{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:36:42Z","timestamp":1791689802430,"version":"4.3.4"},"reference-count":75,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T00:00:00Z","timestamp":1735516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Multiple sclerosis (MS) is a devastating autoimmune disease that leads to the destruction of the myelin sheath in the human central nervous system (CNS). Infection by viruses and bacteria has been found to be strongly associated with the onset of MS or its severity. We postulated that the immune system\u2019s attack on the myelin sheath could be triggered by viruses and bacteria antigens that resemble myelin sheath components. An in-silico bioinformatics approach was undertaken in order to identify viral and bacterial antigens that resemble myelin oligodendrocyte glycoprotein (MOG) and myelin basic protein (MBP). To this end, we simultaneously analyzed both protein structures and amino acid sequences from viral and bacterial proteins and compared them to MOG and MBP. Possible associations between MBP and human parvovirus B19 (HPV-B19) and adeno-associated virus 4 (AAV-4) capsid protein structures were identified. MBP and MOG were associated with antigens from different viruses and bacteria, including <jats:italic>Aspergillus species<\/jats:italic>, <jats:italic>Lactobacillus<\/jats:italic>, <jats:italic>Burkholderia<\/jats:italic>, <jats:italic>Clostridium<\/jats:italic>, <jats:italic>Schizosaccharomyces<\/jats:italic>, SARS-CoV-2, and some gut flora metabolites. We also identified similarities between MBP and MOG proteins and bile salt hydrolase (BSH), glycosyltransferase (WcfQ), and Wzy enzymes. Identical amino acids between MBP and BSH at the active site, and protected amino acids in MOG aligning with WcfQ and Wzy enzymes were observed. Overall, our results offer valuable insights into the role of different viral and bacterial protein antigens in MS pathogenesis and suggest the possibility of identifying new therapeutic targets using in silico bioinformatics approaches. Our proposed approach could also likely be adapted for other CNS diseases in order to develop new biological insights and treatments.<\/jats:p>","DOI":"10.1371\/journal.pone.0308817","type":"journal-article","created":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T18:34:53Z","timestamp":1735583693000},"page":"e0308817","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Bioinformatics analysis of myelin-microbe interactions suggests multiple types of molecular mimicry in the pathogenesis of multiple sclerosis"],"prefix":"10.1371","volume":"19","author":[{"given":"Ali","family":"Bigdeli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa","family":"Ghaderi-Zefrehei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6689-0240","authenticated-orcid":true,"given":"Bluma J.","family":"Lesch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Behmanesh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2739-1617","authenticated-orcid":true,"given":"S. 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Hindawi Limited"},{"key":"pone.0308817.ref008","article-title":"An introduction to the microbiome and MS.","author":"S Trott","year":"2018","journal-title":"Mult Scler."},{"key":"pone.0308817.ref009","article-title":"Viruses and autoimmunity: A review on the potential interaction and molecular mechanisms.","author":"MK Smatti","year":"2019","journal-title":"Viruses. MDPI AG"},{"key":"pone.0308817.ref010","first-page":"1","article-title":"Myelin oligodendrocyte glycoprotein: Deciphering a target in inflammatory demyelinating diseases.","author":"P Peschl","year":"2017","journal-title":"Frontiers in Immunology. Frontiers Media S.A."