohexanes by cobalt-mediated activation of peroxymono sulfate","volume":"57","author":"S Wac\u0142awek","year":"2016","journal-title":"Desalin Water Treat"},{"key":"pone.0304387.ref027","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s13762-017-1417-9","article-title":"Lindane, kepone and pentachlorobenzene: chloropesticides banned by Stockholm convention","volume":"15","author":"R Madaj","year":"2018","journal-title":"Intern J Environ Sci 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Sana","year":"2021","journal-title":"Chemosphere"},{"key":"pone.0304387.ref031","doi-asserted-by":"crossref","first-page":"7328","DOI":"10.1007\/s11356-019-07183-7","article-title":"Organochlorine pesticides in the surrounding soils of POPs destruction facility: source fingerprinting, human health, and ecological risks assessment","volume":"27","author":"SN Ali","year":"2020","journal-title":"Environ Sci Pollut Res Intern"},{"key":"pone.0304387.ref032","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1007\/s11274-010-0628-8","article-title":"Biodegradation of lindane pesticide by non white-rots soil fungus Fusarium sp","volume":"27","author":"V Sagar","year":"2011","journal-title":"World J Microbiol Biotechnol"},{"issue":"29","key":"pone.0304387.ref033","article-title":"Perspectives of lindane (\u03b3-hexachlorocyclohexane) biodegradation from the environment: a review","volume":"5","author":"D Kumar","year":"2018","journal-title":"Bioresour 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Chem"},{"key":"pone.0304387.ref037","doi-asserted-by":"crossref","first-page":"31793","DOI":"10.1007\/s11356-018-3188-3","article-title":"The legacy of pesticides and POPs stockpiles-a threat to health and the environment","volume":"25","author":"J Vijgen","year":"2018","journal-title":"Environ Sci Pollut Res Intern"},{"issue":"2","key":"pone.0304387.ref038","doi-asserted-by":"crossref","first-page":"321","DOI":"10.29261\/pakvetj\/2023.025","article-title":"Azoxystrobin-induced oxidative stress in gills, hematological biomarkers and histopathological ailments in fresh water fish","volume":"43","author":"SAH Kazmi","year":"2023","journal-title":"Pak Vet J"},{"issue":"2","key":"pone.0304387.ref039","doi-asserted-by":"crossref","first-page":"255","DOI":"10.29261\/pakvetj\/2023.031","article-title":"Investigations of hemato-biochemical, histopathological, oxidative stress and reproductive effects of thiram in albino rats","volume":"43","author":"RA Sindi","year":"2023","journal-title":"Pak Vet J"},{"key":"pone.0304387.ref040","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1007\/s10646-010-0465-4","article-title":"Haematological parameters as bioindicators of insecticide exposure in teleosts","volume":"19","author":"NN Singh","year":"2010","journal-title":"Ecotoxicol"},{"key":"pone.0304387.ref041","doi-asserted-by":"crossref","first-page":"5450421","DOI":"10.1155\/2022\/5450421","article-title":"Bisphenol A Induces Histopathological, Hematobiochemical Alterations, Oxidative Stress, and Genotoxicity in Common Carp (Cyprinus carpio L.)","volume":"2022","author":"G Afzal","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"pone.0304387.ref042","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/jai.13763","article-title":"Effect of bisphenol A toxicity on growth performance, biochemical variables, and oxidative stress biomarkers of Nile tilapia, Oreochromis niloticus (L.)","volume":"34","author":"M Abdel-Tawwab","year":"2018","journal-title":"J Appl Ichthyol"},{"key":"pone.0304387.ref043","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.pestbp.2011.04.002","article-title":"Haematological and biochemical responses of freshwater teleost fish Cyprinus carpio (Actinopterygii: Cypriniformes) during acute and chronic sublethal exposure to lindane","volume":"100","author":"M Saravanan","year":"2011","journal-title":"Pest Biochem Physiol"},{"key":"pone.0304387.ref044","first-page":"917","article-title":"Effects of Hexachlorocyclohexane (HCH-\u03b3-Isomer, Lindane) on the Reproductive System of Zebrafish (Danio rerio)","volume":"16","author":"H Yuksel","year":"2016","journal-title":"Turk J Fish Aqua