{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T21:07:59Z","timestamp":1782940079628,"version":"3.54.5"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T00:00:00Z","timestamp":1723161600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Cervical cancer has high incidence and mortality rates, especially in less-developed countries. Prevention methods are well established, but there are still barriers preventing some Brazilian women from undergoing a Pap sample. The objective of the study was to evaluate the acceptance, preferences and completion of four screening methods. This has an experimental design (community trial). A total of 164 participants who had never had a Pap sample or had not had one for more than three years were included. The city\u2019s urban area was stratified by census tracts and divided according to income and education levels. Women belonging to the lower-income strata were considered in the study. Random blocks were numbered into five intervention groups (Group 1- Pap sample at the hospital; Group 2- Pap sample in the mobile unit; Group 3- urine self-collection; Group 4- vaginal self-collection; Group 5- woman\u2019s choice). Only 164 women met all of the eligibility criteria (15.3%). Most of them accepted the assigned method (92%), but only 84% of the women completed the collection step. The acceptance rates were as follows: Group 1 (100%), Group 2 (64.5%), Group 3 (100%) and Group 4 (91.4%). In Group 5, the women\u2019s preferences were distributed as follows: examination performed at the hospital, 13 women (33.3%); examination performed at the mobile unit, 11 women (28.2%); urine self-collection, 11 women (28.2%); and vaginal self-collection, 4 women (10.3%). This study suggests that methods that allow cervical sampling collected near the women\u2019s domicile might improve the acceptance and completion of preventive tests. This finding is relevant for the development of new cervical cancer screening strategies.<\/jats:p>","DOI":"10.1371\/journal.pone.0306130","type":"journal-article","created":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T17:38:39Z","timestamp":1723225119000},"page":"e0306130","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Randomized experimental population-based study to evaluate the acceptance and completion of and preferences for cervical cancer screening"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1714-2964","authenticated-orcid":true,"given":"Marcela Vieira","family":"Lordelo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cleyton Zanardo","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luisa","family":"Aguirre Buexm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9639-7940","authenticated-orcid":true,"given":"Rui Manuel","family":"Vieira Reis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adhemar","family":"Longatto-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falio C\u00e9sar","family":"Possati-Resende","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4109-9521","authenticated-orcid":true,"given":"Fabiana de Lima","family":"Vazquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Humberto Tavares Guerreiro","family":"Fregnani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,8,9]]},"reference":[{"key":"pone.0306130.ref001","unstructured":"IARC. Cancer Today [cited 2023 30 Mar]. Available from: https:\/\/gco.iarc.fr\/today\/home."},{"key":"pone.0306130.ref002","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"H Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"pone.0306130.ref003","unstructured":"INCA. Estimativa 2023: Incid\u00eancia de c\u00e2ncer no Brasil [cited 2023 30 Mar]. Available from: https:\/\/www.gov.br\/inca\/pt-br\/assuntos\/cancer\/numeros\/estimativa."},{"issue":"4","key":"pone.0306130.ref004","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1177\/0969141314555247","article-title":"Self-sampling for cervical screening: could it overcome some of the barriers to the Pap test?","volume":"21","author":"R Mullins","year":"2014","journal-title":"J Med Screen"},{"issue":"7","key":"pone.0306130.ref005","doi-asserted-by":"crossref","first-page":"e0235202","DOI":"10.1371\/journal.pone.0235202","article-title":"Participation in interventions and recommended follow-up for non-attendees in cervical cancer screening -taking the women\u2019s own preferred test method into account-A Swedish randomised controlled trial","volume":"15","author":"C Lilliecreutz","year":"2020","journal-title":"PLoS One"},{"issue":"3","key":"pone.0306130.ref006","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/LGT.0000000000000088","article-title":"The Influence of Human Papillomavirus Genotypes on Visual Screening and Diagnosis of Cervical Precancer and Cancer","volume":"19","author":"J Jeronimo","year":"2015","journal-title":"J Low Genit Tract Dis"},{"issue":"6","key":"pone.0306130.ref007","doi-asserted-by":"crossref","first-page":"G1","DOI":"10.1016\/j.vaccine.2013.10.002","article-title":"Comprehensive control of human papillomavirus infections and related diseases","volume":"31","author":"FX Bosch","year":"2013","journal-title":"Vaccine"},{"issue":"25","key":"pone.0306130.ref008","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.1200\/JCO.2011.38.8389","article-title":"Clinical human papillomavirus detection forecasts cervical cancer risk in women over 18 years of follow-up","volume":"30","author":"PE Castle","year":"2012","journal-title":"J Clin