{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:53:44Z","timestamp":1792518824063,"version":"4.5.0"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T00:00:00Z","timestamp":1728432000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007446","name":"King Khalid University","doi-asserted-by":"publisher","award":["RGP2\/285\/45"],"award-info":[{"award-number":["RGP2\/285\/45"]}],"id":[{"id":"10.13039\/501100007446","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Thirteen components were identified in the methanol extract of <jats:italic>Moricandia sinaica<\/jats:italic> leaves (MSLE) through analysis utilizing HPLC-ESI-MS\/MS., including flavonoids, anthocyanins, phenolic acids, and fatty acids. The methanol extract of <jats:italic>M<\/jats:italic>. <jats:italic>sinaica<\/jats:italic> leaves contained total phenolics and flavonoids (59.37 \u00b1 2.19 mg GAE\/g and 38.94 \u00b1 2.72 mg QE\/g), respectively. Furthermore, it revealed <jats:italic>in vitro<\/jats:italic> antioxidant properties as determined by the DPPH and FRAP assays, with respective IC<jats:sub>50<\/jats:sub> values of 10.22 \u00b1 0.64 and 20.89 \u00b1 1.25 <jats:italic>\u03bc<\/jats:italic>g\/mL. The extract exhibited a notable hepatoprotective effect in rats who experienced paracetamol-induced hepatotoxicity. When a dose of 250 mg\/kg was given, there was a 52% reduction in alanine transaminase and a 30% reduction in aspartate transaminase compared to the group with the disease. Furthermore, it demonstrated a 3.4-fold, 2.2-fold, and 2.6-fold increase in superoxide dismutase, non-protein sulfhydryl, and glutathione peroxidase, respectively. In addition, it demonstrated a 68% decrease in lipid peroxide levels compared to the group with paracetamol-induced condition. The verification was conducted using a histological study, which identified improved liver histology with a small number of distended hepatocytes. Moreover, <jats:italic>in silico<\/jats:italic> studies focused on the enzymes NADPH oxidase, butyrylcholinesterase, and tyrosinase as the targets for the major compounds. In conclusion, MSLE showed promising hepatoprotective and antioxidant activities due to its richness in antioxidant metabolites.<\/jats:p>","DOI":"10.1371\/journal.pone.0307901","type":"journal-article","created":{"date-parts":[[2024,10,9]],"date-time":"2024-10-09T17:26:05Z","timestamp":1728494765000},"page":"e0307901","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Exploring the phytochemicals, antioxidant properties, and hepatoprotective potential of Moricandia sinaica leaves against paracetamol-induced toxicity: Biological evaluations and in Silico insights"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2812-8340","authenticated-orcid":true,"given":"Shaza H.","family":"Aly","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulla M. 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Chem"},{"issue":"3","key":"pone.0307901.ref003","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.foodchem.2011.09.026","article-title":"Antioxidant and hepatoprotective activity of ethanolic extract of leaves of Solidago microglossa containing polyphenolic compounds","volume":"131","author":"SM Sabir","year":"2012","journal-title":"Food Chem"},{"issue":"7","key":"pone.0307901.ref004","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nrgastro.2010.95","article-title":"Nonobese individuals in the developing world are at risk of nonalcoholic fatty liver and liver disease","volume":"7","author":"NJ Wood","year":"2010","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"pone.0307901.ref005","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1053\/gast.1997.v112.pm9024300","article-title":"Morbidity and mortality in compensated cirrhosis type C: A retrospective follow-up study of 384 patients","volume":"112","author":"G Fattovich","year":"1997","journal-title":"Gastroenterology"},{"key":"pone.0307901.ref006","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.fct.2013.07.008","article-title":"Glutathione defense mechanism in liver injury: Insights from animal models","volume":"60","author":"Y Chen","year":"2013","journal-title":"Food and Chemical Toxicology"},{"issue":"7","key":"pone.0307901.ref007","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/nrd2803","article-title":"Targeting cancer cells by ROS-mediated mechanisms: a radical therapeutic approach?","volume":"8","author":"D Trachootham","year":"2009","journal-title":"Nat Rev Drug Discov"},{"issue":"2","key":"pone.0307901.ref008","first-page":"39","article-title":"Phytochemical