{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T23:06:29Z","timestamp":1793315189077,"version":"4.5.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>This meta-analysis compared the efficacy and safety of Proximal Femoral Nail Antirotation (PFNA) and InterTan Nail in the treatment of intertrochanteric fractures. Given the high incidence of femoral intertrochanteric fractures in the elderly population and its impact on quality of life, choosing the most effective and safest surgical option is crucial. PFNA and InterTan are currently two commonly used techniques, but there is a lack of systematic evaluation comparing their safety and effectiveness. This study aims to fill this knowledge gap through Meta-analysis, providing clinicians with evidence-based treatment recommendations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>A computer search was used to search for published literature on PFNA and InterTan in the treatment of intertrochanteric fractures in PubMed (Medline), Web of Science, Embase, Cochrane Library (CENTRAL), Cinahl, CBM, and CNKI.A total of 853 related literatures were retrieved, and 15 literatures were finally included. Newcastle-Ottawa-Scale and Cochrane systematic review methodologies were used to assess the quality of the literature. Meta-analysis was performed using Review Manager 5.4 software, following data extraction.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The comparison found that during the surgical treatment of intertrochanteric fractures, the operation time, fluoroscopy time, and blood loss in the PFNA group were significantly shorter than those in the InterTan group, and the difference was statistically significant. In terms of postoperative complication rates, the InterTan group had a significant advantage over the PFNA group. Shaft fracture, varus collapse, cut out, screw migration, and pain of hip and thigh were the most likely to occur in the PFNA group, and the differences were all statistically significant. In terms of postoperative efficacy, the results of the PFNA group and the InterTan group were comparable, and there was no significant differences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>When selecting surgical techniques for the treatment of femoral intertrochanteric fractures, it is necessary to conduct individualized assessments based on the patient\u2019s overall health status, surgical tolerance, and post-operative recovery needs. For patients who cannot tolerate long-term surgery or are in poor physical condition, PFNA may be more appropriate. While for patients who can tolerate long-term surgery or have more complex conditions, InterTan may be more suitable.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0304654","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T14:07:55Z","timestamp":1720534075000},"page":"e0304654","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["Proximal femoral nail antirotation versus InterTan nail for the treatment of intertrochanteric fractures: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-4805-8905","authenticated-orcid":true,"given":"Chang-sheng","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang-zheng","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi-yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2238-2957","authenticated-orcid":true,"given":"Peng-fei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"key":"pone.0304654.ref001","doi-asserted-by":"crossref","first-page":"5911868","DOI":"10.1155\/2021\/5911868","article-title":"PFNA-II Internal Fixation Helps Hip Joint Recovery and Improves Quality of Life of Patients with Lateral-Wall Dangerous Type of Intertrochanteric Fracture","volume":"2021","author":"W Mu","year":"2021","journal-title":"Biomed Res Int"},{"issue":"9","key":"pone.0304654.ref002","first-page":"1093","article-title":"[Morphological analysis of coronal femoral intertrochanteric fracture and its effect on reduction and internal fixation].","volume":"35","author":"W Wei","year":"2021","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"issue":"15","key":"pone.0304654.ref003","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1503\/cmaj.092220","article-title":"Effect of early surgery after hip fracture on mortality and complications: systematic review and meta-analysis","volume":"182","author":"N Simunovic","year":"2010","journal-title":"CMAJ"},{"issue":"6","key":"pone.0304654.ref004","first-page":"688","article-title":"[Biomechanical effects of three internal fixation modes on femoral subtrochanteric spiral fractures in osteoporotic patients by finite element analysis].","volume":"37","author":"Y An","year":"2023","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi."