{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T22:44:15Z","timestamp":1789685055052,"version":"4.0.1"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T00:00:00Z","timestamp":1721347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The association between atopic dermatitis and childhood overweight and obesity has been studied extensively, but the results are inconclusive; most studies have focused on body mass index as a measure of obesity, with few investigating the relationship with underweight. Therefore, this study aimed to investigate the association between body mass index levels and atopic dermatitis in Korean adolescents.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>3-year (2019\u20132021) of Korea Youth Risk Behavior Web-based Survey were used. Body mass index was used to measure obesity and a recent diagnosis within the past year was used as the criterion for atopic dermatitis. Multiple logistic regression analyses were performed to explore the associations. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 144,183 adolescents aged 12\u201318 years were included in this study (74,704 males and 69,479 females). Over the past year, 5.4% of males and 7.3% of females were diagnosed with atopic dermatitis in the study population. Adolescents with normal weight (males [OR: 1.19, CI: 1.02\u20131.38]; females [OR: 1.26, CI: 1.10\u20131.43]) and overweight (males [OR: 1.37, CI: 1.16\u20131.61]; females [OR: 1.37, CI: 1.19\u20131.58]) were more likely to develop atopic dermatitis than underweight.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Increased degree of obesity may contribute to the development of atopic dermatitis. The normal-weight and obese adolescents had higher likelihood of developing atopic dermatitis compared with the underweight adolescents.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0307140","type":"journal-article","created":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T17:28:19Z","timestamp":1721410099000},"page":"e0307140","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Association between body mass index and atopic dermatitis among adolescents: Findings from a national cross-sectional study in Korea"],"prefix":"10.1371","volume":"19","author":[{"given":"Jae Hyeok","family":"Lim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun Seo","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan Bi","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suk-Yong","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2306-5398","authenticated-orcid":true,"given":"Eun-Cheol","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,7,19]]},"reference":[{"issue":"3","key":"pone.0307140.ref001","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1007\/s12016-021-08880-3","article-title":"Update on the Pathogenesis and Therapy of Atopic Dermatitis","volume":"61","author":"H Li","year":"2021","journal-title":"Clin Rev Allergy Immunol"},{"issue":"8","key":"pone.0307140.ref002","article-title":"Overview of atopic dermatitis","volume":"23","author":"C. Avena-Woods","year":"2017","journal-title":"Am J Manag Care"},{"key":"pone.0307140.ref003","unstructured":"Korea National Health & Nutrition Examination Survey (KNHANES). Statistical collection 2022 [cited 2024 Feb 2]. Available from: https:\/\/knhanes.kdca.go.kr\/knhanes\/sub04\/sub04_04_01.do."},{"issue":"9","key":"pone.0307140.ref004","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/jdv.18225","article-title":"Atopic dermatitis: pathomechanisms and lessons learned from novel systemic therapeutic options","volume":"36","author":"T Bieber","year":"2022","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"11","key":"pone.0307140.ref005","article-title":"Current Insights into Atopic March","volume":"8","author":"M Tsuge","year":"2021","journal-title":"Children (Basel)"},{"issue":"10023","key":"pone.0307140.ref006","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","article-title":"Atopic dermatitis","volume":"387","author":"S Weidinger","year":"2016","journal-title":"Lancet"},{"issue":"8","key":"pone.0307140.ref007","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22084130","article-title":"Molecular Mechanisms of Atopic Dermatitis Pathogenesis","volume":"22","author":"J Sroka-Tomaszewska","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"1","key":"pone.0307140.ref008","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12916-019-1449-8","article-title":"The