investigation and antioxidant activity of Hyophorbe verschaffeltii (Arecaceae)","volume":"5","author":"MR Elgindi","year":"2016","journal-title":"J Pharmacogn Phytochem"},{"key":"pone.0307901.ref009","doi-asserted-by":"crossref","first-page":"128845","DOI":"10.1016\/j.foodchem.2020.128845","article-title":"Antioxidant, hepatoprotective and antifungal activities of black pepper (Piper nigrum L.) essential oil","volume":"346","author":"C Zhang","year":"2021","journal-title":"Food Chem"},{"key":"pone.0307901.ref010","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.foodchem.2018.07.115","article-title":"Hepatoprotective activity of Ganoderma lucidum triterpenoids in alcohol-induced liver injury in mice, an iTRAQ-based proteomic analysis","volume":"271","author":"C Zhao","year":"2019","journal-title":"Food Chem"},{"issue":"1","key":"pone.0307901.ref011","doi-asserted-by":"crossref","first-page":"2292482","DOI":"10.1080\/14756366.2023.2292482","article-title":"Comparative metabolic study of the chloroform fraction of three Cystoseira species based on UPLC\/ESI\/MS analysis and biological activities","volume":"39","author":"SH Aly","year":"2024","journal-title":"J Enzyme Inhib Med Chem"},{"key":"pone.0307901.ref012","doi-asserted-by":"crossref","first-page":"1302371","DOI":"10.3389\/fntpr.2023.1302371","article-title":"Exploring the potential role of genus Sophora in the management of osteoporosis: a phytochemical and biological review","volume":"2","author":"SH Aly","year":"2023","journal-title":"Frontiers in Natural Products"},{"key":"pone.0307901.ref013","doi-asserted-by":"crossref","first-page":"128793","DOI":"10.1016\/j.ijbiomac.2023.128793","article-title":"Electrospun Tamarindus indica-loaded antimicrobial PMMA\/cellulose acetate\/PEO nanofibrous scaffolds for accelerated wound healing: In-vitro and in-vivo assessments","volume":"258","author":"SS Goher","year":"2024","journal-title":"Int J Biol Macromol"},{"issue":"3","key":"pone.0307901.ref014","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1080\/0972060X.2020.1750489","article-title":"Variability of the Chemical Composition of the Essential Oils of Flowers and the Alkaloid Contents of Leaves of Sophora secundiflora and Sophora tomentosa","volume":"23","author":"SH Aly","year":"2020","journal-title":"Journal of Essential Oil-Bearing Plants"},{"issue":"2","key":"pone.0307901.ref015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3390\/md21020117","article-title":"Phytochemical Investigation of Three Cystoseira Species and Their Larvicidal Activity Supported with In Silico Studies","volume":"21","author":"SH Aly","year":"2023","journal-title":"Mar Drugs"},{"issue":"1","key":"pone.0307901.ref016","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3390\/plants12010087","article-title":"Comparative Metabolic Study of Tamarindus indica L.\u2019s Various Organs Based on GC\/MS Analysis, In Silico and In Vitro Anti-Inflammatory and Wound Healing Activities","volume":"12","author":"SH Aly","year":"2022","journal-title":"Plants"},{"issue":"24","key":"pone.0307901.ref017","doi-asserted-by":"crossref","first-page":"8979","DOI":"10.3390\/molecules27248979","article-title":"Chemical Constituents, Antioxidant, and Enzyme Inhibitory Activities Supported by In-Silico Study of n-Hexane Extract and Essential Oil of Guava Leaves","volume":"27","author":"SH Aly","year":"2022","journal-title":"Molecules"},{"issue":"22","key":"pone.0307901.ref018","doi-asserted-by":"crossref","first-page":"2900","DOI":"10.1007\/s00018-007-7237-1","article-title":"Polyphenolic phytochemicals\u2013just antioxidants or much more?","volume":"64","author":"DE Stevenson","year":"2007","journal-title":"Cellular and Molecular Life Sciences"},{"issue":"1","key":"pone.0307901.ref019","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12866-023-02911-z","article-title":"Synergistic antiviral activity of Lactobacillus acidophilus and Glycyrrhiza glabra against Herpes Simplex-1 Virus (HSV-1) and Vesicular Stomatitis Virus (VSV): experimental and In Silico insights","volume":"23","author":"D Elebeedy","year":"2023","journal-title":"BMC Microbiol"},{"key":"pone.0307901.ref020","volume-title":"Edible Medicinal and Non-Medicinal Plants","author":"TK Lim","year":"2016"},{"issue":"5","key":"pone.0307901.ref021","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.3390\/molecules28052193","article-title":"GC\/MS Profiling of the Essential Oil and Lipophilic Extract of Moricandia sinaica Boiss. and Evaluation of Their Cytotoxic and Antioxidant