{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:47:32Z","timestamp":1790815652167,"version":"4.1.0"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T00:00:00Z","timestamp":1720137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Medical Science and Technology Team of the Health Commission of Shanxi Province","award":["No. 2020TD17"],"award-info":[{"award-number":["No. 2020TD17"]}]},{"name":"Oral Health Prevention and Control Technology Innovation Center of Shanxi Province"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This meta-analysis aims to assess the success rate of pulpotomy in the treatment of permanent teeth with carious pulp exposure and to compare the efficacy of different capping materials. Randomized controlled trials were searched in PubMed, EMBASE, Web of Science, Clinicaltrial.gov, and Cochrane Library until August 31, 2023. The pooled success rate was estimated in the overall population and in subgroups. Additional analyses comparing different capping materials using odds ratio (OR) and 95% confidence interval (95%CI) were performed. The certainty of evidence was graded using the GRADE approach. A total of 25 randomized trials with an average follow-up duration \u2265 12 months were finally included. The overall success rate of pulpotomy was 86.7% (95%CI: 82.0\u201390.7%). The success rate was not significantly affected by root development, pulpotomy type, and follow-up duration. Teeth with irreversible pulpitis had a relatively lower success rate than teeth with normal pulp or reversible pulpitis (82.4% [95%CI: 74.6\u201389.0%] <jats:italic>vs<\/jats:italic> 92.0% [95%CI: 87.9\u201395.4%], P = 0.013). Directly compared to conventional calcium hydroxide, mineral trioxide aggregate (88.2% <jats:italic>vs<\/jats:italic> 79.1%, OR = 2.41, 95%CI: 1.28\u20134.51, P = 0.006) and Biodentine (97.5% <jats:italic>vs<\/jats:italic> 82.9%, OR = 6.03, 95%CI: 0.97\u201337.6, P = 0.054) had higher successful rates. No significant difference between MTA and other biomaterials was found. The results were graded as very low to low certainty of evidence. In conclusion, pulpotomy is an effective treatment of permanent teeth with carious pulp exposure. Mineral trioxide aggregate and Biodentine can be recommended with more favorable outcomes as capping materials.<\/jats:p>","DOI":"10.1371\/journal.pone.0305218","type":"journal-article","created":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T17:38:55Z","timestamp":1720201135000},"page":"e0305218","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Efficacy of pulpotomy for permanent teeth with carious pulp exposure: A systematic review and meta-analysis of randomized controlled trials"],"prefix":"10.1371","volume":"19","author":[{"given":"Wenjun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8355-2502","authenticated-orcid":true,"given":"Jing","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,7,5]]},"reference":[{"issue":"9","key":"pone.0305218.ref001","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1016\/j.joen.2021.07.015","article-title":"AAE Position Statement on Vital Pulp Therapy","volume":"47","year":"2021","journal-title":"J Endod"},{"issue":"12","key":"pone.0305218.ref002","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1016\/j.joen.2014.08.010","article-title":"Correlation between clinical and histologic pulp diagnoses","volume":"40","author":"D Ricucci","year":"2014","journal-title":"J Endod"},{"issue":"Suppl 2","key":"pone.0305218.ref003","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/iej.13866","article-title":"Factors that influence the outcome of pulpotomy in permanent teeth","volume":"56","author":"HF Duncan","year":"2023","journal-title":"Int Endod J"},{"issue":"2","key":"pone.0305218.ref004","doi-asserted-by":"crossref","first-page":"178","DOI":"10.14715\/cmb\/2022.68.2.25","article-title":"Comparison of pulpal vitalization and root canal therapy in symptomatic immature permanent molars","volume":"68","author":"J Guang","year":"2022","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"issue":"7","key":"pone.0305218.ref005","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1111\/iej.13128","article-title":"Management of deep