{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T10:34:50Z","timestamp":1787740490620,"version":"build-2784847793"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico, Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN205222"],"award-info":[{"award-number":["IN205222"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CONACYT, 237570"],"award-info":[{"award-number":["CONACYT, 237570"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["Fellowship 298047"],"award-info":[{"award-number":["Fellowship 298047"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>A large body of evidence has shown that treatments that interfere with memory consolidation become ineffective when animals are subjected to an intense learning experience; this effect has been observed after systemic and local administration of amnestic drugs into several brain areas, including the striatum. However, the effects of amnestic treatments on the process of extinction after intense training have not been studied. Previous research demonstrated increased spinogenesis in the dorsomedial striatum, but not in the dorsolateral striatum after intense training, indicating that the dorsomedial striatum is involved in the protective effect of intense training. To investigate this issue, male Wistar rats, previously trained with low, moderate, or high levels of foot shock, were used to study the effect of tetrodotoxin inactivation of dorsomedial striatum on memory consolidation and subsequent extinction of inhibitory avoidance. Performance of the task was evaluated during seven extinction sessions. Tetrodotoxin produced a marked deficit of memory consolidation of inhibitory avoidance trained with low and moderate intensities of foot shock, but normal consolidation occurred when a relatively high foot shock was used. The protective effect of intense training was long-lasting, as evidenced by the high resistance to extinction exhibited throughout the extinction sessions. We discuss the possibility that increased dendritic spinogenesis in dorsomedial striatum may underly this protective effect, and how this mechanism may be related to the resilient memory typical of post-traumatic stress disorder (PTSD).<\/jats:p>","DOI":"10.1371\/journal.pone.0305066","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T17:37:16Z","timestamp":1717695436000},"page":"e0305066","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Intense training prevents the amnestic effect of inactivation of dorsomedial striatum and induces high resistance to extinction"],"prefix":"10.1371","volume":"19","author":[{"given":"Martha","family":"Mart\u00ednez-Degollado","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea C.","family":"Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola C.","family":"Bello-Medina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3928-304X","authenticated-orcid":true,"given":"Gina L.","family":"Quirarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5237-9460","authenticated-orcid":true,"given":"Roberto A.","family":"Prado-Alcal\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,6,6]]},"reference":[{"issue":"1","key":"pone.0305066.ref001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/nlme.1998.3865","article-title":"Neural topography and chronology of memory consolidation: a review of functional inactivation findings","volume":"71","author":"A Ambrogi Lorenzini","year":"1999","journal-title":"Neurobiol Learn Mem"},{"issue":"3","key":"pone.0305066.ref002","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.physbeh.2008.01.024","article-title":"Temporary inactivation of the supramammillary area impairs spatial working memory and spatial reference memory retrieval","volume":"94","author":"L Aranda","year":"2008","journal-title":"Physiol Behav"},{"issue":"5","key":"pone.0305066.ref003","doi-asserted-by":"crossref","first-page":"e64749","DOI":"10.1371\/journal.pone.0064749","article-title":"Hippocampal inactivation with TTX impairs long-term spatial memory retrieval and modifies brain metabolic activity","volume":"8","author":"NM Conejo","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"pone.0305066.ref004","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/hipo.22210","article-title":"Intense aversive training protects memory from the amnestic effects of hippocampal inactivation: Persistent Memory after hippocampus Inactivation","volume":"24","author":"ME Gar\u00edn-Aguilar","year":"2014","journal-title":"Hippocampus"},{"issue":"1","key":"pone.0305066.ref005","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/nlme.1995.1008","article-title":"Time-dependent deficits of rat\u2019s memory consolidation induced