Activities","volume":"28","author":"SH Aly","year":"2023","journal-title":"Molecules"},{"issue":"4","key":"pone.0307901.ref022","doi-asserted-by":"crossref","first-page":"2370","DOI":"10.1016\/j.jksus.2020.03.017","article-title":"The phytochemical screening and antiangiogenic activity of audthan al himar (Moricandia sinaica Boiss.) extracts in zebrafish embryos and human umbilical vein endothelial cells","volume":"32","author":"M Farooq","year":"2020","journal-title":"Journal of King Saud University-Science"},{"issue":"3","key":"pone.0307901.ref023","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.3390\/app11031244","article-title":"Investigating the anticancer activity and characterization of bioactive constituents of Moricandia sinaica (Boiss.) Boiss through in vitro and in silico approaches in triple-negative breast cancer cell line","volume":"11","author":"M Farooq Khan","year":"2021","journal-title":"Applied Sciences"},{"issue":"21","key":"pone.0307901.ref024","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.3390\/molecules25215049","article-title":"A Polyphenols-Rich Extract from Moricandia sinaica Boiss. Exhibits Analgesic, Anti-Inflammatory and Antipyretic Activities In Vivo","volume":"25","author":"S El-Mekkawy","year":"2020","journal-title":"Molecules"},{"key":"pone.0307901.ref025","volume-title":"Guide to wild germplasm of Brassica and allied crops (tribe Brassiceae, Brassicaceae)","author":"SI Warwick","year":"2009"},{"issue":"1","key":"pone.0307901.ref026","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1039\/D3RA06355K","article-title":"In vitro and in vivo studies of Syzygium cumini loaded electrospun PLGA\/PMMA\/collagen nanofibers for accelerating topical wound healing","volume":"14","author":"E Abdelazim","year":"2024","journal-title":"RSC Adv"},{"issue":"7","key":"pone.0307901.ref027","doi-asserted-by":"crossref","first-page":"2994","DOI":"10.3390\/molecules28072994","article-title":"Synergistic Effect of Sophora japonica and Glycyrrhiza glabra Flavonoid-Rich Fractions on Wound Healing: In Vivo and Molecular Docking Studies","volume":"28","author":"SH Aly","year":"2023","journal-title":"Molecules"},{"key":"pone.0307901.ref028","first-page":"152","volume-title":"Methods in enzymology","author":"VL Singleton","year":"1999"},{"issue":"3","key":"pone.0307901.ref029","article-title":"Estimation of total flavonoid content in propolis by two complementary colorimetric methods","volume":"10","author":"C-C Chang","year":"2002","journal-title":"J Food Drug Anal"},{"issue":"3","key":"pone.0307901.ref030","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1021\/jf00039a005","article-title":"Scavenging effect of methanolic extracts of peanut hulls on free-radical and active-oxygen species","volume":"42","author":"GC Yen","year":"1994","journal-title":"J Agric Food Chem"},{"issue":"19","key":"pone.0307901.ref031","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.3390\/molecules25194566","article-title":"Synthesis of novel chalcone-based phenothiazine derivatives as antioxidant and anticancer agents","volume":"25","author":"NA Al Zahrani","year":"2020","journal-title":"Molecules"},{"issue":"4","key":"pone.0307901.ref032","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.foodchem.2005.11.043","article-title":"Free-radical scavenging capacity and reducing power of wild edible mushrooms from northeast Portugal: Individual cap and stipe activity","volume":"100","author":"ICFR Ferreira","year":"2007","journal-title":"Food Chem"},{"key":"pone.0307901.ref033","unstructured":"Morton, D.B., 1998. The use of score sheets in the implementation of humane end points. In Proceedings of the Joint ANZCCART\/NAEAC Conference on Ethical Approaches to Animal-based Science (pp. 75\u201382). Adelaide, Australia and Wellington, New Zealand: ANZCCART."},{"issue":"7","key":"pone.0307901.ref034","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/ptr.3387","article-title":"Hepatoprotective effect of flavonoid glycosides from Lespedeza cuneata against oxidative stress induced by tert\u2010butyl hyperoxide","volume":"25","author":"SM Kim","year":"2011","journal-title":"Phytotherapy Research"},{"issue":"4","key":"pone.0307901.ref035","doi-asserted-by":"crossref","first-page":"993","DOI":"10.3390\/ijms20040993","article-title":"Myristica fragrans kernels prevent paracetamol-induced hepatotoxicity by inducing anti-apoptotic genes and nrf2\/ho-1 pathway","volume":"20","author":"MA