{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T04:00:43Z","timestamp":1793073643500,"version":"4.5.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100015631","name":"Merck Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015631","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Chronic cough (persisting for \u22658 weeks) is a common disorder affecting approximately 5 to 10% of adults worldwide that is sometimes refractory to treatment (refractory chronic cough [RCC]) or has no identifiable cause (unexplained chronic cough [UCC]). There is minimal information on the patient\u2019s experience of RCC\/UCC in Canada. The aim of this study was to evaluate the patient journey and perceptions related to RCC\/UCC management in Canada.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Our exploratory study included Canadians in the Leger Opinion Panel and focused on individuals with RCC or UCC. Key entry criteria were: age \u226518 years, cough on most days for \u22658 weeks, no smoking within 1 year, no serious respiratory disease or lung cancer, and not taking angiotensin-converting enzyme inhibitors. Individuals who met entry criteria were invited to complete an approximately 30-minute online survey with questions on demographic characteristics, healthcare professional (HCP) interactions, diagnosis of underlying conditions, current treatments, and satisfaction with HCPs and chronic cough therapies.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 49,076 individuals completed the chronic cough screening questionnaire (July 30, 2021 to September 1, 2021): 1,620 (3.3%) met entry criteria for RCC or UCC, and 1,046 (2.1%) completed the online survey (mean age of 45 years, 61% female). Most respondents (58%) reported their chronic cough was managed by a general practitioner (GP). Forty-four percent of respondents did not have a diagnosis of an underlying condition for their cough. Breathing tests (39%) and chest imaging (34%) were the most common diagnostic tests. Cough suppressants (18%) were the most frequent current treatment. Respondents were moderately satisfied with their HCPs, but more than half considered their treatment ineffective and 34% had considered no longer seeking medical attention because of a lack of treatment success.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Individuals with RCC\/UCC in Canada are largely unsatisfied with the effectiveness of treatment. Additional HCP education and new treatment options are needed to improve patient satisfaction.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0308275","type":"journal-article","created":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T17:39:29Z","timestamp":1722533969000},"page":"e0308275","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Patient satisfaction with the management of refractory and unexplained chronic cough in Canada: Results from a national survey"],"prefix":"10.1371","volume":"19","author":[{"given":"Sana","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danica","family":"Brister","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Abraham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3442-9505","authenticated-orcid":true,"given":"Samuel","family":"Laventure","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sevag","family":"Sahakian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berta","family":"Juli\u00e1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4206-6000","authenticated-orcid":true,"given":"Imran","family":"Satia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,8,1]]},"reference":[{"issue":"2","key":"pone.0308275.ref001","doi-asserted-by":"crossref","first-page":"00160","DOI":"10.1183\/23120541.00160-2021","article-title":"Prevalence, 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A physician\u2019s survey.","volume":"4","author":"J Dom\u00ednguez-Ortega","year":"2022","journal-title":"Open Respir Arch"},{"issue":"1","key":"pone.0308275.ref015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1378\/chest.15-1496","article-title":"Treatment of unexplained chronic cough: CHEST guideline and expert panel report.","volume":"149","author":"P Gibson","year":"2016","journal-title":"Chest."},{"issue":"6","key":"pone.0308275.ref016","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1080\/24745332.2021.1979904","article-title":"Chronic cough: investigations, management, current and future treatments.","volume":"5","author":"I Satia","year":"2021","journal-title":"Canadian Journal of Respiratory, Critical Care, and Sleep Medicine."},{"key":"pone.0308275.ref017","unstructured":"Canadian Chronic Cough Initiative. 2021 Aug [Cited 27 March 2024]. 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The spectrum and frequency of causes, key components of the diagnostic evaluation, and outcome of specific therapy","volume":"108","author":"NA Smyrnios","year":"1995","journal-title":"Chest"},{"issue":"1 Suppl","key":"pone.0308275.ref019","doi-asserted-by":"crossref","first-page":"169S","DOI":"10.1378\/chest.129.1_suppl.169S","article-title":"Angiotensin-converting enzyme inhibitor-induced cough: ACCP evidence-based clinical practice guidelines.","volume":"129","author":"PV Dicpinigaitis","year":"2006","journal-title":"Chest"},{"issue":"9","key":"pone.0308275.ref020","first-page":"789","article-title":"Investigations and management of chronic cough: a 2020 update from the European Respiratory Society Chronic Cough Task Force.","volume":"139","author":"MAM Farooqi","journal-title":"Pol Arch Intern Med"},{"key":"pone.0308275.ref021","first-page":"00232","article-title":"The demographics, clinical characteristics and quality of life of patients with chronic cough from the Isala Cough 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Brister","year":"2024","journal-title":"Lung"},{"issue":"2","key":"pone.0308275.ref034","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/14728214.2023.2203912","article-title":"Emerging drugs in the treatment of chronic cough.","volume":"28","author":"D Brister","year":"2023","journal-title":"Expert Opin Emerg Drugs"},{"issue":"10328","key":"pone.0308275.ref035","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/S0140-6736(21)02348-5","article-title":"Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials.","volume":"399","author":"LP McGarvey","year":"2022","journal-title":"Lancet"},{"issue":"14","key":"pone.0308275.ref036","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1001\/jama.2023.18035","article-title":"Efficacy and tolerability of gefapixant for treatment of 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intervention for patients with refractory chronic cough: a multicentre randomised control trial.","volume":"72","author":"SA Chamberlain Mitchell","year":"2017","journal-title":"Thorax."}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0308275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T17:39:53Z","timestamp":1722533993000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0308275"}},"subtitle":[],"editor":[{"given":"Kwame 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