by tetrodotoxin injections into the caudate-putamen, nucleus accumbens, and globus pallidus","volume":"63","author":"CA Lorenzini","year":"1995","journal-title":"Neurobiol Learn Mem"},{"issue":"1\u20132","key":"pone.0305066.ref006","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/0006-8993(96)00427-1","article-title":"Role of dorsal hippocampus in acquisition, consolidation and retrieval of rat\u2019s passive avoidance response: a tetrodotoxin functional inactivation study","volume":"730","author":"CA Lorenzini","year":"1996","journal-title":"Brain Res"},{"issue":"2","key":"pone.0305066.ref007","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.nlm.2006.01.006","article-title":"Amygdala or hippocampus inactivation after retrieval induces temporary memory deficit.","volume":"86","author":"RA Prado-Alcal\u00e1","year":"2006","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"pone.0305066.ref008","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0166-4328(03)00209-2","article-title":"Reversible lesion of the rat\u2019s orbitofrontal cortex interferes with hippocampus-dependent spatial memory","volume":"149","author":"AA Vafaei","year":"2004","journal-title":"Behav Brain Res"},{"issue":"4","key":"pone.0305066.ref009","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0361-9230(89)90076-2","article-title":"Retrograde amnesia induced by lidocaine injection into the striatum: protective effect of the negative reinforcer","volume":"22","author":"C P\u00e9rez-Ruiz","year":"1989","journal-title":"Brain Res Bull"},{"key":"pone.0305066.ref010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.3389\/fnbeh.2011.00083","article-title":"Enhanced training protects memory against amnesia produced by concurrent inactivation of amygdala and striatum, amygdala and substantia nigra, or striatum and substantia nigra","volume":"5","author":"R Salado-Castillo","year":"2011","journal-title":"Front Behav Neurosci"},{"issue":"3","key":"pone.0305066.ref011","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1007\/s00221-003-1704-1","article-title":"Enhanced inhibitory avoidance learning prevents the memory-impairing effects of post-training hippocampal inactivation","volume":"153","author":"C Quiroz","year":"2003","journal-title":"Exp Brain Res"},{"key":"pone.0305066.ref012","first-page":"8","article-title":"Differential effects of inactivation of discrete regions of medial prefrontal cortex on memory consolidation of moderate and intense inhibitory avoidance training","author":"ME Torres-Garc\u00eda","year":"2017","journal-title":"Front Pharmacol"},{"issue":"2","key":"pone.0305066.ref013","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.nlm.2011.06.002","article-title":"Parallel associative processing in the dorsal striatum: segregation of stimulus-response and cognitive control subregions","volume":"96","author":"BD Devan","year":"2011","journal-title":"Neurobiol Learn Mem"},{"issue":"1\u20132","key":"pone.0305066.ref014","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0166-4328(98)00107-7","article-title":"Effects of medial and lateral caudate-putamen lesions on place-and cue-guided behaviors in the water maze: relation to thigmotaxis","volume":"100","author":"BD Devan","year":"1999","journal-title":"Behav Brain Res"},{"key":"pone.0305066.ref015","doi-asserted-by":"crossref","first-page":"598570","DOI":"10.3389\/fnbeh.2020.598570","article-title":"Place vs. Response learning: History, controversy, and neurobiology","volume":"14","author":"J. Goodman","year":"2020","journal-title":"Front Behav Neurosci"},{"key":"pone.0305066.ref016","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.nlm.2013.01.001","article-title":"Glucocorticoids in the dorsomedial striatum modulate the consolidation of spatial but not procedural memory","volume":"101","author":"YR Lozano","year":"2013","journal-title":"Neurobiol Learn Mem"},{"key":"pone.0305066.ref017","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.nlm.2017.03.020","article-title":"Glucocorticoid administration into the dorsolateral but not dorsomedial striatum accelerates the shift from a spatial toward procedural memory","volume":"141","author":"C Siller-P\u00e9rez","year":"2017","journal-title":"Neurobiol Learn Mem"},{"issue":"4","key":"pone.0305066.ref018","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1101\/lm.81004","article-title":"Contributions of striatal subregions to place and response learning","volume":"11","author":"HH Yin","year":"2004","journal-title":"Learn Mem"},{"issue":"6","key":"pone.0305066.ref019","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/nrn1919","article-title":"The role of the basal ganglia in