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Drawing inspiration from \u201cbiomimetic camouflage,\u201d we isolated cell membranes (CMs) from human glioblastoma (T98G) cell lines via the extrusion method to facilitate homotypic glioma targeting. At an 8:1 mass ratio of ferric chloride hexahydrate to gallic acid (GA), the resulting iron (Fe)\u2013GA nanoparticles (NPs) proved effective as a T<jats:sub>1<\/jats:sub>-weighted MRI contrast agent. T98G CM\u2013coated Fe\u2013GA NPs demonstrated improved homotypic glioma targeting, validated through Prussian blue staining and <jats:italic>in vitro<\/jats:italic> MRI. This biomimetic camouflage strategy holds promise for the development of targeted theranostic agents in a safe and effective manner.<\/jats:p>","DOI":"10.1371\/journal.pone.0306142","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T18:56:01Z","timestamp":1719946561000},"page":"e0306142","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Iron gallic acid biomimetic nanoparticles for targeted magnetic resonance imaging"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8998-8489","authenticated-orcid":true,"given":"Yan","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhijian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiqing","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aikebaier","family":"Reheman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yifan","family":"Ouyang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuyan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dingtai","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,7,2]]},"reference":[{"issue":"6","key":"pone.0306142.ref001","doi-asserted-by":"crossref","first-page":"926","DOI":"10.3390\/diagnostics11060926","article-title":"Non-Invasive Evaluation of Cerebral Microvasculature Using Pre-Clinical MRI: Principles, Advantages and Limitations","volume":"11","author":"B Callewaert","year":"2021","journal-title":"Diagnostics (Basel)"},{"key":"pone.0306142.ref002","doi-asserted-by":"crossref","first-page":"101286","DOI":"10.1016\/j.progpolymsci.2020.101286","article-title":"Functional polymers as metal-free magnetic resonance imaging contrast agents","volume":"108","author":"CK Fu","year":"2020","journal-title":"Progress in Polymer Science"},{"issue":"3","key":"pone.0306142.ref003","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1021\/acsbiomaterials.2c01386","article-title":"Polymeric Metal Contrast Agents for T1-Weighted Magnetic Resonance Imaging of the Brain","volume":"9","author":"D Foster","year":"2023","journal-title":"ACS Biomater Sci Eng"},{"issue":"9","key":"pone.0306142.ref004","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1177\/02841851211034038","article-title":"Gadoteridol-enhanced MRI of the breast: can contrast agent injection rate impact background parenchymal enhancement?","volume":"63","author":"F Marzocca","year":"2022","journal-title":"Acta Radiol"},{"issue":"1","key":"pone.0306142.ref005","doi-asserted-by":"crossref","DOI":"10.1186\/s12968-020-00676-2","article-title":"Assessment of gadolinium deposition in the brain tissue of pediatric and adult congenital heart disease patients after contrast enhanced cardiovascular magnetic resonance","volume":"22","author":"N Zaki","year":"2020","journal-title":"J Cardiovasc Magn Reson"},{"issue":"19","key":"pone.0306142.ref006","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1021\/acs.accounts.2c00346","article-title":"Targeted Contrast Agents for Magnetic Resonance Molecular Imaging of Cancer","volume":"55","author":"ZR Lu","year":"2022","journal-title":"Acc. 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