{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T15:47:53Z","timestamp":1776872873452,"version":"3.51.2"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T00:00:00Z","timestamp":1725926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p><jats:italic>Neural EGFL like 1 (NELL-1<\/jats:italic>), is a secreted glycoprotein and stimulates osteogenic cell differentiation and bone mineralization. This study aimed to explore the relationship between <jats:italic>NELL-1<\/jats:italic> and Trabecular Bone Score (TBS) as a novel tool for the evaluation of osteoporosis in an elderly population-based cohort study in Iran. A single-locus analysis was performed on TBS using data from 2,071 participants in the Bushehr Elderly Health (BEH) Program. The study investigated 376 independent single nucleotide polymorphisms (SNPs) within the <jats:italic>NELL-1<\/jats:italic> on chromosome 11p15.1. The association between SNPs and the mean TBS L1 to L4 was analyzed through an additive model. Significant variants in the additive model (P<jats:sub>FDR<\/jats:sub>&lt;0.05) were further examined within dominant, recessive, over-dominant, and co-dominant models. Multiple linear regression was employed to assess the relationship between the genetic risk score (GRS) derived from significant SNPs and TBS. Three SNPs within the <jats:italic>NELL-1<\/jats:italic> showed a statistically significant association with TBS after adjusting for age and sex. The associations for rs1901945 (\u03b2 = 0.013, P<jats:sub>FDR<\/jats:sub> = 0.0007), rs1584851 (\u03b2 = -0.011, P<jats:sub>FDR<\/jats:sub> = 0.0003), and rs58028601 (\u03b2 = 0.011, P<jats:sub>FDR<\/jats:sub> = 0.0003) were significant in the additive model. Additionally, significant results were observed for rs1901945 and rs58028601 in the dominant model (P&lt;0.05). The GRS showed a statistically significant relationship with TBS, considering adjustments for age, sex, Body Mass Index, type 2 diabetes, and smoking (\u03b2 = 0.077, P = 1.7\u00d710<jats:sup>\u22125<\/jats:sup>). This study highlights the association of <jats:italic>NELL-1<\/jats:italic> with TBS, underscoring its potential as a candidate for further research and personalized medicine concerning the impact of this gene on bone quality.<\/jats:p>","DOI":"10.1371\/journal.pone.0309401","type":"journal-article","created":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T17:27:43Z","timestamp":1725989263000},"page":"e0309401","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neural EGFL like 1 as a novel gene for Trabecular Bone Score in older adults: The Bushehr Elderly Health (BEH) program"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0965-3679","authenticated-orcid":true,"given":"Mohammad","family":"Bidkhori","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Akbarzadeh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noushin","family":"Fahimfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mina","family":"Jahangiri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0375-9894","authenticated-orcid":true,"given":"Sahar","family":"Seddiq","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5386-7597","authenticated-orcid":true,"given":"Bagher","family":"Larijani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iraj","family":"Nabipour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Mohammad Amoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-7043","authenticated-orcid":true,"given":"Nekoo","family":"Panahi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abbas","family":"Dehghan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kourosh","family":"Holakouie-Naieni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8670-5797","authenticated-orcid":true,"given":"Afshin","family":"Ostovar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,9,10]]},"reference":[{"key":"pone.0309401.ref001","unstructured":"International Osteoporosis Foundation. 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NELL1 neural EGFL like 1 [Homo sapiens (human) ] 2024. [cited 2023 May 10]. 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BMP2 bone morphogenetic protein 2 [Homo sapiens (human) ]. 2024. [cited 2023 May 10]. 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