{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T18:39:29Z","timestamp":1792003169306,"version":"4.4.0"},"reference-count":57,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T00:00:00Z","timestamp":1717113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH","award":["R21NS101311"],"award-info":[{"award-number":["R21NS101311"]}]},{"name":"NIH","award":["R01NS112319"],"award-info":[{"award-number":["R01NS112319"]}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["Graduate Fellowship"],"award-info":[{"award-number":["Graduate Fellowship"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["Graduate Fellowship"],"award-info":[{"award-number":["Graduate Fellowship"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Chinese Natural Science Foundation of Hunan Province","award":["[2023JJ30864]"],"award-info":[{"award-number":["[2023JJ30864]"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Both clinical and animal studies demonstrated that seizure-induced respiratory arrest (S-IRA) contributes importantly to sudden unexpected death in epilepsy (SUDEP). It has been shown that enhancing serotonin (5-HT) function relieves S-IRA in animal models of SUDEP, including DBA\/1 mice. Direct activation of 5-HT<jats:sub>3<\/jats:sub> and 5-HT<jats:sub>4<\/jats:sub> receptors suppresses S-IRA in DBA\/1 mice, indicating that these receptors are involved in S-IRA. However, it remains unknown if other subtypes of 5-HT receptors are implicated in S-IRA in DBA\/1 mice. In this study, we investigated the action of an agonist of the 5-HT<jats:sub>1A<\/jats:sub> (8-OH-DPAT), 5-HT<jats:sub>2A<\/jats:sub> (TCB-2), 5-HT<jats:sub>2B<\/jats:sub> (BW723C86), 5-HT<jats:sub>2C<\/jats:sub> (MK-212), 5-HT<jats:sub>6<\/jats:sub> (WAY-208466) and 5-HT<jats:sub>7<\/jats:sub> (LP-211) receptor on S-IRA in DBA\/1 mice. An agonist of the 5-HT receptor or a vehicle was intraperitoneally administered 30 min prior to acoustic simulation, and the effect of each drug\/vehicle on the incidence of S-IRA was videotaped for offline analysis. We found that the incidence of S-IRA was significantly reduced by TCB-2 at 10 mg\/kg (30%, n = 10; <jats:italic>p<\/jats:italic> &lt; 0.01, Fisher\u2019s exact test) but was not altered by other agonists compared with the corresponding vehicle controls in DBA\/1 mice. Our data demonstrate that 5-HT<jats:sub>2A<\/jats:sub> receptors are implicated in S-IRA, and 5-HT<jats:sub>1A<\/jats:sub>, 5-HT<jats:sub>2B<\/jats:sub>, 5-HT<jats:sub>2C<\/jats:sub>, 5-HT<jats:sub>6<\/jats:sub> and 5-HT<jats:sub>7<\/jats:sub> receptors are not involved in S-IRA in DBA\/1 mice.<\/jats:p>","DOI":"10.1371\/journal.pone.0304601","type":"journal-article","created":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T18:58:46Z","timestamp":1717181926000},"page":"e0304601","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["5-HT receptors exert differential effects on seizure-induced respiratory arrest in DBA\/1 mice"],"prefix":"10.1371","volume":"19","author":[{"given":"Yundan","family":"Pan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheren","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1544-4248","authenticated-orcid":true,"given":"Hua-Jun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,5,31]]},"reference":[{"issue":"10","key":"pone.0304601.ref001","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1111\/epi.12666","article-title":"Sudden unexpected death in epilepsy: Assessing the public health burden","volume":"55","author":"DJ Thurman","year":"2014","journal-title":"Epilepsia"},{"issue":"1","key":"pone.0304601.ref002","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/epi.13234","article-title":"Who to target in sudden unexpected death in epilepsy prevention and how? Risk factors, biomarkers, and intervention study designs","volume":"57","author":"T Tomson","year":"2016","journal-title":"Epilepsia"},{"issue":"282","key":"pone.0304601.ref003","doi-asserted-by":"crossref","first-page":"282ra46","DOI":"10.1126\/scitranslmed.aaa4050","article-title":"Spreading depolarization in the brainstem mediates sudden cardiorespiratory arrest in mouse SUDEP models","volume":"7","author":"I Aiba","year":"2015","journal-title":"Science translational medicine"},{"key":"pone.0304601.ref004","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.eplepsyres.2016.08.004","article-title":"Laryngospasm, central and obstructive apnea during seizures: Defining pathophysiology for sudden death