Dkhil","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"2","key":"pone.0307901.ref036","doi-asserted-by":"crossref","first-page":"167","DOI":"10.3109\/13880209.2014.913066","article-title":"Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats","volume":"53","author":"EM El Morsy","year":"2015","journal-title":"Pharm Biol"},{"key":"pone.0307901.ref037","doi-asserted-by":"crossref","first-page":"108935","DOI":"10.1016\/j.neuropharm.2021.108935","article-title":"Role of PI3K\/Akt axis in mitigating hippocampal ischemia-reperfusion injury via CB1 receptor stimulation by paracetamol and FAAH inhibitor in rat","volume":"207","author":"SS Abdel Mageed","year":"2022","journal-title":"Neuropharmacology"},{"issue":"1","key":"pone.0307901.ref038","doi-asserted-by":"crossref","first-page":"2293639","DOI":"10.1080\/14756366.2023.2293639","article-title":"A multidisciplinary approach to the antioxidant and hepatoprotective activities of Arbutus pavarii Pampan fruit; in vitro and in Vivo biological evaluations, and in silico investigations","volume":"39","author":"FA Elshibani","year":"2024","journal-title":"J Enzyme Inhib Med Chem"},{"key":"pone.0307901.ref039","first-page":"302","volume-title":"Methods in enzymology","author":"JA Buege","year":"1978"},{"issue":"5","key":"pone.0307901.ref040","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/0006-2952(88)90169-4","article-title":"Flavonoids are scavengers of superoxide anions","volume":"37","author":"J Robak","year":"1988","journal-title":"Biochem Pharmacol"},{"key":"pone.0307901.ref041","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-9861(59)90090-6","article-title":"Tissue sulfhydryl groups","volume":"82","author":"GL Ellman","year":"1959","journal-title":"Arch Biochem Biophys"},{"issue":"3","key":"pone.0307901.ref042","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1159\/000136485","article-title":"Bromobenzene-induced liver necrosis. Protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite","volume":"11","author":"DJ Jollow","year":"1974","journal-title":"Pharmacology"},{"issue":"3","key":"pone.0307901.ref043","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.apjtm.2017.03.005","article-title":"Potential antioxidant properties and hepatoprotective effects of Juniperus phoenicea berries against CCl4 induced hepatic damage in rats","volume":"10","author":"A Laouar","year":"2017","journal-title":"Asian Pac J Trop Med"},{"key":"pone.0307901.ref044","volume-title":"Theory and practice of histological techniques","author":"JD Bancroft","year":"2013","edition":"4"},{"issue":"12","key":"pone.0307901.ref045","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.3390\/molecules22122098","article-title":"Comparison of the binding of reversible inhibitors to human butyrylcholinesterase and acetylcholinesterase: A crystallographic, kinetic and calorimetric study","volume":"22","author":"TL Rosenberry","year":"2017","journal-title":"Molecules"},{"issue":"33","key":"pone.0307901.ref046","doi-asserted-by":"crossref","first-page":"9812","DOI":"10.1002\/anie.201704616","article-title":"Structure of Human Tyrosinase Related Protein\u20051 Reveals a Binuclear Zinc Active Site Important for Melanogenesis","volume":"56","author":"X Lai","year":"2017","journal-title":"Angew Chem Int Ed Engl"},{"issue":"32","key":"pone.0307901.ref047","doi-asserted-by":"crossref","first-page":"9648","DOI":"10.1021\/bi060692p","article-title":"The crystal structure of NAD(P)H oxidase from Lactobacillus sanfranciscensis: insights into the conversion of O2 into two water molecules by the flavoenzyme","volume":"45","author":"GT Lountos","year":"2006","journal-title":"Biochemistry"},{"issue":"26","key":"pone.0307901.ref048","doi-asserted-by":"crossref","first-page":"16026","DOI":"10.1039\/D1RA01809D","article-title":"In silico identification of potential SARS COV-2 2\u2032-O-methyltransferase inhibitor: fragment-based screening approach and MM-PBSA calculations","volume":"11","author":"MA El Hassab","year":"2021","journal-title":"RSC Adv"},{"issue":"1","key":"pone.0307901.ref049","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1080\/14756366.2021.2022659","article-title":"Multi-stage structure-based virtual screening approach towards identification of potential SARS-CoV-2 NSP13 helicase inhibitors","volume":"37","author":"MA El Hassab","year":"2022","journal-title":"J Enzyme Inhib Med Chem"},{"key":"pone.0307901.ref050","first-page":"313","article-title":"Optimization of ultrasonic assisted extraction technology and antioxidant activity of Flavonoids from Isatis indigotica root by response surface methodology","volume":"33","author":"WT