{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:07:35Z","timestamp":1791922055570,"version":"4.3.4"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"8","license":[{"start":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T00:00:00Z","timestamp":1724025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"IBIMA Plataforma BIONAND"},{"DOI":"10.13039\/100009473","name":"University of M\u00e1laga","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100009473","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>Occupational therapy (OT) is an effective evidence-based intervention that positively influences stroke patients\u2019independence recovery, leading to new opportunities for better quality of life outcomes.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>To explore the effectiveness of an early OT intervention program (EOTIPS) in the process of hospital to home discharge after stroke in Spain.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Material and methods<\/jats:title>\n<jats:p>We conducted a prospective, randomized controlled clinical trial that included 60 adults who suffered a stroke and were discharged home. Participants assigned to the experimental group (n = 30) were included in EOTIPS and compared with a control group (n = 30). Evaluations assessed quality of life (Stroke and Aphasia Quality of Life Scale [SAQOL-39]), functional independence (Modified Rankin Scale [mRS], Barthel Index [BI] and Stroke Impact Scale-16 [SIS-16]), perceptual-cognitive skills (Montreal Cognitive Assessment [MoCA]), upper limb function (Fugl Meyer Assessment [FMA]), mobility (Berg Balance Scale [BBS] and Timed Up &amp; Go [TUG]), communication skills (Communicative Activity Log [CAL]) and mood disorders (Beck Depression Inventory\u2013II [BDI-II] and Hamilton Anxiety Scale [HAM-A]); they were completed within two weeks post-stroke and after three months follow-up. Statistical analysis included intent-to-treat analysis, considering all participants (dropouts as failures), and efficacy analysis, considering only end-of-treatment participants.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Results<\/jats:title>\n<jats:p>Participants in the intervention group showed a significant better evolution in the main outcome measure of quality of life (SAQOL-39 <jats:italic>p<\/jats:italic> = .029), as well as for independence (mRS<jats:italic>p<\/jats:italic> = .004), perceptual-cognitive skills (MoCA <jats:italic>p<\/jats:italic> = .012)and symptoms of depression (BDI-II <jats:italic>p<\/jats:italic> = .011) compared to the control group.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec005\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>EOTIPS was effective in improving quality of life, as well as enhancing perceptual-cognitive skills, independence and reducing levels of depression for patients who suffered a stroke in a Spanish cohort and could be considered as an applicable non-pharmacologic therapeutic tool that can lead to patients\u2019 positive outcomes after stroke.<\/jats:p>\n<jats:p>This study was registered on ClinicalTrials.gov with the identifier NCT04835363.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0308800","type":"journal-article","created":{"date-parts":[[2024,8,19]],"date-time":"2024-08-19T17:50:28Z","timestamp":1724089828000},"page":"e0308800","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Early Occupational Therapy Intervention post-stroke (EOTIPS): A randomized controlled trial"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4135-7255","authenticated-orcid":true,"given":"Patricia","family":"Garc\u00eda-P\u00e9rez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0428-4798","authenticated-orcid":true,"given":"Mar\u00eda Carmen","family":"Rodr\u00edguez-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Gallardo-Tur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Encarnaci\u00f3n","family":"Blanco-Reina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5389-5106","authenticated-orcid":true,"given":"Carlos","family":"de la Cruz-Cosme","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Pablo","family":"Lara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,8,19]]},"reference":[{"issue":"4","key":"pone.0308800.ref001","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000342652","article-title":"Stroke and transient ischemic attack incidence rate in Spain: the IBERICTUS study.","volume":"34","author":"J D\u00edaz-Guzm\u00e1n","year":"2012","journal-title":"Cerebrovasc Dis"},{"issue":"5","key":"pone.0308800.ref002","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.apmr.2018.06.017","article-title":"Factors Associated With Participation in Life Situations for Adults With Stroke: A Systematic Review","volume":"100","author":"L Ezekiel","year":"2019","journal-title":"Arch Phys Med 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