{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T05:53:23Z","timestamp":1767851603627,"version":"3.49.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T00:00:00Z","timestamp":1727913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Respiratory viruses have clinical and epidemiological importance. With the COVID-19 pandemic, interest has focused on SARS-CoV-2, but as a result, the number of samples available for the differential diagnosis of other respiratory viruses has increased.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Study design<\/jats:title>\n<jats:p>Cross-sectional study.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To describe the epidemiological behavior of respiratory viruses based on a laboratory-based epidemiological surveillance system using data from 2017 to 2023.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Univariate, bivariate and multivariate analyses of data from a laboratory database of respiratory viruses detected by multiplex RT\u2012qPCR were performed.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 4,632 samples with positive results for at least 1 respiratory virus, not including influenza or SARS-CoV-2, were analyzed. The most common virus detected was respiratory syncytial virus in 1,467 (26.3%) samples, followed by rhinovirus in 1,384 (24.8%) samples. Most of the samples were from children under 5 years of age. The age-adjusted odds ratio (OR) of death for patients infected with parainfluenza virus 4 was 4.1 (95% confidence interval [95% CI] 2.0\u20138.2).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec006\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Respiratory syncytial virus and rhinovirus had the highest frequency and proportion of coinfections, whereas parainfluenza virus 4 was associated with an increased risk of death.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0307322","type":"journal-article","created":{"date-parts":[[2024,10,3]],"date-time":"2024-10-03T17:42:27Z","timestamp":1727977347000},"page":"e0307322","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Respiratory virus behavior: Results of laboratory-based epidemiological surveillance"],"prefix":"10.1371","volume":"19","author":[{"given":"Porfirio Felipe","family":"Hern\u00e1ndez Bautista","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5314-4786","authenticated-orcid":true,"given":"David Alejandro","family":"Cabrera Gayt\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfonso","family":"Vallejos Par\u00e1s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Moctezuma Paz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Clara Esperanza","family":"Santacruz Tinoco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julio Elias","family":"Alvarado Yaah","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu Mei","family":"Anguiano Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bernardo","family":"Mart\u00ednez Miguel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lumumba","family":"Arriaga Nieto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Jaimes Betancourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy","family":"Sandoval Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,10,3]]},"reference":[{"key":"pone.0307322.ref001","volume-title":"Children with Hepatitis of Unknown Cause","author":"Centers for Disease Control and Prevention","year":"2022"},{"issue":"11","key":"pone.0307322.ref002","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.3201\/eid2411.180488","article-title":"Adenovirus-Associated Influenza-Like Illness among College Students, Pennsylvania, USA","volume":"24","author":"HM Biggs","year":"2018","journal-title":"Emerg Infect Dis"},{"issue":"15","key":"pone.0307322.ref003","doi-asserted-by":"crossref","first-page":"2200318","DOI":"10.2807\/1560-7917.ES.2022.27.15.2200318","article-title":"Investigation into cases of hepatitis of unknown aetiology among young children, Scotland, 1 January 2022 to 12 April 2022","volume":"27","author":"K Marsh","year":"2022","journal-title":"Euro Surveill"},{"key":"pone.0307322.ref004","volume-title":"Increase in hepatitis (liver inflammation) cases in children under investigation","author":"UK Health Security Agency","year":"2022"},{"issue":"19","key":"pone.0307322.ref005","doi-asserted-by":"crossref","first-page":"2200370","DOI":"10.2807\/1560-7917.ES.2022.27.19.2200370","article-title":"Case numbers of acute hepatitis of unknown aetiology among children in 24 countries up to 18 April 2022 compared to the previous 5 years","volume":"27","author":"J van Beek","year":"2022","journal-title":"Euro Surveill"},{"key":"pone.0307322.ref006","doi-asserted-by":"crossref","first-page":"638","DOI":"10.15585\/mmwr.mm7118e1","article-title":"Acute Hepatitis and Adenovirus Infection Among Children\u2014Alabama, October 2021\u2013February 2022","volume":"71","author":"JM Baker","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"pone.0307322.ref007","unstructured":"Government of Canada. 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