},{"issue":"2","key":"pone.0304654.ref005","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.injury.2016.12.014","article-title":"Removal of a broken trigen intertan intertrochanteric antegrade nail.","volume":"48","author":"XL Zheng","year":"2017","journal-title":"Injury"},{"issue":"1","key":"pone.0304654.ref006","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13018-018-0749-6","article-title":"Comparison of a twin interlocking derotation and compression screw cephalomedullary nail (InterTAN) with a single screw derotation cephalomedullary nail (proximal femoral nail antirotation): a systematic review and meta-analysis for intertrochanteric fractures.","volume":"13","author":"L Nherera","year":"2018","journal-title":"J Orthop Surg Res."},{"issue":"9","key":"pone.0304654.ref007","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10654-010-9491-z","article-title":"Critical evaluation of the Newcastle-Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses","volume":"25","author":"A. Stang","year":"2010","journal-title":"Eur J Epidemiol"},{"issue":"7","key":"pone.0304654.ref008","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1007\/s00590-019-02454-y","article-title":"The impact of proximal femoral nail type on clinical and radiological outcomes in the treatment of intertrochanteric femur fractures: a comparative study.","volume":"29","author":"A Duramaz","year":"2019","journal-title":"Eur J Orthop Surg Traumatol"},{"issue":"6","key":"pone.0304654.ref009","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/BOT.0000000000001145","article-title":"Helical Blade or the Integrated Lag Screws: A Matched Pair Analysis of 100 Patients With Unstable Trochanteric Fractures.","volume":"32","author":"AS Gavaskar","year":"2018","journal-title":"J Orthop Trauma."},{"issue":"8","key":"pone.0304654.ref010","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.asjsur.2021.05.025","article-title":"A comparison between proximal femoral nail antirotation (PFNA) and inter Tan nail for the surgical treatment of unstable intertrochanteric fracture: A case series.","volume":"44","author":"C Guobin","year":"2021","journal-title":"Asian J Surg"},{"issue":"2","key":"pone.0304654.ref011","first-page":"123","article-title":"A comparison of the InterTan nail and proximal femoral fail antirotation in the treatment of reverse intertrochanteric femoral fractures.","volume":"84","author":"A \u0130merci","year":"2018","journal-title":"Acta Orthop Belg"},{"issue":"12","key":"pone.0304654.ref012","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1016\/j.injury.2015.09.038","article-title":"Comparison of the reconstruction trochanteric antigrade nail (TAN) with the proximal femoral nail antirotation (PFNA) in the management of reverse oblique intertrochanteric hip fractures.","volume":"46","author":"D Makki","year":"2015","journal-title":"Injury"},{"issue":"6","key":"pone.0304654.ref013","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1007\/s00776-015-0750-4","article-title":"Do PFNA devices and Intertan nails both have the same effects in the treatment of trochanteric fractures? A prospective clinical study.","volume":"20","author":"M Seyhan","year":"2015","journal-title":"J Orthop Sci"},{"issue":"8","key":"pone.0304654.ref014","first-page":"651","article-title":"[Comparison of three fixations for treatment of intertrochanteric femoral fractures in the elderly].","volume":"26","author":"YG Wang","year":"2013","journal-title":"Zhongguo Gu Shang"},{"issue":"8","key":"pone.0304654.ref015","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1016\/j.injury.2017.06.017","article-title":"Investigation of perioperative hidden blood loss of unstable intertrochanteric fracture in the elderly treated with different intramedullary fixations","volume":"48","author":"X Yang","year":"2017","journal-title":"Injury"},{"key":"pone.0304654.ref016","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s13018-016-0344-7","article-title":"A retrospective analysis of the InterTan nail and proximal femoral nail anti-rotation-Asia in the treatment of unstable intertrochanteric femur fractures in the elderly.","volume":"11","author":"W Yu","year":"2016","journal-title":"J Orthop Surg Res"},{"issue":"6","key":"pone.0304654.ref017","first-page":"469","article-title":"Comparison of clinical outcomes with three different intramedullary nailing devices in the treatment of unstable trochanteric fractures.","volume":"21","author":"S Zehir","year":"2015","journal-title":"Ulus Travma Acil Cerrahi