{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:21:57Z","timestamp":1781763717139,"version":"3.54.5"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T00:00:00Z","timestamp":1725840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>Dementia with Lewy bodies (DLB) is recognized as the second most common cause of degenerative dementia in older people with Alzheimer\u2019s disease (AD), and distinguishing between these 2 diseases may be challenging in clinical practice. However, accurate differentiation is important because these 2 diseases have different prognoses and require different care. Recently, several studies have reported that neuromelanin-sensitive MRI can detect neurodegeneration in the substantia nigra pars compacta (SNc). DLB patients are considered to demonstrate degeneration and a reduction of dopaminergic neurons in the SNc. Therefore, neuromelanin-sensitive MRI may be useful for the diagnosis of DLB. Therefore, in this study, we aimed to investigate the usefulness of neuromelanin-sensitive MRI in the distinguishing DLB from AD.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>A total of 21 probable DLB and 22 probable AD patients were enrolled. All participants underwent both DaT-SPECT and neuromelanin-sensitive MRI. A combined model of neuromelanin-sensitive MRI and Dopamine transporter single-photon emission computed tomography (DaT-SPECT) was created using logistic regression analysis (forced entry method).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>There was no difference in the diagnostic utility of neuromelanin-sensitive MRI and DaT-SPECT in distinguishing DLB from AD. There was no significant correlation between the results of neuromelanin-sensitive MRI and DaT-SPECT in DLB patients. The combination of neuromelanin-sensitive MRI and DaT-SPECT demonstrated higher diagnostic performance in distinguishing between DLB and AD compared with neuromelanin-sensitive MRI alone. Additionally, although the combination of both modalities showed a larger AUC compared with DaT-SPECT alone, the difference was not statistically significant.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Neuromelanin-sensitive MRI may be equally or even more useful than DaT-SPECT in the clinical differentiation of DLB from AD. Furthermore, the combination of neuromelanin-sensitive MRI and DaT-SPECT may be a highly sensitive imaging marker for distinguishing DLB from AD.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0309885","type":"journal-article","created":{"date-parts":[[2024,9,9]],"date-time":"2024-09-09T17:25:06Z","timestamp":1725902706000},"page":"e0309885","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Utility of neuromelanin-sensitive MRI in the diagnosis of dementia with Lewy bodies"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-5792-5483","authenticated-orcid":true,"given":"Yuta","family":"Inagawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoya","family":"Inagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoto","family":"Takenoshita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryo","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akito","family":"Tsugawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mana","family":"Yoshimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiro","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soichiro","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,9,9]]},"reference":[{"issue":"10004","key":"pone.0309885.ref001","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0140-6736(15)00462-6","article-title":"Lewy body dementias","volume":"386","author":"Z Walker","year":"2015","journal-title":"Lancet"},{"issue":"2","key":"pone.0309885.ref002","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1468-1331.2008.02388.x","article-title":"Differences in clinical course between dementia with Lewy bodies and Alzheimer\u2019s disease","volume":"16","author":"H Hanyu","year":"2009","journal-title":"Eur J Neurol"},{"issue":"1","key":"pone.0309885.ref003","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1212\/WNL.0000000000004058","article-title":"Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium","volume":"89","author":"IG McKeith","year":"2017","journal-title":"Neurology"},{"issue":"6","key":"pone.0309885.ref004","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1111\/pcn.12179","article-title":"Latest concept of Lewy body disease.","volume":"68","author":"K. Kosaka","year":"2014","journal-title":"Psychiatry Clin Neurosci"},{"issue":"5","key":"pone.0309885.ref005","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.tins.2007.03.009","article-title":"Multiple hit hypotheses for dopamine neuron loss in Parkinson\u2019s disease","volume":"30","author":"D. Sulzer","year":"2007","journal-title":"Trends Neurosci"},{"issue":"9","key":"pone.0309885.ref006","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1212\/01.WNL.0000123248.39847.1D","article-title":"Striatal dopamine transporter in dementia with Lewy bodies and Parkinson disease: a comparison","volume":"62","author":"Z Walker","year":"2004","journal-title":"Neurology"},{"key":"pone.0309885.ref007","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/978-3-7091-6842-4_2","article-title":"Measurement of the dopaminergic degeneration in Parkinson\u2019s disease with [123I] beta-CIT and SPECT. Correlation with clinical findings and comparison with multiple system atrophy and progressive supranuclear palsy","volume":"50","author":"T Br\u00fccke","year":"1997","journal-title":"J Neural Transm Suppl"},{"issue":"Suppl 7","key":"pone.0309885.ref008","doi-asserted-by":"crossref","first-page":"S43","DOI":"10.1002\/mds.10579","article-title":"Correlation of dopamine transporter imaging with parkinsonian motor handicap: how close is it?","volume":"18","author":"W. 