{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T23:37:49Z","timestamp":1791070669548,"version":"4.1.0"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31860608"],"award-info":[{"award-number":["31860608"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"High-level Talent Project of the Hainan Natural Science Foundation","award":["322RC661"],"award-info":[{"award-number":["322RC661"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Exposure to noise can cause non-auditory health problems and has been widely studied in mammals such as rats and rabbits. However, the non-auditory effects of noise exposure on reptiles (such as red-eared sliders) remain unclear. In this study, we determined the noise exposure-induced transcriptomic changes in the liver of red-eared slider (<jats:italic>Trachemys scripta elegans<\/jats:italic>) using Illumina Novaseq6000 sequencing technology. The transcriptome analysis identified 176 differentially expressed genes (DEGs), which were mainly enriched in lipid metabolism. KEGG analysis showed that by affecting the peroxisome proliferator activated receptor (PPAR) signaling pathway these DEGs increased lipid synthesis and decreased lipid oxidation. The Oil Red O staining results validated our data that noise exposure increased hepatic lipid deposition. Thus, noise exposure may lead to lipid accumulation and toxicity, mitochondrial damage, and accelerated oxidative stress. Our findings provide insights into the molecular process underlying non-auditory damage caused by noise exposure in <jats:italic>T<\/jats:italic>. <jats:italic>scripta elegans<\/jats:italic>.<\/jats:p>","DOI":"10.1371\/journal.pone.0305858","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T17:58:32Z","timestamp":1722535112000},"page":"e0305858","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Comparative analysis of the liver transcriptome in the red-eared slider (Trachemys scripta elegans) post exposure to noise"],"prefix":"10.1371","volume":"19","author":[{"given":"Guangwei","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziye","family":"Zuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Handong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofei","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongliang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5081-2355","authenticated-orcid":true,"given":"Jichao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"issue":"9","key":"pone.0305858.ref001","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1089\/ars.2017.7257","article-title":"Oxidative Stress: A Unifying Mechanism for Cell Damage Induced by Noise, (Water-Pipe) Smoking, and Emotional Stress-Therapeutic Strategies Targeting Redox Imbalance.","volume":"28","author":"S Golbidi","year":"2018","journal-title":"Antioxidants Redox Signaling"},{"issue":"9925","key":"pone.0305858.ref002","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/S0140-6736(13)61613-X","article-title":"Auditory and non-auditory effects of noise on health","volume":"383","author":"M Basner","year":"2014","journal-title":"Lancet"},{"issue":"1","key":"pone.0305858.ref003","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1121\/1.5087126","article-title":"The effects of classroom noise on the reading comprehension of adolescents","volume":"145","author":"D Connolly","year":"2019","journal-title":"Journal of the Acoustical Society of America"},{"key":"pone.0305858.ref004","doi-asserted-by":"crossref","first-page":"k4264","DOI":"10.1136\/bmj.k4264","article-title":"Noise pollution: WHO sets limits on exposure to minimise adverse health effects","volume":"363","author":"S. 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