habit formation","volume":"7","author":"HH Yin","year":"2006","journal-title":"Nat Rev Neurosci"},{"issue":"2","key":"pone.0305066.ref020","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbr.2005.07.012","article-title":"Inactivation of dorsolateral striatum enhances sensitivity to changes in the action\u2013outcome contingency in instrumental conditioning","volume":"166","author":"H Yin","year":"2006","journal-title":"Behav Brain Res"},{"issue":"3","key":"pone.0305066.ref021","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nn.2261","article-title":"Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill","volume":"12","author":"HH Yin","year":"2009","journal-title":"Nat Neurosci"},{"issue":"6","key":"pone.0305066.ref022","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1016\/j.cell.2015.04.049","article-title":"A corticostriatal path targeting striosomes controls decision-making under conflict","volume":"161","author":"A Friedman","year":"2015","journal-title":"Cell"},{"issue":"5","key":"pone.0305066.ref023","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0194-20.2020","article-title":"Retrograde labeling illuminates distinct topographical organization of D1 and D2 receptor-positive pyramidal neurons in the prefrontal cortex of mice","volume":"26","author":"SM Green","year":"2020","journal-title":"eNeuro"},{"issue":"13","key":"pone.0305066.ref024","doi-asserted-by":"crossref","first-page":"5718","DOI":"10.1523\/JNEUROSCI.5248-12.2013","article-title":"The rat prefrontostriatal system analyzed in 3D: evidence for multiple interacting functional units","volume":"33","author":"P Mailly","year":"2013","journal-title":"J Neurosci"},{"issue":"1","key":"pone.0305066.ref025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(91)90247-L","article-title":"Organization of amygdaloid projections to the prefrontal cortex and associated striatum in the rat","volume":"44","author":"AJ McDonald","year":"1991","journal-title":"Neuroscience"},{"issue":"3","key":"pone.0305066.ref026","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/0306-4522(89)90128-0","article-title":"The organization of the projection from the cerebral cortex to the striatum in the rat","volume":"29","author":"AJ McGeorge","year":"1989","journal-title":"Neuroscience"},{"issue":"2","key":"pone.0305066.ref027","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/cne.902900205","article-title":"Topographical organization of the efferent projections of the medial prefrontal cortex in the rat: an anterograde tract-tracing study with Phaseolus vulgaris leucoagglutinin","volume":"290","author":"SR Sesack","year":"1989","journal-title":"J Comp Neurol"},{"issue":"8","key":"pone.0305066.ref028","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.tins.2004.06.006","article-title":"Putting a spin on the dorsal-ventral divide of the striatum","volume":"27","author":"P Voorn","year":"2004","journal-title":"Trends Neurosci"},{"issue":"42","key":"pone.0305066.ref029","article-title":"Mushroom spine dynamics in medium spiny neurons of dorsal striatum associated with memory of moderate and intense training","volume":"113","author":"PC Bello-Medina","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0305066.ref030","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.neuroscience.2021.10.008","article-title":"Dynamics of dendritic spines in dorsal striatum after retrieval of moderate and strong inhibitory avoidance learning","volume":"497","author":"PC Bello-Medina","year":"2022","journal-title":"Neuroscience"},{"issue":"7569","key":"pone.0305066.ref031","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nature15257","article-title":"Labelling and optical erasure of synaptic memory traces in the motor cortex","volume":"525","author":"A Hayashi-Takagi","year":"2015","journal-title":"Nature"},{"key":"pone.0305066.ref032","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.nlm.2014.06.010","article-title":"Habit learning and memory in mammals: behavioral and neural characteristics","volume":"114","author":"A Gasbarri","year":"2014","journal-title":"Neurobiol Learn Mem"},{"issue":"2","key":"pone.0305066.ref033","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1037\/bne0000190","article-title":"Differential effects of neural inactivation of the dorsolateral striatum on response and latent extinction","volume":"131","author":"J Goodman","year":"2017","journal-title":"Behav Neurosci"},{"key":"pone.0305066.ref034","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.neuroscience.2017.03.042","article-title":"Enhancing and impairing extinction of habit memory through modulation of NMDA receptors in the dorsolateral