caries and the exposed pulp","volume":"52","author":"L Bjorndal","year":"2019","journal-title":"Int Endod J"},{"issue":"7","key":"pone.0305218.ref006","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1111\/iej.13080","article-title":"European Society of Endodontology position statement: Management of deep caries and the exposed pulp","volume":"52","author":"European Society of Endodontology","year":"2019","journal-title":"Int Endod J"},{"issue":"2","key":"pone.0305218.ref007","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s00784-013-1003-6","article-title":"Two-year results of vital pulp therapy in permanent molars with irreversible pulpitis: an ongoing multicenter randomized clinical trial","volume":"18","author":"S Asgary","year":"2014","journal-title":"Clin Oral Investig"},{"issue":"12","key":"pone.0305218.ref008","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/j.joen.2017.08.007","article-title":"Comparative Evaluation of Postoperative Pain and Success Rate after Pulpotomy and Root Canal Treatment in Cariously Exposed Mature Permanent Molars: A Randomized Controlled Trial","volume":"43","author":"M Galani","year":"2017","journal-title":"J Endod"},{"issue":"5","key":"pone.0305218.ref009","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.joen.2010.12.004","article-title":"Vital pulp therapy in vital permanent teeth with cariously exposed pulp: a systematic review","volume":"37","author":"P Aguilar","year":"2011","journal-title":"J Endod"},{"issue":"1","key":"pone.0305218.ref010","first-page":"16","article-title":"Primary Tooth Vital Pulp Therapy: A Systematic Review and Meta-analysis","volume":"39","author":"JA Coll","year":"2017","journal-title":"Pediatr Dent"},{"issue":"2","key":"pone.0305218.ref011","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4103\/ijdr.ijdr_1150_21","article-title":"The outcome of partial pulpotomy in traumatized permanent anterior teeth\u2014A systematic review and meta-analysis","volume":"33","author":"S Madhumita","year":"2022","journal-title":"Indian J Dent Res"},{"issue":"3","key":"pone.0305218.ref012","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11030787","article-title":"Short-Term Pain Evolution and Treatment Success of Pulpotomy as Irreversible Pulpitis Permanent Treatment: A Non-Randomized Clinical Study","volume":"11","author":"J Beauquis","year":"2022","journal-title":"J Clin Med"},{"issue":"1","key":"pone.0305218.ref013","first-page":"223","article-title":"Outcome of Mineral Trioxide Aggregate Pulpotomy for Mature Permanent Molars with Symptoms Indicative of Irreversible Pulpitis","volume":"31","author":"MI Hussain","year":"2022","journal-title":"Mymensingh Med J"},{"issue":"1","key":"pone.0305218.ref014","doi-asserted-by":"crossref","first-page":"20280","DOI":"10.1038\/s41598-022-24815-0","article-title":"Factors affecting the outcome of full pulpotomy in permanent posterior teeth diagnosed with reversible or irreversible pulpitis","volume":"12","author":"M Zhang","year":"2022","journal-title":"Sci Rep"},{"issue":"6","key":"pone.0305218.ref015","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.adaj.2023.02.018","article-title":"Effect of full pulpotomy using a calcium silicate-based bioactive ceramic in adult permanent teeth with symptoms indicative of irreversible pulpitis: A retrospective study","volume":"154","author":"X Zhu","year":"2023","journal-title":"J Am Dent Assoc"},{"issue":"1","key":"pone.0305218.ref016","doi-asserted-by":"crossref","first-page":"19664","DOI":"10.1038\/s41598-022-20918-w","article-title":"Outcome of pulpotomy in permanent teeth with irreversible pulpitis: a systematic review and meta-analysis","volume":"12","author":"A Ather","year":"2022","journal-title":"Sci Rep"},{"issue":"11","key":"pone.0305218.ref017","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.joen.2019.07.005","article-title":"Outcome of Partial Pulpotomy in Cariously Exposed Posterior Permanent Teeth: A Systematic Review and Meta-analysis","volume":"45","author":"F Elmsmari","year":"2019","journal-title":"J Endod"},{"issue":"11","key":"pone.0305218.ref018","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/j.joen.2021.08.008","article-title":"Prognosis of Vital