{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:39:03Z","timestamp":1788187143838,"version":"build-2803163510"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["No. 8197152282"],"award-info":[{"award-number":["No. 8197152282"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>The study intended to evaluate the risk factors of postoperative ileus in hysterectomy patients.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Study design<\/jats:title>\n<jats:p>Systematic review and meta-analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This study conducted a systematic review and meta-analysis in accordance with the Preferred Reporting Program for Systematic Review and Meta-analysis statement. PubMed, Web of Science, Embase, the Cochrane Library and China National Knowledge Internet were searched. The search period was restricted from the earliest records to March 2024. Key words used were: (hysterectomy) AND (postoperative ileus OR postoperative intestinal obstruction OR ileus OR intestinal obstruction). Two researchers screened literatures and extracted data, and used Newcastle-Ottawa scale and Joanna Briggs Institute critical appraisal checklist for analytical cross-sectional studies to evaluate their quality. Then, Stata17 software was used for statistical analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Result<\/jats:title>\n<jats:p>A total of 11 literatures were included. Personal factors and previous history of disease factors of postoperative ileus in hysterectomy patients included use opioids (OR = 3.91, 95%CI: 1.08\u201314.24), dysmenorrhea (OR = 2.51, 95%: 1.25\u20135.05), smoking (OR = 1.55, 95%: 1.18\u20132.02), prior abdominal or pelvic surgery (OR = 1.46, 95%CI: 1.16\u20131.83) and age (OR = 1.03, 95%: 1.02\u20131.04). Surgery-related factors included perioperative transfusion (OR = 4.50, 95%CI: 3.29\u20136.16), concomitant bowel surgery (OR = 3.79, 95%CI: 1.86\u20137.71), anesthesia technique (general anesthesia) (OR = 2.73, 95%CI: 1.60, 4.66), adhesiolysis (OR = 1.97, 95%CI: 1.52\u20132.56), duration of operation (OR = 1.78, 95%CI: 1.32\u20132.40), operation approach (laparoscopic hysterectomy) (OR = 0.43, 95%CI: 0.29\u20130.64) and operation approach (vaginal hysterectomy) (OR = 0.35, 95%CI: 0.18\u20130.69).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The results of this study were personal factors and previous history of disease factors, surgery-related factors, which may increase the risk of postoperative ileus in hysterectomy patients. After the conclusion of risk factors, more accurate screening and identification of high-risk groups can be conducted and timely preventive measures can be taken to reduce the incidence of postoperative ileus.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec006\">\n<jats:title>Trial registration<\/jats:title>\n<jats:p>The study protocol for this meta-analysis was registered (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.crd.york.ac.uk\/prospero\/display_record.php?ID=CRD42023407167\" xlink:type=\"simple\">CRD42023407167<\/jats:ext-link>) with the PROSPERO database (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.crd.york.ac.uk\/prospero\" xlink:type=\"simple\">www.crd.york.ac.uk\/prospero<\/jats:ext-link>).<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0308175","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T17:22:13Z","timestamp":1722532933000},"page":"e0308175","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Risk factors for postoperative ileus in hysterectomy: A systematic review and meta-analysis"],"prefix":"10.1371","volume":"19","author":[{"given":"Zhuoer","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangpeng","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7916-3408","authenticated-orcid":true,"given":"Qiuhua","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"issue":"6","key":"pone.0308175.ref001","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.jviscsurg.2016.08.010","article-title":"Postoperative ileus: Pathophysiology, incidence, and prevention","volume":"153","author":"A Venara","year":"2016","journal-title":"J Visc Surg"},{"issue":"5","key":"pone.0308175.ref002","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s11605-013-2148-y","article-title":"Defining postoperative ileus: results of a systematic review and global survey","volume":"17","author":"R Vather","year":"2013","journal-title":"J Gastrointest Surg"},{"issue":"5","key":"pone.0308175.ref003","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1097\/SLA.0b013e318268a693","article-title":"Risk factors for prolonged ileus after resection of colorectal cancer: an observational study of 2400 consecutive patients","volume":"257","author":"PH Chapuis","year":"2013","journal-title":"Ann Surg"},{"issue":"4","key":"pone.0308175.ref004","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1097\/01.AOG.0000140685.30899.24","article-title":"Hysterectomy in obese women: a comparison of abdominal and vaginal routes","volume":"104","author":"EF Isik-Akbay","year":"2004","journal-title":"Obstet Gynecol"},{"key":"pone.0308175.ref005","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1097\/AOG.0b013e3182841594","article-title":"Complications of hysterectomy","volume":"121","author":"DL Clarke-Pearson","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"4","key":"pone.0308175.ref006","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1053\/j.scrs.2006.01.012","article-title":"Economic Impact of POI and Prolonged Length of Stay","volume":"16","author":"RM Bosio","year":"2005","journal-title":"Seminars in Colon and Rectal Surg"},{"issue":"3","key":"pone.0308175.ref007","doi-asserted-by":"crossref","first-page":"251.e1","DOI":"10.1016\/j.ajog.2018.11.1095","article-title":"Incidence and risk factors of early postoperative small bowel obstruction in patients undergoing hysterectomy for benign indications","volume":"220","author":"D Sheyn","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"pone.0308175.ref008","unstructured":"Agency for Healthcare Research and Quality. 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