{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T16:51:52Z","timestamp":1783529512850,"version":"3.55.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T00:00:00Z","timestamp":1725408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82060555"],"award-info":[{"award-number":["82060555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["12132006"],"award-info":[{"award-number":["12132006"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the high-level Innovative Talents Training Program of Guizhou Province - \u201c100\u201d Level Talents","award":["2016-5676"],"award-info":[{"award-number":["2016-5676"]}]},{"DOI":"10.13039\/501100004001","name":"Science and Technology Foundation of Guizhou Province","doi-asserted-by":"crossref","award":["2018-1412"],"award-info":[{"award-number":["2018-1412"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004001","name":"Guizhou Provincial Science and Technology Department","doi-asserted-by":"publisher","award":["2019-1266"],"award-info":[{"award-number":["2019-1266"]}],"id":[{"id":"10.13039\/501100004001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013055","name":"Guizhou Provincial Youth Science and Technology Talents Growth Project","doi-asserted-by":"publisher","award":["YJSKYJJ [2021] 158"],"award-info":[{"award-number":["YJSKYJJ [2021] 158"]}],"id":[{"id":"10.13039\/501100013055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018555","name":"Science and Technology Program of Guizhou Province","doi-asserted-by":"publisher","award":["gzwkj 2021-058"],"award-info":[{"award-number":["gzwkj 2021-058"]}],"id":[{"id":"10.13039\/501100018555","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Radiotherapy is a commonly used method in the treatment of bladder cancers (BC). Radiation-induced immunogenic cell death (ICD) is related to the immune response against cancers and their prognoses. Even though dendritic cells (DC) act as powerful antigen-presenting cells in the body, their precise role in this ICD process remains unclear. Accordingly, an <jats:italic>in vitro<\/jats:italic> study was undertaken to ascertain whether high-dose radiation-induced ICD of BC cells could regulate the immune response of DC. The results indicated that high-dose radiation treatments of BC cells significantly increased their levels of apoptosis, blocked their cell cycle in the G<jats:sub>2<\/jats:sub>\/M phase, increased their expression of ICD-related proteins, and upregulated their secretion of CCL5 and CCL21 which control the directed migration of DC. It was also noted that expression of CD80, CD86, CCR5, and CCR7 on DC was upregulated in the medium containing the irradiated cells. In conclusion, the present findings illustrate that high-dose radiation can induce the occurrence of ICD within BC cells, concomitantly resulting in the activation of DC. Such findings could be of great significance in increasing the understanding how radiotherapy of BC may work to bring about reductions in cell activity and how these processes in turn lead to immunoregulation of the function of DC.<\/jats:p>","DOI":"10.1371\/journal.pone.0307024","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T17:41:28Z","timestamp":1725471688000},"page":"e0307024","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["High-dose radiation-induced immunogenic cell death of bladder cancer cells leads to dendritic cell activation"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-605X","authenticated-orcid":true,"given":"Xianlin","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiqin","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuai","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhonghui","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shichao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijing","family":"Teng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuquan","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhu","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0325-4340","authenticated-orcid":true,"given":"Jinhua","family":"Long","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,9,4]]},"reference":[{"issue":"1","key":"pone.0307024.ref001","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.eururo.2016.06.010","article-title":"Bladder