{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:55:06Z","timestamp":1793382906942,"version":"4.5.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["Finance Code 001"],"award-info":[{"award-number":["Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>\n                    The aim of this research was to evaluate the incidence of congenital syphilis and the ratio between congenital syphilis and syphilis in pregnant women in Brazil according to socioeconomic indicators (inadequate water supply and sanitation; illiteracy at 15 years of age or older; household income per capita; proportion of poor people; Gini index; human development index; and average health expenditure per inhabitant by the health system) and prenatal quality-of-care indicators. We conducted an ecological study using a sample composed of 257 municipalities, each with \u2265 100,000 inhabitants. Data was collected from four public databases: the Brazilian Institute of Geography and Statistics, comprising socioeconomical data from the 2010 census; and the data of 2019 available in the databases of the Department of Informatics of the Brazilian Health System, Information and Management of Primary Care, and the Electronic Citizen Information System. Descriptive analysis of dependent and independent variables and bivariate analysis by Negative Binomial regression were carried out. The mean incidence of congenital syphilis was 38% higher in municipalities with a Human Development Index up to 0.785 (ratio of means [RM] = 1.38;\n                    <jats:italic>p<\/jats:italic>\n                    = 0.049) and 57% higher among populations where less than 50% of primary healthcare services provided a rapid test for syphilis (RM = 1.57;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). The ratio between congenital syphilis and syphilis in pregnant women was 29% higher in municipalities with a low household income per capita (RM = 1.29;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001) and 28% higher in locations where less than 50% of the primary healthcare services provided a rapid test for syphilis (RM = 1.28;\n                    <jats:italic>p<\/jats:italic>\n                    &lt; 0.001). There was no statistical significance of the quality of prenatal care compared to the outcomes. This result underscores the challenges in detecting syphilis infections among pregnant women during prenatal care, consequently increasing the risk of vertical transmission of the disease to the fetus. Traits of inequality in the occurrence of congenital syphilis also draw attention to strategies to reduce health inequities and improve prenatal care.\n                  <\/jats:p>","DOI":"10.1371\/journal.pone.0306120","type":"journal-article","created":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T15:15:26Z","timestamp":1719328526000},"page":"e0306120","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Congenital syphilis, syphilis in pregnancy and prenatal care in Brazil: An ecological study"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0420-8645","authenticated-orcid":true,"given":"Izabelle Bezerra","family":"Costa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isac Davidson Santiago Fernandes","family":"Pimenta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kezauyn Miranda","family":"Aiquoc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c2ngelo Giuseppe Roncalli da Costa","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"pone.0306120.ref001","volume-title":"The Global Elimination of Congenital Syphilis: Rationale and Strategy for Action","author":"World Health Organization","year":"2008"},{"issue":"3","key":"pone.0306120.ref002","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1053\/j.semperi.2018.02.005","article-title":"Congenital