{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:02:18Z","timestamp":1791360138343,"version":"4.3.1"},"reference-count":73,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The Neutrophil-to-Lymphocyte Ratio (NLR) is a clinical indicator of peripheral inflammation that is easily accessible. It is worth noting that the formation of amyloid-\u03b2 (A\u03b2) plaques and neurofibrillary tangles has been linked to inflammation and immune dysregulation. The main objective of this systematic review and meta-analysis is to comprehensively evaluate the existing body of research concerning the NLR in the context of Alzheimer\u2019s disease (AD) and mild cognitive impairment (MCI).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>We conducted a comprehensive online search and included studies that evaluated the NLR in 1) patients with AD or MCI and 2) healthy control (HC) participants. We also pooled mean and standard deviation (SD) data for each group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ultimately, 12 studies encompassed 1,309 individuals diagnosed with AD with mean NLR levels of 2.68, 1,929 individuals with MCI with mean NLR levels of 2.42, and 2,064 HC with mean NLR levels of 2.06 were included in this systematic review and meta-analysis. The mean NLR was 0.59 higher in AD patients compared to HC participants (mean difference (MD) = 0.59 [0.38; 0.80]). Similarly, the mean NLR was higher in AD than MCI patients (MD = 0.23 [0.13; 0.33]). Additionally, the mean NLR was higher in individuals with MCI compared to HC participants (MD = 0.37 [0.22; 0.52]). In the subgroup meta-analysis based on the Mini-Mental State Examination (MMSE), AD patients with lower MMSE scores (using a cut-off of 20) exhibited significantly higher mean NLR (3.10 vs. 2.70, with a p-value for subgroup differences &lt; 0.01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The NLR, which serves as a marker of peripheral inflammation, shows increased levels in individuals with AD and MCI compared to HC participants. Furthermore, our study indicates that NLR levels are significantly higher in AD than MCI. Additionally, our novel finding suggests significantly higher NLR levels among AD patients with more severe cognitive decline compared to AD patients with less severe cognitive decline. So, it can be concluded that the higher cognitive decline in humans is accompanied by higher NLR levels. Further longitudinal researches are needed to explore more details about the relationship between inflammation and dementia.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0305322","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T14:56:54Z","timestamp":1719327414000},"page":"e0305322","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Neutrophil to lymphocyte ratio in Alzheimer\u2019s disease: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3291-1293","authenticated-orcid":true,"given":"Aynaz","family":"Mohammadi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9375-5549","authenticated-orcid":true,"given":"Mohammad","family":"Mohammadi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Almasi\u2010Dooghaee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omid","family":"Mirmosayyeb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"pone.0305322.ref001","author":"E. Nichols","year":"2019","journal-title":"Estimating the global mortality from Alzheimers disease and other dementias: a new method and results from the Global Burden of Disease Study 2019"},{"issue":"11","key":"pone.0305322.ref002","first-page":"377","article-title":"Epidemiolog\u00eda de la enfermedad de Alzheimer y otras demencias","volume":"66","author":"J. Garre-Olmo","year":"2018","journal-title":"Rev Neurol"},{"issue":"4","key":"pone.0305322.ref003","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1002\/alz.12638","article-title":"2022 Alzheimer\u2019s disease facts and figures","volume":"18","author":"J Gaugler","year":"2022","journal-title":"Alzheimers & Dementia"},{"issue":"3","key":"pone.0305322.ref004","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/j.jalz.2015.02.003","article-title":"2015 Alzheimer\u2019s disease facts and figures","volume":"11","author":"Association As","year":"2015","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"3","key":"pone.0305322.ref005","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1111\/joim.12190","article-title":"Mild cognitive impairment: a concept in evolution","volume":"275","author":"RC Petersen","year":"2014","journal-title":"Journal of internal medicine"},{"issue":"1","key":"pone.0305322.ref006","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1177\/15500594211042708","article-title":"Mild cognitive impairment: diagnosis and subtypes","volume":"54","author":"NI Bradfield","year":"2023","journal-title":"Clinical