striatum","volume":"352","author":"J Goodman","year":"2017","journal-title":"Neuroscience"},{"key":"pone.0305066.ref035","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.nlm.2016.09.012","article-title":"The dorsolateral striatum selectively mediates extinction of habit memory","volume":"136","author":"J Goodman","year":"2016","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"pone.0305066.ref036","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.neuropharm.2008.04.013","article-title":"Impairment of endocannabinoids activity in the dorsolateral striatum delays extinction of behavior in a procedural memory task in rats","volume":"55","author":"PE Rueda-Orozco","year":"2008","journal-title":"Neuropharmacology"},{"key":"pone.0305066.ref037","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.nlm.2013.11.009","article-title":"The roles of the nucleus accumbens core, dorsomedial striatum, and dorsolateral striatum in learning: Performance and extinction of Pavlovian fear-conditioned responses and instrumental avoidance responses","volume":"109","author":"E Wendler","year":"2014","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"pone.0305066.ref038","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4778","article-title":"Enhanced flexibility of place discrimination learning by targeting striatal cholinergic interneurons","volume":"5","author":"K Okada","year":"2014","journal-title":"Nat Commun"},{"key":"pone.0305066.ref039","volume-title":"Guide for the Care and Use of Laboratory Animals","edition":"8"},{"key":"pone.0305066.ref040","volume-title":"Rat brain in stereotaxic coordinates","author":"G Paxinos","year":"2007"},{"key":"pone.0305066.ref041","first-page":"6","article-title":"Extinction procedure induces pruning of dendritic spines in CA1 hippocampal field depending on strength of training in rats","author":"ME Gar\u00edn-Aguilar","year":"2012","journal-title":"Front Behav Neurosci"},{"issue":"107428","key":"pone.0305066.ref042","doi-asserted-by":"crossref","first-page":"107428","DOI":"10.1016\/j.nlm.2021.107428","article-title":"Recruitment of neurons in basolateral amygdala after intense training produces a stronger memory trace","volume":"181","author":"CX Ruiz-L\u00f3pez","year":"2021","journal-title":"Neurobiol Learn Mem"},{"key":"pone.0305066.ref043","volume-title":"Neural Plasticity and Memory: From Genes to Brain Imaging","author":"R.A. Prado-Alcal\u00e1","year":"2007"},{"issue":"5\u20136","key":"pone.0305066.ref044","first-page":"501","article-title":"Intense emotional experiences and enhanced training prevent memory loss induced by post-training amnesic treatments administered to the striatum, amygdala, hippocampus or substantia nigra","volume":"23","author":"RA Prado-Alcal\u00e1","year":"2012","journal-title":"Rev Neurosci"},{"key":"pone.0305066.ref045","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.nlm.2017.02.001","article-title":"Differential Arc protein expression in dorsal and ventral striatum after moderate and intense inhibitory avoidance training","volume":"140","author":"DA Gonz\u00e1lez-Franco","year":"2017","journal-title":"Neurobiol Learn Mem"},{"issue":"18","key":"pone.0305066.ref046","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1097\/WNR.0000000000000881","article-title":"Recruitment of prefrontal-striatal circuit in response to skilled motor challenge","volume":"28","author":"Y Guo","year":"2017","journal-title":"Neuroreport"},{"issue":"5","key":"pone.0305066.ref047","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0125-19.2019","article-title":"Chemogenetic silencing of prelimbic cortex to anterior dorsomedial striatum projection attenuates operant responding","volume":"6","author":"ML Shipman","year":"2019","journal-title":"eNeuro"},{"issue":"4","key":"pone.0305066.ref048","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1037\/0735-7044.112.4.885","article-title":"Correlational relationship between shock intensity and corticosterone secretion on the establishment and subsequent expression of contextual fear conditioning","volume":"112","author":"MI Cordero","year":"1998","journal-title":"Behav Neurosci"},{"issue":"4","key":"pone.0305066.ref049","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1111\/j.1460-9568.1997.tb01412.x","article-title":"Experience\u2010dependent facilitating effect of corticosterone on spatial memory formation in the water maze","volume":"9","author":"C Sandi","year":"1997","journal-title":"Eur J Neurosci"},{"issue":"10","key":"pone.0305066.ref050","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1101\/lm.654407","article-title":"Glucocorticoid administration into the dorsal stratium facilitates memory