{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:33:32Z","timestamp":1790382812311,"version":"4.1.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004331","name":"Johnson & Johnson","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100004331","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Psoriasis is a chronic erythematous inflammatory skin disorder. The major challenge with psoriasis is delayed diagnosis, resulting in delayed treatment initiation and reduced quality of life (QoL).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objective<\/jats:title>\n<jats:p>This patient perspective study aimed to explore the emotional and psychosocial burdens faced by patients with psoriasis in Malaysia and their attitudes toward current psoriasis treatment.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Adult patients with mild or moderate-to-severe plaque psoriasis, preferably with concomitant psoriatic arthritis, participated in a patient advisory board meeting along with a senior consultant dermatologist. Patients had to describe their initial symptoms, time of diagnosis, misdiagnosis, treatment initiation delays, treatment course, flare-ups, psychosocial impact, and QoL associated with psoriasis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>The 11 participating patients had a mean age of 46 years with mean age of psoriasis diagnosis and an average year of suffering with psoriasis being 21.9 years and 24.5 years, respectively. The most common initial symptom of psoriasis was itching (62.5%), particularly of the scalp followed by itchiness and red patches on skin. Most patients (90%) reported initial misdiagnosis with other skin diseases by their primary care physicians (PCPs), which led to delayed treatment initiation. Most patients reported an emotional impact of psoriasis, including low self-esteem (18%), lack of confidence (27%), shock (18%), sadness (9%), and outrage (9%). Social discrimination\/stigmatization in public places and at work (45%), and even from relatives (18%) was another reported challenge. However, 73% of patients were highly satisfied with the current treatment. Overall, the patients agreed that the lack of public awareness of psoriasis was responsible for the social stigma.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The evidence obtained from this qualitative study indicated that psoriasis has a significant emotional and psychological impact on the patients affecting their QoL. Lack of awareness of the disease among PCPs, patients, and the public is a major challenge leading to poor treatment outcomes.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0305870","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T17:49:16Z","timestamp":1721324956000},"page":"e0305870","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Patient perspective on psoriasis: Psychosocial burden of psoriasis and its management in Malaysia"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1323-0078","authenticated-orcid":true,"given":"Azura Mohd","family":"Affandi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Thiruchelvam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"issue":"6","key":"pone.0305870.ref001","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3390\/ijms20061475","article-title":"Psoriasis pathogenesis and treatment","volume":"20","author":"A Rendon","year":"2019","journal-title":"Int J Mol Sci"},{"key":"pone.0305870.ref002","doi-asserted-by":"crossref","first-page":"649408","DOI":"10.3389\/fmed.2021.649408","article-title":"Cutaneous and systemic psoriasis: classifications and classification for the distinction","volume":"8","author":"BX Yan","year":"2021","journal-title":"Front Med (Lausanne)"},{"issue":"2","key":"pone.0305870.ref003","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/jid.2012.339","article-title":"Global epidemiology of psoriasis: a systematic review of incidence and prevalence","volume":"133","author":"R Parisi","year":"2013","journal-title":"J Invest Dermatol"},{"key":"pone.0305870.ref004","unstructured":"Global report on psoriasis: World Health Organisation 2016. Available from: https:\/\/www.who.int\/publications\/i\/item\/global-report-on-psoriasis."},{"key":"pone.0305870.ref005","author":"MT Robinson S","year":"2021","journal-title":"The eleventh report of the Malaysian psoriasis registry 2007\u20132019"},{"key":"pone.0305870.ref006","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejpb.2022.05.012","article-title":"Nanocarriers for the topical treatment of psoriasis \u2010 pathophysiology, conventional treatments, nanotechnology, regulatory and toxicology","volume":"176","author":"F Mascarenhas-Melo","year":"2022","journal-title":"Eur J Pharm Biopharm"},{"issue":"11","key":"pone.0305870.ref007","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.3390\/biomedicines9111511","article-title":"Psoriasis as an immune-mediated and inflammatory systemic disease: from pathophysiology to novel therapeutic approaches","volume":"9","author":"A Campanati","year":"2021","journal-title":"Biomedicines"},{"key":"pone.0305870.ref008","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fphar.2020.00117","article-title":"Pathogenesis of chronic plaque psoriasis and its intersection with cardio-metabolic comorbidities","volume":"11","author":"P Gisondi","year":"2020","journal-title":"Front Pharmacol"},{"key":"pone.0305870.ref009","doi-asserted-by":"crossref","first-page":"711060","DOI":"10.3389\/fimmu.2021.711060","article-title":"Metabolic syndrome and psoriasis: mechanisms and future directions","volume":"12","author":"Y Hao","year":"2021","journal-title":"Front Immunol"},{"issue":"12","key":"pone.0305870.ref010","doi-asserted-by":"crossref","first-page":"2058","DOI":"10.1111\/jdv.15177","article-title":"Position statement for the management of comorbidities in psoriasis","volume":"32","author":"E Dauden","year":"2018","journal-title":"J Eur Acad Dermatol 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