epidemiological burden of obesity in childhood: a worldwide epidemic requiring urgent action","volume":"17","author":"M Di Cesare","year":"2019","journal-title":"BMC Med"},{"issue":"2","key":"pone.0307140.ref009","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.mayocp.2016.09.017","article-title":"Review of Childhood Obesity: From Epidemiology, Etiology, and Comorbidities to Clinical Assessment and Treatment","volume":"92","author":"S Kumar","year":"2017","journal-title":"Mayo Clin Proc"},{"issue":"11","key":"pone.0307140.ref010","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1111\/j.1398-9995.2010.02402.x","article-title":"Obesity, insulin resistance and the prevalence of atopy and asthma in US adults","volume":"65","author":"J Ma","year":"2010","journal-title":"Allergy"},{"issue":"11","key":"pone.0307140.ref011","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1136\/thorax.56.11.835","article-title":"Relation of body mass index to asthma and atopy in children: the National Health and Nutrition Examination Study III","volume":"56","author":"E von Mutius","year":"2001","journal-title":"Thorax"},{"issue":"4","key":"pone.0307140.ref012","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.anai.2011.08.001","article-title":"A cross-sectional study assessing the relationship between BMI, asthma, atopy, and eNO among schoolchildren","volume":"107","author":"F Cibella","year":"2011","journal-title":"Ann Allergy Asthma Immunol"},{"issue":"1","key":"pone.0307140.ref013","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13601-016-0124-9","article-title":"Body mass index and physical activity in early childhood are associated with atopic sensitization, atopic dermatitis and asthma in later childhood","volume":"6","author":"KK Byberg","year":"2016","journal-title":"Clin Transl Allergy"},{"issue":"5","key":"pone.0307140.ref014","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1016\/j.jaci.2013.09.041","article-title":"Obesity and adiposity indicators, asthma, and atopy in Puerto Rican children","volume":"133","author":"E Forno","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"3","key":"pone.0307140.ref015","doi-asserted-by":"crossref","first-page":"283","DOI":"10.5114\/fmpcr.2017.69292","article-title":"Prevalence of atopy and asthma in overweight children and adolescents\u2013a cross-sectional study","author":"K Wytrychowski","year":"2017","journal-title":"Family Medicine & Primary Care Review"},{"issue":"5","key":"pone.0307140.ref016","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1164\/rccm.200405-623OC","article-title":"Sex differences in the relation between body mass index and asthma and atopy in a birth cohort","volume":"171","author":"RJ Hancox","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"3","key":"pone.0307140.ref017","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1046\/j.1365-2222.1999.00455.x","article-title":"Association between body mass index and allergy in teenage girls in Taiwan","volume":"29","author":"SL Huang","year":"1999","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"pone.0307140.ref018","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1111\/pde.15110","article-title":"Association between obesity and atopic dermatitis in children: A case-control study in a high obesity prevalence population","volume":"40","author":"C Iturriaga","year":"2023","journal-title":"Pediatr Dermatol"},{"issue":"4","key":"pone.0307140.ref019","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1097\/DER.0000000000000047","article-title":"Association between obesity and eczema prevalence, severity and poorer health in US adolescents","volume":"25","author":"JI Silverberg","year":"2014","journal-title":"Dermatitis"},{"issue":"5","key":"pone.0307140.ref020","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.3349\/ymj.2017.58.5.1040","article-title":"Physical Activity, Sedentary Habits, Sleep, and Obesity are Associated with Asthma, Allergic Rhinitis, and Atopic Dermatitis in Korean Adolescents","volume":"58","author":"MS Lim","year":"2017","journal-title":"Yonsei Med J"},{"issue":"1","key":"pone.0307140.ref021","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/cea.12024","article-title":"The association between BMI, vigorous physical activity