Pulp Therapy on Permanent Dentition: A Systematic Review and Meta-analysis of Randomized Controlled Trials","volume":"47","author":"M Sabeti","year":"2021","journal-title":"J Endod"},{"issue":"6","key":"pone.0305218.ref019","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1002\/cre2.767","article-title":"Comparative efficacy of materials used in patients undergoing pulpotomy or direct pulp capping in carious teeth: A systematic review and meta-analysis","volume":"9","author":"A Fasoulas","year":"2023","journal-title":"Clin Exp Dent Res"},{"issue":"9","key":"pone.0305218.ref020","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1111\/iej.13939","article-title":"Success rate of permanent teeth pulpotomy using bioactive materials: A systematic review and meta-analysis of randomized clinical trials","volume":"56","author":"EJNL Silva","year":"2023","journal-title":"Int Endod J"},{"issue":"1","key":"pone.0305218.ref021","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s00784-022-04830-1","article-title":"Comparative efficacy of medicaments or techniques for pulpotomy of primary molars: a network meta-analysis","volume":"27","author":"J Guo","year":"2023","journal-title":"Clin Oral Investig"},{"issue":"3","key":"pone.0305218.ref022","first-page":"317","article-title":"Outcome of partial pulpotomy verses full pulpotomy using biodentine in vital mature permanent molar with clinical symptoms indicative of irreversible pulpitis: A randomized clinical trial","volume":"25","author":"HC Baranwal","year":"2022","journal-title":"J Conserv Dent"},{"issue":"9","key":"pone.0305218.ref023","doi-asserted-by":"crossref","first-page":"5171","DOI":"10.1007\/s00784-023-05136-6","article-title":"Comparative evaluation of treatment outcome of partial pulpotomy using different agents in permanent teeth-a randomized controlled trial","volume":"27","author":"DVV Singh","year":"2023","journal-title":"Clin Oral Investig"},{"issue":"10","key":"pone.0305218.ref024","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/iej.13955","article-title":"Treatment outcome of partial pulpotomy using two different calcium silicate materials in mature permanent teeth with symptoms of irreversible pulpitis: A randomized clinical trial","volume":"56","author":"GN Tzanetakis","year":"2023","journal-title":"Int Endod J"},{"key":"pone.0305218.ref025","doi-asserted-by":"crossref","first-page":"b2700","DOI":"10.1136\/bmj.b2700","article-title":"The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration","volume":"339","author":"A Liberati","year":"2009","journal-title":"BMJ"},{"key":"pone.0305218.ref026","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"JP Higgins","year":"2011","journal-title":"BMJ"},{"issue":"1","key":"pone.0305218.ref027","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/2049-3258-72-39","article-title":"Metaprop: a Stata command to perform meta-analysis of binomial data","volume":"72","author":"VN Nyaga","year":"2014","journal-title":"Arch Public Health"},{"issue":"7650","key":"pone.0305218.ref028","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","article-title":"GRADE: an emerging consensus on rating quality of evidence and strength of recommendations","volume":"336","author":"GH Guyatt","year":"2008","journal-title":"BMJ"},{"issue":"1","key":"pone.0305218.ref029","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3109\/00016357.2011.654251","article-title":"Treatment outcomes of pulpotomy in permanent molars with irreversible pulpitis using biomaterials: a multi-center randomized controlled trial","volume":"71","author":"S Asgary","year":"2013","journal-title":"Acta Odontol Scand"},{"issue":"9","key":"pone.0305218.ref030","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/iej.12225","article-title":"Randomized control trial comparing calcium hydroxide and mineral trioxide aggregate for partial pulpotomies in cariously exposed pulps of permanent molars","volume":"47","author":"P Chailertvanitkul","year":"2014","journal-title":"Int Endod J"},{"issue":"2","key":"pone.0305218.ref031","doi-asserted-by":"crossref","first-page":"158","DOI":"10.4103\/ccd.ccd_587_17","article-title":"Comparative Evaluation of Three Different Materials: Mineral