EEG and Neuroscience"},{"issue":"5","key":"pone.0305322.ref007","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/S1474-4422(16)00062-4","article-title":"Defeating Alzheimer\u2019s disease and other dementias: a priority for European science and society","volume":"15","author":"B Winblad","year":"2016","journal-title":"The Lancet Neurology"},{"key":"pone.0305322.ref008","doi-asserted-by":"crossref","first-page":"577398","DOI":"10.1016\/j.jneuroim.2020.577398","article-title":"The neutrophil-to-lymphocyte ratio in Alzheimer\u2019s disease: Current understanding and potential applications","volume":"349","author":"A Sayed","year":"2020","journal-title":"Journal of Neuroimmunology"},{"issue":"7","key":"pone.0305322.ref009","doi-asserted-by":"crossref","first-page":"3636","DOI":"10.3390\/ijms23073636","article-title":"Neutrophil to lymphocyte ratio: an emerging marker of the relationships between the immune system and diseases","volume":"23","author":"A Buonacera","year":"2022","journal-title":"International journal of molecular sciences"},{"issue":"7","key":"pone.0305322.ref010","first-page":"474","article-title":"Neutrophil-to-lymphocyte ratio, past, present and future perspectives","volume":"122","author":"R. Zahorec","year":"2021","journal-title":"Bratisl Lek Listy"},{"issue":"1","key":"pone.0305322.ref011","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1186\/s12883-023-03380-7","article-title":"Neutrophil to lymphocyte ratio in Parkinson\u2019s disease: A systematic review and meta-analysis","volume":"23","author":"S Hosseini","year":"2023","journal-title":"BMC neurology"},{"issue":"1","key":"pone.0305322.ref012","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/s41598-019-57366-y","article-title":"High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis","volume":"10","author":"S-J Choi","year":"2020","journal-title":"Scientific reports"},{"issue":"4","key":"pone.0305322.ref013","doi-asserted-by":"crossref","DOI":"10.1177\/2055217318813183","article-title":"The neutrophil-to-lymphocyte ratio is associated with multiple sclerosis","volume":"4","author":"I Hasselbalch","year":"2018","journal-title":"Multiple Sclerosis Journal\u2013Experimental, Translational and Clinical"},{"issue":"2","key":"pone.0305322.ref014","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1159\/000341583","article-title":"The evaluation of neutrophil-lymphocyte ratio in Alzheimer\u2019s disease","volume":"34","author":"ME Kuyumcu","year":"2012","journal-title":"Dementia and geriatric cognitive disorders"},{"issue":"1\u20132","key":"pone.0305322.ref015","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jneuroim.2014.05.005","article-title":"An increased neutrophil\u2013lymphocyte ratio in Alzheimer\u2019s disease is a function of age and is weakly correlated with neocortical amyloid accumulation","volume":"273","author":"A Rembach","year":"2014","journal-title":"Journal of neuroimmunology"},{"key":"pone.0305322.ref016","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2046-4053-4-1","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"D Moher","year":"2015","journal-title":"Systematic reviews"},{"key":"pone.0305322.ref017","author":"GA Wells","year":"2000","journal-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses"},{"key":"pone.0305322.ref018","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fnagi.2019.00332","article-title":"Predictive value of routine peripheral blood biomarkers in Alzheimer\u2019s disease","volume":"11","author":"X Dong","year":"2019","journal-title":"Frontiers in aging neuroscience"},{"issue":"3","key":"pone.0305322.ref019","doi-asserted-by":"crossref","first-page":"799","DOI":"10.12669\/pjms.39.3.7024","article-title":"The importance of Vitamin-D and Neutrophil-Lymphocyte Ratio for Alzheimer\u2019s Disease","volume":"39","author":"A Evlice","year":"2023","journal-title":"Pakistan Journal of Medical Sciences"},{"issue":"9","key":"pone.0305322.ref020","doi-asserted-by":"crossref","first-page":"7909","DOI":"10.3390\/ijms24097909","article-title":"Ultrastructural and Molecular Investigation on Peripheral Leukocytes in Alzheimer\u2019s Disease Patients","volume":"24","author":"R Giannelli","year":"2023","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"pone.0305322.ref021","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13195-022-00968-y","article-title":"Association of peripheral immunity with cognition, neuroimaging, and Alzheimer\u2019s pathology","volume":"14","author":"J-H Hou","year":"2022","journal-title":"Alzheimer\u2019s Research & Therapy"},{"issue":"S1","key":"pone.0305322.ref022","doi-asserted-by":"crossref","first-page":"S655","DOI":"10.1016\/j.eurpsy.2017.01.1099","article-title":"The neutrophil and platelet to lymphocyte ratios in people with subjective, mild