Cancer Incidence and Mortality: A Global Overview and Recent Trends","volume":"71","author":"S Antoni","year":"2017","journal-title":"European urology"},{"issue":"12","key":"pone.0307024.ref002","doi-asserted-by":"crossref","first-page":"e023136","DOI":"10.1136\/bmjopen-2018-023136","article-title":"Long-term urinary tract effect of ileal conduit after radical cystectomy compared with bladder preservation: a nationwide, population-based cohort study with propensity score-matching analysis","volume":"8","author":"YL Liu","year":"2018","journal-title":"BMJ open"},{"issue":"12","key":"pone.0307024.ref003","doi-asserted-by":"crossref","first-page":"e041005","DOI":"10.1136\/bmjopen-2020-041005","article-title":"Protocol for tumour-focused dose-escalated adaptive radiotherapy for the radical treatment of bladder cancer in a multicentre phase II randomised controlled trial (RAIDER): radiotherapy planning and delivery guidance","volume":"10","author":"S Hafeez","year":"2020","journal-title":"BMJ open"},{"issue":"1","key":"pone.0307024.ref004","article-title":"A multi-institutional study of bladder-preserving therapy for stage II-IV bladder cancer: A Korean Radiation Oncology Group Study (KROG 14\u201316)","volume":"14","author":"SJ Byun","year":"2019","journal-title":"PloS one"},{"issue":"1","key":"pone.0307024.ref005","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1158\/1535-7163.MCT-18-0986","article-title":"PD-1\/PD-L1 Immune Checkpoint Inhibition with Radiation in Bladder Cancer: In Situ and Abscopal Effects","volume":"19","author":"A Rompr\u00e9-Brodeur","year":"2020","journal-title":"Mol Cancer Ther"},{"issue":"1","key":"pone.0307024.ref006","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.canlet.2013.09.018","article-title":"Abscopal effects of radiation therapy: a clinical review for the radiobiologist","volume":"356","author":"S Siva","year":"2015","journal-title":"Cancer letters"},{"key":"pone.0307024.ref007","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032712-100008","article-title":"Immunogenic cell death in cancer therapy","volume":"31","author":"G Kroemer","year":"2013","journal-title":"Annual review of immunology"},{"issue":"11","key":"pone.0307024.ref008","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/s41419-020-03221-2","article-title":"Detection of immunogenic cell death and its relevance for cancer therapy","volume":"11","author":"J Fucikova","year":"2020","journal-title":"Cell death & disease"},{"issue":"1","key":"pone.0307024.ref009","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1189\/jlb.0306180","article-title":"High mobility group box-1 protein induces the migration and activation of human dendritic cells and acts as an alarmin","volume":"81","author":"D Yang","year":"2007","journal-title":"J Leukoc Biol"},{"key":"pone.0307024.ref010","doi-asserted-by":"crossref","first-page":"e28222","DOI":"10.4161\/onci.28222","article-title":"The heat shock protein-CD91 pathway mediates tumor immunosurveillance","volume":"3","author":"YJ Zhou","year":"2014","journal-title":"Oncoimmunology"},{"key":"pone.0307024.ref011","doi-asserted-by":"crossref","first-page":"3805","DOI":"10.2147\/OTT.S197516","article-title":"Irradiation increases the immunogenicity of lung cancer cells and irradiation-based tumor cell vaccine elicits tumor-specific T cell responses in vivo","volume":"12","author":"L Luo","year":"2019","journal-title":"OncoTargets and therapy"},{"issue":"9","key":"pone.0307024.ref012","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.clon.2019.06.005","article-title":"Adaptive Radiotherapy for Carcinoma of the Urinary Bladder: Long-term Outcomes With Dose Escalation","volume":"31","author":"V Murthy","year":"2019","journal-title":"Clin Oncol (R Coll Radiol)"},{"key":"pone.0307024.ref013","first-page":"e929004","article-title":"Effect of Selenium and Peroxynitrite on Immune Function of Immature Dendritic Cells in Humans","volume":"27","author":"H Xia","year":"2021","journal-title":"Medical science monitor: international medical journal of experimental and clinical