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With the acceleration of population aging, investigations into aging have garnered widespread global interest. One of the most striking aspects of human aging is the decline in brain function, a phenomenon intricately tied to the onset of neurodegenerative conditions. This study aimed to assess the impact of a fish hydrolysate, rich in low-molecular-weight peptides and n-3 LC-PUFAs, on cognitive function, inflammatory response, and oxidative stress <jats:italic>via<\/jats:italic> the AGE-RAGE axis in a mouse model of accelerated aging. This model induces cognitive decline and biochemical alterations akin to those observed during natural aging. The findings revealed that fish hydrolysate exhibited a protective effect against cognitive impairment induced by D-galactose. This effect was associated with increased protein expression of SOD1 and decreased genetic expression of IL-6 and advanced glycation end products (AGE). Consequently, within the realm of preventive and personalized nutrition, fish hydrolysate emerges as a promising avenue for mitigating age-related declines in memory function.<\/jats:p>","DOI":"10.1371\/journal.pone.0309542","type":"journal-article","created":{"date-parts":[[2024,10,24]],"date-time":"2024-10-24T17:38:02Z","timestamp":1729791482000},"page":"e0309542","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Dietary marine hydrolysate alleviates D-galactose-induced brain aging by attenuating cognitive alterations, oxidative stress and inflammation through the AGE-RAGE axis"],"prefix":"10.1371","volume":"19","author":[{"given":"Camille","family":"Mougin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathilde","family":"Chataigner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Lucas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V\u00e9ronique","family":"Pallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elodie","family":"Bouvret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinne","family":"Joffre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8668-9413","authenticated-orcid":true,"given":"Anne-Laure","family":"Dinel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,24]]},"reference":[{"key":"pone.0309542.ref001","doi-asserted-by":"crossref","DOI":"10.18356\/6a8968ef-en","volume-title":"World population ageing, 2019 highlights.","author":"United Nations, Department of Economic and Social Affairs, Population Division","year":"2020"},{"key":"pone.0309542.ref002","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1093\/bmb\/ldp033","article-title":"Age-associated cognitive decline","volume":"92","author":"IJ Deary","year":"2009","journal-title":"Br Med Bull"},{"key":"pone.0309542.ref003","first-page":"256","author":"T. 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