{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T04:02:55Z","timestamp":1779336175415,"version":"3.51.4"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T00:00:00Z","timestamp":1720483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Benign prostatic hyperplasia (BPH) is a common health disorder of the male genitourinary system with a high prevalence, especially among middle-aged and older adults, which seriously affects men\u2019s quality of life. Inflammatory markers derived from complete blood cell count (CBC) have previously been considered a prognostic indicator for various diseases, but little is known about their relationship with BPH. This study evaluated the relationship between complete blood cell count (CBC)-derived inflammatory biomarkers and BPH.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Data for this cross-sectional study were gathered from the National Health and Nutrition Examination Survey (NHANES) between 2001 and 2008. Using multiple logistic regressions, the study examined the association between benign prostatic hyperplasia(BPH) and Inflammatory biomarkers derived from blood cell counts such as neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), Systemic Inflammatory Response Index (SIRI) and Systemic Immunoinflammatory Index (SII).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>3,919 participants were included, with a median age of 61.00 (52.00\u201371.00) years old. Among them, 609 participants had benign prostatic hyperplasia, with a prevalence of 15.54%. Upon accounting for confounding factors, the study revealed a positive correlation between the plurality of BPH PLR and SII. However, MLR, NLR, and SIRI did not significantly correlate with the prevalence of BPH (p&gt;0.05). In contrast to the lowest quartile, higher quartiles of PLR (OR = 1.93[1.38\u20132.69]) and SII (OR = 1.71[1.22\u20132.40]) were linked to an elevated risk of BPH. Interaction tests showed that age, body mass index, hypertension, diabetes, smoking, and drinking had no significant effect on this positive correlation (p for interaction&gt;0.05). In addition, we found a roughly linear association between SII, PLR, and BPH using smoothed curve fitting.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>According to our research, high levels of PLR and SII are positively linked with an increased risk of BPH in middle-aged and elderly individuals in the United States. The results compensate for previous studies that still need to be validated with larger prospective cohorts.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0306860","type":"journal-article","created":{"date-parts":[[2024,7,9]],"date-time":"2024-07-09T18:02:55Z","timestamp":1720548175000},"page":"e0306860","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":18,"title":["The relationship between complete blood cell count-derived inflammatory biomarkers and benign prostatic hyperplasia in middle-aged and elderly individuals in the United States: Evidence from NHANES 2001\u20132008"],"prefix":"10.1371","volume":"19","author":[{"given":"Chengdong","family":"Shi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongliang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guoqiang","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5029-190X","authenticated-orcid":true,"given":"Yuantao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,7,9]]},"reference":[{"issue":"5 Suppl","key":"pone.0306860.ref001","first-page":"S122","article-title":"BPH: epidemiology and comorbidities","volume":"12","author":"K.T. 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Song","year":"2023","journal-title":"Journal of Inflammation Research"},{"key":"pone.0306860.ref017","doi-asserted-by":"crossref","first-page":"1166265","DOI":"10.3389\/fimmu.2023.1166265","article-title":"Analysis of platelet and monocyte-to-lymphocyte ratio and diabetes mellitus with benign prostatic enlargement","volume":"14","author":"G. Chen","year":"2023","journal-title":"Frontiers in immunology"},{"issue":"1","key":"pone.0306860.ref018","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/01.mou.0000193368.91823.1b","article-title":"Could inflammation be a key component in the Progression of benign prostatic hyperplasia?","volume":"16","author":"G. Kramer","year":"2006","journal-title":"Current opinion in urology"},{"issue":"1","key":"pone.0306860.ref019","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/pros.10084","article-title":"Increased expression of lymphocyte-derived cytokines in benign hyperplastic prostate tissue, identification of the producing cell types, and effect of differentially expressed cytokines on stromal cell proliferation","volume":"52","author":"G. Kramer","year":"2002","journal-title":"The Prostate"},{"issue":"2","key":"pone.0306860.ref020","doi-asserted-by":"crossref","first-page":"582S","DOI":"10.1093\/jn\/133.2.582S","article-title":"Integrated NHANES: use in national policy","volume":"133","author":"C.E. 