consolidation of inhibitory avoidance training but not of the context or footshock components","volume":"14","author":"AC Medina","year":"2007","journal-title":"Learning & Memory"},{"issue":"2","key":"pone.0305066.ref051","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0959-4388(02)00306-9","article-title":"Role of adrenal stress hormones in forming lasting memories in the brain","volume":"12","author":"JL McGaugh","year":"2002","journal-title":"Curr Opin Neurobiol"},{"issue":"7","key":"pone.0305066.ref052","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1016\/j.neubiorev.2011.11.001","article-title":"Interacting brain systems modulate memory consolidation","volume":"36","author":"CK McIntyre","year":"2012","journal-title":"Neurosci Biobehav Rev"},{"issue":"2","key":"pone.0305066.ref053","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/nlme.1996.3765","article-title":"Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage","volume":"67","author":"B Roozendaal","year":"1997","journal-title":"Neurobiol Learn Mem"},{"issue":"1","key":"pone.0305066.ref054","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1111\/j.1460-9568.1997.tb01355.x","article-title":"Basolateral amygdala lesions block the memory-enhancing effect of glucocorticoid administration in the dorsal hippocampus of rats","volume":"9","author":"B Roozendaal","year":"1997","journal-title":"Eur J Neurosci"},{"issue":"4","key":"pone.0305066.ref055","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/j.bbrc.2005.07.173","article-title":"Rapid spinogenesis of pyramidal neurons induced by activation of glucocorticoid receptors in adult male rat hippocampus","volume":"335","author":"Y Komatsuzaki","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"pone.0305066.ref056","doi-asserted-by":"crossref","first-page":"e34124","DOI":"10.1371\/journal.pone.0034124","article-title":"Corticosterone induces rapid spinogenesis via synaptic glucocorticoid receptors and kinase networks in hippocampus","volume":"7","author":"Y Komatsuzaki","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"pone.0305066.ref057","doi-asserted-by":"crossref","first-page":"e12811","DOI":"10.1111\/jne.12811","article-title":"Glucocorticoid and \u03b2-adrenergic regulation of hippocampal dendritic spines","volume":"32","author":"SL Lesuis","year":"2020","journal-title":"J Neuroendocrinol"},{"issue":"2","key":"pone.0305066.ref058","doi-asserted-by":"crossref","first-page":"e12561","DOI":"10.1111\/jne.12561","article-title":"Rapid nongenomic modulation by neurosteroids of dendritic spines in the hippocampus: Androgen, oestrogen and corticosteroid","volume":"30","author":"G Murakami","year":"2018","journal-title":"J Neuroendocrinol"},{"key":"pone.0305066.ref059","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fncir.2013.00191","article-title":"Corticosterone rapidly increases thorns of CA3 neurons via synaptic\/extranuclear glucocorticoid receptor in rat hippocampus","volume":"7","author":"M Yoshiya","year":"2013","journal-title":"Front Neural Circuits"},{"issue":"38","key":"pone.0305066.ref060","doi-asserted-by":"crossref","first-page":"16074","DOI":"10.1073\/pnas.1110444108","article-title":"Glucocorticoids are critical regulators of dendritic spine development and plasticity in vivo","volume":"108","author":"C Liston","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"pone.0305066.ref061","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1038\/nn.3387","article-title":"Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance","volume":"16","author":"C Liston","year":"2013","journal-title":"Nat Neurosci"},{"key":"pone.0305066.ref062","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.ijpsycho.2014.11.006","article-title":"Learning models of PTSD: Theoretical accounts and psychobiological evidence","volume":"98","author":"S Lissek","year":"2015","journal-title":"Int J Psychophysiol"},{"issue":"8","key":"pone.0305066.ref063","doi-asserted-by":"crossref","first-page":"615","DOI":"10.3389\/fphar.2017.00615","article-title":"Using the single prolonged stress model to examine the pathophysiology of PTSD","volume":"11","author":"RR Souza","year":"2017","journal-title":"Front Pharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0305066","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T17:37:59Z","timestamp":1717695479000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0305066"}},"subtitle":[],"editor":[{"given":"Yukiori","family":"Goto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,6,6]]},"references-count":63,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0305066","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,6]]}}}