},{"key":"pone.0308817.ref011","doi-asserted-by":"crossref","DOI":"10.1007\/978-1-4615-5949-8_2","article-title":"Myelin Basic Protein, the \u201cExecutive\u201d Molecule of the Myelin Membrane.","author":"MA Moscarello","year":"1997","journal-title":"Cell Biology and Pathology of Myelin"},{"key":"pone.0308817.ref012","first-page":"6","article-title":"Epstein Barr Virus and Mycobacterium avium subsp. paratuberculosis peptides are recognized in sera and cerebrospinal fluid of MS patients","author":"G Mameli","year":"2016","journal-title":"Sci Rep"},{"key":"pone.0308817.ref013","doi-asserted-by":"crossref","first-page":"3701","DOI":"10.3390\/v4123701","article-title":"Epstein-Barr Virus in Systemic Lupus Erythematosus, Rheumatoid Arthritis and Multiple Sclerosis\u2014Association and Causation.","volume":"4","author":"A Lossius","year":"2012","journal-title":"Viruses"},{"key":"pone.0308817.ref014","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1002\/acn3.199","article-title":"Expanded CD8 T-cell sharing between periphery and CNS in multiple sclerosis.","volume":"2","author":"M Salou","year":"2015","journal-title":"Ann Clin Transl Neurol"},{"key":"pone.0308817.ref015","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1177\/1352458514557304","article-title":"Human interferon regulatory factor 5 homologous epitopes of Epstein-Barr virus and Mycobacterium avium subsp. paratuberculosis induce a specific humoral and cellular immune response in multiple sclerosis patients.","volume":"21","author":"D Cossu","year":"2015","journal-title":"Mult Scler"},{"key":"pone.0308817.ref016","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jneuroim.2014.02.013","article-title":"Epstein\u2013Barr virus and Mycobacterium avium subsp. paratuberculosis peptides are cross recognized by anti-myelin basic protein antibodies in multiple sclerosis patients","volume":"270","author":"G Mameli","year":"2014","journal-title":"J Neuroimmunol"},{"key":"pone.0308817.ref017","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/S1568-9972(03)00014-4","article-title":"Parvovirus B19 infection and autoimmune disease.","volume":"2","author":"HW Lehmann","year":"2003","journal-title":"Autoimmun Rev."},{"key":"pone.0308817.ref018","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1136\/jclinpath-2015-203455","article-title":"The role of parvovirus B19 in the pathogenesis of autoimmunity and autoimmune disease","volume":"69","author":"JR Kerr","year":"2016","journal-title":"J Clin Pathol"},{"key":"pone.0308817.ref019","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1007\/s00415-011-5931-2","article-title":"Mononeuropathy multiplex associated with acute parvovirus B19 infection: characteristics, treatment and outcome","volume":"258","author":"T Lenglet","year":"2011","journal-title":"J Neurol"},{"key":"pone.0308817.ref020","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00415-011-5949-5","article-title":"Parvovirus B19 infection antedating Guillain-Barre\u2019 syndrome variant with prominent facial diplegia","volume":"258","author":"F Barbi","year":"2011","journal-title":"J Neurol"},{"key":"pone.0308817.ref021","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2174\/092986606775101715","article-title":"Autoantibody Reaction to Myelin Basic Protein by Plasma Parvovirus B19 IgG in MS Patients","volume":"13","author":"G Thomas","year":"2005","journal-title":"Protein Pept Lett"},{"key":"pone.0308817.ref022","article-title":"Adeno-associated virus vector as a platform for gene therapy delivery","author":"D Wang","year":"2019","journal-title":"Nature Reviews Drug Discovery"},{"key":"pone.0308817.ref023","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.ymthe.2004.09.011","article-title":"Adeno-associated Virus and the Development of Adeno-associated Virus Vectors: A Historical Perspective","volume":"10","author":"BJ Carter","year":"2004","journal-title":"Mol Ther"},{"key":"pone.0308817.ref024","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/s41576-019-0205-4","article-title":"Engineering adeno-associated virus vectors for gene therapy","volume":"21","author":"C Li","year":"2020","journal-title":"Nat Rev Genet"},{"key":"pone.0308817.ref025","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.ddmod.2020.02.003","article-title":"Viral infections and multiple sclerosis.","volume":"32","author":"D. Donati","year":"2020","journal-title":"Drug Discov Today Dis Model"},{"key":"pone.0308817.ref026","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1002\/jcp.26000","article-title":"Relationship of human herpes virus 6 and multiple sclerosis: A systematic review and meta-analysis","volume":"233","author":"A Pormohammad","year":"2018","journal-title":"J Cell Physiol"},{"key":"pone.0308817.ref027","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1177\/1352458518767327","article-title":"Evidence of Clostridium perfringens epsilon toxin associated with multiple sclerosis.","volume":"25","author":"S Wagley","year":"2019","journal-title":"Mult Scler."