{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T14:21:51Z","timestamp":1782915711034,"version":"3.54.5"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T00:00:00Z","timestamp":1717372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703292"],"award-info":[{"award-number":["81703292"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2016M590622"],"award-info":[{"award-number":["2016M590622"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Qingdao Postdoctoral Application Research Project","award":["2015150"],"award-info":[{"award-number":["2015150"]}]},{"DOI":"10.13039\/100019558","name":"Qingdao Key Health Discipline Development Fund","doi-asserted-by":"publisher","award":["201909A09"],"award-info":[{"award-number":["201909A09"]}],"id":[{"id":"10.13039\/100019558","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Qingdao Outstanding Health Professional Development Fund","award":["20190947"],"award-info":[{"award-number":["20190947"]}]},{"name":"Shandong Medical and Health Science and Technology Development Program","award":["2015wso329"],"award-info":[{"award-number":["2015wso329"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Age-related hearing loss is a complex disease caused by a combination of genetic and environmental factors, and a study have conducted animal experiments to explore the association between <jats:italic>BCL11B<\/jats:italic> heterozygosity and age-related hearing loss. The present study used established genetic models to examine the association between <jats:italic>BCL11B<\/jats:italic> gene polymorphisms and age-related hearing loss. A total of 410 older adults from two communities in Qingdao, China, participated in this study. The case group comprised individuals aged \u2265 60 years with age-related hearing loss, and the control group comprised individuals without age-related hearing loss from the same communities. The groups were matched 1:1 for age and sex. The individual characteristics of the participants were analyzed descriptively using the Mann\u2013Whitney U test and the chi-square test. To explore the association between <jats:italic>BCL11B<\/jats:italic> gene polymorphisms and age-related hearing loss, conditional logistic regression was performed to construct genetic models for two single-nucleotide-polymorphisms (SNPs) of <jats:italic>BCL11B<\/jats:italic>, and haplotype analysis was conducted to construct their haplotype domains. Two SNP sites of the <jats:italic>BCL11B<\/jats:italic> gene, four genetic models of rs1152781 (additive, dominant, recessive, and codominant), and five genetic models of rs1152783 (additive, dominant, recessive, codominant, and over dominant) were significantly associated with age-related hearing loss in the models both unadjusted and adjusted for all covariates (<jats:italic>P<\/jats:italic> &lt; 0.05). Additionally, a linkage disequilibrium between rs1152781 and rs1152783 was revealed through haplotype analysis. Our study revealed that <jats:italic>BCL11B<\/jats:italic> gene polymorphisms were significantly associated with age-related hearing loss.<\/jats:p>","DOI":"10.1371\/journal.pone.0304770","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T17:35:27Z","timestamp":1717436127000},"page":"e0304770","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Association between BCL11B gene polymorphisms and age-related hearing loss in the elderly: A case-control study in Qingdao, China"],"prefix":"10.1371","volume":"19","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingkai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jifeng","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hainan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaoyao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfeng","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-7004","authenticated-orcid":true,"given":"Haiping","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,6,3]]},"reference":[{"issue":"8","key":"pone.0304770.ref001","article-title":"Age-Related Hearing Loss.","volume":"9","author":"MR Bowl","year":"2019","journal-title":"Cold Spring Harbor perspectives in medicine"},{"issue":"1","key":"pone.0304770.ref002","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1186\/s12920-021-01044-4","article-title":"Association between NR3C1 gene polymorphisms and age-related hearing impairment in Qingdao Chinese elderly.","volume":"14","author":"W Song","year":"2021","journal-title":"BMC medical genomics"},{"issue":"3","key":"pone.0304770.ref003","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/WAD.0000000000000325","article-title":"Age-related Hearing Loss and Dementia.","volume":"33","author":"A Chern","year":"2019","journal-title":"Alzheimer disease and associated disorders."},{"key":"pone.0304770.ref004","author":"World Health Organization","journal-title":"WORLD REPORT ON HEARING"},{"key":"pone.0304770.ref005","first-page":"276","article-title":"Age-related hearing impairment and the triad of acquired hearing loss","volume":"9","author":"CH Yang","year":"2015","journal-title":"Frontiers in cellular neuroscience"},{"issue":"2","key":"pone.0304770.ref006","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/AUD.0000000000000610","article-title":"Heritability of Age-Related Hearing Loss in Middle-Aged and Elderly Chinese: A Population-Based Twin Study.","volume":"40","author":"H Duan","year":"2019","journal-title":"Ear and hearing."