and television viewing and the risk of symptoms of asthma, rhinoconjunctivitis and eczema in children and adolescents: ISAAC Phase Three","volume":"43","author":"EA Mitchell","year":"2013","journal-title":"Clin Exp Allergy"},{"issue":"1","key":"pone.0307140.ref022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-018-0001-z","article-title":"Atopic dermatitis","volume":"4","author":"S Weidinger","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"5","key":"pone.0307140.ref023","doi-asserted-by":"crossref","first-page":"396","DOI":"10.3961\/jpmph.2010.43.5.396","article-title":"Validity of self-reported height, weight, and body mass index of the Korea Youth Risk Behavior Web-based Survey questionnaire","volume":"43","author":"J Bae","year":"2010","journal-title":"J Prev Med Public Health"},{"issue":"5","key":"pone.0307140.ref024","doi-asserted-by":"crossref","first-page":"403","DOI":"10.3961\/jpmph.2010.43.5.403","article-title":"Test-retest reliability of a questionnaire for the Korea Youth Risk Behavior Web-based Survey","volume":"43","author":"J Bae","year":"2010","journal-title":"J Prev Med Public Health"},{"issue":"5","key":"pone.0307140.ref025","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3345\/kjp.2018.61.5.135","article-title":"The 2017 Korean National Growth Charts for children and adolescents: development, improvement, and prospects","volume":"61","author":"JH Kim","year":"2018","journal-title":"Korean J Pediatr"},{"issue":"7","key":"pone.0307140.ref026","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/1346-8138.15386","article-title":"Health-related behaviors and mental health states of South Korean adolescents with atopic dermatitis","volume":"47","author":"Y Kyung","year":"2020","journal-title":"J Dermatol"},{"issue":"1","key":"pone.0307140.ref027","doi-asserted-by":"crossref","first-page":"19461","DOI":"10.1038\/s41598-020-76532-1","article-title":"Identification of oral symptoms associated with atopic dermatitis in adolescents: Results from the Korea national representative survey 2009\u20132017","volume":"10","author":"JS Shim","year":"2020","journal-title":"Sci Rep"},{"key":"pone.0307140.ref028","article-title":"Regression analysis for continuous independent variables in medical research: statistical standard and guideline of Life Cycle Committee","volume":"2","author":"SW Lee","year":"2022","journal-title":"Life cycle"},{"issue":"10247","key":"pone.0307140.ref029","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/S0140-6736(20)31286-1","article-title":"Atopic dermatitis","volume":"396","author":"SM Langan","year":"2020","journal-title":"Lancet"},{"issue":"8","key":"pone.0307140.ref030","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1111\/jdv.14879","article-title":"Is atopic dermatitis associated with obesity? A systematic review of observational studies","volume":"32","author":"Z Ali","year":"2018","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"pone.0307140.ref031","doi-asserted-by":"crossref","first-page":"123","DOI":"10.4168\/aair.2022.14.1.123","article-title":"Time Trends in the Prevalence of Atopic Dermatitis in Korean Children According to Age","volume":"14","author":"JY Lee","year":"2022","journal-title":"Allergy Asthma Immunol Res"},{"key":"pone.0307140.ref032","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1186\/1471-2458-11-469","article-title":"High body mass index is not associated with atopy in schoolchildren living in rural and urban areas of Ghana","volume":"11","author":"IA Larbi","year":"2011","journal-title":"BMC Public Health"},{"issue":"8","key":"pone.0307140.ref033","doi-asserted-by":"crossref","first-page":"804","DOI":"10.3109\/02770903.2011.611956","article-title":"U-shaped association between body mass index and the prevalence of wheeze and asthma, but not eczema or rhinoconjunctivitis: the ryukyus child health study","volume":"48","author":"K Tanaka","year":"2011","journal-title":"J Asthma"},{"issue":"4","key":"pone.0307140.ref034","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.jaci.2014.09.035","article-title":"Loss of sirtuin 1 (SIRT1) disrupts skin barrier integrity and sensitizes mice to epicutaneous allergen challenge","volume":"135","author":"M Ming","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"4","key":"pone.0307140.ref035","doi-asserted-by":"crossref","first-page":"476","DOI":"10.5021\/ad.2019.31.4.476","article-title":"The