{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:21:36Z","timestamp":1747196496485,"version":"3.40.5"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T00:00:00Z","timestamp":1718236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The value and influencing factors of the ultrasound combined with magnetic resonance imaging for the classification of fetal hypospadias in high-risk pregnant women at 20-24+6 weeks of gestation","award":["20230883"],"award-info":[{"award-number":["20230883"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To explore the association between demographic characteristics and perinatal deaths attributable to <jats:bold>congenital heart defects (CHDs)<\/jats:bold>.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Data were obtained from the Birth Defects Surveillance System of Hunan Province, China, 2016\u20132020. The surveillance population included fetuses and infants from 28 weeks of gestation to 7 days after birth whose mothers delivered in the surveillance hospitals. Surveillance data included demographic characteristics such as sex, residence, maternal age, and other key information, and were used to calculate the prevalence of CHDs and perinatal mortality rates (PMR) with 95% confidence intervals (CI). Multivariable logistic regression analysis (method: Forward, Wald, \u03b1 = 0.05) and adjusted odds ratios (ORs) were used to identify factors associated with perinatal deaths attributable to CHDs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>This study included 847755 fetuses, and 4161 CHDs were identified, with a prevalence of 0.49% (95%CI: 0.48\u20130.51). A total of 976 perinatal deaths attributable to CHDs were identified, including 16 (1.64%) early neonatal deaths and 960 (98.36%) stillbirths, with a PMR of 23.46% (95%CI: 21.98\u201324.93). In stepwise logistic regression analysis, perinatal deaths attributable to CHDs were more common in rural areas than urban areas (OR = 2.21, 95%CI: 1.76\u20132.78), more common in maternal age &lt;20 years (OR = 2.40, 95%CI: 1.05\u20135.47), 20\u201324 years (OR = 2.13, 95%CI: 1.46\u20133.11) than maternal age of 25\u201329 years, more common in 2 (OR = 1.60, 95%CI: 1.18\u20132.18) or 3 (OR = 1.43, 95%CI: 1.01\u20132.02) or 4 (OR = 1.84, 95%CI: 1.21\u20132.78) or &gt; = 5 (OR = 2.02, 95%CI: 1.28\u20133.18) previous pregnancies than the first pregnancy, and more common in CHDs diagnosed in &gt; = 37 gestional weeks (OR = 77.37, 95%CI: 41.37\u2013144.67) or 33\u201336 gestional weeks (OR = 305.63, 95%CI: 172.61\u2013541.15) or &lt; = 32 gestional weeks (OR = 395.69, 95%CI: 233.23\u2013671.33) than diagnosed in postnatal period (within 7 days), and less common in multiple births than singletons (OR = 0.48, 95%CI: 0.28\u20130.80).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Perinatal deaths were common in CHDs in Hunan in 2016\u20132020. Several demographic characteristics were associated with perinatal deaths attributable to CHDs, which may be summarized mainly as economic and medical conditions, severity of CHDs, and parental attitudes toward CHDs.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0304615","type":"journal-article","created":{"date-parts":[[2024,6,13]],"date-time":"2024-06-13T17:53:40Z","timestamp":1718301220000},"page":"e0304615","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Perinatal deaths attributable to congenital heart defects in Hunan Province, China, 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