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Zhou","year":"2023","journal-title":"Renal failure"},{"key":"pone.0306860.ref023","doi-asserted-by":"crossref","first-page":"804457","DOI":"10.3389\/fendo.2021.804457","article-title":"Exposure to Di-2-ethylhexyl Phthalate and Benign Prostatic Hyperplasia, NHANES 2001\u20132008","volume":"12","author":"L. Yang","year":"2021","journal-title":"Frontiers in endocrinology"},{"key":"pone.0306860.ref024","doi-asserted-by":"crossref","first-page":"1205687","DOI":"10.3389\/fimmu.2023.1205687","article-title":"Associations of complete blood cell count-derived inflammatory biomarkers with asthma and adult mortality: a population-based study","volume":"14","author":"J. Ke","year":"2023","journal-title":"Frontiers in immunology"},{"issue":"5","key":"pone.0306860.ref025","doi-asserted-by":"crossref","DOI":"10.3390\/nu15051177","article-title":"Association between Systemic Immunity-Inflammation Index and Hyperlipidemia: A Population-Based Study from the NHANES (2015\u20132020)","volume":"15","author":"N. Mahemuti","year":"2023","journal-title":"Nutrients"},{"issue":"2","key":"pone.0306860.ref026","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/JU.0000000000000542","article-title":"Associations between Socio-economic Status and Urge Urinary Incontinence: An Analysis of NHANES 2005 to 2016","volume":"203","author":"J.A. Lee","year":"2020","journal-title":"The Journal of Urology"},{"issue":"6","key":"pone.0306860.ref027","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.2337\/dc21-2371","article-title":"Associations of Serum Carotenoids With Risk of Cardiovascular Mortality Among Individuals With Type 2 Diabetes: Results From NHANES","volume":"45","author":"Z. Qiu","year":"2022","journal-title":"Diabetes care"},{"issue":"3","key":"pone.0306860.ref028","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0094-0143(21)00961-7","article-title":"Pathology of benign prostatic hyperplasia. Insight into etiology","volume":"17","author":"J. McNeal","year":"1990","journal-title":"The Urologic Clinics of North America"},{"issue":"8","key":"pone.0306860.ref029","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1097\/01.LAB.0000081388.40145.65","article-title":"Cytokine expression pattern in benign prostatic hyperplasia infiltrating T cells and impact of lymphocytic infiltration on cytokine mRNA profile in prostatic tissue","volume":"83","author":"G.E. Steiner","year":"2003","journal-title":"Laboratory investigation; a journal of technical methods and pathology"},{"issue":"6","key":"pone.0306860.ref030","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1464-410X.1990.tb14828.x","article-title":"Inflammatory infiltrate in prostatic hyperplasia\u2014evidence of a host response to intraprostatic spermatozoa?","volume":"65","author":"S. McClinton","year":"1990","journal-title":"British journal of urology"},{"issue":"1","key":"pone.0306860.ref031","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.eururo.2011.03.055","article-title":"The controversial relationship between benign prostatic hyperplasia and prostate cancer: the role of inflammation","volume":"60","author":"C. De Nunzio","year":"2011","journal-title":"European urology"},{"issue":"12","key":"pone.0306860.ref032","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15123110","article-title":"The Molecular Basis and Clinical Consequences of Chronic Inflammation in Prostatic Diseases: Prostatitis, Benign Prostatic Hyperplasia, and Prostate Cancer","volume":"15","author":"S.O. Oseni","year":"2023","journal-title":"Cancers"},{"issue":"9","key":"pone.0306860.ref033","doi-asserted-by":"crossref","first-page":"2641","DOI":"10.1007\/s00262-021-02884-w","article-title":"Prognostic role of the systemic immune-inflammation index in upper tract urothelial carcinoma treated with radical nephroureterectomy: results from an extensive multicenter international collaboration","volume":"CII70","author":"K. Mori","year":"2021","journal-title":"Cancer immunology, immunotherapy"},{"issue":"13","key":"pone.0306860.ref034","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15133339","article-title":"Prognostic Values of Systemic Inflammatory Immunological Markers in Glioblastoma: A Systematic Review and Meta-Analysis","volume":"15","author":"P. Jarmuzek","year":"2023","journal-title":"Cancers"},{"issue":"9\u201310","key":"pone.0306860.ref035","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1159\/000512894","article-title":"Association of Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Lymphocyte-to-Monocyte Ratio with Benign Prostatic Hyperplasia: A Propensity Score-Matched Analysis","volume":"105","author":"J.Y. Kang","year":"2021","journal-title":"Urologia internationalis"},{"issue":"4","key":"pone.0306860.ref036","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1159\/000448289","article-title":"Association between Benign Prostatic Hyperplasia and Neutrophil-Lymphocyte Ratio, an Indicator of Inflammation and Metabolic Syndrome","volume":"98","author":"K. Ozer","year":"2017","journal-title":"Urologia internationalis"},{"issue":"3","key":"pone.0306860.ref037","first-page":"147","article-title":"role of inflammation in benign prostatic hyperplasia","volume":"13","author":"B. Chughtai","year":"2011","journal-title":"Reviews in urology"},{"issue":"17","key":"pone.0306860.ref038","doi-asserted-by":"crossref","first-page":"23581","DOI":"10.18632\/oncotarget.8051","article-title":"Progression of benign prostatic hyperplasia is associated with pro-inflammatory mediators and chronic activation of prostate-infiltrating lymphocytes","volume":"7","author":"M.M. Norstr\u00f6m","year":"2016","journal-title":"Oncotarget"},{"issue":"5","key":"pone.0306860.ref039","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/pros.20896","article-title":"The vitamin D receptor agonist elocalcitol inhibits IL-8-dependent benign prostatic hyperplasia stromal cell proliferation and inflammatory response by targeting the RhoA\/Rho kinase and NF-kappaB pathways","volume":"69","author":"G. 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