{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T17:36:50Z","timestamp":1791221810048,"version":"4.1.0"},"reference-count":56,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Taif University, Saudi Arabia","award":["TU-DSPP-2024-53"],"award-info":[{"award-number":["TU-DSPP-2024-53"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Alzheimer\u2019s disease (AD) is a brain illness that causes gradual memory loss. AD has no treatment and cannot be cured, so early detection is critical. Various AD diagnosis approaches are used in this regard, but Magnetic Resonance Imaging (MRI) provides the most helpful neuroimaging tool for detecting AD. In this paper, we employ a DenseNet-201 based transfer learning technique for diagnosing different Alzheimer\u2019s stages as Non-Demented (ND), Moderate Demented (MOD), Mild Demented (MD), Very Mild Demented (VMD), and Severe Demented (SD). The suggested method for a dataset of MRI scans for Alzheimer\u2019s disease is divided into five classes. Data augmentation methods were used to expand the size of the dataset and increase DenseNet-201\u2019s accuracy. It was found that the proposed strategy provides a very high classification accuracy. This practical and reliable model delivers a success rate of 98.24%. The findings of the experiments demonstrate that the suggested deep learning approach is more accurate and performs well compared to existing techniques and state-of-the-art methods.<\/jats:p>","DOI":"10.1371\/journal.pone.0304995","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T13:53:21Z","timestamp":1725630801000},"page":"e0304995","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Classification of Alzheimer disease using DenseNet-201 based on deep transfer learning technique"],"prefix":"10.1371","volume":"19","author":[{"family":"Zia-ur-Rehman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Khalid","family":"Awang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3416-9720","authenticated-orcid":true,"given":"Javed","family":"Rashid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghulam","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samy F.","family":"Mahmoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia I.","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafiz Ishfaq","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"key":"pone.0304995.ref001","doi-asserted-by":"crossref","unstructured":"Mahyoub M, Randles M, Baker T, Yang P. 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