},{"issue":"12","key":"pone.0304770.ref007","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1111\/j.1532-5415.2009.02553.x","article-title":"Hearing acuity as a predictor of walking difficulties in older women","volume":"57","author":"A Viljanen","year":"2009","journal-title":"Journal of the American Geriatrics Society"},{"issue":"6","key":"pone.0304770.ref008","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1111\/j.1532-5415.2010.02880.x","article-title":"Hearing impairment affects older people\u2019s ability to drive in the presence of distracters","volume":"58","author":"L Hickson","year":"2010","journal-title":"Journal of the American Geriatrics Society"},{"issue":"5","key":"pone.0304770.ref009","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1093\/geront\/43.5.661","article-title":"The impact of hearing loss on quality of life in older adults.","volume":"43","author":"DS Dalton","year":"2003","journal-title":"The Gerontologist"},{"key":"pone.0304770.ref010","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.heares.2013.01.021","article-title":"Current concepts in age-related hearing loss: epidemiology and mechanistic pathways","volume":"303","author":"T Yamasoba","year":"2013","journal-title":"Hearing research"},{"issue":"2","key":"pone.0304770.ref011","doi-asserted-by":"crossref","first-page":"170","DOI":"10.5152\/iao.2018.5109","article-title":"The Association of GRM7 Single Nucleotide Polymorphisms with Age-Related Hearing Impairment in a Taiwanese Population.","volume":"14","author":"NC Chang","year":"2018","journal-title":"The journal of international advanced otology"},{"issue":"1","key":"pone.0304770.ref012","first-page":"31","article-title":"The association of heat shock protein genetic polymorphisms with age-related hearing impairment in Taiwan","volume":"50","author":"NC Chang","year":"2021","journal-title":"Journal of otolaryngology\u2014head & neck surgery = Le Journal d\u2019oto-rhino-laryngologie et de chirurgie cervico-faciale"},{"key":"pone.0304770.ref013","doi-asserted-by":"crossref","first-page":"241","DOI":"10.3389\/fnagi.2018.00241","article-title":"CDH23 Methylation Status and Presbycusis Risk in Elderly Women","volume":"10","author":"A Bouzid","year":"2018","journal-title":"Frontiers in aging neuroscience"},{"key":"pone.0304770.ref014","doi-asserted-by":"crossref","first-page":"669498","DOI":"10.3389\/fimmu.2021.669498","article-title":"Epigenetic Dynamics in the Function of T-Lineage Regulatory Factor Bcl11b","volume":"12","author":"T Sidwell","year":"2021","journal-title":"Frontiers in immunology"},{"issue":"13","key":"pone.0304770.ref015","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1038\/emboj.2012.142","article-title":"A dual function of Bcl11b\/Ctip2 in hippocampal neurogenesis","volume":"31","author":"R Simon","year":"2012","journal-title":"The EMBO journal"},{"key":"pone.0304770.ref016","doi-asserted-by":"crossref","first-page":"581674","DOI":"10.3389\/fcell.2020.581674","article-title":"Bcl11b\/Ctip2 in Skin, Tooth, and Craniofacial System.","volume":"8","author":"MT Daher","year":"2020","journal-title":"Frontiers in cell and developmental biology"},{"issue":"4","key":"pone.0304770.ref017","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1538\/expanim.60.355","article-title":"Bcl11b heterozygosity leads to age-related hearing loss and degeneration of outer hair cells of the mouse cochlea","volume":"60","author":"H Okumura","year":"2011","journal-title":"Experimental animals"},{"issue":"4","key":"pone.0304770.ref018","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1001\/jamainternmed.2013.1868","article-title":"Hearing loss and cognitive decline in older adults","volume":"173","author":"FR Lin","year":"2013","journal-title":"JAMA internal medicine"},{"issue":"9","key":"pone.0304770.ref019","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1093\/aje\/kwu333","article-title":"Hearing impairment and cognitive decline: a pilot study conducted within the atherosclerosis risk in communities neurocognitive study","volume":"181","author":"JA Deal","year":"2015","journal-title":"American journal of epidemiology"},{"issue":"6","key":"pone.0304770.ref020","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.annepidem.2010.03.011","article-title":"Associations between hearing impairment and mortality risk in older persons: the Blue Mountains Hearing Study.","volume":"20","author":"MJ Karpa","year":"2010","journal-title":"Annals of epidemiology."},{"issue":"2","key":"pone.0304770.ref021","first-page":"214","article-title":"Hearing loss and incident dementia","volume":"68","author":"FR Lin","year":"2011","journal-title":"Archives of neurology"},{"issue":"4","key":"pone.0304770.ref022","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1097\/MAO.0b013e318168d23b","article-title":"Sequence variants in host cell factor C1 are associated with M\u00e9ni\u00e8re\u2019s disease.","volume":"29","author":"JT Vrabec","year":"2008","journal-title":"Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology."