{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T08:56:50Z","timestamp":1765961810915,"version":"3.40.5"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T00:00:00Z","timestamp":1721260800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>The acceptability of latent tuberculosis infection (LTBI) therapy remains low among healthcare workers (HCWs). Up to 10% of LTBI cases can reactivate into active tuberculosis, posing risks to HCWs and patients. Understanding HCWs\u2019 intention to undergo LTBI treatment is crucial for designing effective management policies, especially where no LTBI policy exists. This cross-sectional study investigated the intention to receive LTBI therapy and its associated factors among HCWs in a Malaysian teaching hospital. The study was conducted from 5<jats:sup>th<\/jats:sup> to 30<jats:sup>th<\/jats:sup> May 2023, in a hospital without an LTBI screening program. Stratified random sampling was used to select HCWs, excluding those undergoing TB or LTBI therapy. Respondents completed a questionnaire measuring intention to receive LTBI treatment, LTBI knowledge, attitude, perceived norm, and perceived behavioral control. Of the 256 respondents, the majority were female (63.7%), under 35 years old (64.45%), had no comorbidities (82.0%), and worked in clinical settings (70.3%). However, 60.5% of respondents had low LTBI knowledge and 60.5% held unfavorable attitudes toward LTBI treatment. Despite this, 53.5% of respondents intended to undergo LTBI therapy if diagnosed. Factors positively associated with this intention included being female [aOR: 2.033, 95% CI: 1.080\u20133.823], having high LTBI knowledge [aOR 1.926, 95% CI: 1.093\u20133.397], had favorable attitude [aOR 3.771, 95% CI: 1.759\u20138.084], and strongly perceiving social norms supportive of LTBI treatment [aOR 4.593, 95% CI: 2.104\u201310.023]. These findings emphasize the need for an LTBI management policy in the teaching hospital. To boost HCWs\u2019 intention and acceptance of LTBI treatment, a focused program improving knowledge, attitude, and perception of social norms could be introduced.<\/jats:p>","DOI":"10.1371\/journal.pone.0307199","type":"journal-article","created":{"date-parts":[[2024,7,18]],"date-time":"2024-07-18T17:36:48Z","timestamp":1721324208000},"page":"e0307199","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Intention to receive Latent Tuberculosis Infection (LTBI) treatment and its associated factors among healthcare workers in a Malaysian teaching university hospital"],"prefix":"10.1371","volume":"19","author":[{"given":"Wan Muhammad Zainol","family":"Zakaria","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3460-2459","authenticated-orcid":true,"given":"Zawiah","family":"Mansor","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,7,18]]},"reference":[{"key":"pone.0307199.ref001","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41577-018-0025-3","article-title":"Immunological mechanisms of human resistance to persistent Mycobacterium tuberculosis infection","volume":"18","author":"JD Simmons","year":"2018","journal-title":"Nat Rev Immunol"},{"volume-title":"Latent tuberculosis infection: updated and consolidated guidelines for programmatic management","year":"2018","author":"WHO","key":"pone.0307199.ref002"},{"key":"pone.0307199.ref003","first-page":"11","article-title":"Diagnosis for Latent Tuberculosis Infection: New Alternatives.","author":"C Carranza","year":"2020","journal-title":"Front Immunol"},{"key":"pone.0307199.ref004","doi-asserted-by":"crossref","first-page":"101925","DOI":"10.1016\/j.tube.2020.101925","article-title":"Contributing risk factors towards the prevalence of multidrug-resistant tuberculosis in Malaysia: A systematic review","volume":"122","author":"M Rajendran","year":"2020","journal-title":"Tuberculosis"},{"key":"pone.0307199.ref005","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofad500.1729","article-title":"High Prevalence of Latent Tuberculosis Infection in a Malaysian Prison.","volume":"10","author":"L Zhang","year":"2023","journal-title":"Open Forum Infect Dis"},{"key":"pone.0307199.ref006","first-page":"00254","article-title":"Prevalence of latent tuberculosis among refugee children in Malaysia.","volume":"6","author":"YJ Wong","year":"2020","journal-title":"ERJ Open Res"},{"key":"pone.0307199.ref007","first-page":"1","volume-title":"Ujian Saringan Tibi Dengan Kaedah IGRA Dan Rawatan Pencegahan Tibi (TPT) bagi Program Kawalan Tibi Kebangsaan.","author":"MOH","year":"2021"},{"key":"pone.0307199.ref008","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1093\/cid\/ciz1044","article-title":"Duration of Exposure Among Close Contacts of Patients With Infectious Tuberculosis and Risk of Latent Tuberculosis Infection","volume":"71","author":"MR Reichler","year":"2020","journal-title":"Clin Infect Dis"},{"issue":"Suppl 5","key":"pone.0307199.ref009","doi-asserted-by":"crossref","first-page":"S422","DOI":"10.1513\/AnnalsATS.201602-095AW","article-title":"Aging of the Immune System. 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