Sci"},{"key":"pone.0304387.ref045","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.3390\/w12061837","article-title":"Multi-biomarker assessment in common carp (cyprinus carpio, linnaeus 1758) liver after acute chlorpyrifos exposure","volume":"12","author":"S Stoyanova","year":"2020","journal-title":"Water"},{"key":"pone.0304387.ref046","first-page":"237","article-title":"Histopathological alterations in the liver, gills and kidneys of fish Labeo rohita after the exposure of endosulfan and lindane","volume":"4","author":"KK Sharma","year":"2016","journal-title":"Intern J Adv Sci Eng Technol"},{"key":"pone.0304387.ref047","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.marenvres.2011.10.011","article-title":"Lindane toxicity: histopathological, behavioural and biochemical changes in Etroplus maculatus (Bloch, 1795)","volume":"76","author":"S B Nandan","year":"2012","journal-title":"Mar Environ Res"},{"key":"pone.0304387.ref048","first-page":"1","article-title":"Histopathological Alterations Induced by Lindane (Gamma-Hexachlorocyclohexane) in a Minor Carp, Aspidoparia Morar Inhabiting Jammu Waters","volume":"3","author":"A Sachar","year":"2014a","journal-title":"Intern J Sci Res Public"},{"key":"pone.0304387.ref049","first-page":"53","article-title":"Histopathological changes induced by lindane (\u03b3-HCH) in various organs of fishes","volume":"67","author":"JB Ortiz","year":"2003","journal-title":"Sci"},{"key":"pone.0304387.ref050","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1080\/02772240903090573","article-title":"Lindane toxicity range-finding test in Senegal sole (Solea senegalensis) juvenile: note on histopathological alterations","volume":"92","author":"M Oliva","year":"2010","journal-title":"Toxicol Environ Chem"},{"key":"pone.0304387.ref051","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1080\/03601230802598953","article-title":"Toxicity of lindane (\u03b3-hexachloroxiclohexane) in Sparus aurata, Crassostrea angulata and Scrobicularia plana","volume":"44","author":"MLG De Canales","year":"2009","journal-title":"J Environ Sci Health Part B"},{"key":"pone.0304387.ref052","first-page":"281","article-title":"Effect of Lindane on the Haemopoietic Tissues in a Minor Carp Labeo Boga (Ham.)","volume":"2","author":"K Gupta","year":"2009","journal-title":"Biomed Pharmacol J"},{"key":"pone.0304387.ref053","first-page":"38","article-title":"Haematological alterations induced by lindane in a fish, Aspidoparia morar","volume":"3","author":"A Sachar","year":"2014b","journal-title":"Global J Biol Agri Health Sci"},{"key":"pone.0304387.ref054","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.anireprosci.2017.03.012","article-title":"Effects of natural environment on reproductive histo-morphometric dynamics of female dromedary camel","volume":"181","author":"HM Ali","year":"2017","journal-title":"Anim Reprod Sci"},{"issue":"2024","key":"pone.0304387.ref055","doi-asserted-by":"crossref","first-page":"e27859","DOI":"10.1016\/j.heliyon.2024.e27859","article-title":"Molecular identification of different toxinogenic strains of Clostridium perfringens and histo-pathological observations of camels died of per-acute entero-toxaemia","volume":"10","author":"HM Ali","year":"2024","journal-title":"Heliyon\u2013Microbiol"},{"key":"pone.0304387.ref056","first-page":"654","article-title":"Effects of Bacillus subtilis on performance, immune system and gut in Salmonella-challenged broiler chickens","volume":"50","author":"A Sikandar","year":"2020","journal-title":"South African J Anim Sci"},{"key":"pone.0304387.ref057","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1080\/15569543.2017.1366921","article-title":"Analysis of different toxic Impacts of Fipronil on growth, hemato-biochemistry, protoplasm and reproduction in adult cockerel","volume":"37","author":"R Hussain","year":"2017","journal-title":"Toxin Reviews"},{"key":"pone.0304387.ref058","first-page":"29","article-title":"Evaluation of hematological, antioxidant enzymes and oxidative stress parameters in buffaloes infected with babesiosis","volume":"2","author":"ZA Bhutta","year":"2022","journal-title":"Cont Vet J"},{"issue":"Pt