Oncol"},{"issue":"3","key":"pone.0306130.ref009","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/jnci\/djr532","article-title":"Pooled analysis of a self-sampling HPV DNA Test as a cervical cancer primary screening method","volume":"104","author":"FH Zhao","year":"2012","journal-title":"J Natl Cancer Inst"},{"issue":"9806","key":"pone.0306130.ref010","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1016\/S0140-6736(11)61522-5","article-title":"Self-collection of vaginal specimens for human papillomavirus testing in cervical cancer prevention (MARCH): a community-based randomised controlled trial","volume":"378","author":"E Lazcano-Ponce","year":"2011","journal-title":"Lancet"},{"issue":"9","key":"pone.0306130.ref011","doi-asserted-by":"crossref","first-page":"e0238291","DOI":"10.1371\/journal.pone.0238291","article-title":"Cost effectiveness of strategies for cervical cancer prevention in India","volume":"15","author":"AS Chauhan","year":"2020","journal-title":"PLoS One"},{"issue":"5","key":"pone.0306130.ref012","doi-asserted-by":"crossref","first-page":"e0215945","DOI":"10.1371\/journal.pone.0215945","article-title":"A novel sequencing-based vaginal health assay combining self-sampling, HPV detection and genotyping, STI detection, and vaginal microbiome analysis","volume":"14","author":"EM Bik","year":"2019","journal-title":"PLoS One"},{"issue":"2","key":"pone.0306130.ref013","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ygyno.2014.11.076","article-title":"Primary cervical cancer screening with human papillomavirus: end of study results from the ATHENA study using HPV as the first-line screening test","volume":"136","author":"TC Wright","year":"2015","journal-title":"Gynecol Oncol"},{"key":"pone.0306130.ref014","unstructured":"IBGE. Censo 2010 [cited 2019 9 Dec]. Guia do Censo: Available from: https:\/\/censo2010.ibge.gov.br\/materiais\/guia-do-censo\/operacao-censitaria.html."},{"key":"pone.0306130.ref015","unstructured":"Caixa. Cadastro \u00danico\u2014Cadastros Sociais [cited 2019 9 Dec]. Available from: http:\/\/www.caixa.gov.br\/cadastros\/cadastro-unico\/Paginas\/default.aspx."},{"key":"pone.0306130.ref016","unstructured":"Decreto N\u00b0 9.661, de 1\u00b0 de Janeiro de 2019 [Internet]. 2019 [cited 11 Dec 2019]. Available from: http:\/\/www.normaslegais.com.br\/legislacao\/decreto9661-2019.htm."},{"key":"pone.0306130.ref017","unstructured":"INCA. Diretrizes brasileiras para o rastreamento do c\u00e2ncer do colo do \u00fatero 2018 [cited 2019 16 Dec]. Available from: https:\/\/www.inca.gov.br\/publicacoes\/livros\/diretrizes-brasileiras-para-o-rastreamento-do-cancer-do-colo-do-utero."},{"key":"pone.0306130.ref018","unstructured":"Ltd FH-LR. cobas\u00ae 4800 System [cited 2019 10 Dec]. Available from: https:\/\/diagnostics.roche.com\/global\/en\/products\/systems\/cobas-4800-system.html."},{"key":"pone.0306130.ref019","doi-asserted-by":"crossref","DOI":"10.1007\/978-3-319-11074-5","volume-title":"Bethesda System for Reporting Cervical Cytology: Definitions, Criteria, and Explanatory Notes","author":"R Nayar","year":"2015"},{"issue":"3","key":"pone.0306130.ref020","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1158\/1940-6207.CAPR-18-0419","article-title":"Participation in Cervical Screening by Self-collection, Pap, or a Choice of Either in Brazil.","volume":"12","author":"PE Castle","year":"2019","journal-title":"Cancer Prev Res (Phila)"},{"issue":"6","key":"pone.0306130.ref021","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1371\/journal.pmed.0050132","article-title":"Coverage of cervical cancer screening in 57 countries: low average levels and large inequalities","volume":"5","author":"E Gakidou","year":"2008","journal-title":"PLoS Med"},{"issue":"6","key":"pone.0306130.ref022","doi-asserted-by":"crossref","first-page":"e0199220","DOI":"10.1371\/journal.pone.0199220","article-title":"Cervical cancer screening among incarcerated women","volume":"13","author":"PJ Kelly","year":"2018","journal-title":"PLoS One"},{"issue":"10","key":"pone.0306130.ref023","doi-asserted-by":"crossref","first-page":"e46583","DOI":"10.1371\/journal.pone.0046583","article-title":"Cervical cancer and pap smear awareness and utilization of pap smear test among Federal civil servants in North Central Nigeria","volume":"7","author":"HI Hyacinth","year":"2012","journal-title":"PLoS One"},{"issue":"6","key":"pone.0306130.ref024","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ypmed.2011.03.018","article-title":"Comparative community outreach to increase cervical cancer screening in the Mississippi Delta","volume":"52","author":"PE Castle","year":"2011","journal-title":"Prev Med"},{"issue":"1","key":"pone.0306130.ref025","first-page":"10","article-title":"Non-Adherence to recommended Pap smear screening guidelines and its associated factors among women attending health clinic in Malaysia","volume":"13","author":"NA Yunus","year":"2018","journal-title":"Malays Fam Physician"},{"key":"pone.0306130.ref026","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ypmed.2016.11.018","article-title":"Personal and provider level factors influence participation to cervical cancer screening: A retrospective register-based study of 1.3 million women in Norway","volume":"94","author":"MK Leinonen","year":"2017","journal-title":"Prev Med"},{"issue":"15","key":"pone.0306130.ref027","doi-asserted-by":"crossref","first-page":"e17510","DOI":"10.1200\/JCO.2018.36.15_suppl.e17510","article-title":"Social