Derg"},{"issue":"3","key":"pone.0304654.ref018","doi-asserted-by":"crossref","first-page":"e288","DOI":"10.3928\/01477447-20130222-16","article-title":"InterTan nail versus Proximal Femoral Nail Antirotation-Asia in the treatment of unstable trochanteric fractures.","volume":"36","author":"S Zhang","year":"2013","journal-title":"Orthopedics"},{"issue":"1","key":"pone.0304654.ref019","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13018-017-0648-2","article-title":"A retrospective analysis of the InterTan nail and proximal femoral nail anti-rotation in the treatment of intertrochanteric fractures in elderly patients with osteoporosis: a minimum follow-up of 3 years.","volume":"12","author":"H Zhang","year":"2017","journal-title":"J Orthop Surg Res"},{"issue":"7","key":"pone.0304654.ref020","first-page":"597","article-title":"[Comparison of PFNA and InterTAN intramedullary nail in treating unstable femoral intertrochanteric fractures].","volume":"30","author":"J Zhang","year":"2017","journal-title":"Zhongguo Gu Shang"},{"issue":"4","key":"pone.0304654.ref021","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1177\/0300060517710584","article-title":"INTERTAN nail versus proximal femoral nail antirotation-Asia for intertrochanteric femur fractures in elderly patients with primary osteoporosis","volume":"45","author":"H Zhang","year":"2017","journal-title":"J Int Med Res"},{"issue":"5","key":"pone.0304654.ref022","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1177\/0300060518761504","article-title":"Optimizing stability in AO\/OTA 31-A2 intertrochanteric fracture fixation in older patients with osteoporosis","volume":"46","author":"C Zhang","year":"2018","journal-title":"J Int Med Res"},{"issue":"1","key":"pone.0304654.ref023","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1186\/s13018-021-02874-9","article-title":"All-cause mortality risk in aged femoral intertrochanteric fracture patients.","volume":"16","author":"XP Li","year":"2021","journal-title":"J Orthop Surg Res"},{"issue":"2","key":"pone.0304654.ref024","doi-asserted-by":"crossref","first-page":"2309499019848778","DOI":"10.1177\/2309499019848778","article-title":"The calcar femorale: A new perspective","volume":"27","author":"A. Hammer","year":"2019","journal-title":"J Orthop Surg (Hong Kong)."},{"issue":"8","key":"pone.0304654.ref025","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.injury.2018.04.015","article-title":"Epidemiology and social costs of hip fracture.","volume":"49","author":"N Veronese","year":"2018","journal-title":"Injury"},{"issue":"2 Suppl. 1","key":"pone.0304654.ref026","first-page":"175","article-title":"Single- versus double-integrated screws in intramedullary nailing systems for surgical management of extracapsular hip fractures in the elderly: a systematic review.","volume":"33","author":"L Cipollaro","year":"2019","journal-title":"J Biol Regul Homeost Agents."},{"key":"pone.0304654.ref027","doi-asserted-by":"crossref","first-page":"e936923","DOI":"10.12659\/MSM.936923","article-title":"A Retrospective Study of 98 Elderly Patients with High-Risk Lateral Femoral Wall Intertrochanteric Hip Fractures to Compare Outcomes Following Surgery with Proximal Femoral Nail Antirotation (PFNA) Versus Dynamic Hip Screw (DHS).","volume":"28","author":"Z Tian","year":"2022","journal-title":"Med Sci Monit"},{"issue":"9","key":"pone.0304654.ref028","first-page":"1085","article-title":"[Effectiveness of proximal femoral nail anti-rotation combined with minimally invasive percutaneous plate osteosynthesis versus Intertan intramedullary nail fixation in treatment of intertrochanteric fracture with incomplete lateral wall].","volume":"34","author":"Z Chen","year":"2020","journal-title":"Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi"},{"issue":"9","key":"pone.0304654.ref029","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/BOT.0b013e3182a1f54b","article-title":"Biomechanical evaluation of interlocking lag screw design in intramedullary nailing of unstable pertrochanteric fractures.","volume":"27","author":"S Hoffmann","year":"2013","journal-title":"J Orthop Trauma"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0304654","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,23]],"date-time":"2024-11-23T13:57:38Z","timestamp":1732370258000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0304654"}},"subtitle":[],"editor":[{"given":"Alessandra","family":"Aldieri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,7,9]]},"references-count":29,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0304654","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,9]]}}}