A","key":"pone.0304387.ref059","doi-asserted-by":"crossref","first-page":"115896","DOI":"10.1016\/j.envpol.2020.115896","article-title":"Evaluation of Oxidative stress, antioxidant enzymes and genotoxic potential of bisphenol A in fresh water bighead carp (Aristichthys nobils) fish at low concentrations","volume":"268","author":"R Akram","year":"2021","journal-title":"Environ Pollut"},{"key":"pone.0304387.ref060","first-page":"1","article-title":"Sodium dodecyl sulfate polyacrylamide gel electrophoretic expression of serologic proteins from sera of patients with gastric cancer","volume":"1","author":"I Ayub","year":"2018","journal-title":"Pak-Euro J Med Life Sci"},{"key":"pone.0304387.ref061","first-page":"88","article-title":"Serum enzyme activities and electrolyte concentration of breeding donkeys (Equus asinus): effect of sex, age, lactation and\/or pregnancy","volume":"26","author":"AS Qureshi","year":"2016","journal-title":"J Anim Plant Sci"},{"key":"pone.0304387.ref062","first-page":"140","article-title":"Prevalence and characterization of trypanosoma species from livestock of cholistan desert of Pakistan","volume":"35","author":"S Malik","year":"2018","journal-title":"Trop Biomed"},{"key":"pone.0304387.ref063","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1080\/13510002.1996.11747079","article-title":"Glutathione metabolizing enzymes and oxidative stress in ferric nitrilotriacetate mediated hepatic injury","volume":"2","author":"M Iqbal","year":"1996","journal-title":"Redox Rep"},{"key":"pone.0304387.ref064","doi-asserted-by":"crossref","first-page":"309","DOI":"10.31580\/pjmls.v5i2.2528","article-title":"Evaluation of Anti-inflammatory, Antioxidant and Xanthine Oxidase Inhibitory Potential of N-(2-hydroxy phenyl) Acetamide","volume":"5","author":"A Arif","year":"2022","journal-title":"Pak-Euro J Med Life 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Singh","year":"2007","journal-title":"J Appl Toxicol"},{"issue":"1","key":"pone.0304387.ref082","first-page":"202007391","article-title":"Investigation of antioxidant and anti-hemolytic properties of Algerian Bunium incrassatum tubers and their effects as diet on histological and biochemical parameters of normal Wistar rats","volume":"2022","author":"F Berroukeche","year":"2022","journal-title":"Asian J Agric Biol"},{"key":"pone.0304387.ref083","first-page":"597","article-title":"Antioxidant Activity and GC-MS Analysis of the Essential Oil of Amygdalus Spinosissima Seeds Grown in Balochistan","volume":"5","author":"Z Kaneez","year":"2022","journal-title":"Pak-Euro J Med Life Sci"},{"key":"pone.0304387.ref084","first-page":"467","article-title":"The relationship between antioxidant trace elements (Zn-Cu and Se) and oxidative stress in dogs affected with dermatophytosis","volume":"11","author":"NM El-Motaily","year":"2022","journal-title":"Intern J Vet 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hens","volume":"93","author":"HN Liu","year":"2014","journal-title":"Poultry Sci"},{"key":"pone.0304387.ref088","first-page":"277","article-title":"Vitamin E and selenium attenuate hepatotoxicity, nephrotoxicity and oxidative stress induced by rifampicin in rabbits","volume":"40","author":"A Naseer","year":"2020","journal-title":"Pak Vet J"},{"issue":"2","key":"pone.0304387.ref089","doi-asserted-by":"crossref","first-page":"241","DOI":"10.29261\/pakvetj\/2023.036","article-title":"Calcium nanoparticles induce oxidative stress in erythrocytes, neurotoxicity and testicular toxicity in albino rats (Rattus norvegicus)","volume":"43","author":"A Ullah","year":"2023","journal-title":"Pak Vet J"},{"key":"pone.0304387.ref090","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.toxrep.2022.04.010","article-title":"Application of fenitrothion on Heteropneustesfossilis causes alteration in morphology of erythrocytes via modifying hematological parameters","volume":"9","author":"RF Ritu","year":"2022","journal-title":"Toxicol Rep"},{"key":"pone.0304387.ref091","doi-asserted-by":"crossref","first-page":"e04768","DOI":"10.1016\/j.heliyon.2020.e04768","article-title":"Comparative assessment of the acute toxicity, haematological and genotoxic effects of ten commonly used pesticides on the African Catfish, Clarias