cognitive impairment and early Alzheimer\u2019s disease","volume":"41","author":"T Kalelioglu","year":"2017","journal-title":"European Psychiatry"},{"key":"pone.0305322.ref023","first-page":"1","article-title":"Investigation of the peripheral inflammation (neutrophil\u2013lymphocyte ratio) in two neurodegenerative diseases of the central nervous system","author":"SP Kara","year":"2022","journal-title":"Neurological Sciences"},{"issue":"1","key":"pone.0305322.ref024","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1038\/s41598-023-34012-2","article-title":"Peripheral immune cell imbalance is associated with cortical beta-amyloid deposition and longitudinal cognitive decline","volume":"13","author":"NH Mehta","year":"2023","journal-title":"Scientific Reports"},{"issue":"1","key":"pone.0305322.ref025","doi-asserted-by":"crossref","first-page":"289","DOI":"10.3233\/JAD-180135","article-title":"High-density lipoprotein subclasses and mild cognitive Impairment: Study of outcome and aPolipoproteins in dementia (STOP-dementia)","volume":"66","author":"R Ohtani","year":"2018","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"11","key":"pone.0305322.ref026","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.3390\/brainsci12111424","article-title":"White blood cell and platelet counts are not suitable as biomarkers in the differential diagnostics of dementia","volume":"12","author":"S Schr\u00f6der","year":"2022","journal-title":"Brain Sciences"},{"issue":"14","key":"pone.0305322.ref027","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.2174\/1567205017666200103110521","article-title":"Association of neutrophil-lymphocyte ratio with mild cognitive impairment in elderly Chinese adults: a case-control study","volume":"16","author":"P An","year":"2019","journal-title":"Current Alzheimer Research"},{"issue":"2","key":"pone.0305322.ref028","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.cell.2019.09.001","article-title":"Alzheimer disease: an update on pathobiology and treatment strategies","volume":"179","author":"JM Long","year":"2019","journal-title":"Cell"},{"issue":"5","key":"pone.0305322.ref029","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/archneur.60.5.729","article-title":"Neurofibrillary tangles, amyloid, and memory in aging and mild cognitive impairment","volume":"60","author":"AL Guillozet","year":"2003","journal-title":"Archives of neurology"},{"key":"pone.0305322.ref030","unstructured":"Alzheimer\u2019s Disease Fact Sheet: National Institutes of Health; 2023 [https:\/\/www.nia.nih.gov\/health\/alzheimers-and-dementia\/alzheimers-disease-fact-sheet."},{"issue":"1","key":"pone.0305322.ref031","first-page":"32","article-title":"Neuropathology of Alzheimer\u2019s disease","volume":"77","author":"DP Perl","year":"2010","journal-title":"Mount Sinai Journal of Medicine: A Journal of Translational and Personalized Medicine: A Journal of Translational and Personalized Medicine"},{"issue":"16","key":"pone.0305322.ref032","doi-asserted-by":"crossref","first-page":"10837","DOI":"10.1073\/pnas.162350199","article-title":"Prominent neurodegeneration and increased plaque formation in complement-inhibited Alzheimer\u2019s mice","volume":"99","author":"T Wyss-Coray","year":"2002","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"4","key":"pone.0305322.ref033","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1016\/j.neuron.2006.01.022","article-title":"Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer\u2019s disease","volume":"49","author":"AR Simard","year":"2006","journal-title":"Neuron"},{"issue":"1","key":"pone.0305322.ref034","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1212\/01.wnl.0000338622.27876.0d","article-title":"Microglial activation and amyloid deposition in mild cognitive impairment: a PET study","volume":"72","author":"A Okello","year":"2009","journal-title":"Neurology"},{"issue":"1\u20132","key":"pone.0305322.ref035","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0304-3940(87)90696-3","article-title":"Reactive microglia in patients with senile dementia of the Alzheimer type are positive for the histocompatibility glycoprotein HLA-DR","volume":"79","author":"PL McGeer","year":"1987","journal-title":"Neuroscience letters"},{"issue":"1","key":"pone.0305322.ref036","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40035-016-0054-4","article-title":"The dual roles of cytokines in Alzheimer\u2019s disease: update on interleukins, TNF-\u03b1, TGF-\u03b2 and IFN-\u03b3","volume":"5","author":"C Zheng","year":"2016","journal-title":"Translational neurodegeneration"},{"issue":"2","key":"pone.0305322.ref037","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1083\/jcb.201709069","article-title":"Microglia in Alzheimer\u2019s disease","volume":"217","author":"DV