},{"key":"pone.0304770.ref023","doi-asserted-by":"crossref","first-page":"3629624","DOI":"10.1155\/2021\/3629624","article-title":"A Genome-Wide Association Study of Age-Related Hearing Impairment in Middle- and Old-Aged Chinese Twins.","volume":"2021","author":"H Duan","year":"2021","journal-title":"BioMed research international"},{"key":"pone.0304770.ref024","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/978-1-4939-6442-0_5","article-title":"The MassARRAY(\u00ae) System for Targeted SNP Genotyping.","volume":"1492","author":"JA Ellis","year":"2017","journal-title":"Methods in molecular biology (Clifton, NJ)."},{"issue":"63","key":"pone.0304770.ref025","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abe6968","article-title":"Human cytomegalovirus expands a CD8(+) T cell population with loss of BCL11B expression and gain of NK cell identity.","volume":"6","author":"R Sottile","year":"2021","journal-title":"Science immunology"},{"issue":"6","key":"pone.0304770.ref026","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1161\/CIRCRESAHA.120.316666","article-title":"BCL11B Regulates Arterial Stiffness and Related Target Organ Damage","volume":"128","author":"JAC Valisno","year":"2021","journal-title":"Circulation research"},{"issue":"3","key":"pone.0304770.ref027","doi-asserted-by":"crossref","first-page":"C559","DOI":"10.1152\/ajpcell.00431.2009","article-title":"Actin polymerization in differentiated vascular smooth muscle cells requires vasodilator-stimulated phosphoprotein","volume":"298","author":"HR Kim","year":"2010","journal-title":"American journal of physiology Cell physiology"},{"issue":"4","key":"pone.0304770.ref028","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1161\/CIRCULATIONAHA.109.886655","article-title":"Arterial stiffness and cardiovascular events: the Framingham Heart Study","volume":"121","author":"GF Mitchell","year":"2010","journal-title":"Circulation"},{"issue":"25","key":"pone.0304770.ref029","doi-asserted-by":"crossref","first-page":"3384","DOI":"10.1161\/CIRCULATIONAHA.104.483628","article-title":"Elevated aortic pulse wave velocity, a marker of arterial stiffness, predicts cardiovascular events in well-functioning older adults","volume":"111","author":"K Sutton-Tyrrell","year":"2005","journal-title":"Circulation"},{"issue":"15","key":"pone.0304770.ref030","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1093\/eurheartj\/ehq024","article-title":"Prediction of cardiovascular events and all-cause mortality with central haemodynamics: a systematic review and meta-analysis","volume":"31","author":"C Vlachopoulos","year":"2010","journal-title":"European heart journal"},{"issue":"7","key":"pone.0304770.ref031","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1177\/00033197211068936","article-title":"The Association of Arterial Stiffness With Significant Carotid Atherosclerosis and Carotid Plaque Vulnerability.","volume":"73","author":"NPE Kadoglou","year":"2022","journal-title":"Angiology"},{"issue":"2","key":"pone.0304770.ref032","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1161\/01.STR.32.2.454","article-title":"Association between arterial stiffness and atherosclerosis: the Rotterdam Study","volume":"32","author":"NM van Popele","year":"2001","journal-title":"Stroke"},{"issue":"9","key":"pone.0304770.ref033","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1001\/2012.jama.10503","article-title":"Aortic stiffness, blood pressure progression, and incident hypertension","volume":"308","author":"BM Kaess","year":"2012","journal-title":"Jama"},{"issue":"14","key":"pone.0304770.ref034","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1016\/j.jacc.2007.10.065","article-title":"Pulse wave velocity is an independent predictor of the longitudinal increase in systolic blood pressure and of incident hypertension in the Baltimore Longitudinal Study of Aging","volume":"51","author":"SS Najjar","year":"2008","journal-title":"Journal of the American College of Cardiology"},{"issue":"3","key":"pone.0304770.ref035","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.bbrc.2019.12.100","article-title":"Hearing loss through apoptosis of the spiral ganglion neurons in apolipoprotein E knockout mice fed with a western diet","volume":"523","author":"YY Kim","year":"2020","journal-title":"Biochemical and biophysical research communications"},{"issue":"9","key":"pone.0304770.ref036","first-page":"e18025","article-title":"Association Between Hypertension and Hearing Loss.","volume":"13","author":"MU Nawaz","year":"2021","journal-title":"Cureus"},{"issue":"Suppl 1","key":"pone.0304770.ref037","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s12070-021-02378-2","article-title":"Hearing Loss and Hypertension: A Literature Review.","volume":"74","author":"A Umashankar","year":"2022","journal-title":"Indian journal of otolaryngology and head and neck surgery: official publication of the Association of Otolaryngologists of India."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0304770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T17:35:53Z","timestamp":1717436153000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0304770"}},"subtitle":[],"editor":[{"given":"Tadashi","family":"Ito","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,6,3]]},"references-count":37,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0304770","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,3]]}}}