{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:10:03Z","timestamp":1740147003183,"version":"3.37.3"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100015567","name":"EDF Energy","doi-asserted-by":"publisher","award":["V2-1002"],"award-info":[{"award-number":["V2-1002"]}],"id":[{"id":"10.13039\/100015567","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\"><jats:title>Background<\/jats:title><jats:p>Exposure to ionizing radiation has been linked to cardiovascular diseases. However, the impact of moderate doses of radiation on abdominal aortic aneurysm (AAA) remains unknown.<\/jats:p><\/jats:sec><jats:sec id=\"sec002\"><jats:title>Methods<\/jats:title><jats:p>Angiotensin II-infused<jats:italic>Apoe<\/jats:italic><jats:sup><jats:italic>-\/-<\/jats:italic><\/jats:sup>mice were irradiated (acute, 1 Gray) either 3 days before (Day-3) or 1 day after (Day+1) pomp implantation. Isolated primary aortic vascular smooth muscle cells (VSMCs) were irradiated (acute 1 Gray) for mechanistic studies and functional testing in vitro.<\/jats:p><\/jats:sec><jats:sec id=\"sec003\"><jats:title>Results<\/jats:title><jats:p>Day-3 and Day+1 irradiation resulted in a significant reduction in aorta dilation (Control: 1.39+\/-0.12; Day-3: 1.12+\/-0.11; Day+1: 1.15+\/-0.08 mm, P&lt;0.001) and AAA incidence (Control: 81.0%; Day-3: 33.3%, Day+1: 53.3%) compared to the non-irradiated group. Day-3 and Day+1 irradiation led to an increase in collagen content in the adventitia (Thickness control: 23.64+\/-2.9; Day-3: 54.39+\/-15.5; Day+1 37.55+\/-10.8 mm, P = 0.006). However, the underlying protective mechanisms were different between Day-3 and Day+1 groups. Irradiation before Angiotensin II (AngII) infusion mainly modulated vascular smooth muscle cell (VSMC) phenotype with a decrease in contractile profile and enhanced proliferative and migratory activity. Irradiation after AngII infusion led to an increase in macrophage content with a local anti-inflammatory phenotype characterized by the upregulation of M2-like gene and IL-10 expression.<\/jats:p><\/jats:sec><jats:sec id=\"sec004\"><jats:title>Conclusion<\/jats:title><jats:p>Moderate doses of ionizing radiation mitigate AAA either through VSCM phenotype or inflammation modulation, depending on the time of irradiation.<\/jats:p><\/jats:sec>","DOI":"10.1371\/journal.pone.0308273","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T18:21:44Z","timestamp":1722536504000},"page":"e0308273","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of moderate doses of ionizing radiation on experimental abdominal aortic aneurysm"],"prefix":"10.1371","volume":"19","author":[{"given":"Goran","family":"Riazi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe","family":"Brizais","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Imene","family":"Garali","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rida","family":"Al-rifai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5079-7943","authenticated-orcid":true,"given":"Helene","family":"Quelquejay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginie","family":"Monceau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6191-9032","authenticated-orcid":true,"given":"Guillaume","family":"Vares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lea","family":"Ould-Boukhitine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damien","family":"Aubeleau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florian","family":"Gilain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celine","family":"Gloaguen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgane","family":"Dos Santos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafid","family":"Ait-Oufella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teni","family":"Ebrahimian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"issue":"5","key":"pone.0308273.ref001","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1667\/RR14492.1","article-title":"Solid Cancer Incidence among the Life Span Study of Atomic Bomb Survivors: 1958\u20132009","volume":"187","author":"EJ Grant","year":"2017","journal-title":"Radiation Research. mai"},{"issue":"2","key":"pone.0308273.ref002","doi-asserted-by":"crossref","first-page":"024003","DOI":"10.1088\/1361-6498\/acdfd7","article-title":"The scientific basis for the use of the linear no-threshold (LNT) model at low doses and dose rates in radiological protection","volume":"43","author":"D Laurier","year":"2023","journal-title":"J Radiol Prot"},{"issue":"2","key":"pone.0308273.ref003","doi-asserted-by":"crossref","first-page":"1559325820921651","DOI":"10.1177\/1559325820921651","article-title":"Until There Is a Resolution of the Pro-LNT\/Anti-LNT Debate, We Should Head Toward a More Sensible Graded Approach for Protection From Low-Dose Ionizing Radiation","volume":"18","author":"PJ Sykes","year":"2020","journal-title":"Dose-Response"},{"key":"pone.0308273.ref004","unstructured":"Cardiovascular diseases (CVDs) [Internet]. 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