{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:49:29Z","timestamp":1790423369134,"version":"4.1.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"9","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"\nObjectives<\/jats:title>\nThis study aimed to examine the potential correlation between myosteatosis and the prognosis of patients diagnosed with liver cirrhosis by a meta-analysis.<\/jats:p>\n<\/jats:sec>\n\nMethods<\/jats:title>\nCohort studies of relevance were acquired through comprehensive searches of the Medline, Web of Science, and Embase databases. To account for heterogeneity, a random-effects model was employed to combine the findings.<\/jats:p>\n<\/jats:sec>\n\nResults<\/jats:title>\nThe meta-analysis included 10 retrospective and four prospective cohort studies, encompassing a total of 4287 patients diagnosed with cirrhosis. The pooled findings indicated a notable decline in transplant-free survival (TFS) among individuals with liver cirrhosis and myosteatosis compared to those without this condition (risk ratio: 1.94; 95% confidence interval: 1.61 to 2.34, p<\/jats:italic> < 0.001; I2<\/jats:sup> = 49%). The predefined subgroup analyses demonstrated consistent findings across various categories, including Asian and non-Asian studies, prospective and retrospective cohort studies, patients with cirrhosis overall and those who underwent transjugular intrahepatic portosystemic shunt, studies with different follow-up durations (< or \u2265 24 months), studies employing univariate and multivariate analyses, and studies with and without an adjustment for sarcopenia (p<\/jats:italic> > 0.05 for all subgroup differences). Additionally, Egger\u2019s regression test indicated the presence of significant publication bias (p<\/jats:italic> = 0.044). However, trim-and-fill analysis by including three hypothesized studies showed consistent results.<\/jats:p>\n<\/jats:sec>\n\nConclusions<\/jats:title>\nThe presence of myosteatosis in individuals diagnosed with liver cirrhosis may potentially be linked to a poor TFS prognosis. Further investigations are required to ascertain whether enhancing myosteatosis could potentially yield a survival advantage for this particular patient population.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0310017","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T17:34:08Z","timestamp":1726162448000},"page":"e0310017","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Myosteatosis and the clinical outcomes of patients with liver cirrhosis: A 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