in a rat model","volume":"128","author":"K Nakase","year":"2016","journal-title":"Epilepsy research"},{"key":"pone.0304601.ref005","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.yebeh.2015.06.008","article-title":"Abnormalities of serotonergic neurotransmission in animal models of SUDEP","volume":"71","author":"HJ Feng","year":"2017","journal-title":"Epilepsy Behav"},{"key":"pone.0304601.ref006","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.nbd.2017.11.003","article-title":"Optogenetic activation of 5-HT neurons in the dorsal raphe suppresses seizure-induced respiratory arrest and produces anticonvulsant effect in the DBA\/1 mouse SUDEP model","volume":"110","author":"H Zhang","year":"2018","journal-title":"Neurobiology of disease"},{"issue":"10","key":"pone.0304601.ref007","doi-asserted-by":"crossref","first-page":"e0223468","DOI":"10.1371\/journal.pone.0223468","article-title":"Simultaneous cardiac and respiratory inhibition during seizure precedes death in the DBA\/1 audiogenic mouse model of SUDEP","volume":"14","author":"WP Schilling","year":"2019","journal-title":"PloS one"},{"key":"pone.0304601.ref008","doi-asserted-by":"crossref","first-page":"107188","DOI":"10.1016\/j.yebeh.2020.107188","article-title":"Mechanisms and prevention of acid reflux induced laryngospasm in seizing rats","volume":"111","author":"RB Budde","year":"2020","journal-title":"Epilepsy & behavior: E&B"},{"key":"pone.0304601.ref009","doi-asserted-by":"crossref","first-page":"910535","DOI":"10.3389\/fphar.2022.910535","article-title":"Adenosine-A2A Receptor Signaling Plays a Crucial Role in Sudden Unexpected Death in Epilepsy","volume":"13","author":"HY Shen","year":"2022","journal-title":"Frontiers in pharmacology"},{"issue":"2","key":"pone.0304601.ref010","doi-asserted-by":"crossref","first-page":"fcae052","DOI":"10.1093\/braincomms\/fcae052","article-title":"Peri-ictal activation of dorsomedial dorsal raphe serotonin neurons reduces mortality associated with maximal electroshock seizures","volume":"6","author":"AN Petrucci","year":"2024","journal-title":"Brain Commun"},{"issue":"1","key":"pone.0304601.ref011","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/epi.13236","article-title":"From unwitnessed fatality to witnessed rescue: Pharmacologic intervention in sudden unexpected death in epilepsy","volume":"57","author":"GB Richerson","year":"2016","journal-title":"Epilepsia"},{"issue":"4","key":"pone.0304601.ref012","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1111\/epi.17521","article-title":"A unified hypothesis of SUDEP: Seizure-induced respiratory depression induced by adenosine may lead to SUDEP but can be prevented by autoresuscitation and other restorative respiratory response mechanisms mediated by the action of serotonin on the periaqueductal gray","volume":"64","author":"CL Faingold","year":"2023","journal-title":"Epilepsia"},{"issue":"11","key":"pone.0304601.ref013","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1111\/j.1528-1157.2000.tb00128.x","article-title":"Postictal central apnea as a cause of SUDEP: Evidence from Near-SUDEP incident","volume":"41","author":"EL So","year":"2000","journal-title":"Epilepsia"},{"issue":"2","key":"pone.0304601.ref014","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1136\/jnnp.68.2.211","article-title":"Sudden unexpected death in epilepsy: a series of witnessed deaths","volume":"68","author":"Y Langan","year":"2000","journal-title":"Journal of neurology, neurosurgery, and psychiatry"},{"key":"pone.0304601.ref015","doi-asserted-by":"crossref","first-page":"3239","DOI":"10.1093\/brain\/awn277","article-title":"Ictal hypoxemia in localization-related epilepsy: analysis of incidence, severity and risk factors","volume":"131","author":"LM Bateman","year":"2008","journal-title":"Brain: a journal of neurology"},{"issue":"5","key":"pone.0304601.ref016","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/WNP.0b013e3181b7f14d","article-title":"Respiratory physiology of seizures","volume":"26","author":"AS Blum","year":"2009","journal-title":"Journal of clinical neurophysiology: official publication of the American Electroencephalographic Society"},{"issue":"4","key":"pone.0304601.ref017","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/j.yebeh.2009.02.012","article-title":"Severe pulmonary congestion in a near miss at the first seizure: further evidence for respiratory dysfunction in sudden unexpected death in