{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T22:12:21Z","timestamp":1773267141247,"version":"3.50.1"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T00:00:00Z","timestamp":1734048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"the National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["Grant No. 82172682 and 82373221"],"award-info":[{"award-number":["Grant No. 82172682 and 82373221"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100005230","name":"the Chongqing Natural Science Foundation","doi-asserted-by":"crossref","award":["Grant No. CSTB2023NSCQ-MSX0472"],"award-info":[{"award-number":["Grant No. CSTB2023NSCQ-MSX0472"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"crossref"}]},{"name":"and the First-class discipline construction project of the First Affiliated Hospital of Chongqing Medical University","award":["Grant No. CYYY-BSYJSCXXM-202207 and CYYY-BSYJSCXXM-202304"],"award-info":[{"award-number":["Grant No. CYYY-BSYJSCXXM-202207 and CYYY-BSYJSCXXM-202304"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objectives<\/jats:title>\n<jats:p>This study aimed to evaluate and compare the clinical predictive value of prognostic nutritional index (PNI) and naples prognostic score (NPS) as biomarkers for the prognosis of incisional wound healing in patients who underwent thoracolumbar tuberculosis surgery through the posterior approach.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>From January 2019 to October 2021, a total of 124 patients with thoracolumbar tuberculosis who underwent posterior approach debridement and internal fixation were included in this study. We retrospectively analyzed the clinical data, including PNI and NPS. They were divided into poor wound healing (PWH) and non-PWH groups according to whether PWH developed after the operation. And according to the receiver operating characteristic curve, patients were divided into two groups through the threshold value. Risk factors were found using logistic regression analysis.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>The unfavorable outcome group had lower hemoglobin, serum albumin, Pre-albumin, PNI, and higher estimated blood loss, instrumented segments, neutrophil count, and NPS (P &lt; 0.05). Both PNI and NPS were strongly correlated with PWH (r = 0.373, P &lt; 0.05; r = \u22120.306, P &lt; 0.05, respectively). The area under the curve (AUC) of PNI for predicting unfavorable outcomes was 0.764 (95% CI 0.662\u20130.865, P &lt; 0.001), which was similar to NPS (0.808, 95% CI: 0.719\u20130.897, P &lt; 0.001). Multivariate stepwise logistic regression analysis showed that PNI, NPS, the neutrophil count, the level of serum albumin, and the number of instrumented segments were independent risk factors for PWH.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Both PNI and NPS might be novel independent biomarkers and predictors of poor outcomes in incisional wound healing after STB surgery.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0309267","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T18:24:28Z","timestamp":1734114268000},"page":"e0309267","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prognostic nutritional index and naples prognostic score as biomarkers for the prognosis of incisional wound healing after thoracolumbar tuberculosis surgery"],"prefix":"10.1371","volume":"19","author":[{"given":"Tuotuo","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wanyuan","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8578-3523","authenticated-orcid":true,"given":"Yunsheng","family":"Ou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,12,13]]},"reference":[{"issue":"4","key":"pone.0309267.ref001","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1302\/0301-620X.100B4.BJJ-2017-1040.R1","article-title":"Spinal tuberculosis: review of current management","volume":"100-B","author":"RN Dunn","year":"2018","journal-title":"Bone Joint J"},{"issue":"Pt 4","key":"pone.0309267.ref002","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1099\/mic.0.2006\/002154-0","article-title":"First report of Mycobacterium bovis DNA in human remains from the Iron Age","volume":"153","author":"GM Taylor","year":"2007","journal-title":"Microbiology (Reading)"},{"issue":"11","key":"pone.0309267.ref003","doi-asserted-by":"crossref","first-page":"1858","DOI":"10.1016\/j.spinee.2019.05.002","article-title":"Spinal tuberculosis: a comprehensive review for the modern spine surgeon","volume":"19","author":"K Khanna","year":"2019","journal-title":"Spine J"},{"issue":"8","key":"pone.0309267.ref004","doi-asserted-by":"crossref","first-page":"e659","DOI":"10.1016\/j.ijid.2009.11.009","article-title":"Is spinal tuberculosis contagious?","volume":"14","author":"P Schirmer","year":"2010","journal-title":"Int J Infect Dis"},{"issue":"159","key":"pone.0309267.ref005","first-page":"106","article-title":"Pott\u2019s spine and paraplegia","volume":"44","author":"MP Gautam","year":"2005","journal-title":"JNMA J Nepal Med Assoc"},{"issue":"7","key":"pone.0309267.ref006","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1302\/0301-620X.92B7.24668","article-title":"Tuberculosis of the spine: a fresh look at an old disease","volume":"92","author":"AK Jain","year":"2010","journal-title":"J Bone Joint Surg Br"},{"issue":"7","key":"pone.0309267.ref007","first-page":"617","article-title":"Tuberculosis of the Spine","volume":"102","author":"AK Jain","year":"2020","journal-title":"The Journal of Bone and Joint Surgery"},{"issue":"398","key":"pone.0309267.ref008","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1097\/00003086-200205000-00011","article-title":"Treatment of tuberculosis of the spine with neurologic complications","author":"AK Jain","year":"2002","journal-title":"Clin Orthop Relat Res"},{"issue":"Suppl 4","key":"pone.0309267.ref009","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1007\/s00586-012-2335-7","article-title":"Tuberculosis of spine: neurological deficit","volume":"22","author":"AK Jain","year":"2013","journal-title":"Eur Spine J"},{"issue":"3","key":"pone.0309267.ref010","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/BF03545549","article-title":"Tuberculosis of the skeletal system (bones, joints, spine and bursal sheaths)","volume":"44","author":"AK Jain","year":"2010","journal-title":"Indian J Orthop"},{"issue":"5","key":"pone.0309267.ref011","first-page":"e838","article-title":"Retrospective Study of 967 Patients With Spinal Tuberculosis","volume":"39","author":"T Shi","year":"2016","journal-title":"Orthopedics. 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