Trioxide Aggregate, Triple Antibiotic Paste, and Abscess Remedy on Apical Development of Vital Young Permanent Teeth","volume":"9","author":"HR Eppa","year":"2018","journal-title":"Contemp Clin Dent"},{"issue":"5","key":"pone.0305218.ref032","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.joen.2014.01.009","article-title":"Comparative evaluation of platelet-rich fibrin and mineral trioxide aggregate as pulpotomy agents in permanent teeth with incomplete root development: a randomized controlled trial","volume":"40","author":"D Keswani","year":"2014","journal-title":"J Endod"},{"issue":"4","key":"pone.0305218.ref033","doi-asserted-by":"crossref","first-page":"512","DOI":"10.4103\/0976-237X.194107","article-title":"Comparative evaluation of platelet-rich fibrin, mineral trioxide aggregate, and calcium hydroxide as pulpotomy agents in permanent molars with irreversible pulpitis: A randomized controlled trial","volume":"7","author":"V Kumar","year":"2016","journal-title":"Contemp Clin Dent"},{"issue":"1","key":"pone.0305218.ref034","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-263X.2012.01224.x","article-title":"Pulpotomy in caries-exposed immature permanent molars using calcium-enriched mixture cement or mineral trioxide aggregate: a randomized clinical trial","volume":"23","author":"A Nosrat","year":"2013","journal-title":"Int J Paediatr Dent"},{"issue":"5","key":"pone.0305218.ref035","first-page":"364","article-title":"Partial Pulpotomy in Immature Permanent Molars After Carious Exposures Using Different Hemorrhage Control and Capping Materials","volume":"39","author":"B Ozgur","year":"2017","journal-title":"Pediatr Dent"},{"issue":"2","key":"pone.0305218.ref036","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF03262577","article-title":"Calcium hydroxide vs mineral trioxide aggregates for partial pulpotomy of permanent molars with deep caries","volume":"8","author":"MA Qudeimat","year":"2007","journal-title":"Eur Arch Paediatr Dent"},{"issue":"9","key":"pone.0305218.ref037","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1016\/j.joen.2017.03.033","article-title":"Partial Pulpotomy in Mature Permanent Teeth with Clinical Signs Indicative of Irreversible Pulpitis: A Randomized Clinical Trial","volume":"43","author":"NA Taha","year":"2017","journal-title":"J Endod"},{"issue":"6","key":"pone.0305218.ref038","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1111\/iej.13071","article-title":"Partial pulpotomy with two bioactive cements in permanent teeth of 6- to 18-year-old patients with signs and symptoms indicative of irreversible pulpitis: a noninferiority randomized controlled trial","volume":"52","author":"N Uesrichai","year":"2019","journal-title":"Int Endod J"},{"issue":"11","key":"pone.0305218.ref039","first-page":"ZC01","article-title":"A randomised clinical randiological study using platelet rich fibrin and MTA in pulpotomy of first permanent immature molars","volume":"14","author":"M Alawwad","year":"2020","journal-title":"J Clin Diagn Res"},{"issue":"1","key":"pone.0305218.ref040","first-page":"19","article-title":"Evaluation of Mineral Trioxide Aggregate and Biodentine as pulpotomy agents in immature first permanent molars with carious pulp exposure: A randomised clinical trial","volume":"22","author":"GM Abuelniel","year":"2021","journal-title":"Eur J Paediatr Dent"},{"issue":"11","key":"pone.0305218.ref041","doi-asserted-by":"crossref","first-page":"1672","DOI":"10.1016\/j.joen.2021.08.009","article-title":"Clinical and Radiographic Assessments of Potassium Nitrate in Polycarboxylate Versus Mineral Trioxide Aggregate as Pulpotomy Biomaterials in Immature Mandibular First Permanent Molars: A Randomized Clinical Trial","volume":"47","author":"MI Ahmed","year":"2021","journal-title":"J Endod"},{"issue":"11","key":"pone.0305218.ref042","first-page":"e31806","article-title":"Evaluation of Bioceramic Putty in Pulpotomy of Immature Permanent Molars With Symptoms of Irreversible Pulpitis","volume":"14","author":"I Alnassar","year":"2022","journal-title":"Cureus"},{"issue":"3","key":"pone.0305218.ref043","doi-asserted-by":"crossref","first-page":"3287","DOI":"10.1007\/s00784-021-04310-y","article-title":"Outcomes of root