epilepsy","volume":"14","author":"M Pezzella","year":"2009","journal-title":"Epilepsy & behavior: E&B"},{"issue":"4","key":"pone.0304601.ref018","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.yebeh.2010.02.007","article-title":"DBA\/1 mice exhibit chronic susceptibility to audiogenic seizures followed by sudden death associated with respiratory arrest","volume":"17","author":"CL Faingold","year":"2010","journal-title":"Epilepsy & behavior: E&B"},{"issue":"10","key":"pone.0304601.ref019","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/S1474-4422(13)70214-X","article-title":"Incidence and mechanisms of cardiorespiratory arrests in epilepsy monitoring units (MORTEMUS): a retrospective study","volume":"12","author":"P Ryvlin","year":"2013","journal-title":"Lancet neurology"},{"key":"pone.0304601.ref020","doi-asserted-by":"crossref","first-page":"4395","DOI":"10.1113\/jphysiol.2014.277574","article-title":"Serotonin neurones have anti-convulsant effects and reduce seizure-induced mortality","volume":"592","author":"GF Buchanan","year":"2014","journal-title":"J Physiol"},{"issue":"8","key":"pone.0304601.ref021","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/epi.13430","article-title":"5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest","volume":"57","author":"H Zhang","year":"2016","journal-title":"Epilepsia"},{"issue":"3","key":"pone.0304601.ref022","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1172\/JCI94999","article-title":"Severe peri-ictal respiratory dysfunction is common in Dravet syndrome","volume":"128","author":"Y Kim","year":"2018","journal-title":"The Journal of clinical investigation"},{"key":"pone.0304601.ref023","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.nbd.2019.04.006","article-title":"Cardiorespiratory profiling reveals primary breathing dysfunction in Kcna1-null mice: Implications for sudden unexpected death in epilepsy","volume":"127","author":"H Dhaibar","year":"2019","journal-title":"Neurobiology of disease"},{"issue":"12","key":"pone.0304601.ref024","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.1111\/epi.16374","article-title":"Brainstem activity, apnea, and death during seizures induced by intrahippocampal kainic acid in anaesthetized rats","volume":"60","author":"JGR Jefferys","year":"2019","journal-title":"Epilepsia"},{"issue":"5","key":"pone.0304601.ref025","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/ana.26053","article-title":"Postictal Death Is Associated with Tonic Phase Apnea in a Mouse Model of Sudden Unexpected Death in Epilepsy","volume":"89","author":"IC Wenker","year":"2021","journal-title":"Ann Neurol"},{"key":"pone.0304601.ref026","doi-asserted-by":"crossref","first-page":"1288600","DOI":"10.3389\/fncel.2023.1288600","article-title":"Neural correlate of reduced respiratory chemosensitivity during chronic epilepsy","volume":"17","author":"AM Bhandare","year":"2023","journal-title":"Frontiers in cellular neuroscience"},{"issue":"2","key":"pone.0304601.ref027","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.yebeh.2011.06.015","article-title":"Prevention of seizure-induced sudden death in a chronic SUDEP model by semichronic administration of a selective serotonin reuptake inhibitor","volume":"22","author":"CL Faingold","year":"2011","journal-title":"Epilepsy & behavior: E&B"},{"key":"pone.0304601.ref028","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.brainres.2011.08.043","article-title":"Differences in serotonin receptor expression in the brainstem may explain the differential ability of a serotonin agonist to block seizure-induced sudden death in DBA\/2 vs. DBA\/1 mice","volume":"1418","author":"CL Faingold","year":"2011","journal-title":"Brain Res"},{"key":"pone.0304601.ref029","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.pharmthera.2015.01.009","article-title":"Structure and function of serotonin G protein-coupled receptors","volume":"150","author":"JD McCorvy","year":"2015","journal-title":"Pharmacology & therapeutics"},{"issue":"2\u20133","key":"pone.0304601.ref030","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.eplepsyres.2009.11.004","article-title":"Abnormal serotonin receptor expression in DBA\/2 mice associated with susceptibility to sudden death due to respiratory arrest","volume":"88","author":"VV Uteshev","year":"2010","journal-title":"Epilepsy research"},{"key":"pone.0304601.ref031","first-page":"64","article-title":"Serotonergic agents act on 5-HT3 