{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T14:12:53Z","timestamp":1780668773857,"version":"3.54.1"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002907","name":"Coloplast","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002907","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Ostomy surgery is a common procedure that poses various challenges for patients and healthcare professionals. There are numerous guidelines addressing different ostomy-related problems (ORPs) and supporting an interdisciplinary approach for ostomy care, but evidence-based literature for optimizing drug therapy after ostomy surgery is lacking.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Aim<\/jats:title>\n<jats:p>To investigate and characterize typical ORPs in relation to drug therapy and provide best practice recommendations from a pharmaceutical point of view.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Patients with an ileo- or colostomy were consecutively enrolled in a prospective, interventional monocentric cohort study during hospitalization, with particular attention to medication. A clinical pharmacist assessed DRPs by performing level 3 medication reviews and patient interviews. Pharmacists\u2019 interventions (PIs) were evaluated by two senior clinical pharmacists and documented in DokuPIK (Documentation of Pharmacists\u2019 Interventions in the Hospital). Following interdisciplinary discussions, physicians either accepted or rejected the proposed changes in drug therapy. Comparisons were made between ileostomy and colostomy patients regarding type and extent of PIs.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>Out of the 80 patients included in the cohort, 54 (67.5%) had an ileostomy and 26 (32.5%) a colostomy. In this study, 288 PIs were documented (234 ileostomy <jats:italic>vs<\/jats:italic>. 54 colostomy), of wich 94.0% were accepted and implemented by the physicians. The most common reason for PIs in both subgroups (29.6% ileostomy <jats:italic>vs<\/jats:italic>. 26.1% colostomy) was a missing drug although indicated (e.g. no loperamide, but high stoma output). The proportion of PIs associated with the ostomy was higher in ileostomy patients (48.3% ileostomy <jats:italic>vs<\/jats:italic>. 31.5% colostomy; p = 0.025). Typical ORPs were extracted and analyzed as case studies including recommendations for their respective management and prevention.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study highlights the importance of clinical pharmacists being a part of interdisciplinary teams to collaboratively improve ostomy care and patient safety. Especially ileostomy patients are more vulnerable for ORPs in the context of drug therapy and need to be monitored carefully.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0305047","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T17:49:17Z","timestamp":1717696157000},"page":"e0305047","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Enhancing drug therapy in ostomy patients: Best practice recommendations for medication management"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6424-6013","authenticated-orcid":true,"given":"Vivien","family":"Berger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Reeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Scherer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"H\u00e4rterich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sven","family":"M\u00f6ller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria Anette","family":"Wansing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"van der Linde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Langebrake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"issue":"10","key":"pone.0305047.ref001","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1463-1318.2009.01941.x","article-title":"Stoma-related complications and stoma size\u2014a 2-year follow up.","volume":"12","author":"E Persson","year":"2010","journal-title":"Colorectal Disease"},{"issue":"3","key":"pone.0305047.ref002","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1055\/s-0038-1676995","article-title":"Ostomy-Related Complications.","volume":"32","author":"DR Murken","year":"2019","journal-title":"Clin Colon Rect Surg"},{"issue":"3","key":"pone.0305047.ref003","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1097\/00004836-200203000-00003","article-title":"Nutritional management of short bowel syndrome in adults.","volume":"34","author":"A Sundaram","year":"2002","journal-title":"J Clin Gastroenterol"},{"issue":"5","key":"pone.0305047.ref004","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/0115426505020005493","article-title":"Short bowel syndrome: clinical guidelines for nutrition management.","volume":"20","author":"LE Matarese","year":"2005","journal-title":"Nutr Clin Pract."},{"issue":"9","key":"pone.0305047.ref005","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1080\/17425255.2023.2256216","article-title":"Drug absorption from oral formulations in patients with short bowel syndrome: a comprehensive update of the literature.","volume":"19","author":"S Azuz","year":"2023","journal-title":"Expert Opin Drug Metab Toxicol"},{"issue":"10","key":"pone.0305047.ref006","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1016\/j.clnu.2023.07.019","article-title":"ESPEN guideline on chronic intestinal failure in adults- Update 2023.","volume":"42","author":"L Pironi","year":"2023","journal-title":"Clinical Nutrition"},{"issue":"4","key":"pone.0305047.ref007","first-page":"320","article-title":"[Clinical nutrition in surgery","volume":"85","author":"A Weimann","year":"2014","journal-title":"Guidelines of the German Society for Nutritional Medicine]. 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