},{"key":"pone.0308817.ref028","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076359","article-title":"Isolation of Clostridium perfringens type B in an individual at first clinical presentation of multiple sclerosis provides clues for environmental triggers of the disease.","volume":"8","author":"KR Rumah","year":"2013","journal-title":"PLoS One."},{"key":"pone.0308817.ref029","article-title":"Gut microorganisms act together to exacerbate inflammation in spinal cords","author":"E Miyauchi","year":"2020","journal-title":"Nature"},{"key":"pone.0308817.ref030","doi-asserted-by":"crossref","first-page":"4101","DOI":"10.4049\/jimmunol.1001443","article-title":"Central Nervous System Demyelinating Disease Protection by the Human Commensal Bacteroides fragilis Depends on Polysaccharide A Expression","volume":"185","author":"J Ochoa-Rep\u00e1raz","year":"2010","journal-title":"J Immunol"},{"key":"pone.0308817.ref031","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1194\/jlr.R500013-JLR200","article-title":"Bile salt biotransformations by human intestinal bacteria","volume":"47","author":"JM Ridlon","year":"2006","journal-title":"J Lipid Res"},{"key":"pone.0308817.ref032","doi-asserted-by":"crossref","first-page":"D437","DOI":"10.1093\/nar\/gkaa1038","article-title":"RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences","volume":"49","author":"SK Burley","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"pone.0308817.ref033","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"SF Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"pone.0308817.ref034","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1093\/nar\/28.1.235","article-title":"The Protein Data Bank","volume":"28","author":"HM Berman","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"pone.0308817.ref035","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1002\/prot.26257","article-title":"Applying and improving AlphaFold at CASP14","volume":"89","author":"J Jumper","year":"2021","journal-title":"Proteins Struct Funct Bioinforma"},{"key":"pone.0308817.ref036","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1038\/s41586-021-03819-2","article-title":"Highly accurate protein structure prediction with AlphaFold","volume":"596","author":"J Jumper","year":"2021","journal-title":"Nat"},{"key":"pone.0308817.ref037","article-title":"PRALINE: A multiple sequence alignment toolbox that integrates homology-extended and secondary structure information","author":"VA Simossis","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"pone.0308817.ref038","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/978-1-62703-646-7_16","article-title":"PRALINE: A versatile multiple sequence alignment toolkit","volume":"1079","author":"P Bawono","year":"2014","journal-title":"Methods Mol Biol"},{"key":"pone.0308817.ref039","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-4939-7366-8_4","article-title":"YASARA: A tool to obtain structural guidance in biocatalytic investigations.","author":"H Land","year":"2018","journal-title":"Methods in Molecular Biology. Humana Press Inc."},{"key":"pone.0308817.ref040","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/prot.20921","article-title":"MUSTANG: a multiple structural alignment algorithm","volume":"64","author":"AS Konagurthu","year":"2006","journal-title":"Proteins"},{"key":"pone.0308817.ref041","doi-asserted-by":"crossref","first-page":"11059","DOI":"10.1073\/pnas.1833158100","article-title":"The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis","volume":"100","author":"CS Clements","year":"2003","journal-title":"Proc Natl Acad Sci U S A"},{"key":"pone.0308817.ref042","doi-asserted-by":"crossref","first-page":"W24","DOI":"10.1093\/nar\/gkx346","article-title":"BepiPred-2.0: improving sequence-based B-cell epitope prediction using conformational epitopes","volume":"45","author":"MC Jespersen","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"pone.0308817.ref043","first-page":"197","article-title":"BcePred: Prediction of continuous B-cell epitopes in antigenic sequences using physico-chemical properties.","volume":"3239","author":"S Saha","year":"2004","journal-title":"Lect Notes Comput Sci (including Subser Lect Notes Artif Intell Lect Notes Bioinformatics)."