canal therapy or full pulpotomy using two endodontic biomaterials in mature permanent teeth: a randomized controlled trial","volume":"26","author":"S Asgary","year":"2022","journal-title":"Clin Oral Investig"},{"issue":"6","key":"pone.0305218.ref044","doi-asserted-by":"crossref","first-page":"606","DOI":"10.4103\/jcd.jcd_264_21","article-title":"Comparative assessment of titanium-prepared platelet-rich fibrin, EndoSequence root repair material, and calcium hydroxide as pulpotomy agents in permanent teeth with irreversible pulpitis: A randomized controlled trial","volume":"24","author":"S Doranala","year":"2021","journal-title":"J Conserv Dent"},{"issue":"3","key":"pone.0305218.ref045","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/iej.13872","article-title":"Outcome of partial and full pulpotomy in cariously exposed mature molars with symptoms indicative of irreversible pulpitis: A randomized controlled trial","volume":"56","author":"A Jassal","year":"2023","journal-title":"Int Endod J"},{"issue":"5","key":"pone.0305218.ref046","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1111\/iej.13714","article-title":"Comparative evaluation of complete and partial pulpotomy in mature permanent teeth with symptomatic irreversible pulpitis: A randomized clinical trial","volume":"55","author":"A Ramani","year":"2022","journal-title":"Int Endod J"},{"issue":"3","key":"pone.0305218.ref047","first-page":"106","article-title":"Mineral Trioxide Aggregate vs Calcium-Enriched Mixture Pulpotomy in Young Permanent Molars with a Diagnosis of Irreversible Pulpitis: A Randomized Clinical Trial","volume":"17","author":"M Sharaan","year":"2022","journal-title":"Iran Endod J"},{"issue":"4","key":"pone.0305218.ref048","first-page":"402","article-title":"Comparative assessment of the outcome of complete pulpotomy using mineral trioxide aggregate and Biodentine in mature permanent mandibular molars with symptomatic irreversible pulpitis: A randomized clinical trial with 18 months of follow-up","volume":"26","author":"R Singla","year":"2023","journal-title":"J Conserv Dent"},{"issue":"5","key":"pone.0305218.ref049","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1111\/iej.13707","article-title":"Outcome of full pulpotomy in mature permanent molars using 3 calcium silicate-based materials: A parallel, double blind, randomized controlled trial","volume":"55","author":"NA Taha","year":"2022","journal-title":"Int Endod J"},{"issue":"10","key":"pone.0305218.ref050","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.4103\/njcp.njcp_686_20","article-title":"Evaluation of partial pulpotomy treatment in cariously exposed immature permanent molars: Randomized controlled trial","volume":"24","author":"DS Uyar","year":"2021","journal-title":"Niger J Clin Pract"},{"issue":"7","key":"pone.0305218.ref051","first-page":"547","article-title":"Long-term radiologic pulp evaluation after partial pulpotomy in young permanent molars","volume":"42","author":"E Mass","year":"2011","journal-title":"Quintessence Int"},{"issue":"6","key":"pone.0305218.ref052","doi-asserted-by":"crossref","first-page":"573","DOI":"10.3390\/medicina57060573","article-title":"Vital Pulp Therapy in Permanent Mature Posterior Teeth with Symptomatic Irreversible Pulpitis: A Systematic Review of Treatment Outcomes","volume":"57","author":"JM Santos","year":"2021","journal-title":"Medicina (Kaunas)"},{"issue":"8","key":"pone.0305218.ref053","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1111\/iej.12903","article-title":"Outcome of full pulpotomy using Biodentine in adult patients with symptoms indicative of irreversible pulpitis","volume":"51","author":"NA Taha","year":"2018","journal-title":"Int Endod J"},{"issue":"8","key":"pone.0305218.ref054","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1111\/j.1365-2591.2011.01886.x","article-title":"Properties and applications of calcium hydroxide in endodontics and dental traumatology","volume":"44","author":"Z Mohammadi","year":"2011","journal-title":"Int Endod J"},{"issue":"5","key":"pone.0305218.ref055","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1046\/j.1365-2591.1999.00275.x","article-title":"Mechanisms of antimicrobial activity of