receptors in the brain to block seizure-induced respiratory arrest in the","author":"CL Faingold","year":"2016","journal-title":"DBA\/"},{"key":"pone.0304601.ref032","doi-asserted-by":"crossref","first-page":"1192022","DOI":"10.3389\/fphar.2023.1192022","article-title":"Fenfluramine: a plethora of mechanisms?","volume":"14","author":"J Sourbron","year":"2023","journal-title":"Frontiers in pharmacology"},{"key":"pone.0304601.ref033","doi-asserted-by":"crossref","first-page":"106777","DOI":"10.1016\/j.eplepsyres.2021.106777","article-title":"Serotonin 5-HT4 receptors play a critical role in the action of fenfluramine to block seizure-induced sudden death in a mouse model of SUDEP","volume":"177","author":"S Tupal","year":"2021","journal-title":"Epilepsy research"},{"issue":"12","key":"pone.0304601.ref034","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.molmed.2003.10.010","article-title":"Serotonin receptors: guardians of stable breathing","volume":"9","author":"DW Richter","year":"2003","journal-title":"Trends in molecular medicine"},{"issue":"9","key":"pone.0304601.ref035","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1002\/neu.20253","article-title":"Endogenous 5-HT2B receptor activation regulates neonatal respiratory activity in vitro","volume":"66","author":"S Gunther","year":"2006","journal-title":"J Neurobiol"},{"issue":"1","key":"pone.0304601.ref036","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neuroscience.2009.09.078","article-title":"Postnatal changes in the expressions of serotonin 1A, 1B, and 2A receptors in ten brain stem nuclei of the rat: implication for a sensitive period","volume":"165","author":"Q Liu","year":"2010","journal-title":"Neuroscience"},{"key":"pone.0304601.ref037","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.bbr.2013.04.024","article-title":"The effects of systemic and local microinjection into the central nervous system of the selective serotonin 5-HT6 receptor agonist WAY-208466 on sleep and wakefulness in the rat","volume":"249","author":"JM Monti","year":"2013","journal-title":"Behavioural brain research"},{"key":"pone.0304601.ref038","doi-asserted-by":"crossref","first-page":"761912","DOI":"10.3389\/fneur.2021.761912","article-title":"Genistein, a Natural Isoflavone, Alleviates Seizure-Induced Respiratory Arrest in DBA\/1 Mice","volume":"12","author":"J Guo","year":"2021","journal-title":"Front Neurol"},{"issue":"1","key":"pone.0304601.ref039","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1528-1167.2006.00365.x","article-title":"Evidence supporting a role of serotonin in modulation of sudden death induced by seizures in DBA\/2 mice","volume":"47","author":"S Tupal","year":"2006","journal-title":"Epilepsia"},{"key":"pone.0304601.ref040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yebeh.2015.02.013","article-title":"Fluoxetine prevents respiratory arrest without enhancing ventilation in DBA\/1 mice","volume":"45","author":"C Zeng","year":"2015","journal-title":"Epilepsy & behavior: E&B"},{"key":"pone.0304601.ref041","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yebeh.2019.06.029","article-title":"The association of serotonin reuptake inhibitors and benzodiazepines with ictal central apnea","volume":"98","author":"N Lacuey","year":"2019","journal-title":"Epilepsy & behavior: E&B"},{"issue":"15","key":"pone.0304601.ref042","doi-asserted-by":"crossref","first-page":"e1485","DOI":"10.1212\/WNL.0000000000008244","article-title":"Postictal serotonin levels are associated with peri-ictal apnea","volume":"93","author":"A Murugesan","year":"2019","journal-title":"Neurology"},{"issue":"10","key":"pone.0304601.ref043","doi-asserted-by":"crossref","first-page":"105228","DOI":"10.1016\/j.isci.2022.105228","article-title":"Dorsal raphe nucleus to pre-Botzinger complex serotonergic neural circuit is involved in seizure-induced respiratory arrest","volume":"25","author":"H Ma","year":"2022","journal-title":"iScience"},{"key":"pone.0304601.ref044","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.yebeh.2014.06.028","article-title":"Serotonin and sudden death: Differential effects of serotonergic drugs on seizure-induced respiratory arrest in DBA\/1 mice","volume":"37","author":"CL Faingold","year":"2014","journal-title":"Epilepsy & behavior: E&B"},{"issue":"6","key":"pone.0304601.ref045","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1111\/epi.14759","article-title":"Neural activity in the periaqueductal gray