{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T19:52:05Z","timestamp":1781812325326,"version":"3.54.5"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Providing care for individuals dealing with long-term illnesses like cancer demands significant amounts of time, energy, and emotional investment, potentially resulting in a challenging and overwhelming quality of life for those providing the care.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>The purpose of this study was to assess the level of health-related quality of life (HRQoL) and associated factors among family caregivers of patients with cancer in oncologic centers of Northwest Ethiopia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Method<\/jats:title>\n<jats:p>A cross-sectional study was conducted among 412 family caregivers of patients with cancer who were following treatment at oncologic centers in Northwest Ethiopia from August to October 2023. Systematic random sampling was used to enroll study participants. Epi-data version 4.6.1 and SPSS version 26 were used for data entry and analysis, respectively. The relationship between quality of life and independent variables was examined using linear regression. Statistical significance was determined for variables having a p-value of less than 0.05 at a 95% confidence range.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Result<\/jats:title>\n<jats:p>A total of 412 eligible caregivers were included in the study out of 422 approached samples, yielding a 97.6% response rate. The mean score of the overall Quality of Life Brief\u2014Scale Version was 52.7 \u00b1 9.57. Being Spouse (\u03b2 = -3.39; 95% CI: -6.49, -0.29), presence of chronic illness (\u03b2 = -3.43; 95% CI: -5.56, -1.31), depression, (\u03b2 = -2.55; 95% CI: -4.34, -0.75), anxiety (\u03b2 = -3.27; 95% CI: -5.22, -1.32),and social support, (\u03b2 = -3.61; 95% CI: -6.20, -1.02) were negatively associated with quality of life.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion and recommendation<\/jats:title>\n<jats:p>In this study, the psychological domain had the lowest mean score. Caregivers being as spouse, who were with chronic illness, manifested depression and anxiety and had a poor social support needs attention and support to improve HRQoL.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0304392","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T19:58:46Z","timestamp":1717185526000},"page":"e0304392","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Health-related quality of life and associated factors among family caregivers of patients with cancer in oncologic centers of Northwest Ethiopia"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-3026-6584","authenticated-orcid":true,"given":"Fasil Bayafers","family":"Tamene","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endalamaw Aschale","family":"Mihiretie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akalu Fetene","family":"Desalew","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fasika Argaw","family":"Tafesse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel Agegnew","family":"Wondm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"key":"pone.0304392.ref001","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.3390\/ijerph20021570","article-title":"Quality of life in caregivers of cancer patients: a literature review","volume":"20","author":"MD Guerra-Mart\u00edn","year":"2023","journal-title":"International Journal of Environmental Research and Public 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