syphilis.","volume":"42","author":"JM Cooper","year":"2018","journal-title":"Semin Perinatol"},{"key":"pone.0306120.ref003","first-page":"8877962","article-title":"Risk factors for stillbirth among pregnant women infected with syphilis in the Zhejiang Province of China, 2010\u20132016.","volume":"2021","author":"C Duan","journal-title":"Can J Infect Dis Med Microbiol"},{"issue":"1","key":"pone.0306120.ref004","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s12887-021-02502-9","article-title":"Outcomes of infants born to pregnant women with syphilis: A nationwide study in Korea","volume":"21","author":"J Lim","year":"2021","journal-title":"BMC Pediatr"},{"issue":"8","key":"pone.0306120.ref005","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/S2214-109X(19)30248-7","article-title":"Syphilis diagnosis and treatment during antenatal care: The potential catalytic impact of the dual HIV and syphilis rapid diagnostic test","volume":"7","author":"A Storey","year":"2019","journal-title":"Lancet Glob Health"},{"key":"pone.0306120.ref006","volume-title":"New Generations Free of HIV, Syphilis, Hepatitis B, and Chagas Disease in the Americas.","author":"Pan American Health Organization","year":"2019"},{"key":"pone.0306120.ref007","first-page":"94","article-title":"Effect of the coverage of rapid tests for syphilis in primary care on the syphilis in pregnancy in Brazil.","volume":"55","author":"AG Roncalli","year":"2021","journal-title":"Rev Saude Publica"},{"issue":"4","key":"pone.0306120.ref008","article-title":"Tend\u00eancias da s\u00edfilis no Brasil: Um retrato do crescimento da epidemia trepon\u00eamica.","volume":"15","author":"SM Marques","year":"2020","journal-title":"PLoS ONE"},{"issue":"2","key":"pone.0306120.ref009","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.clp.2021.03.005","article-title":"Syphilis in neonates and infants.","volume":"48","author":"AK Medoro","year":"2021","journal-title":"Clin Perinatol"},{"issue":"9","key":"pone.0306120.ref010","doi-asserted-by":"crossref","first-page":"e124","DOI":"10.1097\/OLQ.0000000000001352","article-title":"Congenital syphilis: A case report demonstrating missed opportunities for screening and inadequate treatment despite multiple health care encounters during pregnancy.","volume":"48","author":"A Fukuda","year":"2021","journal-title":"Sex Transm Dis"},{"issue":"11","key":"pone.0306120.ref011","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1097\/INF.0000000000002833","article-title":"Missed opportunities for prevention of congenital syphilis\u2014United States, 2018.","volume":"39","author":"A Kimball","year":"2020","journal-title":"Pediatr Infect Dis J"},{"issue":"6","key":"pone.0306120.ref012","doi-asserted-by":"crossref","first-page":"e00170918","DOI":"10.1590\/0102-311x00170918","article-title":"Inequalities in access to HIV and syphilis tests in prenatal care in Brazil.","volume":"35","author":"Forte FDS Freitas CHSM","year":"2019","journal-title":"Cad Sa\u00fade P\u00fablica"},{"issue":"4","key":"pone.0306120.ref013","first-page":"865","article-title":"Epidemiological profile of patients with congenital and gestational syphilis in a city in the State of S\u00e3o Paulo, Brazil.","volume":"19","author":"T Maschio-Lima","year":"2019","journal-title":"Rev Bras Sa\u00fad Mat Inf"},{"issue":"7","key":"pone.0306120.ref014","first-page":"2883","article-title":"Primary care-sensitive hospitalization conditions in children under the age of 1 in Brazil.","volume":"25","author":"EP Pinto J\u00fanior","year":"2020","journal-title":"Cienc Saud Colet"},{"key":"pone.0306120.ref015","unstructured":"Minist\u00e9rio da Sa\u00fade (Brazil). Portaria n\u00b0 1.459, de 24 de junho de 2011. Institui, no \u00e2mbito do Sistema \u00danico de Sa\u00fade\u2014SUS\u2014a Rede Cegonha. Bras\u00edlia (DF): Minist\u00e9rio da Sa\u00fade; 2011. Available from: https:\/\/bvsms.saude.gov.br\/bvs\/saudelegis\/gm\/2011\/prt1459_24_06_2011.html."