},{"key":"pone.0308817.ref044","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/0014-5793(90)80535-Q","article-title":"A semi-empirical method for prediction of antigenic determinants on protein antigens","volume":"276","author":"AS Kolaskar","year":"1990","journal-title":"FEBS Lett"},{"key":"pone.0308817.ref045","article-title":"Cross-reactivity with myelin basic protein and human herpesvirus-6 in multiple sclerosis","author":"V. Tejada-Simon M","year":"2003","journal-title":"Ann Neurol"},{"key":"pone.0308817.ref046","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.jim.2015.03.022","article-title":"Development and validation of a broad scheme for prediction of HLA class II restricted T cell epitopes","volume":"422","author":"S Paul","year":"2015","journal-title":"J Immunol Methods"},{"key":"pone.0308817.ref047","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-04732-5","article-title":"DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis.","volume":"9","author":"L Kular","year":"2018","journal-title":"Nat Commun"},{"key":"pone.0308817.ref048","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/B978-0-12-355510-6.50015-4","article-title":"Molecular Biology of Bacteriocins Produced by Lactobacillus.","author":"TR KLAENHAMMER","year":"1993","journal-title":"Bacteriocins of Lactic Acid Bacteria. Elsevier"},{"key":"pone.0308817.ref049","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003783","article-title":"Sinus microbiome diversity depletion and Corynebacterium tuberculostearicum enrichment mediates rhinosinusitis.","volume":"4","author":"NA Abreu","year":"2012","journal-title":"Sci Transl Med."},{"key":"pone.0308817.ref050","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.3389\/fmicb.2018.02003","article-title":"Phenotypic diversity of Lactobacillus sakei strains.","volume":"9","author":"C Montanari","year":"2018","journal-title":"Front Microbiol"},{"key":"pone.0308817.ref051","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ijbiomac.2005.09.002","article-title":"Structural analysis of the sheath of a sheathed bacterium, Leptothrix cholodnii","volume":"37","author":"M Takeda","year":"2005","journal-title":"Int J Biol Macromol"},{"key":"pone.0308817.ref052","first-page":"235","volume-title":"Microbial Contamination and Food Degradation","author":"E Mani-L\u00f3pez","year":"2018"},{"key":"pone.0308817.ref053","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1533\/9781845691417.4.451","volume-title":"Food spoilage microorganisms","author":"AD Hocking","year":"2006"},{"key":"pone.0308817.ref054","doi-asserted-by":"crossref","first-page":"613","DOI":"10.3390\/toxins2040613","article-title":"Biosynthesis and toxicological effects of patulin.","volume":"2","author":"O Puel","year":"2010","journal-title":"Toxins (Basel)."},{"key":"pone.0308817.ref055","first-page":"1","volume-title":"Encyclopedia of Microbiology.","author":"S DasSarma","year":"2009"},{"key":"pone.0308817.ref056","first-page":"814","volume-title":"Applied and Environmental Microbiology.","author":"WK Nip","year":"1977"},{"key":"pone.0308817.ref057","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/B978-0-12-411552-1.00006-5","volume-title":"Postharvest Decay: Control Strategies","author":"D. Errampalli","year":"2014"},{"key":"pone.0308817.ref058","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a019786","article-title":"Aspergillus fumigatus and Related Species.","volume":"5","author":"JA Sugui","year":"2015","journal-title":"Cold Spring Harb Perspect Med."},{"key":"pone.0308817.ref059","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/B978-0-323-37715-7.50113-4","article-title":"*Klebsiella* Pneumonia.","author":"S Suster","year":"2017","journal-title":"Diagnostic Pathol Thorac"},{"key":"pone.0308817.ref060","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/B978-0-444-52149-1.00003-3","article-title":"Yeast Biotechnology.","volume":"1","author":"EA Johnson","year":"2011","journal-title":"The Yeasts"},{"key":"pone.0308817.ref061","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1111\/j.1469-0691.2010.03237.x","article-title":"Burkholderia cenocepacia in cystic fibrosis: epidemiology and molecular mechanisms of virulence","volume":"16","author":"E M P D","year":"2010","journal-title":"Clin Microbiol Infect"},{"key":"pone.0308817.ref062","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1128\/IAI.00626-08","article-title":"Burkholderia thailandensis as a model system for the study