Expression of Epidermal Stem Cell Marker and SIRT1 in Atopic Dermatitis: A Discussion of Regenerative Potential","volume":"31","author":"JW Shin","year":"2019","journal-title":"Ann Dermatol"},{"key":"pone.0307140.ref036","doi-asserted-by":"crossref","first-page":"449","DOI":"10.3389\/fendo.2018.00449","article-title":"Inverse Association of Circulating SIRT1 and Adiposity: A Study on Underweight, Normal Weight, and Obese Patients","volume":"9","author":"S Mariani","year":"2018","journal-title":"Front Endocrinol (Lausanne)"},{"issue":"3","key":"pone.0307140.ref037","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.jadohealth.2009.06.023","article-title":"Body mass index and waist-to-height changes during teen years in girls are influenced by childhood body mass index","volume":"46","author":"FM Biro","year":"2010","journal-title":"Journal of Adolescent Health"},{"issue":"3","key":"pone.0307140.ref038","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1111\/j.1365-2133.2011.10694.x","article-title":"Association between atopic dermatitis and obesity in adulthood","volume":"166","author":"J Silverberg","year":"2012","journal-title":"British Journal of Dermatology"},{"issue":"8","key":"pone.0307140.ref039","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1111\/exd.14138","article-title":"Can moderate-intensity aerobic exercise ameliorate atopic dermatitis?","volume":"29","author":"WK Son","year":"2020","journal-title":"Exp Dermatol"},{"issue":"Suppl","key":"pone.0307140.ref040","doi-asserted-by":"crossref","first-page":"s73","DOI":"10.11607\/ofph.2577","article-title":"Associations of Sleep Disturbance, Atopy, and Other Health Measures with Chronic Overlapping Pain Conditions","volume":"34","author":"AE Sanders","year":"2020","journal-title":"J Oral Facial Pain Headache"},{"issue":"3","key":"pone.0307140.ref041","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s13555-017-0192-3","article-title":"Frequency and Management of Sleep Disturbance in Adults with Atopic Dermatitis: A Systematic Review","volume":"7","author":"C Jeon","year":"2017","journal-title":"Dermatol Ther (Heidelb)"},{"issue":"8","key":"pone.0307140.ref042","doi-asserted-by":"crossref","first-page":"e67890","DOI":"10.1371\/journal.pone.0067890","article-title":"Does stress increase the risk of atopic dermatitis in adolescents? results of the Korea Youth Risk Behavior Web-based Survey (KYRBWS-VI)","volume":"8","author":"JA Kwon","year":"2013","journal-title":"PLoS One"},{"issue":"1","key":"pone.0307140.ref043","doi-asserted-by":"crossref","first-page":"52","DOI":"10.7762\/cnr.2013.2.1.52","article-title":"Nutrient intake and food restriction in children with atopic dermatitis","volume":"2","author":"H Lim","year":"2013","journal-title":"Clin Nutr Res"},{"issue":"4","key":"pone.0307140.ref044","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/thoraxjnl-2012-202285","article-title":"Do fast foods cause asthma, rhinoconjunctivitis and eczema? Global findings from the International Study of Asthma and Allergies in Childhood (ISAAC) phase three","volume":"68","author":"P Ellwood","year":"2013","journal-title":"Thorax"},{"issue":"2","key":"pone.0307140.ref045","article-title":"Health Behavior and Social-Emotional Health Status of School-Aged Children According to their Experience with Atopic Dermatitis Diagnosis: Based on the 12th (2019) Panel Study on Korean Children","volume":"10","author":"DJ Kum","year":"2023","journal-title":"Children (Basel)"},{"issue":"5","key":"pone.0307140.ref046","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1111\/bjd.19597","article-title":"Atopic eczema and obesity: a population\u2010based study*","volume":"184","author":"A Ascott","year":"2021","journal-title":"British Journal of Dermatology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0307140","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,19]],"date-time":"2024-07-19T17:28:45Z","timestamp":1721410125000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0307140"}},"subtitle":[],"editor":[{"given":"Dong Keon","family":"Yon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,7,19]]},"references-count":46,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,7,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0307140","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,19]]}}}