},{"key":"pone.0306120.ref016","unstructured":"Minist\u00e9rio da Sa\u00fade (Brazil). Portaria n\u00b0 650, de 5 de outubro de 2011. Disp\u00f5e sobre os Planos de A\u00e7\u00e3o Regional e Municipal da Rede Cegonha, e sobre o repasse dos recursos, o monitoramento e a avalia\u00e7\u00e3o da implementa\u00e7\u00e3o da Rede Cegonha. Bras\u00edlia (DF): Minist\u00e9rio da Sa\u00fade; 2011. Available from: https:\/\/bvsms.saude.gov.br\/bvs\/saudelegis\/sas\/2011\/prt0650_05_10_2011.html."},{"issue":"2","key":"pone.0306120.ref017","doi-asserted-by":"crossref","first-page":"1","DOI":"10.21680\/2446-7286.2022v8n2ID26632","article-title":"Associa\u00e7\u00e3o da ades\u00e3o das regi\u00f5es do brasil \u00e0 rede cegonha com a mortalidade materna e outros indicadores de sa\u00fade.","volume":"8","author":"DRS Souza","year":"2022","journal-title":"Rev. Ci\u00eanc. Plur."},{"issue":"44","key":"pone.0306120.ref018","doi-asserted-by":"crossref","first-page":"e27118","DOI":"10.1097\/MD.0000000000027118","article-title":"Maternal health indicators in Brazil: a time series study.","volume":"100","author":"DRS Souza","year":"2021","journal-title":"Medicine (Baltimore)"},{"issue":"4","key":"pone.0306120.ref019","article-title":"Implementation of the Rede Cegonha (Stork Network) in a Regional Health Department in the state of Goi\u00e1s, Brazil: what do health indicators show about maternal and child care?","volume":"13","author":"TR Assis","year":"2019","journal-title":"RECIIS"},{"key":"pone.0306120.ref020","unstructured":"Barros VL. Redes de Aten\u00e7\u00e3o \u00e0 Sa\u00fade: An\u00e1lise do processo de implanta\u00e7\u00e3o da rede cegonha no estado do Piau\u00ed. MSc Thesis, Universidade Federal do Piau\u00ed, 2018."},{"key":"pone.0306120.ref021","unstructured":"Campos ALB. Os desafios nas entrelinhas: An\u00e1lise do Plano de Elimina\u00e7\u00e3o da S\u00edfilis Cong\u00eanita no estado de Sergipe no contexto da Rede Cegonha. MSc Thesis, Universidade Estadual de Campinas, 2015. Avaliable from: https:\/\/repositorio.unicamp.br\/acervo\/detalhe\/948453."},{"key":"pone.0306120.ref022","unstructured":"Montalv\u00e3o AS. Desafios para redu\u00e7\u00e3o da S\u00edfilis Cong\u00eanita: Avalia\u00e7\u00e3o da implanta\u00e7\u00e3o das A\u00e7\u00f5es do Pr\u00e9-Natal no \u00e2mbito da Rede Cegonha na Aten\u00e7\u00e3o B\u00e1sica em Palmas Tocantins. MSc Thesis, Universidade Federal da Bahia. 2017. Available from: http:\/\/repositorio.ufba.br\/ri\/handle\/ri\/25728."},{"key":"pone.0306120.ref023","volume-title":"Portal do IBGE.","author":"Instituto Brasileiro de Geografia e Estat\u00edstica (Brazil)","year":"2021"},{"issue":"4","key":"pone.0306120.ref024","doi-asserted-by":"crossref","first-page":"767","DOI":"10.5123\/S1679-49742016000400010","article-title":"Estratifica\u00e7\u00e3o de munic\u00edpios brasileiros para avalia\u00e7\u00e3o de desempenho em sa\u00fade.","volume":"25","author":"MCM Calvo","year":"2016","journal-title":"Epidemiol Serv Sa\u00fade."},{"key":"pone.0306120.ref025","unstructured":"Governo do Brasil (Brazil). Sistema Eletr\u00f4nico de Informa\u00e7\u00f5es ao Cidad\u00e3o (e-SIC). Bras\u00edlia (DF); 2021."},{"key":"pone.0306120.ref026","volume-title":"Bioestad\u00edstica Amigable.","author":"MAM Gonz\u00e1lez","year":"2014"},{"key":"pone.0306120.ref027","unstructured":"Minist\u00e9rio da Sa\u00fade (Brazil). Conselho Nacional de Sa\u00fade. Resolu\u00e7\u00e3o n\u00b0 466, de dezembro de 2012. Aprova diretrizes e normas regulamentadoras de pesquisas envolvendo seres humanos. Bras\u00edlia (DF): Minist\u00e9rio da Sa\u00fade; 2012. Available from: https:\/\/conselho.saude.gov.br\/resolucoes\/2012\/Reso466.pdf."