of the virulence-associated type III secretion system of burkholderia pseudomallei","volume":"76","author":"A Haraga","year":"2008","journal-title":"Infect Immun"},{"key":"pone.0308817.ref063","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3201\/eid1501.071677","article-title":"Isolation of Bordetella avium and Novel Bordetella Strain from Patients with Respiratory Disease","volume":"15","author":"AT Harrington","year":"2009","journal-title":"Emerg Infect Dis"},{"key":"pone.0308817.ref064","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/B978-0-444-52512-3.00183-2","article-title":"Poultry and Avian Diseases.","author":"AJ Chaves Hern\u00e1ndez","year":"2014","journal-title":"Encycl Agric Food Syst"},{"key":"pone.0308817.ref065","first-page":"569","article-title":"Mycobacterium avium Subspecies Paratuberculosis and Human Disease: Bridging Infection and Autoimmunity.","author":"CT Dow","year":"2015","journal-title":"Infect Autoimmun"},{"key":"pone.0308817.ref066","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.3390\/md11082894","article-title":"Development of Synechocystis sp. PCC 6803 as a Phototrophic Cell Factory.","volume":"11","author":"Y Yu","year":"2013","journal-title":"Mar Drugs."},{"key":"pone.0308817.ref067","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1038\/ng.3395","article-title":"Class II HLA interactions modulate genetic risk for multiple sclerosis","volume":"47","author":"L Moutsianas","year":"2015","journal-title":"Nat Genet"},{"key":"pone.0308817.ref068","article-title":"Characterizing the Pathogenic, Genomic, and Chemical Traits of Aspergillus fischeri, a Close Relative of the Major Human Fungal Pathogen Aspergillus fumigatus.","volume":"4","author":"ME Mead","year":"2019","journal-title":"mSphere."},{"key":"pone.0308817.ref069","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1007\/s00284-020-02036-w","article-title":"Optimized Solid-State Fermentation Medium Enhances the Multienzymes Production from Penicillium citrinum and Aspergillus clavatus","volume":"77","author":"BR Shruthi","year":"2020","journal-title":"Curr Microbiol"},{"key":"pone.0308817.ref070","first-page":"118","article-title":"How human leukocytes track down and destroy pathogens: lessons learned from the model organism Dictyostelium discoideum.","volume":"43","author":"T Jin","year":"2008","journal-title":"Immunol Res 2008 431"},{"key":"pone.0308817.ref071","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1615\/CritRevImmunol.v30.i2.20","article-title":"The pathogenesis of murine coronavirus infection of the central nervous system.","volume":"30","author":"MP Hosking","year":"2010","journal-title":"Crit Rev Immunol"},{"key":"pone.0308817.ref072","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1007\/s12026-007-0079-y","article-title":"Pathogenesis of acute and chronic central nervous system infection with variants of mouse hepatitis virus, strain JHM.","volume":"39","author":"SP Templeton","year":"2007","journal-title":"Immunol Res."},{"key":"pone.0308817.ref073","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1080\/135502801753170273","article-title":"Multiple regions of the murine coronavirus spike glycoprotein influence neurovirulence","volume":"7","author":"JJ Phillips","year":"2001","journal-title":"J Neurovirol"},{"key":"pone.0308817.ref074","first-page":"1641","article-title":"SARS-CoV-2 and Multiple Sclerosis: Potential for Disease Exacerbation.","volume":"0","author":"M MacDougall","year":"2022","journal-title":"Front Immunol."},{"key":"pone.0308817.ref075","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/j.1750-3639.2007.00064.x","article-title":"The Immunopathology of Multiple Sclerosis: An Overview","volume":"17","author":"H Lassmann","year":"2007","journal-title":"Brain Pathol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0308817","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,30]],"date-time":"2024-12-30T18:35:24Z","timestamp":1735583724000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0308817"}},"subtitle":[],"editor":[{"given":"Awatif Abid","family":"Al-Judaibi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,12,30]]},"references-count":75,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2024,12,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0308817","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12,30]]}}}