{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:15:20Z","timestamp":1791292520510,"version":"4.1.0"},"reference-count":15,"publisher":"Public Library of Science (PLoS)","issue":"10","license":[{"start":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T00:00:00Z","timestamp":1730246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:sec id=\"sec001\">\n<jats:title>Objective<\/jats:title>\n<jats:p>To describe the treatment outcomes of locally advanced cervical cancer managed with neoadjuvant chemotherapy (NACT) plus radical surgery at a gynecology oncology center in Ethiopia.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec002\">\n<jats:title>Methods<\/jats:title>\n<jats:p>This was a retrospective descriptive study of management of locally advanced cervical cancer (LACC) at St. Paul\u2019s Hospital Millennium Medical College (Ethiopia) over 5 years. Data were collected by reviewing patient records. Data were analyzed using SPSS version 23. Simple descriptive analysis was employed to analyze clinical, histologic, and treatment outcomes of LACC managed with NACT+ radical surgery. Frequency and proportions were used to present the results\u2019 significance.<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec003\">\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 98 patients were analyzed. One-third (31.6%) of cervical cancer patients with locally advanced disease were operable after neoadjuvant chemotherapy. Out of this, nodal metastasis was found in 2 patients (all pelvic lymph node metastasis). Disease recurrence within 2 years was 3% (1 recurrence within 6\u201312 months and 2 recurrences at 12\u201324 months).<\/jats:p>\n<\/jats:sec>\n<jats:sec id=\"sec004\">\n<jats:title>Conclusion<\/jats:title>\n<jats:p>This study supports utilization of NACT plus radical surgery for locally advanced cervical cancer, where chemoradiation is not readily available. Our findings imply that this treatment modality is a life-saving alternative treatment in a low-income setting, which is often married by shortage or unavailability of radiotherapy at the needed time before disease progression ensues.<\/jats:p>\n<\/jats:sec>","DOI":"10.1371\/journal.pone.0310457","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T17:38:21Z","timestamp":1730309901000},"page":"e0310457","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":2,"title":["Locally advanced cervical cancer: Neoadjuvant chemotherapy plus radical surgery an alternative approach to chemo-radiation in a low-income setting: A descriptive study"],"prefix":"10.1371","volume":"19","author":[{"given":"Malede","family":"Birara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadesse","family":"Urgie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5812-0804","authenticated-orcid":true,"given":"Abraham Fessehaye","family":"Sium","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2024,10,30]]},"reference":[{"issue":"2","key":"pone.0310457.ref001","doi-asserted-by":"crossref","first-page":"e191","DOI":"10.1016\/S2214-109X(19)30482-6","article-title":"Estimates of incidence and mortality of cervical cancer in 2018: a worldwide analysis.","volume":"8","author":"M Arbyn","year":"2020","journal-title":"The Lancet Global Health"},{"issue":"3","key":"pone.0310457.ref002","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1447-0756.2006.00404.x","article-title":"Randomized study of preoperative chemotherapy versus primary surgery for stage IB cervical cancer","volume":"32","author":"HB Cai","year":"2006","journal-title":"J Obstet Gynaecol Res"},{"key":"pone.0310457.ref003","doi-asserted-by":"crossref","first-page":"A39","DOI":"10.1016\/j.vaccine.2008.11.110","article-title":"Treatment of cervical cancer in Italy: strategies and their impact on the women","volume":"27","author":"R De Vincenzo","year":"2009","journal-title":"Vaccine"},{"issue":"1","key":"pone.0310457.ref004","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1097\/00001703-200102000-00010","article-title":"Locally advanced cervical cancer","volume":"13","author":"PG Rose","year":"2001","journal-title":"Current Opinion in Obstetrics and Gynecology"},{"issue":"1","key":"pone.0310457.ref005","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s00404-010-1385-5","article-title":"Radiochemotherapy versus radiotherapy in locally advanced cervical cancer: a meta-analysis","volume":"283","author":"N Wang","year":"2011","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"pone.0310457.ref006","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1200\/JCO.2002.20.1.179","article-title":"Neoadjuvant chemotherapy and radical surgery versus exclusive radiotherapy in locally advanced squamous cell cervical cancer: results from the Italian multicenter randomized study","volume":"20","author":"P Benedetti-Panici","year":"2002","journal-title":"Journal of Clinical Oncology"},{"issue":"8","key":"pone.0310457.ref007","article-title":"Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer","author":"F Kokka","year":"2022","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"8","key":"pone.0310457.ref008","first-page":"1840","article-title":"Randomized trial of neoadjuvant cisplatin, vincristine, bleomycin, and radical hysterectomy versus radiation therapy for bulky stage IB and IIA cervical cancer","volume":"18","author":"T-C Chang","year":"2000","journal-title":"Journal of Clinical Oncology"},{"issue":"2","key":"pone.0310457.ref009","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1089\/gyn.2009.0039","article-title":"A randomized trial of neoadjuvant chemotherapy followed by radical surgery versus radiotherapy alone in stage IIIb carcinoma of the uterine cervix","volume":"26","author":"Y Noriyuki","year":"2010","journal-title":"Journal Of Gynecologic Surgery"},{"issue":"8","key":"pone.0310457.ref010","article-title":"Hysterectomy with radiotherapy or chemotherapy or both for women with locally advanced cervical cancer","author":"F Kokka","year":"2022","journal-title":"Cochrane Database of Systematic Reviews"},{"issue":"3","key":"pone.0310457.ref011","doi-asserted-by":"crossref","first-page":"190","DOI":"10.4274\/tjod.galenos.2021.70493","article-title":"Neoadjuvant chemotherapy for locally advanced stage (IB2-IIA2-IIB) cervical carcinoma: Experience of a tertiary center and comprehensive review of the literature.","volume":"18","author":"C \u00c7ak\u0131r","year":"2021","journal-title":"Turk J Obstet Gynecol."},{"issue":"1","key":"pone.0310457.ref012","article-title":"Impact of neoadjuvant chemotherapy in improving operative intervention in the management of cervical cancer in low resource setting: a preliminary report.","volume":"36","author":"TO Nwankwo","year":"2020","journal-title":"Pan African Medical Journal"},{"key":"pone.0310457.ref013","first-page":"312","article-title":"Surgical treatment of early cervical cancer, Semin","volume":"9","author":"L. S. Morgan","year":"1982","journal-title":"Oncol"},{"key":"pone.0310457.ref014","first-page":"422","article-title":"Recurrent cancer of the cervix following radical hysterectomy and pelvic node dissection, Obstet.","volume":"59","author":"H. Krebs","year":"1982","journal-title":"Gyneol"},{"key":"pone.0310457.ref015","first-page":"422","article-title":"Recurrent cancer of the cervix following radical hysterectomy and pelvic node dissection, Obstet","volume":"59","author":"H. Krebs","year":"1982","journal-title":"Gyneol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0310457","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T17:38:27Z","timestamp":1730309907000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0310457"}},"subtitle":[],"editor":[{"given":"Nwamaka","family":"Lasebikan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2024,10,30]]},"references-count":15,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2024,10,30]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0310457","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,30]]}}}