calcium hydroxide: a critical review","volume":"32","author":"JF Siqueira","year":"1999","journal-title":"Int Endod J"},{"issue":"1","key":"pone.0305218.ref056","first-page":"4","article-title":"Tunnel defects in dentin bridges: their formation following direct pulp capping","volume":"21","author":"CF Cox","year":"1996","journal-title":"Oper Dent"},{"issue":"6","key":"pone.0305218.ref057","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1034\/j.1600-9657.2000.016006240.x","article-title":"Pulp capping with adhesive resin-based composite vs. calcium hydroxide: a review","volume":"16","author":"AH Schuurs","year":"2000","journal-title":"Endod Dent Traumatol"},{"issue":"9","key":"pone.0305218.ref058","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/00004770-200009000-00010","article-title":"Pulp capping of carious exposures: treatment outcome after 5 and 10 years: a retrospective study","volume":"26","author":"CR Barthel","year":"2000","journal-title":"J Endod"},{"issue":"4","key":"pone.0305218.ref059","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/iej.13449","article-title":"Efficacy of direct pulp capping for management of cariously exposed pulps in permanent teeth: a systematic review and meta-analysis","volume":"54","author":"S Cushley","year":"2021","journal-title":"Int Endod J"},{"issue":"8","key":"pone.0305218.ref060","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.joen.2005.12.008","article-title":"A prospective clinical study of mineral trioxide aggregate for partial pulpotomy in cariously exposed permanent teeth","volume":"32","author":"KM Barrieshi-Nusair","year":"2006","journal-title":"J Endod"},{"issue":"2","key":"pone.0305218.ref061","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/iej.12841","article-title":"Mineral trioxide aggregate and other bioactive endodontic cements: an updated overview\u2014part I: vital pulp therapy","volume":"51","author":"M Parirokh","year":"2018","journal-title":"Int Endod J"},{"issue":"12","key":"pone.0305218.ref062","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1097\/00004770-200312000-00007","article-title":"Mineral trioxide aggregate (MTA) solubility and porosity with different water-to-powder ratios","volume":"29","author":"M Fridland","year":"2003","journal-title":"J Endod"},{"issue":"6","key":"pone.0305218.ref063","doi-asserted-by":"crossref","first-page":"377","DOI":"10.4103\/1735-3327.270787","article-title":"Evaluation of tooth discoloration after treatment with mineral trioxide aggregate, calcium-enriched mixture, and Biodentine((R)) in the presence and absence of blood","volume":"16","author":"Z Madani","year":"2019","journal-title":"Dent Res J (Isfahan)"},{"issue":"1","key":"pone.0305218.ref064","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5395\/rde.2015.40.1.1","article-title":"Current perspectives of bio-ceramic technology in endodontics: calcium enriched mixture cement\u2014review of its composition, properties and applications","volume":"40","author":"S Utneja","year":"2015","journal-title":"Restor Dent Endod"},{"issue":"3","key":"pone.0305218.ref065","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1111\/j.1600-9657.1987.tb00610.x","article-title":"Partial pulpotomy as a treatment alternative for exposed pulps in crown-fractured permanent incisors","volume":"3","author":"AB Fuks","year":"1987","journal-title":"Endod Dent Traumatol"},{"issue":"2","key":"pone.0305218.ref066","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/iej.12605","article-title":"Assessment of Mineral Trioxide Aggregate pulpotomy in mature permanent teeth with carious exposures","volume":"50","author":"NA Taha","year":"2017","journal-title":"Int Endod J"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0305218","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,5]],"date-time":"2024-07-05T17:39:45Z","timestamp":1720201185000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0305218"}},"subtitle":[],"editor":[{"given":"Carlos Alberto Antunes","family":"Viegas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,7,5]]},"references-count":66,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0305218","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,5]]}}}