{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T08:22:21Z","timestamp":1780474941424,"version":"3.54.1"},"reference-count":38,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T00:00:00Z","timestamp":1742428800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"UNITAID through Population International Services","award":["2017-16-PSI-STAR"],"award-info":[{"award-number":["2017-16-PSI-STAR"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec040\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Diagnostics are critical for preventing COVID-19 transmission, enabling disease management and engagement with care. However, COVID-19 testing uptake remained low in low- and middle- income countries in Sub-Saharan Africa (SSA) during the recent pandemic, due to issues of supply, access and acceptability. Early studies conducted outside of the region provide insight into uptake of COVID-19 testing, however there has been no systematic research within the region. The aim of this scoping review is to investigate factors influencing uptake of COVID-19 testing in different settings across SSA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec041\">\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Inclusion criteria was any study employing qualitative or mixed methodologies, addressing uptake of COVID-19 testing conducted in SSA. MEDLINE, PubMed, Google Scholar, Web of Science, and Africa-Wide Information were searched. Thematic content analysis was conducted across all included articles until saturation was attained.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec042\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In total 2994 articles were identified and fourteen reviewed. Structural, social, epidemiological, informational, and political elements affected how the public interacted with COVID-19 testing. Coverage was limited by insufficient diagnostic capabilities caused by a shortage of laboratory resources and trained personnel. False information spread through social media led to testing misperceptions and apprehension. Testing hesitancy was ascribed to fear of restrictive measures and the possibility of social harms if positive. Facility-based testing was physically inaccessible and perceived as lacking privacy, whereas self-testing distributed by the community removed lengthy distances and prevented stigma. Perceptions that COVID-19 was not severe and low numbers of confirmed cases in comparison to other settings undermined public urgency for testing. Low testing frequency led to low-rate assumptions, which in turn generated denial and othering narratives. Politicians\u2019 acceptance or denial of COVID-19 affected the mobilization of the health system, and their model actions\u2014such as testing openly\u2014promoted public confidence and involvement in interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec043\">\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This review emphasizes the necessity of strong political commitments to enhancing health systems for future pandemic preparedness. Response plans should consider contextual elements that affect how people react to interventions and perceive health emergencies. Community-driven self-testing distribution could enhance the uptake of diagnostics through addressing socio-economic constraints impacting facility-delivered testing.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0305512","type":"journal-article","created":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T16:42:54Z","timestamp":1742488974000},"page":"e0305512","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Factors influencing uptake of COVID-19 diagnostics in Sub-Saharan Africa: a rapid scoping review"],"prefix":"10.1371","volume":"20","author":[{"given":"Mackwellings 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