},{"key":"pone.0306120.ref028","unstructured":"Minist\u00e9rio da Sa\u00fade (Brazil). Conselho Nacional de Sa\u00fade. Resolu\u00e7\u00e3o n\u00b0 510, de 07 de abril de 2016. Bras\u00edlia (DF): Minist\u00e9rio da Sa\u00fade; 2016. Available from: https:\/\/www.in.gov.br\/materia\/-\/asset_publisher\/Kujrw0TZC2Mb\/content\/id\/22917581."},{"key":"pone.0306120.ref029","article-title":"An\u00e1lise multivariada de dados.","author":"JF Hair","year":"2009","journal-title":"Bookman editora"},{"key":"pone.0306120.ref030","doi-asserted-by":"crossref","first-page":"78","DOI":"10.11606\/s1518-8787.2017051007066","article-title":"Risk factors for syphilis in women: Case-control study.","volume":"51","author":"VC Mac\u00eado","year":"2017","journal-title":"Rev Saude Publica"},{"issue":"3","key":"pone.0306120.ref031","article-title":"Faces of inequality in Brazil: A look at those left behind.","volume":"42","author":"T Campello","year":"2018","journal-title":"Sa\u00fade Debate"},{"key":"pone.0306120.ref032","first-page":"77","article-title":"Social inequality and health in Brazil.","volume":"18","author":"M Neri","year":"2002","journal-title":"Cad Sa\u00fade P\u00fablica"},{"issue":"6","key":"pone.0306120.ref033","first-page":"1","article-title":"Inequality in access to health services between urban and rural areas in Brazil: A disaggregation of factors from 1998 to 2008.","volume":"34","author":"NM Arruda","journal-title":"Cad Saud Publ. 2018"},{"issue":"2","key":"pone.0306120.ref034","article-title":"Incidence and risk factors for congenital syphilis in Belo Horizonte, Minas Gerais, 2001\u20132008.","volume":"18","author":"MG Lima","journal-title":"Ci\u00eanc Sa\u00fade Colet. 2013"},{"issue":"11","key":"pone.0306120.ref035","doi-asserted-by":"crossref","first-page":"e009408","DOI":"10.1136\/bmjgh-2022-009408","article-title":"Barriers and facilitators to HIV and syphilis rapid diagnostic testing in antenatal care settings in low-income and middle-income countries: a systematic review.","volume":"7","author":"Y Zhang","year":"2022","journal-title":"BMJ Glob. Health"},{"issue":"06","key":"pone.0306120.ref036","article-title":"Fatores associados ao tratamento inadequado da s\u00edfilis na gesta\u00e7\u00e3o: revis\u00e3o integrativa.","volume":"75","author":"PMA Torres","year":"2022","journal-title":"Rev. Bras. Enferm"},{"issue":"3","key":"pone.0306120.ref037","article-title":"Quality of prenatal services in primary healthcare in Brazil: Indicators and social inequalities.","volume":"33","author":"E Tomasi","year":"2017","journal-title":"Cad Saud Publ"},{"issue":"7","key":"pone.0306120.ref038","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0219613","article-title":"Correction: Global burden of maternal and congenital syphilis and associated adverse birth outcomes\u2014Estimates for 2016 and progress since 2012.","volume":"14","author":"EL Korenromp","year":"2019","journal-title":"PLoS ONE"},{"key":"pone.0306120.ref039","volume-title":"Protocolo Cl\u00ednico e Diretrizes Terap\u00eauticas para Aten\u00e7\u00e3o Integral \u00e0s Pessoas com Infec\u00e7\u00f5es Sexualmente Transmiss\u00edveis (IST).","author":"Minist\u00e9rio da Sa\u00fade (Brazil).","year":"2020"},{"issue":"9","key":"pone.0306120.ref040","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1056\/NEJMra1901593","article-title":"The modern epidemic of syphilis","volume":"382","author":"KG Ghanem","year":"2020","journal-title":"N Engl J Med"},{"issue":"8","key":"pone.0306120.ref041","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.3201\/eid2508.180298","article-title":"Randau KP. Congenital