gariepinus Burchell 1822","volume":"6","author":"NH Amaeze","year":"2020","journal-title":"Heliyon"},{"key":"pone.0304387.ref092","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1080\/15569543.2020.1824190","article-title":"Age-dependent effect of chlorpyrifos on the hematological parameters in male rats","volume":"40","author":"B Roshanravan","year":"2020","journal-title":"Toxin Reviews"},{"key":"pone.0304387.ref093","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1590\/1413-81232018246.13142017","article-title":"Occupational exposure to pesticides and hematological alterations: A survey of farm residents in the South of Brazil","volume":"24","author":"C Piccoli","year":"2019","journal-title":"Cien Saude Colet"},{"key":"pone.0304387.ref094","first-page":"15","article-title":"Effects of exposure to three environmental chemicals on the selected biochemical parameters of the blood plasma of rainbow trout, Oncorhynchus mykiss (Walbaum)","volume":"65","author":"J Rehulka","year":"2016","journal-title":"Acta Mus Siles Sci Natur"},{"key":"pone.0304387.ref095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pestbp.2010.09.001","article-title":"Effects of diazinon onbiochemical parameters of blood in rainbow trout (Oncorhynchus mykiss)","volume":"99","author":"M Banaee","year":"2011","journal-title":"Pesticide Biochem Physio"},{"key":"pone.0304387.ref096","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1007\/s10695-011-9466-3","article-title":"A comparative study on the effects of a pesticide (cypermethrin) and two metals (copper, lead) to serum biochemistry of Nile tilapia, Oreochromis niloticus","volume":"37","author":"O F\u0131rat","year":"2011","journal-title":"Fish Physiol Biochem"},{"key":"pone.0304387.ref097","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.pestbp.2007.01.001","article-title":"Biochemical Alterations Induced by Monocrotophos in the Blood Plasma of Fish Channa punctatus (Bloch)","volume":"88","author":"S Agrahari","year":"2007","journal-title":"Pesticide Biochem Physio"},{"key":"pone.0304387.ref098","doi-asserted-by":"crossref","first-page":"980948","DOI":"10.1155\/2014\/980948","article-title":"Evaluation of biochemical, haematological, and histopathological responses and recovery ability of common carp (Cyprinus carpio L.) after acute exposure to atrazine herbicide","volume":"2014","author":"J Blahova","year":"2014","journal-title":"Biomed Res Intern"},{"issue":"47","key":"pone.0304387.ref099","article-title":"Toxic effects of an organophosphate pesticide, envoy 50 SC on the histopathological, hematological, and brain acetylcholinesterase activities in stinging catfish (Heteropneustes fossilis)","volume":"81","author":"R Akter","year":"2020","journal-title":"J Basic Applied Zool"},{"key":"pone.0304387.ref100","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/j.ecoenv.2009.01.008","article-title":"Sublethal cyfluthrin toxicity to carp (Cyprinus carpio L.) fingerlings: biochemical, hematological, histopathological alterations","volume":"72","author":"A Sepici-Din\u00e7el","year":"2009","journal-title":"Ecotoxicol Environ Saf"},{"key":"pone.0304387.ref101","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.aquatox.2007.06.013","article-title":"Assessing the sensitivity of Atlantic salmon (Salmo salar) to dietary endosulfan exposure using tissue biochemistry and histology","volume":"84","author":"CN Glover","year":"2007","journal-title":"Aqua 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(Common Carp)","volume":"3","author":"R Vinodhini","year":"2009","journal-title":"Intern J Environ Res"},{"key":"pone.0304387.ref105","first-page":"267","article-title":"Histological Changes in Tilapia Exposed to Bisphenol A (BPA) Compound","volume":"4","author":"G Vasu","year":"2019","journal-title":"Intern J Adv Sci Res Manag"},{"key":"pone.0304387.ref106","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1007\/s13530-019-0386-4","article-title":"Histopathological effects of bisphenol a on soft tissues of corbicula fluminea Mull","volume":"11","author":"K Benjamin","year":"2019","journal-title":"Toxicol Environ. 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