research"},{"issue":"1","key":"pone.0307024.ref014","doi-asserted-by":"crossref","first-page":"585","DOI":"10.4049\/jimmunol.172.1.585","article-title":"Soluble fractalkine prevents monocyte chemoattractant protein-1-induced monocyte migration via inhibition of stress-activated protein kinase 2\/p38 and matrix metalloproteinase activities","volume":"172","author":"S Vitale","year":"2004","journal-title":"Journal of immunology"},{"key":"pone.0307024.ref015","doi-asserted-by":"crossref","first-page":"114475","DOI":"10.1016\/j.bcp.2021.114475","article-title":"Fangchinoline exerts anticancer effects on colorectal cancer by inducing autophagy via regulation AMPK\/mTOR\/ULK1 pathway","volume":"186","author":"X Xiang","year":"2021","journal-title":"Biochem Pharmacol"},{"issue":"3","key":"pone.0307024.ref016","first-page":"532","article-title":"A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples","volume":"15","author":"P. Chomczynski","year":"1993","journal-title":"BioTechniques"},{"issue":"4","key":"pone.0307024.ref017","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"KJ Livak","year":"2001","journal-title":"Methods (San Diego, Calif)"},{"issue":"1","key":"pone.0307024.ref018","article-title":"STAT3 enhances radiation-induced tumor migration, invasion and stem-like properties of bladder cancer","volume":"23","author":"F Wang","year":"2021","journal-title":"Molecular medicine reports"},{"issue":"22","key":"pone.0307024.ref019","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228877","article-title":"The Impact of Radiation-Induced DNA Damage on cGAS-STING-Mediated Immune Responses to Cancer","volume":"21","author":"Q Storozynsky","year":"2020","journal-title":"International journal of molecular sciences"},{"issue":"6","key":"pone.0307024.ref020","doi-asserted-by":"crossref","first-page":"467","DOI":"10.48095\/ccko2021467","article-title":"Incidence, mortality and survival of bladder neoplasms in the Czech Republic in the period 1977\u20132017: a time trend analysis","volume":"34","author":"L Pehalova","year":"2021","journal-title":"Klinicka onkologie: casopis Ceske a Slovenske onkologicke spolecnosti"},{"issue":"18","key":"pone.0307024.ref021","doi-asserted-by":"crossref","first-page":"3524","DOI":"10.1002\/cncr.30719","article-title":"Concurrent chemotherapy is associated with improved survival in elderly patients with bladder cancer undergoing radiotherapy","volume":"123","author":"MC Korpics","year":"2017","journal-title":"Cancer"},{"issue":"2","key":"pone.0307024.ref022","doi-asserted-by":"crossref","first-page":"e94","DOI":"10.1016\/j.clgc.2021.11.002","article-title":"Trends and Predictors of Hypofractionated and Intensity-Modulated Radiotherapy for Organ Preservation in Bladder Cancer","volume":"20","author":"M Xiang","year":"2022","journal-title":"Clinical genitourinary cancer"},{"key":"pone.0307024.ref023","doi-asserted-by":"crossref","first-page":"8262989","DOI":"10.1155\/2019\/8262989","article-title":"Irradiated Bladder Cancer Cells Expressing both GM-CSF and IL-21 versus Either GM-CSF or IL-21 Alone as Tumor Vaccine in a Mouse Xenograft Model","volume":"2019","author":"J Peng","year":"2019","journal-title":"BioMed research international"},{"issue":"1","key":"pone.0307024.ref024","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.eururo.2019.01.011","article-title":"Impact of Immune and Stromal Infiltration on Outcomes Following Bladder-Sparing Trimodality Therapy for Muscle-Invasive Bladder Cancer","volume":"76","author":"JA Efstathiou","year":"2019","journal-title":"European urology"},{"issue":"5","key":"pone.0307024.ref025","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1189\/jlb.3MR0516-224R","article-title":"Caspase-1 as a multifunctional inflammatory mediator: noncytokine maturation roles","volume":"100","author":"Q Sun","year":"2016","journal-title":"J Leukoc Biol"},{"issue":"1","key":"pone.0307024.ref026","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.1600-065X.2011.01044.x","article-title":"Caspase-1-induced pyroptotic cell death","volume":"243","author":"EA Miao","year":"2011","journal-title":"Immunological