{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,12]],"date-time":"2025-07-12T22:59:34Z","timestamp":1752361174257,"version":"3.40.5"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T00:00:00Z","timestamp":1719446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This study evaluated the effect of the systemic immune-inflammation index\/albumin ratio (SII\/ALB) on the prognosis of immunotherapy-treated patients receiving opioids.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A retrospective analysis was conducted of 185 immunotherapy-treated patients who received opioids at Xuzhou Central Hospital from 01\/09\/2021 to 01\/09\/2023. The results of related clinical data were collected during the week before the cancer patients received immunotherapy. The SII\/ALB cut-off value was determined, and the relationship between the SII\/ALB and clinical pathological parameters was analyzed using the chi-square test. The effect of the SII\/ALB on progression-free survival (PFS) was examined using Kaplan-Meier curves and the Cox proportional hazard model.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Result<\/jats:title>\n<jats:p>The SII\/ALB cut-off value was 20.86, and patients were divided into low (SII\/ALB \u2264 20.86) and high (SII\/ALB &gt; 20.86) SII\/ALB groups. Adverse reactions (hazard ratio [HR] = 0.108; 95% confidence interval [CI]: 0.061\u20130.192, P &lt; 0.001) and the SII\/ALB (HR = 0.093; 95% CI: 0.057\u20130.151, P &lt; 0.001) were independent prognostic factors for PFS. Compared with the high SII\/ALB group, the low SII\/ALB group had longer PFS after opioid treatment (12.2 vs. 5.2 months, P &lt; 0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>The SII\/ALB is a potentially important prognostic parameter in immunotherapy-treated patients receiving opioids.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0305119","type":"journal-article","created":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T18:35:46Z","timestamp":1719513346000},"page":"e0305119","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Prognostic value of systemic immune-inflammation index\/albumin ratio for immunotherapy-treated patients receiving opioids"],"prefix":"10.1371","volume":"19","author":[{"given":"Lei","family":"Yan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pan","family":"Kang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chengsong","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bu","family":"Jinhui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5082-5404","authenticated-orcid":true,"given":"Liu","family":"Yong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,6,27]]},"reference":[{"issue":"3","key":"pone.0305119.ref001","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries [J].","volume":"71","author":"H Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"pone.0305119.ref002","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev-pathol-042020-042741","article-title":"Immune Checkpoint Inhibitors for the Treatment of Cancer: Clinical Impact and Mechanisms of Response and Resistance [J].","volume":"16","author":"S Bagchi","year":"2021","journal-title":"Annu Rev Pathol"},{"issue":"9","key":"pone.0305119.ref003","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1093\/annonc\/mdm056","article-title":"Prevalence of pain in patients with cancer: a systematic review of the past 40 years [J].","volume":"18","author":"Everdingen M H van den Beuken-van","year":"2007","journal-title":"Ann Oncol"},{"issue":"3","key":"pone.0305119.ref004","doi-asserted-by":"crossref","first-page":"329","DOI":"10.6004\/jnccn.2021.0012","article-title":"Colon Cancer, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology [J].","volume":"19","author":"B Benson A","year":"2021","journal-title":"J Natl Compr Canc Netw"},{"issue":"6","key":"pone.0305119.ref005","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1213\/ANE.0b013e318232b35a","article-title":"Morphine-induced epidermal growth factor pathway activation in non-small cell lung cancer [J].","volume":"113","author":"N Fujioka","year":"2011","journal-title":"Anesthesia & Analgesia"},{"key":"pone.0305119.ref006","first-page":"13","article-title":"Effect of Concomitant Use of Analgesics on Prognosis in Patients Treated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-Analysis [J]","author":"Z Mao","year":"2022","journal-title":"Frontiers in Immunology"},{"issue":"1","key":"pone.0305119.ref007","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/s12967-021-02784-8","article-title":"The role of opioids in cancer response to immunotherapy [J].","volume":"19","author":"A Botticelli","year":"2021","journal-title":"J Transl Med"},{"key":"pone.0305119.ref008","article-title":"Opioids impair Nivolumab outcomes: a retrospective propensity score analysis in non-small-cell lung cancer [J].","author":"Y Taniguchi","year":"2020","journal-title":"BMJ Support Palliat Care"},{"issue":"9","key":"pone.0305119.ref009","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1007\/s12094-019-02282-w","article-title":"Impact of antibiotic use and other concomitant medications on the efficacy of immune checkpoint inhibitors in patients with advanced cancer [J].","volume":"22","author":"A. 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