disparities and patients\u2019 attitudes are associated with lower rates of cervical cancer screening in Brazil: Results of EVITA study (LACOG 0215)","volume":"36","author":"AN Rodrigues","year":"2018","journal-title":"Journal of Clinical Oncology"},{"issue":"1","key":"pone.0306130.ref028","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12889-017-4631-y","article-title":"A tailored within-community specimen collection strategy increased uptake of cervical cancer screening in a cross-sectional study in Ghana","volume":"18","author":"AK Awua","year":"2017","journal-title":"BMC Public Health"},{"issue":"3","key":"pone.0306130.ref029","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.7314\/APJCP.2016.17.3.1083","article-title":"Detection of Genital HPV Infection Using Urine Samples: a Population Based Study in India","volume":"17","author":"S Sabeena","year":"2016","journal-title":"Asian Pac J Cancer Prev"},{"key":"pone.0306130.ref030","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.canep.2017.07.008","article-title":"Acceptability and feasibility of a community based participatory research project comparing cytology and urine HPV DNA testing for cervical cancer screening in Yap, Federated States of Micronesia","volume":"50","author":"AU Sy","year":"2017","journal-title":"Cancer Epidemiol"},{"issue":"1\u20132","key":"pone.0306130.ref031","first-page":"1","article-title":"Implementation of a cervical cancer screening strategy using HPV self-sampling for women living in rural areas","volume":"64","author":"JC Possati-Resende","year":"2020","journal-title":"Acta Cytologica"},{"issue":"7","key":"pone.0306130.ref032","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1007\/s11606-018-4404-z","article-title":"HPV Self-Sampling for Cervical Cancer Screening Among Ethnic Minority Women in South Florida: a Randomized Trial","volume":"33","author":"O Carrasquillo","year":"2018","journal-title":"J Gen Intern Med"},{"issue":"10","key":"pone.0306130.ref033","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1111\/tmi.12549","article-title":"Uptake of community-based, self-collected HPV testing vs. visual inspection with acetic acid for cervical cancer screening in Kampala, Uganda: preliminary results of a randomised controlled trial","volume":"20","author":"E Moses","year":"2015","journal-title":"Trop Med Int Health"},{"issue":"4","key":"pone.0306130.ref034","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1002\/cam4.429","article-title":"Cervical cancer screening with clinic-based Pap test versus home HPV test among Somali immigrant women in Minnesota: a pilot randomized controlled trial","volume":"4","author":"B Sewali","year":"2015","journal-title":"Cancer Med"},{"issue":"2","key":"pone.0306130.ref035","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1016\/S2214-109X(14)70354-7","article-title":"Effect of self-collection of HPV DNA offered by community health workers at home visits on uptake of screening for cervical cancer (the EMA study): a population-based cluster-randomised trial","volume":"3","author":"S Arrossi","year":"2015","journal-title":"Lancet Glob Health"},{"issue":"2","key":"pone.0306130.ref036","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1177\/0969141320941056","article-title":"Evaluation of human papillomavirus self-collection offered by community health workers at home visits among under-screened women in Brazil","volume":"28","author":"NP Pantano","year":"2021","journal-title":"J Med Screen"},{"issue":"1","key":"pone.0306130.ref037","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1186\/s13063-019-3959-2","article-title":"Impact of human papillomavirus (HPV) self-collection on subsequent cervical cancer screening completion among under-screened US women: MyBodyMyTest-3 protocol for a randomized controlled trial","volume":"20","author":"LP Spees","year":"2019","journal-title":"Trials"},{"issue":"4","key":"pone.0306130.ref038","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s13304-017-0491-3","article-title":"Tumor markers of uterine cervical cancer: a new scenario to guide surgical practice?","volume":"69","author":"G Valenti","year":"2017","journal-title":"Updates Surg"},{"issue":"3","key":"pone.0306130.ref039","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s13304-017-0456-6","article-title":"New procedures for the identification of sentinel lymph node: shaping the horizon of future management in early stage uterine cervical cancer","volume":"69","author":"D Rossetti","year":"2017","journal-title":"Updates Surg"},{"issue":"1","key":"pone.0306130.ref040","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.ygyno.2021.01.020","article-title":"High-risk HPV-positive and -negative high-grade cervical dysplasia: Analysis of 5-year outcomes","volume":"161","author":"G Bogani","year":"2021","journal-title":"Gynecol Oncol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0306130","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,9]],"date-time":"2024-08-09T17:39:03Z","timestamp":1723225143000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0306130"}},"subtitle":[],"editor":[{"given":"Lucy W.","family":"Kivuti-Bitok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,8,9]]},"references-count":40,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2024,8,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0306130","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8,9]]}}}