and other specific subcortical structures is enhanced when a selective serotonin reuptake inhibitor selectively prevents seizure-induced sudden death in the DBA\/1 mouse model of sudden unexpected death in epilepsy","volume":"60","author":"SP Kommajosyula","year":"2019","journal-title":"Epilepsia"},{"issue":"7","key":"pone.0304601.ref046","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1212\/WNL.0000000000001260","article-title":"Association of prone position with sudden unexpected death in epilepsy","volume":"84","author":"JA Liebenthal","year":"2015","journal-title":"Neurology"},{"issue":"3","key":"pone.0304601.ref047","doi-asserted-by":"crossref","first-page":"e227","DOI":"10.1212\/WNL.0000000000007778","article-title":"SUDEP in the North American SUDEP Registry: The full spectrum of epilepsies","volume":"93","author":"C Verducci","year":"2019","journal-title":"Neurology"},{"key":"pone.0304601.ref048","doi-asserted-by":"crossref","first-page":"107775","DOI":"10.1016\/j.yebeh.2021.107775","article-title":"The probability of sudden unexpected death in epilepsy given postictal prone position.","volume":"116","author":"B Esmaeili","year":"2021","journal-title":"Epilepsy & behavior: E&B"},{"issue":"1\u20133","key":"pone.0304601.ref049","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejphar.2006.09.027","article-title":"Effects of the serotonin 5-HT2A\/2C receptor agonist DOI and of the selective 5-HT2A or 5-HT2C receptor antagonists EMD 281014 and SB-243213, respectively, on sleep and waking in the rat","volume":"553","author":"JM Monti","year":"2006","journal-title":"Eur J Pharmacol"},{"issue":"11","key":"pone.0304601.ref050","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/nn1130","article-title":"Midbrain serotonergic neurons are central pH chemoreceptors","volume":"6","author":"CA Severson","year":"2003","journal-title":"Nat Neurosci"},{"key":"pone.0304601.ref051","doi-asserted-by":"crossref","first-page":"896204","DOI":"10.3389\/fneur.2022.896204","article-title":"Functional MRI Correlates of Carbon Dioxide Chemosensing in Persons With Epilepsy","volume":"13","author":"JP Hampson","year":"2022","journal-title":"Front Neurol"},{"key":"pone.0304601.ref052","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.brainres.2016.01.002","article-title":"Norepinephrine at the nexus of arousal, motivation and relapse","volume":"1641","author":"RA Espana","year":"2016","journal-title":"Brain Res"},{"key":"pone.0304601.ref053","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.eplepsyres.2017.08.005","article-title":"The effect of atomoxetine, a selective norepinephrine reuptake inhibitor, on respiratory arrest and cardiorespiratory function in the DBA\/1 mouse model of SUDEP","volume":"137","author":"H Zhao","year":"2017","journal-title":"Epilepsy research"},{"key":"pone.0304601.ref054","doi-asserted-by":"crossref","first-page":"119912","DOI":"10.1016\/j.lfs.2021.119912","article-title":"Adrenergic alpha2 receptors are implicated in seizure-induced respiratory arrest in DBA\/1 mice","volume":"284","author":"R Zhang","year":"2021","journal-title":"Life Sci"},{"issue":"1","key":"pone.0304601.ref055","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1021\/cn300184t","article-title":"Activation of 5-HT6 receptors modulates sleep-wake activity and hippocampal theta oscillation","volume":"4","author":"S Ly","year":"2013","journal-title":"ACS chemical neuroscience"},{"issue":"4","key":"pone.0304601.ref056","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1038\/ng0897-387","article-title":"Sound-induced seizures in serotonin 5-HT2c receptor mutant mice","volume":"16","author":"TJ Brennan","year":"1997","journal-title":"Nat Genet"},{"key":"pone.0304601.ref057","first-page":"3","article-title":"X-linked serotonin 2C receptor is associated with a non-canonical pathway for sudden unexpected death in epilepsy","author":"CA Massey","year":"2021","journal-title":"Brain Commun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0304601","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,31]],"date-time":"2024-05-31T18:59:22Z","timestamp":1717181962000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0304601"}},"subtitle":[],"editor":[{"given":"Giuseppe","family":"Biagini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,5,31]]},"references-count":57,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0304601","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,31]]}}}