Hansen","year":"2018","journal-title":"Journal of Cell Biology"},{"issue":"48","key":"pone.0305322.ref038","doi-asserted-by":"crossref","first-page":"11125","DOI":"10.1523\/JNEUROSCI.2545-05.2005","article-title":"Invasion of hematopoietic cells into the brain of amyloid precursor protein transgenic mice","volume":"25","author":"AK Stalder","year":"2005","journal-title":"Journal of Neuroscience"},{"issue":"4","key":"pone.0305322.ref039","doi-asserted-by":"crossref","first-page":"e60921","DOI":"10.1371\/journal.pone.0060921","article-title":"Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology","volume":"8","author":"G Krabbe","year":"2013","journal-title":"PloS one"},{"issue":"10","key":"pone.0305322.ref040","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1038\/s41380-021-01249-0","article-title":"The amyloid-\u03b2 pathway in Alzheimer\u2019s disease","volume":"26","author":"H Hampel","year":"2021","journal-title":"Molecular psychiatry"},{"issue":"19","key":"pone.0305322.ref041","doi-asserted-by":"crossref","first-page":"7606","DOI":"10.1073\/pnas.86.19.7606","article-title":"Interleukin 1 regulates synthesis of amyloid beta-protein precursor mRNA in human endothelial cells","volume":"86","author":"D Goldgaber","year":"1989","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"12","key":"pone.0305322.ref042","doi-asserted-by":"crossref","first-page":"6539","DOI":"10.4049\/jimmunol.1100620","article-title":"Blocking IL-1 signaling rescues cognition, attenuates tau pathology, and restores neuronal \u03b2-catenin pathway function in an Alzheimer\u2019s disease model","volume":"187","author":"M Kitazawa","year":"2011","journal-title":"The Journal of Immunology"},{"issue":"47","key":"pone.0305322.ref043","doi-asserted-by":"crossref","first-page":"49523","DOI":"10.1074\/jbc.M402034200","article-title":"Tumor necrosis factor-\u03b1, interleukin-1\u03b2, and interferon-\u03b3 stimulate \u03b3-secretase-mediated cleavage of amyloid precursor protein through a JNK-dependent MAPK pathway","volume":"279","author":"Y-F Liao","year":"2004","journal-title":"Journal of Biological Chemistry"},{"issue":"10","key":"pone.0305322.ref044","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.biopsych.2010.06.012","article-title":"A meta-analysis of cytokines in Alzheimer\u2019s disease","volume":"68","author":"W Swardfager","year":"2010","journal-title":"Biological psychiatry"},{"key":"pone.0305322.ref045","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1002\/eji.200425091","article-title":"The survival effect of TNF-\u03b1 in human neutrophils is mediated via NF-\u03baB-dependent IL-8 release","volume":"34","author":"C. AS","year":"2004","journal-title":"Eur J Immunol"},{"issue":"6","key":"pone.0305322.ref046","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1002\/jcla.21791","article-title":"Neutrophil\u2010to\u2010lymphocyte ratio positively correlates to age in healthy population","volume":"29","author":"J Li","year":"2015","journal-title":"Journal of clinical laboratory analysis"},{"issue":"1\u20132","key":"pone.0305322.ref047","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.jpsychires.2006.01.010","article-title":"Altered lymphocyte distribution in Alzheimer\u2019s disease","volume":"41","author":"E Richartz-Salzburger","year":"2007","journal-title":"Journal of psychiatric research"},{"issue":"1","key":"pone.0305322.ref048","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-017-0910-x","article-title":"Adaptive lymphocyte profiles correlate to brain A\u03b2 burden in patients with mild cognitive impairment","volume":"14","author":"AM Stowe","year":"2017","journal-title":"Journal of neuroinflammation"},{"issue":"11","key":"pone.0305322.ref049","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1089\/107999099312957","article-title":"Selective proteolytic cleavage of IL-2 receptor and IL-6 receptor ligand binding chains by neutrophil-derived serine proteases at foci of inflammation","volume":"19","author":"U Bank","year":"1999","journal-title":"Journal of interferon & cytokine research"},{"issue":"5","key":"pone.0305322.ref050","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1182\/blood-2006-11-010389","article-title":"Suppression of T-cell functions by human granulocyte arginase","volume":"108","author":"M Munder","year":"2006","journal-title":"Blood"},{"issue":"22","key":"pone.0305322.ref051","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1182\/bloodadvances.2019031609","article-title":"Activated neutrophils exert myeloid-derived suppressor cell activity damaging T cells beyond repair","volume":"3","author":"CE Aarts","year":"2019","journal-title":"Blood advances"},{"issue":"7","key":"pone.0305322.ref052","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.4049\/jimmunol.139.7.2406","article-title":"Immunosuppression