{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:54:02Z","timestamp":1791978842963,"version":"4.4.0"},"reference-count":55,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Although rare, small intestine cancer is on the rise in the developed world. We aimed to investigate the incidence trends of small intestine cancer by sex, race\/ethnicity, age, and histological subgroups in the United States (US) over 2000\u20132020. Also, we evaluated the COVID-19 impacts on the incidence trends of this cancer.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Data were collected from the Surveillance, Epidemiology, and End Results 22 database. Both the average annual percent change (AAPC) and age-standardized incidence rates (ASIRs) were determined. The findings were expressed as counts and incidence rates adjusted for age per 100,000 people with 95% confidence intervals (CIs).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 67,815 cases of small intestine cancer across all age groups were reported in the US between 2000 and 2019. Neuroendocrine carcinoma was the most often reported subtype (54.26%). The age group of 55 to 69 years (38.08%), men (53.10%), and Non-Hispanic Whites (69.07%) accounted for the majority of cases. Over 2000\u20132019, the ASIRs for small intestine cancer among men and women were 2.61 (95% CI: 2.59\u20132.64) and 1.92 (95% CI: 1.89\u20131.94) per 100,000, indicating a significant increase of 2.01% and 2.12%, respectively. Non-Hispanic Black men had the highest ASIR (4.25 per 100,000). Also, those aged 80\u201384 age group had the highest ASIR. During COVID-19, the ASIR of small intestine cancer decreased by 8.94% (5.06\u201312.81%).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Small intestine cancer incidence raised in all sexes and ethnicities. Following COVID-19, reported cases declined, possibly due to pandemic-related diagnostic challenges. The impact of underdiagnosis on patient survival needs further investigations.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0307019","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T17:49:01Z","timestamp":1724089741000},"page":"e0307019","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["A population-based study on incidence trends of small intestine cancer in the United States from 2000 to 2020"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4747-5639","authenticated-orcid":true,"given":"Seyed Ehsan","family":"Mousavi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehran","family":"Ilaghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vahid","family":"Mahdavizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rasoul","family":"Ebrahimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Aslani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Yekta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-9720","authenticated-orcid":true,"given":"Seyed Aria","family":"Nejadghaderi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"issue":"9","key":"pone.0307019.ref001","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.6004\/jnccn.2019.7344","article-title":"Small Bowel Adenocarcinoma: Etiology, Presentation, and Molecular Alterations.","volume":"17","author":"KS Pedersen","year":"2019","journal-title":"J Natl Compr Canc Netw"},{"issue":"11","key":"pone.0307019.ref002","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1001\/jamaoncol.2017.1051","article-title":"Genomic Profiling of Small-Bowel Adenocarcinoma","volume":"3","author":"AB Schrock","year":"2017","journal-title":"JAMA Oncol"},{"issue":"3","key":"pone.0307019.ref003","article-title":"Epidemiology of Cancers of the Small Intestine: Trends, Risk Factors, and Prevention.","volume":"7","author":"A Barsouk","year":"2019","journal-title":"Med Sci (Basel)."},{"issue":"1","key":"pone.0307019.ref004","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3322\/caac.21654","article-title":"Cancer Statistics, 2021.","volume":"71","author":"RL Siegel","year":"2021","journal-title":"CA Cancer J Clin."},{"issue":"2","key":"pone.0307019.ref005","doi-asserted-by":"crossref","first-page":"413","DOI":"10.4251\/wjgo.v14.i2.413","article-title":"Small bowel adenocarcinoma: An overview.","volume":"14","author":"D Khosla","year":"2022","journal-title":"World J Gastrointest Oncol"},{"issue":"6","key":"pone.0307019.ref006","first-page":"2539","article-title":"Clinicopathological features and treatment outcomes of metastatic or locally unresectable small bowel adenocarcinoma.","volume":"24","author":"X Li","year":"2019","journal-title":"J buon"},{"issue":"4","key":"pone.0307019.ref007","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/DCR.0000000000000562","article-title":"Treatment and Survival of Small-bowel Adenocarcinoma in the United States: A Comparison With Colon Cancer","volume":"59","author":"JI Young","year":"2016","journal-title":"Dis Colon Rectum"},{"issue":"1","key":"pone.0307019.ref008","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3322\/caac.21763","article-title":"Cancer statistics, 2023.","volume":"73","author":"RL Siegel","year":"2023","journal-title":"CA Cancer J Clin."},{"key":"pone.0307019.ref009","doi-asserted-by":"crossref","first-page":"675038","DOI":"10.3389\/fonc.2021.675038","article-title":"Has COVID-19 Affected Cancer Screening Programs? 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