{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T01:01:08Z","timestamp":1768093268143,"version":"3.49.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T00:00:00Z","timestamp":1731369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Shaanxi provincial People's Hospital Science and Technology Personnel Support Program","award":["No.2021LJ-02"],"award-info":[{"award-number":["No.2021LJ-02"]}]},{"name":"Key Research and development program of Shaanxi Province","award":["No.2022KWZ-20"],"award-info":[{"award-number":["No.2022KWZ-20"]}]},{"name":"Shaanxi provincial People's Hospital Science and Technology Development Incubation Fund","award":["2023YJ-22"],"award-info":[{"award-number":["2023YJ-22"]}]},{"name":"Key Research and development program of Shaanxi Province","award":["2024SF-YBXM-081"],"award-info":[{"award-number":["2024SF-YBXM-081"]}]},{"name":"Shaanxi Provincial Health and Medical Research Innovation Capacity Enhancement Plan","award":["2024PT-01"],"award-info":[{"award-number":["2024PT-01"]}]},{"name":"Shaanxi Province Innovation Capability Support Program Project","award":["S2024-ZC-TD-27"],"award-info":[{"award-number":["S2024-ZC-TD-27"]}]},{"name":"Shaanxi Provincal health high-level talent cultivation program"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"abstract":"<jats:p>To prevent the residual sulfur dioxide in Chinese herbal medicines (CHM) caused by sulfur fumigation, which may lead to severe health issues, there is an urgent need for a rapid and quantitative detection technique. Sodium borohydride was used as a reducing agent to convert sulfur dioxide into hydrogen sulfide, which was then detected using lead acetate test strip. An accurate testing apparatus was designed, consisting of reaction bottle cap, reaction bottle, lead acetate test strip, and sulfur dioxide detector. The effect of different reaction variables on detection, including reductant quality, pH of initial media, reaction time, lead acetate concentration, and membrane type was investigated. The optimal conditions were determined by orthogonal experiments. The reaction membrane type and lead acetate concentration on the membrane were optimized to enhance detection accuracy. Standardized gray cards were fabricated and used to calibrate the detector. The detection system demonstrated an exceptional linear correlation (r2 = 0.9992), with a linear detection range of 0\u2013750 mg\u00b7kg<jats:sup>\u22121<\/jats:sup>. The colored substances and sulfur-containing substances within the matrix of CHM did not affect the detection results. Therefore, the detection method exhibited superior accuracy and stability. The proposed technique proved to be swift, reliable, and provides a straightforward and convenient approach for the quantitative determination of sulfur dioxide in CHMs. The results of this work may provide insights into the development of test strips for quantitative detection.<\/jats:p>","DOI":"10.1371\/journal.pone.0310628","type":"journal-article","created":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T18:28:21Z","timestamp":1731436101000},"page":"e0310628","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":3,"title":["Lead acetate\u2013based test strip method for rapid and quantitative detection of residual sulfur dioxide in Chinese herbal medicines"],"prefix":"10.1371","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-352X","authenticated-orcid":true,"given":"Penghua","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoyan","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiyu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongliang","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cuixiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2024,11,12]]},"reference":[{"key":"pone.0310628.ref001","doi-asserted-by":"crossref","first-page":"21295","DOI":"10.1016\/j.jep.2017.10.023","article-title":"Effects of sulfur- fumigation on the pharmacokinetics, metabolites and analgesic activity of Radix Paeoniae Alba","volume":"212","author":"M. 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