{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:50:25Z","timestamp":1791654625739,"version":"4.3.4"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T00:00:00Z","timestamp":1725580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"ALF-agreement","award":["ALFGBG-719531"],"award-info":[{"award-number":["ALFGBG-719531"]}]},{"name":"ALF-agreement","award":["ALFGBG-772591"],"award-info":[{"award-number":["ALFGBG-772591"]}]},{"name":"ALF-agreement","award":["ALFGBG-966066"],"award-info":[{"award-number":["ALFGBG-966066"]}]},{"name":"ALF-agreement","award":["ALFGBG-965653"],"award-info":[{"award-number":["ALFGBG-965653"]}]},{"name":"The Local Research and Development Council Gothenburg and S\u00f6dra Bohusl\u00e4n","award":["VGFOUGSB-768341"],"award-info":[{"award-number":["VGFOUGSB-768341"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>Various factors may affect cognition in patients with pituitary adenoma, including size and extension of the tumor, degree of pituitary hormone deficiencies, and treatment of the tumor, most often being transsphenoidal surgery (TSS). The aim of this cross-sectional study was to evaluate cognitive function in patients with clinically significant pituitary adenoma and to identify factors influencing cognition. Sixty-eight patients with pituitary adenoma were included. Of these, 31 patients were evaluated before TSS and 37 patients 12 months following TSS. Cognitive function was evaluated by using the Repeatable Battery for the Assessment of Neuropsychological Status. Patients had lower mean scores on cognitive assessment compared to age-adjusted normative data. Variability in cognition, analyzed by linear regression analysis, was explained by sex, educational level, and self-perceived fatigue, but not by pituitary hormone deficiencies, diabetes insipidus, or surgical treatment. Our results are in line with previous findings, namely that pituitary adenoma affects cognition. To better evaluate the factors affecting cognition, longitudinal studies are recommended. Such studies would allow for within-individual comparisons, effectively controlling for the considerable influence of sex and education on test results.<\/jats:p>","DOI":"10.1371\/journal.pone.0309586","type":"journal-article","created":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T17:25:28Z","timestamp":1725643528000},"page":"e0309586","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cognitive function in pituitary adenoma patients: A cross-sectional study"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9363-9991","authenticated-orcid":true,"given":"David","family":"Krabbe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5940-4400","authenticated-orcid":true,"given":"Katharina S.","family":"Sunnerhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9734-0786","authenticated-orcid":true,"given":"Daniel S.","family":"Olsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Hall\u00e9n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oskar","family":"Ragnarsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Skoglund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3484-8440","authenticated-orcid":true,"given":"Gudmundur","family":"Johannsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,9,6]]},"reference":[{"issue":"5","key":"pone.0309586.ref001","first-page":"319","article-title":"Pituitary adenomas: An overview","volume":"88","author":"MG Lake","year":"2013","journal-title":"Am Fam Physician"},{"key":"pone.0309586.ref002","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.jocn.2017.02.028","article-title":"Cognitive function surrounding resection of nonfunctioning pituitary adenomas with suprasellar extension: A prospective matched-control study.","volume":"40","author":"P Hendrix","year":"2017","journal-title":"J Clin Neurosci"},{"issue":"9","key":"pone.0309586.ref003","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/nrendo.2016.84","article-title":"The chronic syndromes after previous treatment of pituitary tumours.","volume":"12","author":"JA Romijn","year":"2016","journal-title":"Nat Rev Endocrinol"},{"issue":"5","key":"pone.0309586.ref004","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.beem.2009.05.002","article-title":"Surgical treatment of pituitary tumours","volume":"23","author":"M Buchfelder","year":"2009","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"pone.0309586.ref005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jocn.2017.01.015","article-title":"The impact of transsphenoidal surgery on neurocognitive function: A systematic review","volume":"42","author":"A Alsumali","year":"2017","journal-title":"J Clin Neurosci"},{"key":"pone.0309586.ref006","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jocn.2020.03.007","article-title":"A prospective study of the cognitive and psychiatric effects of pituitary tumours and their treatments.","volume":"75","author":"L Marsh","year":"2020","journal-title":"J Clin Neurosci"},{"issue":"7","key":"pone.0309586.ref007","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1007\/s10072-017-2980-z","article-title":"The impact on cognitive functions of patients with pituitary adenoma before and after surgery","volume":"38","author":"X Wang","year":"2017","journal-title":"Neurol Sci"},{"issue":"7","key":"pone.0309586.ref008","doi-asserted-by":"crossref","first-page":"e17697","DOI":"10.2196\/17697","article-title":"Extended support within a person-centered practice after surgery for patients with pituitary tumors: Protocol for a quasiexperimental study","volume":"9","author":"S Jakobsson","year":"2020","journal-title":"JMIR Res Protoc"},{"issue":"11","key":"pone.0309586.ref009","doi-asserted-by":"crossref","first-page":"3888","DOI":"10.1210\/jc.2016-2118","article-title":"Hormonal replacement in hypopituitarism in adults: An Endocrine Society Clinical Practice Guideline","volume":"101","author":"M Fleseriu","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"pone.0309586.ref010","volume-title":"Repeatable Battery for the Assessment of Neuropsychological Status Update","author":"C. 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