{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,13]],"date-time":"2025-02-13T05:25:54Z","timestamp":1739424354285,"version":"3.37.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T00:00:00Z","timestamp":1739318400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>This cross-sectional study aimed to investigate morphological changes in the human mandible in archaeological collections associated with the presence of bony exostoses at the mandibular angle, which is described in the literature as related to specific behaviours of the masticatory apparatus like parafunctional activities. The skeletal sample investigated comprised adult individuals from two archaeological series. Sixteen measurements of the mandible were selected to evaluate anatomic variation in the two populations. Mandibles from both series were pooled for statistical analysis into two groups according to the number of exostoses at the mandibular angles: group 1 (number of exostoses \u22641) and group 2 (number of exostoses \u2265 2). Measurements could be made on eighty mandibles. A statistically significant difference was demonstrated between group 1 and group 2 for the following parameters: distance between mandibular angles, bicondylar width, ramus height, left condyle length, and right and left coronoid process height. For each of these parameters, values were higher in group 2 than in group 1. This study presents an original methodology for studying anatomical variations of the mandible in the context of parafunctional activity, highlighting certain mandibular modifications. The impact of parafunctional behaviours such as bruxism on the mandible therefore has many anatomical expressions. The considerable variability of results found in the literature shows that more studies are needed to reach a consensus on the impact of parafunctional activities on the mandible.<\/jats:p>","DOI":"10.1371\/journal.pone.0306501","type":"journal-article","created":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T18:33:24Z","timestamp":1739385204000},"page":"e0306501","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Morphological changes in the human mandible associated with the presence of exostoses: A cross-sectional study in two archaeological populations from southern France"],"prefix":"10.1371","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3316-7267","authenticated-orcid":true,"given":"Estelle","family":"Casazza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benoit","family":"Ballester","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Philip-Alliez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yann","family":"Ardagna","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6284-7037","authenticated-orcid":true,"given":"Anne","family":"Raskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2025,2,12]]},"reference":[{"key":"pone.0306501.ref001","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1007\/BF00302070","article-title":"Mechanotransduction and the functional response of bone to mechanical strain","volume":"57","author":"RL Duncan","year":"1995","journal-title":"Calcif Tissue Int"},{"key":"pone.0306501.ref002","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1210\/er.2015-1106","article-title":"Role of Thyroid Hormones in Skeletal Development and Bone Maintenance","volume":"37","author":"JHD Bassett","year":"2016","journal-title":"Endocr Rev"},{"key":"pone.0306501.ref003","doi-asserted-by":"crossref","first-page":"606947","DOI":"10.3389\/fendo.2020.606947","article-title":"Muscle-Bone Crosstalk in the Masticatory System: From Biomechanical to Molecular Interactions","volume":"11","author":"S Buvinic","year":"2020","journal-title":"Front Endocrinol"},{"key":"pone.0306501.ref004","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/jicd.12112","article-title":"Biomechanics and functional distortion of the human mandible","volume":"6","author":"AH Choi","year":"2015","journal-title":"J Investig Clin Dent"},{"key":"pone.0306501.ref005","volume-title":"Das Gesetz der Transformation der Knochen","author":"JD Wolff","year":"1892"},{"key":"pone.0306501.ref006","first-page":"3","article-title":"A 2003 update of bone physiology and Wolff\u2019s Law for clinicians","volume":"74","author":"HM Frost","year":"2004","journal-title":"Angle Orthod"},{"key":"pone.0306501.ref007","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bone.2015.02.010","article-title":"Bone and muscle: Interactions beyond mechanical","volume":"80","author":"M Brotto","year":"2015","journal-title":"Bone"},{"key":"pone.0306501.ref008","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1007\/s11926-013-0373-8","article-title":"Measuring bone quality","volume":"15","author":"E Torres-del-Pliego","year":"2013","journal-title":"Curr Rheumatol Rep"},{"key":"pone.0306501.ref009","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11282-022-00612-3","article-title":"Evaluation of mandibular bone density in bruxers: the value of panoramic radiographs","volume":"39","author":"E Casazza","year":"2023","journal-title":"Oral Radiol"},{"key":"pone.0306501.ref010","first-page":"209","article-title":"Idiopathic masseter muscle hypertrophy","volume":"21","author":"B Kebede","year":"2011","journal-title":"Ethiop J Health Sci"},{"key":"pone.0306501.ref011","doi-asserted-by":"crossref","DOI":"10.31744\/einstein_journal\/2019AI4506","article-title":"Idiopathic masseter muscle hypertrophy: a case report","volume":"17","author":"JJ Antunes","year":"2019","journal-title":"Einstein"},{"key":"pone.0306501.ref012","article-title":"The development of the Standardised Tool for the Assessment of Bruxism (STAB): An international road map","author":"D Manfredini","year":"2022","journal-title":"J Oral Rehabil"},{"key":"pone.0306501.ref013","unstructured":"Richier A, Weydert N. Bouches-du-Rh\u00f4ne, Marseille, prolongement de la ligne 2 du m\u00e9tro de Bougainville vers Capitaine G\u00e8ze\u201472 avenue F\u00e9lix Zoccola. Ancien cimeti\u00e8re des Crottes. Rapport final d\u2019op\u00e9ration pr\u00e9ventive. Inrap M\u00e9diterran\u00e9e, SRA PACA. N\u00eemes: 2016."