{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T11:15:35Z","timestamp":1772622935509,"version":"3.50.1"},"reference-count":17,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:00:00Z","timestamp":1723680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008005","name":"Yonsei University College of Medicine","doi-asserted-by":"publisher","award":["2022-32-0074"],"award-info":[{"award-number":["2022-32-0074"]}],"id":[{"id":"10.13039\/501100008005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019266","name":"Korea Medical Device Development Fund","doi-asserted-by":"publisher","award":["KMDF202011A01-04"],"award-info":[{"award-number":["KMDF202011A01-04"]}],"id":[{"id":"10.13039\/100019266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>This study aims to compare outcomes following a negative surveillance MRI study by surgery-MRI interval and investigate factors associated with second breast cancers in women with a personal history of breast cancer (PHBC).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This retrospective study included 1552 consecutive women (mean age, 53 years) with a PHBC and a negative prevalence surveillance breast MRI result between August 2014 and December 2016. The incidence and characteristics of second breast cancers were reviewed and compared according to surgery-MRI interval (&lt; 3 years vs \u2265 3 years). Logistic regression analysis was used to investigate associations with clinical-pathologic characteristics.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Twenty-five second breast cancers occurred after negative MRI. The incidence of second breast cancers or local-regional recurrence did not significantly differ by surgery-MRI interval. The median intervals between MRI to second breast cancer detection showed no significant difference between the two groups (surgery-MRI interval &lt;3 years vs. \u2265 3 years). Two node-positive second breast cancers were detected in the group with &lt;3 years interval. BRCA mutation status, receipt of breast-conserving surgery, and adjuvant chemotherapy (all <jats:italic>p<\/jats:italic> &lt; .05) were significant factors associated with the development of second breast cancers.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Outcomes following a negative surveillance MRI did not differ by surgery-MRI interval. BRCA mutation status, receipt of breast-conserving surgery and adjuvant chemotherapy were independently associated with the risk of developing second breast cancers after negative surveillance MRI.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0306828","type":"journal-article","created":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T17:28:42Z","timestamp":1723742922000},"page":"e0306828","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["Second breast cancer following negative breast MRI: Analysis by interval from surgery and risk factors"],"prefix":"10.1371","volume":"19","author":[{"given":"Yohan","family":"Joo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hyun","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miribi","family":"Rho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5135-4058","authenticated-orcid":true,"given":"Vivian Youngjean","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,8,15]]},"reference":[{"key":"pone.0306828.ref001","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1200\/JCO.2014.56.8626","article-title":"Triple-modality screening trial for familial breast cancer underlines the importance of magnetic resonance imaging and questions the role of mammography and ultrasound regardless of patient mutation status, age, and breast density.","volume":"33","author":"CC Riedl","year":"2015","journal-title":"J Clin Oncol."},{"key":"pone.0306828.ref002","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1001\/jamaoncol.2017.1256","article-title":"Breast cancer screening with mammography plus ultrasonography or magnetic resonance imaging in women 50 years or younger at diagnosis and treated with breast conservation therapy.","volume":"3","author":"N Cho","year":"2017","journal-title":"JAMA Oncol."},{"key":"pone.0306828.ref003","doi-asserted-by":"crossref","first-page":"2091","DOI":"10.1056\/NEJMoa1903986","article-title":"Supplemental MRI screening for women with extremely dense breast tissue","volume":"381","author":"MF Bakker","year":"2019","journal-title":"N Engl J Med"},{"key":"pone.0306828.ref004","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1001\/jama.2020.0572","article-title":"Comparison of abbreviated breast MRI vs digital breast tomosynthesis for breast cancer detection among women with dense breasts undergoing screening","volume":"323","author":"CE Comstock","year":"2020","journal-title":"JAMA"},{"key":"pone.0306828.ref005","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.jacr.2017.11.034","article-title":"Breast cancer screening in women at higher-than-average risk: recommendations from the ACR","volume":"15","author":"DL Monticciolo","year":"2018","journal-title":"J Am Coll Radiol"},{"key":"pone.0306828.ref006","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1148\/radiol.2021203074","article-title":"Interval cancers after negative supplemental screening breast MRI results in women with a personal history of breast cancer","volume":"300","author":"GR Kim","year":"2021","journal-title":"Radiology"},{"key":"pone.0306828.ref007","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1148\/radiol.2021204217","article-title":"Outcomes following negative screening MRI results in Korean women with a personal history of breast cancer: implications for the next MRI interval","volume":"300","author":"VY Park","year":"2021","journal-title":"Radiology"},{"key":"pone.0306828.ref008","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1002\/ijc.31914","article-title":"Ten-year recurrence rates for breast cancer subtypes in the Netherlands: A large population-based study","volume":"144","author":"MC Van Maaren","year":"2019","journal-title":"Int J Cancer"},{"key":"pone.0306828.ref009","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12885-018-3998-1","article-title":"Breast magnetic resonance imaging for surveillance of women with a personal history of breast cancer: outcomes stratified by interval between definitive surgery and surveillance MR imaging","volume":"18","author":"VY Park","year":"2018","journal-title":"BMC Cancer"},{"key":"pone.0306828.ref010","volume-title":"ACR BI-RADS\u00ae Atlas, Breast Imaging Reporting and Data System.","author":"CJ 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Radiol."},{"key":"pone.0306828.ref014","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1002\/cac2.12207","article-title":"Global patterns of breast cancer incidence and mortality: A population-based cancer registry data analysis from 2000 to 2020","volume":"41","author":"S Lei","year":"2021","journal-title":"Cancer Commun (Lond)."},{"key":"pone.0306828.ref015","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s10549-020-06040-3","article-title":"Conditional local recurrence risk: the effect of event-free years in different subtypes of breast cancer","volume":"186","author":"M Moossdorff","year":"2021","journal-title":"Breast Cancer Res Treat"},{"key":"pone.0306828.ref016","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1158\/1055-9965.EPI-12-1208-T","article-title":"Risk factors for second screen-detected or interval breast cancers in women with a personal history of breast cancer participating in mammography screening","volume":"22","author":"N Houssami","year":"2013","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"pone.0306828.ref017","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s10549-009-0566-z","article-title":"Prognosis of BRCA-associated breast cancer: a summary of evidence","volume":"119","author":"L Bordeleau","year":"2010","journal-title":"Breast Cancer Res Treat"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0306828","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T17:28:56Z","timestamp":1723742936000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0306828"}},"subtitle":[],"editor":[{"given":"Daniele 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