{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:44:23Z","timestamp":1784691863835,"version":"3.55.0"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T00:00:00Z","timestamp":1732147200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Background<\/jats:title>\n<jats:p>The diagnosis of Meniere\u2019s Disease (MD) presents significant challenges due to its complex symptomatology and the absence of definitive biomarkers. Advancements in MRI technology have spotlighted endolymphatic hydrops (EH) as a key pathological marker, necessitating a reevaluation of its diagnostic utility amidst the need for standardized and validated MRI-based grading scales.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>Our meta-analysis scrutinized the diagnostic efficacy of semi-quantitative MRI-based cochlear endolymphatic hydrops (EH) and perilymphatic enhancement (PLE) grading systems in delineating clinically relevant discriminations: \u201cSpotting\u201d the shift from normal or asymptomatic ears to possible\/probable MD (pMD), \u201cConfirming\u201d the progression to definite MD (dMD), and \u201cEstablishing\u201d the presence of dMD. A thorough literature search up to October 2023 resulted in 35 pertinent studies, forming the basis of our analysis through a bivariate mixed-effects regression model.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>Using criteria from the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) and Barany Society, across varying thresholds and disease probabilities; the Establishment model at an EH grade 1 threshold revealed a sensitivity of 85.4% and a specificity of 82.7%. Adjusting the threshold to EH grade 2 results in a sensitivity increase to 92.1% (CI: 85.9\u201395.7) and a specificity decrease to 70.6% (CI: 64.5\u201376.1), with a DOR of 28.056 (CI: 14.917\u201352.770). The Confirmation model yields a DOR of 5.216, indicating a lower diagnostic accuracy. The Spotting model demonstrates a sensitivity of 48.3% (CI: 34.8\u201362.1) and a specificity of 88.0% (CI: 77.8\u201393.9), with a DOR of 6.882. The normal ears subgroup demonstrated a notably high specificity of 89.7%, while employing Nakashima\u2019s criteria resulted in a reduced sensitivity of 74.9%, significantly diverging from other systems (p-value &lt; 0.001). The PLE grading system showcased exceptional sensitivity of 98.4% (CI: 93.7\u201399.6, p-value &lt; 0.001).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>Our meta-analysis supports a tailored diagnostic approach for MD, emphasizing the need for effective grading systems at each stage. For \"Spotting,\" the model shows high specificity but requires improved sensitivity, suggesting additional criteria are needed. The \"Confirming\" stage highlights the need for refined, sensitive grading systems due to lower diagnostic accuracy. In the \"Establishing\" stage, an EH grade 1 threshold is effective, but grade 2 enhances sensitivity while reducing specificity, indicating a need for balance. The PLE grading system excels in sensitivity, making it highly reliable. High specificity in the normal ears subgroup confirms accurate non-pathological distinction, though Nakashima\u2019s criteria show reduced sensitivity, underscoring variability in grading systems. These findings advocate for a standardized, unified grading system balancing sensitivity and specificity across all MD stages to optimize diagnostics and clinical outcomes.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0310045","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T18:36:08Z","timestamp":1732214168000},"page":"e0310045","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":1,"title":["The diagnostic performance of cochlear endolymphatic hydrops and perilymphatic enhancement in stratifying M\u00e9ni\u00e8re\u2019s disease probabilities: A meta-analysis of semi-quantitative MRI-based grading 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