},{"key":"pone.0306501.ref014","volume-title":"BAR International Series","author":"M. Perrin","year":"2021"},{"key":"pone.0306501.ref015","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/ajpa.10012","article-title":"A method for visual determination of sex, using the human hip bone","volume":"117","author":"J. Bruzek","year":"2002","journal-title":"American Journal of Physical Anthropology"},{"key":"pone.0306501.ref016","doi-asserted-by":"crossref","first-page":"167","DOI":"10.4000\/bmsap.1157","article-title":"DSP: A tool for probabilistic sex diagnosis using worldwide variability in hip-bone measurements","volume":"17","author":"P Murail","year":"2005","journal-title":"Bull M\u00e9m Soci\u00e9t\u00e9 D\u2019Anthropologie Paris BMSAP"},{"key":"pone.0306501.ref017","unstructured":"Richier A. Bouches-du-Rh\u00f4ne, La Ciotat. Carr\u00e9 Saint-Jacques: L\u2019\u00eelot Saint-Jacques, du vignoble champ\u00eatre au cimeti\u00e8re paroissial. Rapport final d\u2019op\u00e9ration pr\u00e9ventive. Inrap M\u00e9diterran\u00e9e, SRA PACA. N\u00eemes: 2011."},{"key":"pone.0306501.ref018","first-page":"107","volume-title":"Data collection procedures for forensic skeletal material 2.0","author":"NR Langley","year":"2016"},{"key":"pone.0306501.ref019","volume-title":"Arkansas Archeological Survey Research Series","author":"J Buikstra","year":"1994"},{"key":"pone.0306501.ref020","doi-asserted-by":"crossref","first-page":"102322","DOI":"10.1016\/j.legalmed.2023.102322","article-title":"Size and shape of the human mandible: Sex differences and influence of age on sex estimation accuracy","volume":"65","author":"DH Toneva","year":"2023","journal-title":"Leg Med Tokyo Jpn"},{"key":"pone.0306501.ref021","volume-title":"StatPearls","author":"G Breeland","year":"2024"},{"key":"pone.0306501.ref022","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1186\/s12903-021-01804-9","article-title":"Bone apposition at the mandibular angles as a radiological sign of bruxism: a retrospective study","volume":"21","author":"JC T\u00fcrp","year":"2021","journal-title":"BMC Oral Health"},{"key":"pone.0306501.ref023","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1186\/s12903-023-03209-2","article-title":"Relationship between bruxism and mandibular bone modifications based on medical imaging: a scoping review","volume":"23","author":"E Casazza","year":"2023","journal-title":"BMC Oral Health"},{"key":"pone.0306501.ref024","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jds.2020.09.008","article-title":"Evaluation of jaw bone density and morphology in bruxers using panoramic radiography","volume":"16","author":"O. Isman","year":"2021","journal-title":"J Dent Sci"},{"key":"pone.0306501.ref025","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1016\/j.joms.2014.05.024","article-title":"Mandibular Tori Are Associated With Mechanical Stress and Mandibular Shape","volume":"72","author":"ARG Cortes","year":"2014","journal-title":"J Oral Maxillofac Surg"},{"key":"pone.0306501.ref026","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.oooo.2021.01.017","article-title":"Investigation of mandibular fractal dimension on digital panoramic radiographs in bruxist individuals","volume":"131","author":"\u0130 Eninan\u00e7","year":"2021","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol"},{"key":"pone.0306501.ref027","doi-asserted-by":"crossref","first-page":"753","DOI":"10.2174\/1745017901814010753","article-title":"Assessment of Mandibular Surface Area Changes in Bruxers Versus Controls on Panoramic Radiographic Images: A Case Control Study","volume":"12","author":"L Padmaja Satheeswarakumar","year":"2018","journal-title":"Open Dent J"},{"key":"pone.0306501.ref028","article-title":"Evaluation of the mandibular trabecular bone in patients with bruxism using fractal analysis","author":"M Gulec","year":"2020","journal-title":"Oral Radiol"},{"key":"pone.0306501.ref029","first-page":"1","article-title":"Impact of bruxism on craniomandibular morphology: A cone-beam computed tomographic study","author":"I Serafim","year":"2022","journal-title":"Cranio J Craniomandib Pract"},{"key":"pone.0306501.ref030","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0022-3913(82)90306-7","article-title":"Asymptomatic morphologic variations in the mandibular condyle-ramus region","volume":"47","author":"SM Sheppard","year":"1982","journal-title":"J Prosthet Dent"},{"key":"pone.0306501.ref031","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1016\/j.bone.2007.08.033","article-title":"Regional variations in mineralization and strain distributions in the cortex of the human mandibular condyle","volume":"41","author":"I Cioffi","year":"2007","journal-title":"Bone"},{"key":"pone.0306501.ref032","first-page":"19","article-title":"The association between bruxism and mandibular morphology: A cross-sectional study","volume":"11","author":"B Cezairli","year":"2022","journal-title":"J Oral Health Oral Epidemiol"},{"key":"pone.0306501.ref033","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1177\/10454411000110010101","article-title":"Biomechanics of the mandible","volume":"11","author":"TM van Eijden","year":"2000","journal-title":"Crit Rev Oral Biol Med Off Publ Am Assoc Oral Biol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0306501","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T18:33:48Z","timestamp":1739385228000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0306501"}},"subtitle":[],"editor":[{"given":"Sameh","family":"Attia","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2025,2,12]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2025,2,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0306501","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2,12]]}}}