Zhao","year":"2016","journal-title":"Chin Modern Appl Pharm"},{"issue":"9","key":"pone.0307901.ref051","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1093\/jpp\/rgab014","article-title":"Isatis indigotica: a review of phytochemistry, pharmacological activities and clinical applications","volume":"73","author":"Q Chen","year":"2021","journal-title":"J Pharm Pharmacol"},{"issue":"2","key":"pone.0307901.ref052","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3390\/molecules22020325","article-title":"Analysis of the total biflavonoids extract from Selaginella doederleinii by HPLC-QTOF-MS and its in vitro and in vivo anticancer effects","volume":"22","author":"H Yao","year":"2017","journal-title":"Molecules"},{"issue":"6","key":"pone.0307901.ref053","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1021\/jf072313k","article-title":"Cyanidin 3-Rutinoside and Cyanidin 3-Xylosylrutinoside as Primary Phenolic Antioxidants in Black Raspberry","volume":"56","author":"AZ Tulio","year":"2008","journal-title":"J Agric Food Chem"},{"issue":"10","key":"pone.0307901.ref054","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.3390\/pr10101911","article-title":"Differential Metabolomic Fingerprinting of the Crude Extracts of Three Asteraceae Species with Assessment of Their In Vitro Antioxidant and Enzyme-Inhibitory Activities Supported by In Silico Investigations","volume":"10","author":"G Zengin","year":"2022","journal-title":"Processes"},{"issue":"6","key":"pone.0307901.ref055","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.3390\/molecules26061710","article-title":"Phytochemical Profiling of Lavandula coronopifolia Poir. Aerial Parts Extract and Its Larvicidal, Antibacterial, and Antibiofilm Activity against Pseudomonas aeruginosa","volume":"26","author":"M Emam","year":"2021","journal-title":"molecules"},{"issue":"12","key":"pone.0307901.ref056","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/antiox9121286","article-title":"Chemical profiling, antioxidant, cytotoxic activities and molecular docking simulation of Carrichtera annua DC. (cruciferae)","volume":"9","author":"EE Eltamany","year":"2020","journal-title":"Antioxidants"},{"key":"pone.0307901.ref057","doi-asserted-by":"crossref","first-page":"104079","DOI":"10.1016\/j.bse.2020.104079","article-title":"Specialized natural product analysis and chemophenetics of some Turkish endemic Centaurea L. (Asteraceae) taxa by electrospray ionization mass spectrometry fingerprinting and liquid chromatography-tandem mass spectrometry","volume":"91","author":"Y. G\u00fczel","year":"2020","journal-title":"Biochem Syst Ecol"},{"key":"pone.0307901.ref058","doi-asserted-by":"crossref","first-page":"116213","DOI":"10.1016\/j.jep.2023.116213","article-title":"Chemical characterization of the polyphenolic rich fraction of Thunbergia erecta and its therapeutic potential against doxorubicin and cyclophosphamide-induced cognitive impairment in rats","author":"MIG El-Din","year":"2023","journal-title":"J Ethnopharmacol"},{"issue":"7","key":"pone.0307901.ref059","first-page":"1655","article-title":"Flavone C-glycosides from Isatis tinctoria leaves","volume":"65","author":"Y Cheng","year":"2005","journal-title":"Heterocycles-Sendai Institute of Heterocyclic Chemistry"},{"issue":"18","key":"pone.0307901.ref060","doi-asserted-by":"crossref","first-page":"16013","DOI":"10.1021\/acsomega.2c01148","article-title":"Anticancer and Neuroprotective Activities of Ethyl Acetate Fractions from Morus macroura Miq. 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Rats","volume":"29","author":"AA Shahat","year":"2022","journal-title":"Evidence-based Complementary and Alternative Medicine"},{"key":"pone.0307901.ref075","first-page":"2023","article-title":"A Comprehensive Review of the Pharmacological Importance of Dietary Flavonoids as Hepatoprotective Agents","author":"A Mazumder","year":"2023","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"issue":"6","key":"pone.0307901.ref076","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1055\/s-2004-827163","article-title":"Hepatoprotective flavonol glycosides from the aerial parts of Rodgersia podophylla","volume":"70","author":"Y-W Chin","year":"2004","journal-title":"Planta Med"},{"issue":"7","key":"pone.0307901.ref077","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.3390\/antiox11071390","article-title":"Rhodomyrtus tomentosa Fruits in Two Ripening Stages: Chemical Compositions, Antioxidant Capacity and Digestive Enzymes Inhibitory 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