{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T11:00:38Z","timestamp":1767178838207,"version":"build-2238731810"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T00:00:00Z","timestamp":1719532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>We aimed to determine the rate and impact of post-pericardiotomy syndrome after native valve-sparing aortic valve surgery and the perioperative factors associated with its occurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec002\">\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>All consecutive patients who underwent native valve-sparing aortic valve surgery (i.e., repair \u00b1 ascending aorta replacement, valve-sparing root replacement, Ross procedure \u00b1 ascending aorta replacement) at our institution between January 2021 and August 2023 served as our study population. Post-pericardiotomy syndrome was diagnosed if patients showed at least two of the following diagnostic criteria: evidence of (I) new\/worsening pericardial effusion, or (II) new\/worsening pleural effusions, (III) pleuritic chest pain, (IV) fever or (V) elevated inflammatory markers without alternative causes. A logistic regression model was calculated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec003\">\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>During the study period, 91 patients underwent native valve-sparing aortic valve surgery. A total of 21 patients (23%) developed post-pericardiotomy syndrome early after surgery (PPS group). The remaining 70 patients (77%) showed no signs of post-pericardiotomy syndrome (non-PPS group). Multivariate logistic regression revealed blood type O (OR: 3.15, 95% CI: 1.06\u20139.41, p = 0.040), valve-sparing root replacement (OR: 3.12, 95% CI: 1.01\u20139.59, p = 0.048) and peak C-reactive protein &gt;15 mg\/dl within 48 hours postoperatively (OR: 4.27, 95% CI: 1.05\u201317.29, p = 0.042) as independent risk factors. 73% (8\/11) of patients displaying all three risk factors, 60% (9\/15) of patients with blood type O and valve-sparing root replacement, 52% (11\/21) of patients with blood type O and early postoperative peak C-reactive protein &gt;15 mg\/dl and 45% (13\/29) of patients with early postoperative peak C-reactive protein &gt;15 mg\/dl and valve-sparing root replacement developed post-pericardiotomy syndrome.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec id=\"sec004\">\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In summary, blood type O, valve-sparing root replacement and peak C-reactive protein &gt;15 mg\/dl within 48 hours postoperatively are significantly associated with post-pericardiotomy syndrome after native valve-sparing aortic valve surgery. Particularly, the presence of all three risk factors is linked to a particularly high risk of post-pericardiotomy syndrome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1371\/journal.pone.0306306","type":"journal-article","created":{"date-parts":[[2024,6,28]],"date-time":"2024-06-28T13:47:58Z","timestamp":1719582478000},"page":"e0306306","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Predictors of post-pericardiotomy syndrome after native valve-sparing aortic valve surgery"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8057-9555","authenticated-orcid":true,"given":"Theresa","family":"Holst","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"M\u00fcller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noureldin","family":"Abdelmoteleb","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sina","family":"Stock","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana M.","family":"Sequeira 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