by activated human neutrophils. Dependence on the myeloperoxidase system","volume":"139","author":"A El-Hag","year":"1987","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"4","key":"pone.0305322.ref053","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1080\/10715760902751902","article-title":"Involvement of ROS in BBB dysfunction","volume":"43","author":"PB Pun","year":"2009","journal-title":"Free radical research"},{"issue":"2","key":"pone.0305322.ref054","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/ana.25159","article-title":"Neutrophil hyperactivation correlates with Alzheimer\u2019s disease progression","volume":"83","author":"Y Dong","year":"2018","journal-title":"Annals of neurology"},{"issue":"3","key":"pone.0305322.ref055","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d: a practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"MF Folstein","year":"1975","journal-title":"Journal of psychiatric research"},{"issue":"3","key":"pone.0305322.ref056","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.3233\/JAD-150852","article-title":"Describing the sequence of cognitive decline in Alzheimer\u2019s disease patients: results from an observational study","volume":"52","author":"C Henneges","year":"2016","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"7","key":"pone.0305322.ref057","doi-asserted-by":"crossref","first-page":"O236","DOI":"10.1111\/codi.13373","article-title":"The neutrophil\u2010to\u2010lymphocyte ratio predicts major perioperative complications in patients undergoing colorectal surgery","volume":"18","author":"J Josse","year":"2016","journal-title":"Colorectal Disease"},{"issue":"2","key":"pone.0305322.ref058","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/j.athoracsur.2017.07.033","article-title":"Neutrophil-lymphocyte ratio: prognostic impact in heart surgery. Early outcomes and late survival","volume":"105","author":"S Silberman","year":"2018","journal-title":"The Annals of thoracic surgery"},{"issue":"1","key":"pone.0305322.ref059","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.amjsurg.2019.04.018","article-title":"Neutrophil-to-lymphocyte ratio predicts acute appendicitis and distinguishes between complicated and uncomplicated appendicitis: A systematic review and meta-analysis","volume":"219","author":"S Hajibandeh","year":"2020","journal-title":"The American Journal of Surgery"},{"issue":"3","key":"pone.0305322.ref060","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.ijcard.2013.12.019","article-title":"Neutrophil lymphocyte ratio significantly improves the Framingham risk score in prediction of coronary heart disease mortality: insights from the National Health and Nutrition Examination Survey-III","volume":"171","author":"N Shah","year":"2014","journal-title":"International journal of cardiology"},{"key":"pone.0305322.ref061","doi-asserted-by":"crossref","first-page":"686983","DOI":"10.3389\/fneur.2021.686983","article-title":"Prognostic value of neutrophil-to-lymphocyte ratio in stroke: a systematic review and meta-analysis","volume":"12","author":"W Li","year":"2021","journal-title":"Frontiers in Neurology"},{"issue":"2","key":"pone.0305322.ref062","doi-asserted-by":"crossref","first-page":"e0296838","DOI":"10.1371\/journal.pone.0296838","article-title":"The neutrophil-to-lymphocyte ratio is associated with coronary heart disease risk in adults: A population-based study","volume":"19","author":"Y Wang","year":"2024","journal-title":"Plos one"},{"issue":"2","key":"pone.0305322.ref063","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.imr.2018.02.006","article-title":"Neutrophil to lymphocyte ratio as a predictor of myocardial damage and cardiac dysfunction in acute coronary syndrome patients","volume":"7","author":"C Chen","year":"2018","journal-title":"Integrative medicine research"},{"key":"pone.0305322.ref064","article-title":"The neutrophil-to-lymphocyte ratio: a narrative review","volume":"10","author":"SS Faria","year":"2016","journal-title":"ecancermedicalscience"},{"key":"pone.0305322.ref065","first-page":"1","article-title":"Neutrophil to lymphocyte ratio and cancer prognosis: an umbrella review of systematic reviews and meta-analyses of observational studies","volume":"18","author":"MA Cupp","year":"2020","journal-title":"BMC medicine"},{"issue":"1","key":"pone.0305322.ref066","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/cncr.32506","article-title":"High neutrophil\u2010to\u2010lymphocyte ratio (NLR) is associated with treatment failure and death in patients who have melanoma treated with PD\u20101 inhibitor monotherapy","volume":"126","author":"EK Bartlett","year":"2020","journal-title":"Cancer"},{"key":"pone.0305322.ref067","article-title":"Neutrophil lymphocyte ratio 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