reviews"},{"issue":"4","key":"pone.0307024.ref027","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1002\/ijc.31374","article-title":"Caspase-3 regulates the migration, invasion and metastasis of colon cancer cells","volume":"143","author":"M Zhou","year":"2018","journal-title":"Int J Cancer"},{"issue":"7","key":"pone.0307024.ref028","article-title":"Expression levels of cleaved caspase-3 and caspase-3 in tumorigenesis and prognosis of oral tongue squamous cell carcinoma","volume":"12","author":"PF Liu","year":"2017","journal-title":"PloS one"},{"key":"pone.0307024.ref029","first-page":"6","article-title":"Disordered clusters of Bak dimers rupture mitochondria during apoptosis","author":"RT Uren","year":"2017","journal-title":"eLife"},{"issue":"2","key":"pone.0307024.ref030","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/s41419-020-2309-3","article-title":"Low expression of pro-apoptotic proteins Bax, Bak and Smac indicates prolonged progression-free survival in chemotherapy-treated metastatic melanoma","volume":"11","author":"C Gutt\u00e0","year":"2020","journal-title":"Cell death & disease"},{"issue":"7015","key":"pone.0307024.ref031","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/nature03097","article-title":"Cell-cycle checkpoints and cancer","volume":"432","author":"MB Kastan","year":"2004","journal-title":"Nature"},{"issue":"23","key":"pone.0307024.ref032","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21239296","article-title":"Policing Cancer: Vitamin D Arrests the Cell Cycle","volume":"21","author":"S Bhoora","year":"2020","journal-title":"International journal of molecular sciences"},{"key":"pone.0307024.ref033","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.3389\/fimmu.2018.03077","article-title":"Targeting Innate Immunity to Enhance the Efficacy of Radiation Therapy","volume":"9","author":"TB Dar","year":"2018","journal-title":"Frontiers in immunology"},{"issue":"4","key":"pone.0307024.ref034","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1158\/1078-0432.CCR-18-3518","article-title":"Postablation Modulation after Single High-Dose Radiation Therapy Improves Tumor Control via Enhanced Immunomodulation","volume":"26","author":"T Savage","year":"2020","journal-title":"Clinical cancer research: an official journal of the American Association for Cancer Research"},{"key":"pone.0307024.ref035","doi-asserted-by":"crossref","first-page":"e28518","DOI":"10.4161\/onci.28518","article-title":"Radiation fosters dose-dependent and chemotherapy-induced immunogenic cell death","volume":"3","author":"EB Golden","year":"2014","journal-title":"Oncoimmunology"},{"issue":"2","key":"pone.0307024.ref036","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/S1470-2045(20)30607-0","article-title":"Hypofractionated radiotherapy in locally advanced bladder cancer: an individual patient data meta-analysis of the BC2001 and BCON trials","volume":"22","author":"A Choudhury","year":"2021","journal-title":"The Lancet Oncology"},{"key":"pone.0307024.ref037","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1038\/ncomms1524","article-title":"CD91-dependent programming of T-helper cell responses following heat shock protein immunization","volume":"2","author":"S Pawaria","year":"2011","journal-title":"Nature communications"},{"issue":"9","key":"pone.0307024.ref038","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1084\/jem.20120189","article-title":"Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release","volume":"209","author":"E Venereau","year":"2012","journal-title":"The Journal of experimental medicine"},{"issue":"1","key":"pone.0307024.ref039","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1002\/hep.26320","article-title":"ASC\/caspase-1\/IL-1\u03b2 signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia\/reperfusion injury","volume":"58","author":"N Kamo","year":"2013","journal-title":"Hepatology (Baltimore, Md)"},{"key":"pone.0307024.ref040","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1146\/annurev-immunol-030409-101323","article-title":"HMGB1 is a therapeutic target for sterile inflammation and infection","volume":"29","author":"U Andersson","year":"2011","journal-title":"Annual review of