syphilis as a measure of maternal and child healthcare","volume":"25","author":"Fernandes FECV Bezerra MLMB","year":"2019","journal-title":"Brazil Emerg Infect Dis"},{"issue":"7","key":"pone.0306120.ref042","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1089\/jwh.2021.0282","article-title":"A New Call to Action to Combat an Old Nemesis: Addressing Rising Congenital Syphilis Rates in the United States.","volume":"30","author":"AM Machefsky","year":"2021","journal-title":"J Womens Health (Larchmt)"},{"issue":"2","key":"pone.0306120.ref043","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/hpm.2463","article-title":"Management of syphilis in pregnancy: Knowledge and practices of health care providers and barriers to the control of disease in Teresina, Brazil.","volume":"33","author":"DC Rodrigues","year":"2018","journal-title":"Int. J. Health Plann. Manage"},{"key":"pone.0306120.ref044","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1055\/s-0036-1593603","article-title":"Syphilis in pregnancy and congenital syphilis: why can we not yet face this problem?","volume":"38","author":"H. Milanez","year":"2016","journal-title":"Rev. Bras. de Ginecol. e Obstet"},{"key":"pone.0306120.ref045","first-page":"775","article-title":"Rede Cegonha network and the methodological challenges of implementing networks in the SUS.","volume":"26","author":"SBD Santos Filho","year":"2021","journal-title":"Cien Saude Colet"},{"issue":"2","key":"pone.0306120.ref046","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1071\/SH14156","article-title":"Public health interventions to control syphilis.","volume":"12","author":"TA Peterman","year":"2015","journal-title":"Sex. Health"},{"issue":"1","key":"pone.0306120.ref047","first-page":"1","article-title":"Analyzing the reach of public health campaigns based on multidimensional aspects: the case of the syphilis epidemic in Brazil.","volume":"21","author":"R Morais Pinto","year":"2021","journal-title":"Pereira de Oliveira CABMC public health."},{"issue":"2","key":"pone.0306120.ref048","first-page":"E76","article-title":"Impact of training conferences on high-school students\u2019 knowledge of sexually transmitted infections (STIs).","volume":"60","author":"G Orlando","year":"2019","journal-title":"J. Prev. Med. Hyg"},{"key":"pone.0306120.ref049","volume-title":"Global health sector strategies on, respectively, HIV, viral hepatitis and sexually transmitted infections for the period 2022\u20132030.","author":"World Health Organization","year":"2022"},{"issue":"4","key":"pone.0306120.ref050","doi-asserted-by":"crossref","first-page":"529","DOI":"10.4103\/0970-0218.74374","article-title":"Knowledge regarding reproductive health among urban adolescent girls of Haryana.","volume":"35","author":"K Mittal","year":"2010","journal-title":"Indian J. Community Med"},{"key":"pone.0306120.ref051","unstructured":"Minist\u00e9rio da Sa\u00fade (Brazil). Portaria n\u00b0 715, de 4 de abril de 2022. Altera a Portaria de Consolida\u00e7\u00e3o GM\/MS n\u00b0 3, de 28 de setembro de 2017, para instituir a Rede de Aten\u00e7\u00e3o Materna e Infantil (Rami). Bras\u00edlia (DF): Minist\u00e9rio da Sa\u00fade; 2022. Available from: https:\/\/bvsms.saude.gov.br\/bvs\/saudelegis\/gm\/2022\/prt2228_01_07_2022.html."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0306120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T15:16:11Z","timestamp":1719328571000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0306120"}},"subtitle":[],"editor":[{"given":"Karina Cardoso","family":"Meira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,6,25]]},"references-count":51,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0306120","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,25]]}}}