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A practical method for grading the cognitive state of patients for the clinician.","volume":"12","author":"MF Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"3","key":"pone.0309885.ref020","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer\u2019s disease: recommendations from the National Institute on Aging-Alzheimer\u2019s Association workgroups on diagnostic guidelines for Alzheimer\u2019s disease","volume":"7","author":"GM McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"issue":"1","key":"pone.0309885.ref021","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/mds.21198","article-title":"Movement Disorder Society-sponsored revision of the Unified Parkinson\u2019s Disease Rating Scale (MDS-UPDRS): Process, format, and clinimetric testing plan","volume":"22","author":"CG Goetz","year":"2007","journal-title":"Mov Disord"},{"issue":"2","key":"pone.0309885.ref022","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1007\/s00259-007-0621-0","article-title":"Dopamine transporter imaging with [(123)I]FP-CIT SPECT: potential effects of drugs","volume":"35","author":"J Booij","year":"2008","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"1","key":"pone.0309885.ref023","doi-asserted-by":"crossref","first-page":"154","DOI":"10.2967\/jnumed.111.100784","article-title":"SNM practice guideline for dopamine transporter imaging with 123I-ioflupane SPECT 1.0","volume":"53","author":"DS Djang","year":"2012","journal-title":"J Nucl Med"},{"issue":"9","key":"pone.0309885.ref024","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1002\/mds.27365","article-title":"Neuromelanin imaging and midbrain volumetry in progressive supranuclear palsy and Parkinson\u2019s disease","volume":"33","author":"D Taniguchi","year":"2018","journal-title":"Mov Disord"},{"issue":"4","key":"pone.0309885.ref025","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s00702-017-1688-9","article-title":"Neuromelanin MRI is useful for monitoring motor complications in Parkinson\u2019s and PARK2 disease","volume":"124","author":"T Hatano","year":"2017","journal-title":"J Neural Transm (Vienna)"},{"issue":"12","key":"pone.0309885.ref026","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00259-006-0155-x","article-title":"Quantification of [123I]FP-CIT SPECT brain images: an accurate technique for measurement of the specific binding ratio","volume":"33","author":"L Tossici-Bolt","year":"2006","journal-title":"Eur J Nucl Med Mol Imaging"},{"issue":"1","key":"pone.0309885.ref027","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00234-016-1773-z","article-title":"Diagnostic imaging of dementia with Lewy bodies by susceptibility-weighted imaging of nigrosomes versus striatal dopamine transporter single-photon emission computed tomography: a retrospective observational study.","volume":"59","author":"K Kamagata","year":"2017","journal-title":"Neuroradiology"},{"key":"pone.0309885.ref028","doi-asserted-by":"crossref","first-page":"120660","DOI":"10.1016\/j.jns.2023.120660","article-title":"Degeneration of nigrostriatal dopaminergic neurons in the early to intermediate stage of dementia with Lewy bodies and Parkinson\u2019s disease","volume":"449","author":"M Okitsu","year":"2023","journal-title":"J Neurol Sci"},{"issue":"1","key":"pone.0309885.ref029","first-page":"29","article-title":"The impact of DaTscan on the diagnosis and management of movement disorders: A retrospective study","volume":"2","author":"KD Seifert","year":"2013","journal-title":"Am J Neurodegener Dis"},{"issue":"2","key":"pone.0309885.ref030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/S0168-0102(02)00027-5","article-title":"Functional significance of the cortico-subthalamo-pallidal \u2019hyperdirect\u2019 pathway.","volume":"43","author":"A Nambu","year":"2002","journal-title":"Neurosci Res"},{"issue":"10","key":"pone.0309885.ref031","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1212\/WNL.58.10.1489","article-title":"Striatal dopamine transporter and extrapyramidal symptoms in frontotemporal dementia","volume":"58","author":"JO Rinne","year":"2002","journal-title":"Neurology"},{"issue":"9","key":"pone.0309885.ref032","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1212\/WNL.56.9.1143","article-title":"Practice parameter: diagnosis of dementia (an evidence-based review). 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