immunology"},{"issue":"3\u20134","key":"pone.0307024.ref041","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s10495-019-01532-0","article-title":"Calreticulin in phagocytosis and cancer: opposite roles in immune response outcomes","volume":"24","author":"A Schcolnik-Cabrera","year":"2019","journal-title":"Apoptosis: an international journal on programmed cell death"},{"issue":"4","key":"pone.0307024.ref042","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2174\/1389203718666170111123253","article-title":"Emerging Roles of Calreticulin in Cancer: Implications for Therapy","volume":"19","author":"K Venkateswaran","year":"2018","journal-title":"Current protein & peptide science"},{"issue":"1","key":"pone.0307024.ref043","doi-asserted-by":"crossref","first-page":"5006","DOI":"10.1038\/s41467-018-07344-1","article-title":"PTEN expression by an oncolytic herpesvirus directs T-cell mediated tumor clearance","volume":"9","author":"L Russell","year":"2018","journal-title":"Nature communications"},{"issue":"8","key":"pone.0307024.ref044","doi-asserted-by":"crossref","first-page":"4854","DOI":"10.1111\/jcmm.14356","article-title":"Immunogenic cell death in cancer therapy: Present and emerging inducers","volume":"23","author":"J Zhou","year":"2019","journal-title":"Journal of cellular and molecular medicine"},{"key":"pone.0307024.ref045","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3389\/fimmu.2015.00505","article-title":"Radio-Immunotherapy-Induced Immunogenic Cancer Cells as Basis for Induction of Systemic Anti-Tumor Immune Responses \u2010 Pre-Clinical Evidence and Ongoing Clinical Applications","volume":"6","author":"A Derer","year":"2015","journal-title":"Frontiers in immunology"},{"issue":"4","key":"pone.0307024.ref046","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20040959","article-title":"Realizing the Clinical Potential of Immunogenic Cell Death in Cancer Chemotherapy and Radiotherapy","volume":"20","author":"BL Rapoport","year":"2019","journal-title":"International journal of molecular sciences"},{"issue":"5","key":"pone.0307024.ref047","first-page":"888","article-title":"Evaluation of TGF-\u03b21, CCL5\/RANTES and sFas\/Apo-1 urine concentration in children with ureteropelvic junction obstruction. Archives of medical science","volume":"9","author":"A Gaw\u0142owska-Marciniak","year":"2013","journal-title":"AMS"},{"issue":"5","key":"pone.0307024.ref048","first-page":"479","article-title":"Role of CCL5\/CCR5 in the perineural invasion of salivary adenoid cystic carcinoma cells","volume":"35","author":"L Tianyi","year":"2017","journal-title":"Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology"},{"issue":"4","key":"pone.0307024.ref049","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.immuni.2005.02.010","article-title":"CCL19 and CCL21 induce a potent proinflammatory differentiation program in licensed dendritic cells","volume":"22","author":"BJ Marsland","year":"2005","journal-title":"Immunity"},{"issue":"4","key":"pone.0307024.ref050","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3109\/1547691X.2014.880533","article-title":"Norm- and hypo-fractionated radiotherapy is capable of activating human dendritic cells","volume":"11","author":"L Kulzer","year":"2014","journal-title":"Journal of immunotoxicology"},{"issue":"23","key":"pone.0307024.ref051","doi-asserted-by":"crossref","first-page":"6044","DOI":"10.1158\/0008-5472.CAN-19-0181","article-title":"A Model of Indirect Cell Death Caused by Tumor Vascular Damage after High-Dose Radiotherapy","volume":"79","author":"P Rodr\u00edguez-Barbeito","year":"2019","journal-title":"Cancer research"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0307024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T17:42:12Z","timestamp":1725471732000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0307024"}},"subtitle":[],"editor":[{"given":"Sadiq","family":"Umar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,9,4]]},"references-count":51,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2024,9,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0307024","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,4]]}}}